• 1485 Citations
  • 22 h-Index
20082020

Research output per year

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Research Output

  • 1485 Citations
  • 22 h-Index
  • 50 Article
  • 16 Review article
  • 2 Comment/debate
  • 1 Chapter
2 Citations (Scopus)
2 Citations (Scopus)
1 Citation (Scopus)

Steering the antitumor drug discovery campaign towards structurally diverse indolines

Thakur, A., Singh, A., Kaur, N., Ojha, R. & Nepali, K., Jan 2020, In : Bioorganic Chemistry. 94, 103436.

Research output: Contribution to journalReview article

1 Citation (Scopus)
2019

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2 Citations (Scopus)

Benzoflavone derivatives as potent antihyperuricemic agents

Singh, J. V., Mal, G., Kaur, G., Gupta, M. K., Singh, A., Nepali, K., Singh, H., Sharma, S. & Bedi, S. P. M., Jan 1 2019, In : MedChemComm. 10, 1, p. 128-147 20 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Correction: Benzoflavone derivatives as potent antihyperuricemic agents(MedChemCommun (2019) DOI: 10.1039/c8md00512e)

Singh, J. V., Mal, G., Kaur, G., Gupta, M. K., Singh, A. P., Nepali, K., Singh, H., Sharma, S. & Bedi, P. M. S., Jan 1 2019, In : MedChemComm. 10, 1, 1 p.

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Nitro-Group-Containing Drugs

Nepali, K., Lee, H. Y. & Liou, J. P., Mar 28 2019, In : Journal of Medicinal Chemistry. 62, 6, p. 2851-2893 43 p.

Research output: Contribution to journalReview article

68 Citations (Scopus)
2018

(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo

Lee, H. Y., Nepali, K., Huang, F. I., Chang, C. Y., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Feb 8 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 905-917 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC

Ojha, R., Huang, H. L., HuangFu, W. C., Wu, Y. W., Nepali, K., Lai, M. J., Su, C. J., Sung, T. Y., Chen, Y. L., Pan, S. L. & Liou, J. P., Apr 25 2018, In : European Journal of Medicinal Chemistry. 150, p. 667-677 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Antitumour, acute toxicity and molecular modeling studies of 4-(pyridin-4-yl)-6-(thiophen-2-yl) pyrimidin-2(1H)-one against Ehrlich ascites carcinoma and sarcoma-180

Kumar, D., Sharma, P., Nepali, K., Mahajan, G., Mintoo, M. J., Singh, A., Singh, G., Mondhe, D. M., Singh, G., Jain, S. K., Gupta, G. K. & Ntie-Kang, F., Jun 1 2018, In : Heliyon. 4, 6, e00661.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Correction: 2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition (Org. Biomol. Chem. (2016) 14 (716-723))

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J. Y., Liou, J. P. & Lee, H. Y., Jan 1 2018, In : Organic and Biomolecular Chemistry. 16, 25, p. 4734 1 p.

Research output: Contribution to journalArticle

2017

An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015)

Ojha, R., Singh, J., Ojha, A., Singh, H., Sharma, S. & Nepali, K., Mar 4 2017, In : Expert Opinion on Therapeutic Patents. 27, 3, p. 311-345 35 p.

Research output: Contribution to journalReview article

27 Citations (Scopus)

Benzoflavones as cholesterol esterase inhibitors: Synthesis, biological evaluation and docking studies

Singh, H., Singh, J. V., Gupta, M. K., Singh, P., Sharma, S., Nepali, K. & Bedi, P. M. S., Jan 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 4, p. 850-854 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Hydroxamic acids as potent antioxidants and their methods of evaluation

Mehndiratta, S., Nepali, K. & Satapathy, M. K., Oct 24 2017, Oxidative Stress: Diagnostic Methods and Applications in Medical Science. Springer Singapore, p. 97-112 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Idiopathic pulmonary fibrosis: Current status, recent progress, and emerging targets

Liu, Y. M., Nepali, K. & Liou, J. P., Jan 26 2017, In : Journal of Medicinal Chemistry. 60, 2, p. 527-553 27 p.

Research output: Contribution to journalReview article

38 Citations (Scopus)

Ring-opened tetrahydro-γ-carbolines display cytotoxicity and selectivity with histone deacetylase isoforms

Nepali, K., Lee, H-Y., Lai, M-J., Ojha, R., Wu, T. Y., Wu, G. X., Chen, M-C. & Liou, J-P., Feb 15 2017, In : European Journal of Medicinal Chemistry. 127, p. 115-127 13 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Synthesis, screening and docking of fused pyrano[3,2-d]pyrimidine derivatives as xanthine oxidase inhibitor

Kaur, M., Kaur, A., Mankotia, S., Singh, H., Singh, A., Singh, J. V., Gupta, M. K., Sharma, S., Nepali, K. & Bedi, P. M. S., Jan 1 2017, In : European Journal of Medicinal Chemistry. 131, p. 14-28 15 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

The value of pyrans as anticancer scaffolds in medicinal chemistry

Kumar, D., Sharma, P., Singh, H., Nepali, K., Gupta, G. K., Jain, S. K. & Ntie-Kang, F., Jan 1 2017, In : RSC Advances. 7, 59, p. 36977-36999 23 p.

Research output: Contribution to journalReview article

50 Citations (Scopus)

Triazole tethered isatin-coumarin based molecular hybrids as novel antitubulin agents: Design, synthesis, biological investigation and docking studies

Singh, H., Singh, J. V., Gupta, M. K., Saxena, A. K., Sharma, S., Nepali, K. & Bedi, P. M. S., Jan 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 17, p. 3974-3979 6 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)
2016

Design strategies, structure activity relationship and mechanistic insights for purines as kinase inhibitors

Sharma, S., Singh, J., Ojha, R., Singh, H., Kaur, M., Bedi, P. M. S. & Nepali, K., Apr 13 2016, In : European Journal of Medicinal Chemistry. 112, p. 298-346 49 p.

Research output: Contribution to journalReview article

28 Citations (Scopus)

Early investigational tubulin inhibitors as novel cancer therapeutics

Nepali, K., Ojha, R., Lee, H. Y. & Liou, J. P., Aug 2 2016, In : Expert Opinion on Investigational Drugs. 25, 8, p. 917-936 20 p.

Research output: Contribution to journalReview article

17 Citations (Scopus)

Estimation of crotepoxide in the fruits of Piper attenuatum buch.-ham. using high-performance thin layer chromatography and high- performance liquid chromatography

Kumar, S., Gauttam, V., Bande, M. S. R., Nepali, K., Tyagi, A. & Dhar, K. L., Jan 1 2016, In : Current Pharmaceutical Analysis. 12, 4, p. 343-348 6 p.

Research output: Contribution to journalArticle

Naphthoflavones as antiproliferative agents: Design, synthesis and biological evaluation

Kumar, D., Singh, O., Nepali, K., Bedi, P. M. S., Qayum, A., Singh, S. & Jain, S. K., Jul 1 2016, In : Anti-Cancer Agents in Medicinal Chemistry. 16, 7, p. 881-890 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Quinazolines as apoptosis inducers and inhibitors: A review of patent literature

Mehndiratta, S., Sapra, S., Singh, G., Singh, M. & Nepali, K., Feb 1 2016, In : Recent Patents on Anti-Cancer Drug Discovery. 11, 1, p. 2-66 65 p.

Research output: Contribution to journalReview article

10 Citations (Scopus)

Topoisomerase I and II inhibitors: A patent review

Singh, A., Kaur, N., Singh, G., Sharma, P., Bedi, P. M. S., Sharma, S. & Nepali, K., Nov 1 2016, In : Recent Patents on Anti-Cancer Drug Discovery. 11, 4, p. 401-423 23 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)

Triazole tethered C5-curcuminoid-coumarin based molecular hybrids as novel antitubulin agents: Design, synthesis, biological investigation and docking studies

Singh, H., Kumar, M., Nepali, K., Gupta, M. K., Saxena, A. K., Sharma, S. & Bedi, P. M. S., Jun 30 2016, In : European Journal of Medicinal Chemistry. 116, p. 102-115 14 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
2015

2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J. Y., Liou, J. P. & Lee, H. Y., 2015, In : Organic and Biomolecular Chemistry. 14, 2, p. 716-723 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

4,6-diaryl pyrimidones as constrained chalcone analogues: Design, synthesis and evaluation as antiproliferative agents

Kumar, D., Nepali, K., Bedi, P. M. S., Kumar, S., Malik, F. & Jain, S., Jul 1 2015, In : Anti-Cancer Agents in Medicinal Chemistry. 15, 6, p. 793-803 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Anti-cancer pyrimidines in diverse scaffolds: A review of patent literature

Kaur, R., Kaur, P., Sharma, S., Singh, G., Mehndiratta, S., Bedi, P. M. S. & Nepali, K., Jan 1 2015, In : Recent Patents on Anti-Cancer Drug Discovery. 10, 1, p. 23-71 49 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Design, synthesis and evaluation of 2,4-diarylpyrano[3,2-c]chromen-5(4H)-one as a new class of non-purine xanthine oxidase inhibitors

Virdi, H. S., Sharma, S., Mehndiratta, S., Bedi, P. M. S. & Nepali, K., Sep 3 2015, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 30, 5, p. 730-736 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Purine analogues as kinase inhibitors: A review

Sharma, S., Mehndiratta, S., Kumar, S., Singh, J., Bedi, P. M. S. & Nepali, K., Oct 1 2015, In : Recent Patents on Anti-Cancer Drug Discovery. 10, 3, p. 308-341 34 p.

Research output: Contribution to journalReview article

19 Citations (Scopus)

Screening of a library of 4-aryl/heteroaryl-4H-fused pyrans for xanthine oxidase inhibition: Synthesis, biological evaluation and docking studies

Kaur, R., Naaz, F., Sharma, S., Mehndiratta, S., Gupta, M. K., Bedi, P. M. S. & Nepali, K., Aug 23 2015, In : Medicinal Chemistry Research. 24, 8, p. 3334-3349 16 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2014

4,6-Diaryl/heteroarylpyrimidin-2(1H)-ones as a new class of xanthine oxidase inhibitors

Shukla, S., Kumar, D., Ojha, R., Gupta, M. K., Nepali, K. & Bedi, P. M. S., Jan 1 2014, In : Archiv der Pharmazie. 347, 7, p. 486-495 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Anti-asthmatic activity of azepino [2, 1-b] quinazolones, synthetic analogues of vasicine, an alkaloid from Adhatoda vasica

Rayees, S., Satti, N. K., Mehra, R., Nargotra, A., Rasool, S., Sharma, A., Sahu, P. K., Rajnikant, Gupta, V. K., Nepali, K. & Singh, G., Aug 5 2014, In : Medicinal Chemistry Research. 23, 9, p. 4269-4279 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Anticancer hybrids- a patent survey

Nepali, K., Sharma, S., Kumar, D., Budhiraja, A. & Dhar, K. L., Jan 1 2014, In : Recent Patents on Anti-Cancer Drug Discovery. 9, 3, p. 303-339 37 p.

Research output: Contribution to journalReview article

32 Citations (Scopus)

Chalcone based azacarboline analogues as novel antitubulin agents: Design, synthesis, biological evaluation and molecular modelling studies

Sharma, S., Kaur, C., Budhiraja, A., Nepali, K., Gupta, M. K., Saxena, A. K. & Bedi, P. M. S., Oct 6 2014, In : European Journal of Medicinal Chemistry. 85, p. 648-660 13 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Microwave assisted synthesis of naphthopyrans catalysed by silica supported fluoroboric acid as a new class of non purine xanthine oxidase inhibitors

Sharma, S., Sharma, K., Ojha, R., Kumar, D., Singh, G., Nepali, K. & Bedi, P. M. S., Jan 15 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 2, p. 495-500 6 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids

Nepali, K., Sharma, S., Sharma, M., Bedi, P. M. S. & Dhar, K. L., Apr 22 2014, In : European Journal of Medicinal Chemistry. 77, p. 422-487 66 p.

Research output: Contribution to journalReview article

243 Citations (Scopus)

Synthesis and cytotoxicity studies of 3,5-diaryl N-acetyl pyrazoline - Isatin hybrids

Sharma, M., Sharma, S., Buddhiraja, A., Saxena, A. K., Nepali, K. & Bedi, P. M. S., Oct 1 2014, In : Medicinal Chemistry Research. 23, 10, p. 4337-4344 8 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Synthesis and evaluation of naphthoflavones as a new class of non purine xanthine oxidase inhibitors This Letter is dedicated to Dr. K. L. Dhar on the occasion of his 78th birthday.

Singh, H., Sharma, S., Ojha, R., Gupta, M. K., Nepali, K. & Bedi, P. M. S., Sep 1 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 17, p. 4192-4197 6 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Tubulin inhibitors: A patent survey

Nepali, K., Ojha, R., Sharma, S., Bedi, P. M. S. & Dhar, K. L., Jan 1 2014, In : Recent Patents on Anti-Cancer Drug Discovery. 9, 2, p. 176-220 45 p.

Research output: Contribution to journalReview article

27 Citations (Scopus)
2013

Aza analogs of flavones as potential antimicrobial agents

Sharma, S., Thakur, V., Ojha, R., Budhiraja, A., Nepali, K. & Singh Bedi, P. M., May 1 2013, In : Letters in Drug Design and Discovery. 10, 4, p. 327-334 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Bioactive metabolites from an endophytic fungus of Aspergillus species isolated from seeds of Gloriosa superba Linn.

Budhiraja, A., Nepali, K., Sapra, S., Gupta, S., Kumar, S. & Dhar, K. L., Jan 1 2013, In : Medicinal Chemistry Research. 22, 1, p. 323-329 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Colchicine and its various physicochemical and biological aspects

Sapra, S., Bhalla, Y., Nandani, Sharma, S., Singh, G., Nepali, K., Budhiraja, A. & Dhar, K. L., Feb 1 2013, In : Medicinal Chemistry Research. 22, 2, p. 531-547 17 p.

Research output: Contribution to journalReview article

20 Citations (Scopus)

Design, synthesis and evaluation of arylidene pyrrolo and pyrido fused quinazolones as antimicrobial agents

Nepali, K., Ojha, R., Singh, A., Budhiraja, A., Bedi, P. M. S. & Dhar, K. L., Jul 1 2013, In : Letters in Drug Design and Discovery. 10, 6, p. 522-528 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Design and synthesis of aza-flavones as a new class of xanthine oxidase inhibitors

Dhiman, R., Sharma, S., Singh, G., Nepali, K. & Singh Bedi, P. M., Jan 1 2013, In : Archiv der Pharmazie. 346, 1, p. 7-16 10 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)