Ku-Chung Chen

Personal profile

Research Interests

Medical biochemistry and molecular biology
cellular signaling transduction
Epigenetic regulation
microRNA regulation
glioma tumorigenesis

Education

2005-2009 PhD Institute of Biomedical Sciences, National Sun Yat-sen University, Taiwan
1998-2000 M.S Department of Biochemistry, Kaohsiung Medical University, Taiwan
1994-1995 B.S. Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taiwan

Experience

Associate Professor, Department of Biochemistry and molecular cell biology, School of Medicine, Taipei Medical University,Taiwan
2012.10-2017.07 Assistant Professor, Department of Biochemistry and molecular cell biology, School of Medicine, Taipei Medical University,Taiwan
2012.08-2012.09 Assistant Researcher, Department of Biochemistry and molecular cell biology, School of Medicine, Taipei Medical University,Taiwan
2009.10-2012.08 Postdoctoral Fellow, School of Medicine, Kaohsiung Medical University, Taiwan

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MicroRNAs Medicine & Life Sciences

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Phospholipases A2 Chemical Compounds

Chemical activation Chemical Compounds

Cells Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

探討 microRNA sponge-like long non-coding RNAs (lncRNAs) 在腦瘤進程及temozolomide 抗藥性機轉發生時所扮演的角色(3/3)

Chen, K.

8/1/19 → 7/1/20

Project: A - Government Institution › b - Ministry of Science and Technology

陳顧中-107研究計畫績效獎

Chen, K.

8/1/18 → 7/31/20

Project: B - Project of TMU › h - Other (Funded by TMU)

探討 microRNA sponge-like long non-coding RNAs (lncRNAs) 在腦瘤進程及temozolomide 抗藥性機轉發生時所扮演的角色(2/3)

Chen, K.

8/1/18 → 7/1/19

Project: A - Government Institution › b - Ministry of Science and Technology

探討 microRNA sponge-like long non-coding RNAs (lncRNAs) 在腦瘤進程及temozolomide 抗藥性機轉發生時所扮演的角色(1/3)

Chen, K.

8/1/17 → 7/31/18

Project: A - Government Institution › b - Ministry of Science and Technology

探討受甲基化調控 MicroRNA-4792參與 Temozolomide腦瘤抗藥性形成之分子機轉

Chen, K.

3/1/17 → 2/28/18

Project: C - Project of Alliance › p - Cathay General Hospital

Research Output 1999 2019

1402 Citations
21 h-Index
70 Article
1 Comment/debate

Phthalate plasticizer di(2-ethyl-hexyl) phthalate induces cyclooxygenase-2 expression in gastric adenocarcinoma cells

Wong, J. H., Wang, Y. S., Nam, S., Ho, K. H., Chang, C. M., Chen, K. C., Chen, Y. F. & Chang, W. C., Jan 1 2019, In : Environmental Toxicology.

Research output: Contribution to journal › Article

Plasticizers

phthalate

Cyclooxygenase 2

Stomach

Adenocarcinoma

1 Citation (Scopus)

Reduction in MnSOD promotes the migration and invasion of squamous carcinoma cells

Fan, J. J., Hsu, W. H., Hung, H. H., Zhang, W. J., A Lee, Y. L., Chen, K. C., Chu, C. Y., Ko, T. P., Lee, M. T., Lin, C. W. & Cheng, C. H., Apr 1 2019, In : International Journal of Oncology. 54, 5, p. 1639-1650 12 p.

Research output: Contribution to journal › Article

Open Access

Superoxide Dismutase

Squamous Cell Carcinoma

Reactive Oxygen Species

Luteolin

Cell Line

Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

Wong, J. Y. Y., Zhang, H., Hsiung, C. A., Shiraishi, K., Yu, K., Matsuo, K., Wong, M. P., Hong, Y. C., Wang, J., Seow, W. J., Wang, Z., Song, M., Kim, H. N., Chang, I. S., Chatterjee, N., Hu, W., Wu, C., Mitsudomi, T., Zheng, W., Kim, J. H. & 166 others, Seow, A., Caporaso, N. E., Shin, M. H., Chung, L. P., An, S. J., Wang, P., Yang, Y., Zheng, H., Yatabe, Y., Zhang, X. C., Kim, Y. T., Cai, Q., Yin, Z., Kim, Y. C., Bassig, B. A., Chang, J., Ho, J., Ji, B. T., Daigo, Y., Ito, H., Momozawa, Y., Ashikawa, K., Kamatani, Y., Honda, T., Hosgood, H. D., Sakamoto, H., Kunitoh, H., Tsuta, K., Watanabe, S. I., Kubo, M., Miyagi, Y., Nakayama, H., Matsumoto, S., Tsuboi, M., Goto, K., Shi, J., Song, L., Hua, X., Takahashi, A., Goto, A., Minamiya, Y., Shimizu, K., Tanaka, K., Wei, F., Matsuda, F., Su, J., Kim, Y. H., Oh, I. J., Song, F., Su, W. C., Chen, Y. M., Chang, G. C., Chen, K. Y., Huang, M. S., Chien, L. H., Xiang, Y. B., Park, J. Y., Kweon, S. S., Chen, C. J., Lee, K. M., Blechter, B., Li, H., Gao, Y. T., Qian, B., Lu, D., Liu, J., Jeon, H. S., Hsiao, C. F., Sung, J. S., Tsai, Y. H., Jung, Y. J., Guo, H., Hu, Z., Wang, W. C., Chung, C. C., Burdett, L., Yeager, M., Hutchinson, A., Berndt, S. I., Wu, W., Pang, H., Li, Y., Choi, J. E., Park, K. H., Sung, S. W., Liu, L., Kang, C. H., Zhu, M., Chen, C. H., Yang, T. Y., Xu, J., Guan, P., Tan, W., Wang, C. L., Hsin, M., Sit, K. Y., Ho, J., Chen, Y., Choi, Y. Y., Hung, J. Y., Kim, J. S., Yoon, H. I., Lin, C. C., Park, I. K., Xu, P., Wang, Y., He, Q., Perng, R. P., Chen, C. Y., Vermeulen, R., Wu, J., Lim, W. Y., Chen, K. C., Li, Y. J., Li, J., Chen, H., Yu, C. J., Jin, L., Chen, T. Y., Jiang, S. S., Liu, J., Yamaji, T., Hicks, B., Wyatt, K., Li, S. A., Dai, J., Ma, H., Jin, G., Song, B., Wang, Z., Cheng, S., Li, X., Ren, Y., Cui, P., Iwasaki, M., Shimazu, T., Tsugane, S., Zhu, J., Yang, K., Jiang, G., Fei, K., Wu, G., Lin, H. C., Chen, H. L., Fang, Y. H., Tsai, F. Y., Hsieh, W. S., Yu, J., Stevens, V. L., Laird-Offringa, I. A., Marconett, C. N., Rieswijk, L., Chao, A., Yang, P. C., Shu, X. O., Wu, T., Wu, Y. L., Lin, D., Chen, K., Zhou, B., Huang, Y. C., Kohno, T., Shen, H., Chanock, S. J., Rothman, N. & Lan, Q., Jan 1 2019, In : Genomics.

Research output: Contribution to journal › Article

Mendelian Randomization Analysis

Genome-Wide Association Study

Tuberculosis

Smoking

Infection

5 Citations (Scopus)

Activation of fibroblasts by nicotine promotes the epithelial-mesenchymal transition and motility of breast cancer cells

Chen, P. C., Lee, W. Y., Ling, H. H., Cheng, C. H., Chen, K. C. & Lin, C. W., Jan 1 2018, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journal › Article

Epithelial-Mesenchymal Transition

Fibroblasts

Nicotine

Chemical activation

Cells

10 Citations (Scopus)

Flavonoids Luteolin and Quercetin Inhibit RPS19 and contributes to metastasis of cancer cells through c-Myc reduction

Chen, K. C., Hsu, W. H., Ho, J. Y., Lin, C. W., Chu, C. Y., Kandaswami, C. C., Lee, M. T. & Cheng, C. H., Jan 1 2018, (Accepted/In press) In : Journal of Food and Drug Analysis.

Research output: Contribution to journal › Article

Luteolin

luteolin

Quercetin

Flavonoids

metastasis