Ku-Chung Chen

Department of Biochemistry and Molecular Cell Biology

https://orcid.org/0000-0002-4696-3924

Emailkuchung@tmu.edu.tw

Source: Scopus
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Personal profile

Education

2005-2009 Ph.D., Institute of Biomedical Sciences, National Sun Yat-sen University
1998-2000 M.S., Department of Biochemistry, Kaohsiung Medical University
1994-1998 B.S., Department of Medical Laboratory and Biotechnology, Chung Shan Medical University

Experience

2017.08- Associate Professor, Department of Biochemistry and molecular cell biology, School of Medicine, Taipei Medical University,Taiwan
2012.10-2017.07 Assistant Professor, Department of Biochemistry and molecular cell biology, School of Medicine, Taipei Medical University,Taiwan
2012.08-2012.09 Assistant Researcher, Department of Biochemistry and molecular cell biology, School of Medicine, Taipei Medical University,Taiwan
2009.10-2012.08 Postdoctoral Fellow, School of Medicine, Kaohsiung Medical University, Taiwan

Research Interests

Medical biochemistry and molecular biology
cellular signaling transduction
Epigenetic regulation
microRNA regulation
glioma tumorigenesis

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1 Active
12 Finished

探討 ABCC3 調控基因/lncRNA 網絡，進而評估其抑制藥物 Fidaxomicin 作為增強 temozolomide 對腦瘤毒殺能力佐劑之可行性
Chen, K.
8/1/20 → 7/1/21
Project: A - Government Institution › b - Ministry of Science and Technology
The Roles of Microrna Sponge-Like Long Non-Coding Rnas (Lncrnas) in Progression and Temozolomide Chemoresistance of Glioblastoma(3/3)
Chen, K.
8/1/19 → 7/31/20
Project: A - Government Institution › b - Ministry of Science and Technology
The Roles of Microrna Sponge-Like Long Non-Coding Rnas (Lncrnas) in Progression and Temozolomide Chemoresistance of Glioblastoma
Chen, K.
8/1/18 → 7/1/19
Project: A - Government Institution › b - Ministry of Science and Technology
The Roles of Microrna Sponge-Like Long Non-Coding Rnas (Lncrnas) in Progression and Temozolomide Chemoresistance of Glioblastoma
Chen, K.
8/1/17 → 7/31/18
Project: A - Government Institution › b - Ministry of Science and Technology
探討受甲基化調控 MicroRNA-4792參與 Temozolomide腦瘤抗藥性形成之分子機轉
Chen, K.
3/1/17 → 2/28/18
Project: C - Project of Alliance › q - Cathay General Hospital

1718 Citations
24 h-Index
75 Article
1 Comment/debate

A Key Role of DNA Damage-Inducible Transcript 4 (DDIT4) Connects Autophagy and GLUT3-Mediated Stemness To Desensitize Temozolomide Efficacy in Glioblastomas
Ho, K. H., Chen, P. H., Chou, C. M., Shih, C. M., Lee, Y. T., Cheng, C. H. & Chen, K. C., Jan 1 2020, (Accepted/In press) In: Neurotherapeutics. 17, 3, p. 1212-1227 16 p.
Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus)
Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women
Wong, J. Y. Y., Zhang, H., Hsiung, C. A., Shiraishi, K., Yu, K., Matsuo, K., Wong, M. P., Hong, Y. C., Wang, J., Seow, W. J., Wang, Z., Song, M., Kim, H. N., Chang, I. S., Chatterjee, N., Hu, W., Wu, C., Mitsudomi, T., Zheng, W., Kim, J. H. & 166 others, Seow, A., Caporaso, N. E., Shin, M. H., Chung, L. P., An, S. J., Wang, P., Yang, Y., Zheng, H., Yatabe, Y., Zhang, X. C., Kim, Y. T., Cai, Q., Yin, Z., Kim, Y. C., Bassig, B. A., Chang, J., Ho, J., Ji, B. T., Daigo, Y., Ito, H., Momozawa, Y., Ashikawa, K., Kamatani, Y., Honda, T., Hosgood, H. D., Sakamoto, H., Kunitoh, H., Tsuta, K., Watanabe, S. I., Kubo, M., Miyagi, Y., Nakayama, H., Matsumoto, S., Tsuboi, M., Goto, K., Shi, J., Song, L., Hua, X., Takahashi, A., Goto, A., Minamiya, Y., Shimizu, K., Tanaka, K., Wei, F., Matsuda, F., Su, J., Kim, Y. H., Oh, I. J., Song, F., Su, W. C., Chen, Y. M., Chang, G. C., Chen, K. Y., Huang, M. S., Chien, L. H., Xiang, Y. B., Park, J. Y., Kweon, S. S., Chen, C. J., Lee, K. M., Blechter, B., Li, H., Gao, Y. T., Qian, B., Lu, D., Liu, J., Jeon, H. S., Hsiao, C. F., Sung, J. S., Tsai, Y. H., Jung, Y. J., Guo, H., Hu, Z., Wang, W. C., Chung, C. C., Burdett, L., Yeager, M., Hutchinson, A., Berndt, S. I., Wu, W., Pang, H., Li, Y., Choi, J. E., Park, K. H., Sung, S. W., Liu, L., Kang, C. H., Zhu, M., Chen, C. H., Yang, T. Y., Xu, J., Guan, P., Tan, W., Wang, C. L., Hsin, M., Sit, K. Y., Ho, J., Chen, Y., Choi, Y. Y., Hung, J. Y., Kim, J. S., Yoon, H. I., Lin, C. C., Park, I. K., Xu, P., Wang, Y., He, Q., Perng, R. P., Chen, C. Y., Vermeulen, R., Wu, J., Lim, W. Y., Chen, K. C., Li, Y. J., Li, J., Chen, H., Yu, C. J., Jin, L., Chen, T. Y., Jiang, S. S., Liu, J., Yamaji, T., Hicks, B., Wyatt, K., Li, S. A., Dai, J., Ma, H., Jin, G., Song, B., Wang, Z., Cheng, S., Li, X., Ren, Y., Cui, P., Iwasaki, M., Shimazu, T., Tsugane, S., Zhu, J., Yang, K., Jiang, G., Fei, K., Wu, G., Lin, H. C., Chen, H. L., Fang, Y. H., Tsai, F. Y., Hsieh, W. S., Yu, J., Stevens, V. L., Laird-Offringa, I. A., Marconett, C. N., Rieswijk, L., Chao, A., Yang, P. C., Shu, X. O., Wu, T., Wu, Y. L., Lin, D., Chen, K., Zhou, B., Huang, Y. C., Kohno, T., Shen, H., Chanock, S. J., Rothman, N. & Lan, Q., Mar 2020, In: Genomics. 112, 2, p. 1223-1232 10 p.
Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus)
Dietary flavonoids luteolin and quercetin inhibit migration and invasion of squamous carcinoma through reduction of src/stat3/s100a7 signaling
Fan, J. J., Hsu, W. H., Lee, K. H., Chen, K. C., Lin, C. W., Lee, Y. L. A., Ko, T. P., Lee, L. T., Lee, M. T., Chang, M. S. & Cheng, C. H., Nov 2019, In: Antioxidants. 8, 11, 557.
Research output: Contribution to journal › Article › peer-review

Open Access
14 Citations (Scopus)
IGF-1-enhanced miR-513a-5p signaling desensitizes glioma cells to temozolomide by targeting the NEDD4L-inhibited Wnt/β-catenin pathway
Chen, K. C., Chen, P. H., Ho, K. H., Shih, C. M., Chou, C. M., Cheng, C. H. & Lee, C. C., Jan 1 2019, In: PLoS ONE. 14, 12, e0225913.
Research output: Contribution to journal › Article › peer-review

Open Access
2 Citations (Scopus)
miR-140 targeting CTSB signaling suppresses the mesenchymal transition and enhances temozolomide cytotoxicity in glioblastoma multiforme
Ho, K. H., Cheng, C. H., Chou, C. M., Chen, P. H., Liu, A. J., Lin, C. W., Shih, C. M. & Chen, K. C., Sep 2019, In: Pharmacological Research. 147, 104390.
Research output: Contribution to journal › Article › peer-review
16 Citations (Scopus)