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Ku-Chung Chen

Associate Professor

 https://orcid.org/0000-0002-4696-3924
  • 1641 Citations
  • 24 h-Index
19992020

Research output per year

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Personal profile

Education

  • 2005-2009 Ph.D., Institute of Biomedical Sciences, National Sun Yat-sen University
  • 1998-2000 M.S., Department of Biochemistry, Kaohsiung Medical University
  • 1994-1998 B.S., Department of Medical Laboratory and Biotechnology, Chung Shan Medical University

Experience

  • 2017.08- Associate Professor, Department of Biochemistry and molecular cell biology, School of Medicine, Taipei Medical University,Taiwan
  • 2012.10-2017.07 Assistant Professor, Department of Biochemistry and molecular cell biology, School of Medicine, Taipei Medical University,Taiwan
  • 2012.08-2012.09 Assistant Researcher, Department of Biochemistry and molecular cell biology, School of Medicine, Taipei Medical University,Taiwan
  • 2009.10-2012.08 Postdoctoral Fellow, School of Medicine, Kaohsiung Medical University, Taiwan

Research Interests

  • Medical biochemistry and molecular biology
  • cellular signaling transduction
  • Epigenetic regulation
  • microRNA regulation
  • glioma tumorigenesis

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Projects

探討 ABCC3 調控基因/lncRNA 網絡，進而評估其抑制藥物 Fidaxomicin 作為增強 temozolomide 對腦瘤毒殺能力佐劑之可行性

Chen, K.

8/1/20 → 7/1/21

Project: A - Government Institution › b - Ministry of Science and Technology

The Roles of Microrna Sponge-Like Long Non-Coding Rnas (Lncrnas) in Progression and Temozolomide Chemoresistance of Glioblastoma(3/3)

Chen, K.

8/1/19 → 7/31/20

Project: A - Government Institution › b - Ministry of Science and Technology

The Roles of Microrna Sponge-Like Long Non-Coding Rnas (Lncrnas) in Progression and Temozolomide Chemoresistance of Glioblastoma

Chen, K.

8/1/18 → 7/1/19

Project: A - Government Institution › b - Ministry of Science and Technology

The Roles of Microrna Sponge-Like Long Non-Coding Rnas (Lncrnas) in Progression and Temozolomide Chemoresistance of Glioblastoma

Chen, K.

8/1/17 → 7/31/18

Project: A - Government Institution › b - Ministry of Science and Technology

探討受甲基化調控 MicroRNA-4792參與 Temozolomide腦瘤抗藥性形成之分子機轉

Chen, K.

3/1/17 → 2/28/18

Project: C - Project of Alliance › q - Cathay General Hospital

Research Output

  • 1641 Citations
  • 24 h-Index
  • 75 Article
  • 1 Comment/debate

A Key Role of DNA Damage-Inducible Transcript 4 (DDIT4) Connects Autophagy and GLUT3-Mediated Stemness To Desensitize Temozolomide Efficacy in Glioblastomas

Ho, K. H., Chen, P. H., Chou, C. M., Shih, C. M., Lee, Y. T., Cheng, C. H. & Chen, K. C., Jan 1 2020, (Accepted/In press) In : Neurotherapeutics.

Research output: Contribution to journal › Article

    • 1 Citation (Scopus)

    Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

    Wong, J. Y. Y., Zhang, H., Hsiung, C. A., Shiraishi, K., Yu, K., Matsuo, K., Wong, M. P., Hong, Y. C., Wang, J., Seow, W. J., Wang, Z., Song, M., Kim, H. N., Chang, I. S., Chatterjee, N., Hu, W., Wu, C., Mitsudomi, T., Zheng, W., Kim, J. H. & 166 others, Seow, A., Caporaso, N. E., Shin, M. H., Chung, L. P., An, S. J., Wang, P., Yang, Y., Zheng, H., Yatabe, Y., Zhang, X. C., Kim, Y. T., Cai, Q., Yin, Z., Kim, Y. C., Bassig, B. A., Chang, J., Ho, J., Ji, B. T., Daigo, Y., Ito, H., Momozawa, Y., Ashikawa, K., Kamatani, Y., Honda, T., Hosgood, H. D., Sakamoto, H., Kunitoh, H., Tsuta, K., Watanabe, S. I., Kubo, M., Miyagi, Y., Nakayama, H., Matsumoto, S., Tsuboi, M., Goto, K., Shi, J., Song, L., Hua, X., Takahashi, A., Goto, A., Minamiya, Y., Shimizu, K., Tanaka, K., Wei, F., Matsuda, F., Su, J., Kim, Y. H., Oh, I. J., Song, F., Su, W. C., Chen, Y. M., Chang, G. C., Chen, K. Y., Huang, M. S., Chien, L. H., Xiang, Y. B., Park, J. Y., Kweon, S. S., Chen, C. J., Lee, K. M., Blechter, B., Li, H., Gao, Y. T., Qian, B., Lu, D., Liu, J., Jeon, H. S., Hsiao, C. F., Sung, J. S., Tsai, Y. H., Jung, Y. J., Guo, H., Hu, Z., Wang, W. C., Chung, C. C., Burdett, L., Yeager, M., Hutchinson, A., Berndt, S. I., Wu, W., Pang, H., Li, Y., Choi, J. E., Park, K. H., Sung, S. W., Liu, L., Kang, C. H., Zhu, M., Chen, C. H., Yang, T. Y., Xu, J., Guan, P., Tan, W., Wang, C. L., Hsin, M., Sit, K. Y., Ho, J., Chen, Y., Choi, Y. Y., Hung, J. Y., Kim, J. S., Yoon, H. I., Lin, C. C., Park, I. K., Xu, P., Wang, Y., He, Q., Perng, R. P., Chen, C. Y., Vermeulen, R., Wu, J., Lim, W. Y., Chen, K. C., Li, Y. J., Li, J., Chen, H., Yu, C. J., Jin, L., Chen, T. Y., Jiang, S. S., Liu, J., Yamaji, T., Hicks, B., Wyatt, K., Li, S. A., Dai, J., Ma, H., Jin, G., Song, B., Wang, Z., Cheng, S., Li, X., Ren, Y., Cui, P., Iwasaki, M., Shimazu, T., Tsugane, S., Zhu, J., Yang, K., Jiang, G., Fei, K., Wu, G., Lin, H. C., Chen, H. L., Fang, Y. H., Tsai, F. Y., Hsieh, W. S., Yu, J., Stevens, V. L., Laird-Offringa, I. A., Marconett, C. N., Rieswijk, L., Chao, A., Yang, P. C., Shu, X. O., Wu, T., Wu, Y. L., Lin, D., Chen, K., Zhou, B., Huang, Y. C., Kohno, T., Shen, H., Chanock, S. J., Rothman, N. & Lan, Q., Mar 2020, In : Genomics. 112, 2, p. 1223-1232 10 p.

    Research output: Contribution to journal › Article

    • 1 Citation (Scopus)

    Dietary flavonoids luteolin and quercetin inhibit migration and invasion of squamous carcinoma through reduction of src/stat3/s100a7 signaling

    Fan, J. J., Hsu, W. H., Lee, K. H., Chen, K. C., Lin, C. W., Lee, Y. L. A., Ko, T. P., Lee, L. T., Lee, M. T., Chang, M. S. & Cheng, C. H., Nov 2019, In : Antioxidants. 8, 11, 557.

    Research output: Contribution to journal › Article

    Open Access
    • 11 Citations (Scopus)

    IGF-1-enhanced miR-513a-5p signaling desensitizes glioma cells to temozolomide by targeting the NEDD4L-inhibited Wnt/β-catenin pathway

    Chen, K. C., Chen, P. H., Ho, K. H., Shih, C. M., Chou, C. M., Cheng, C. H. & Lee, C. C., Jan 1 2019, In : PLoS ONE. 14, 12, e0225913.

    Research output: Contribution to journal › Article

    Open Access
    • 2 Citations (Scopus)

    miR-140 targeting CTSB signaling suppresses the mesenchymal transition and enhances temozolomide cytotoxicity in glioblastoma multiforme

    Ho, K. H., Cheng, C. H., Chou, C. M., Chen, P. H., Liu, A. J., Lin, C. W., Shih, C. M. & Chen, K. C., Sep 2019, In : Pharmacological Research. 147, 104390.

    Research output: Contribution to journal › Article

    • 10 Citations (Scopus)