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Research Output

  • 1648 Citations
  • 21 h-Index
  • 34 Article
  • 4 Review article
  • 2 Comment/debate
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Article
2020

A multicenter, phase I/II trial of biweekly S-1, leucovorin, oxaliplatin and gemcitabine in metastatic pancreatic adenocarcinoma–TCOG T1211 study

Chiang, N. J., Tsai, K. K., Hsiao, C. F., Yang, S. H., Hsiao, H. H., Shen, W. C., Hsu, C., Lin, Y. L., Chen, J. S., Shan, Y. S. & Chen, L. T., Jan 2020, In : European Journal of Cancer. 124, p. 123-130 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma

Liao, W. Y., Hsu, C. C., Chan, T. S., Yen, C. J., Chen, W. Y., Pan, H. W. & Tsai, K. K., Mar 10 2020, In : Stem Cell Reports. 14, 3, p. 462-477 16 p.

Research output: Contribution to journalArticle

Open Access
2019

ASPM promotes prostate cancer stemness and progression by augmenting Wnt−Dvl-3−β-catenin signaling

Pai, V. C., Hsu, C. C., Chan, T. S., Liao, W. Y., Chuu, C. P., Chen, W-Y., Li, C. R., Lin, C. Y., Huang, S. P., Chen, L. T. & Tsai, K. K., Feb 21 2019, In : Oncogene. 38, 8, p. 1340-1353 14 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Histone demethylase KDM4C stimulates the proliferation of prostate cancer cells via activation of AKT and c-Myc

Lin, C. Y., Wang, B. J., Chen, B. C., Tseng, J. C., Jiang, S. S., Tsai, K. K., Shen, Y. Y., Yuh, C. H., Sie, Z. L., Wang, W. C., Kung, H. J. & Chuu, C. P., Nov 13 2019, In : Cancers. 11, 11, 1785.

Research output: Contribution to journalArticle

Open Access

The differential distributions of ASPM isoforms and their roles in Wnt signaling, cell cycle progression, and pancreatic cancer prognosis

Hsu, C. C., Liao, W. Y., Chan, T. S., Chen, W. Y., Lee, C. T., Shan, Y. S., Huang, P. J., Hou, Y. C., Li, C. R. & Tsai, K. K., Dec 1 2019, In : Journal of Pathology. 249, 4, p. 498-508 11 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)
2018
18 Citations (Scopus)
2017

Stress stimuli induce cancer-stemness gene expression via Sp1 activation leading to therapeutic resistance in glioblastoma

Chang, K. Y., Huang, C. T., Hsu, T. I., Hsu, C. C., Liu, J. J., Chuang, C. K., Hung, J. J., Chang, W. C., Tsai, K. K. & Chuang, J. Y., Nov 4 2017, In : Biochemical and Biophysical Research Communications. 493, 1, p. 14-19 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2016

Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells

Chan, T. S., Hsu, C. C., Pai, V. C., Liao, W. Y., Huang, S. S., Tan, K. T., Yen, C. J., Hsu, S. C., Chen, W. Y., Shan, Y. S., Li, C. R., Lee, M. T., Jiang, K. Y., Chu, J. M., Lien, G. S., Weaver, V. M. & Tsai, K-C., 2016, In : Journal of Experimental Medicine. 213, 13, p. 2967-2988 22 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
2015

Targeting chemotherapy-induced PTX3 in tumor stroma to prevent the progression of drug-resistant cancers

Chi, J. Y., Hsiao, Y. W., Li, C. F., Lo, Y. C., Lin, Z. Y., Hong, J. Y., Liu, Y. M., Han, X., Wang, S. M., Chen, B. K., Tsai, K-C. & Wang, J. M., 2015, In : Oncotarget. 6, 27, p. 23987-24001 15 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2014

Cancer/stroma interplay via cyclooxygenase-2 and indoleamine 2,3-dioxygenase promotes breast cancer progression

Chen, J. Y., Li, C. F., Kuo, C. C., Tsai, K. K., Hou, M. F. & Hung, W. C., Jul 25 2014, In : Breast Cancer Research. 16, 4, 410.

Research output: Contribution to journalArticle

67 Citations (Scopus)
2013

A gene expression signature of epithelial tubulogenesis and a role for ASPM in pancreatic tumor progression

Wang, W. Y., Hsu, C. C., Wang, T. Y., Li, C. R., Hou, Y. C., Chu, J. M., Lee, C. T., Liu, M. S., Su, J. J. M., Jian, K. Y., Huang, S. S., Jiang, S. S., Shan, Y. S., Lin, P. W., Shen, Y. Y., Lee, M. T. L., Chan, T. S., Chang, C. C., Chen, C. H., Chang, I. S. & 3 others, Lee, Y. L., Chen, L. T. & Tsai, K-C., Nov 2013, In : Gastroenterology. 145, 5, p. 1110-1120 11 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Cholestane-3β, 5α, 6β-triol Suppresses Proliferation, Migration, and Invasion of Human Prostate Cancer Cells

Lin, C. Y., Huo, C., Kuo, L. K., Hiipakka, R. A., Jones, R. B., Lin, H. P., Hung, Y., Su, L. C., Tseng, J. C., Kuo, Y. Y., Wang, L. Y., Fukui, Y., Kao, Y. H., Kokontis, J. M., Yeh, C. C., Chen, L., Yang, S. D., Fu, H. H., Chen, Y. W., Tsai, K-C. & 2 others, Chang, J. Y. & Chuu, C. P., Jun 13 2013, In : PLoS One. 8, 6, e65734.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Complete microscale profiling of tumor microangiogenesis. A microradiological methodology reveals fundamental aspects of tumor angiogenesis and yields an array of quantitative parameters for its characterization.

Chien, C. C., Kempson, I. M., Wang, C. L., Chen, H., Hwu, Y., Chen, Y. N., Lee, T-K., Tsai, K. K. C., Liu, M. S., Chang, K. Y., Yang, C. S. & Margaritondo, G., May 2013, In : Biotechnology Advances. 31, 3, p. 396-401 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer

Li, C. R., Su, J. J. M., Wang, W. Y., Lee, M. T. L., Wang, T. Y., Jiang, K. Y., Li, C. F., Hsu, J. M., Chen, C. K., Chen, M., Jiang, S. S., Weaver, V. M. & Tsai, K. K. C., Feb 2013, In : American Journal of Pathology. 182, 2, p. 363-374 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2012

Control of cyclooxygenase-2 expression and tumorigenesis by endogenous 5-methoxytryptophan

Cheng, H. H., Kuo, C. C., Yan, J. L., Chen, H. L., Lin, W. C., Wang, K. H., Tsai, K. K. C., Guvén, H., Flaberg, E., Szekelyd, L., Klein, G. & Wu, K. K., Aug 14 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 33, p. 13231-13236 6 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Effects of intravenous iron saccharate on improving severe anemia in rheumatoid arthritis patients

Chen, W. S., Liu, C. Y., Lee, H. T., Tsai, K., Lin, Y. C., Tarng, D. C., Ho, C. H. & Lin, H. Y., Mar 1 2012, In : Clinical Rheumatology. 31, 3, p. 469-477 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Krüppel-like factor 10 expression as a prognostic indicator for pancreatic adenocarcinoma

Chang, V. H. S., Chu, P. Y., Peng, S. L., Mao, T. L., Shan, Y. S., Hsu, C. F., Lin, C. Y., Tsai, K-C., Yu, W. C. Y. & Ch'Ang, H. J., Aug 2012, In : American Journal of Pathology. 181, 2, p. 423-430 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

The Skp2-SCF E3 ligase regulates akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis

Chan, C. H., Li, C. F., Yang, W. L., Gao, Y., Lee, S. W., Feng, Z., Huang, H. Y., Tsai, K. K. C., Flores, L. G., Shao, Y., Hazle, J. D., Yu, D., Wei, W., Sarbassov, D. D., Hung, M. C., Nakayama, K. I. & Lin, H. K., May 25 2012, In : Cell. 149, 5, p. 1098-1111 14 p.

Research output: Contribution to journalArticle

213 Citations (Scopus)
2010

HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype

Gilbert, P. M., Mouw, J. K., Unger, M. A., Lakins, J. N., Gbegnon, M. K., Clemmer, V. B., Benezra, M., Licht, J. D., Boudreau, N. J., Tsai, K. K. C., Welm, A. L., Feldman, M. D., Weber, B. L. & Weaver, V. M., May 3 2010, In : Journal of Clinical Investigation. 120, 5, p. 1535-1550 16 p.

Research output: Contribution to journalArticle

Open Access
72 Citations (Scopus)
2009

Low-dose radiation-induced senescent stromal fibroblasts render nearby breast cancer cells radioresistant

Tsai, K. K. C., Stuart, J., Chuang, Y. Y. E., Little, J. B. & Yuan, Z. M., Sep 2009, In : Radiation Research. 172, 3, p. 306-313 8 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2008

Deleterious effects of short-term, high-intensity exercise on immune function: Evidence from leucocyte mitochondrial alterations and apoptosis

Tuan, T. C., Hsu, T. G., Fong, M. C., Hsu, C. F., Tsai, K. K. C., Lee, C. Y. & Kong, C. W., Jan 2008, In : British Journal of Sports Medicine. 42, 1, p. 11-15 5 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)
2005

c-Abl regulates Early Growth Response Protein (EGR1) in response to oxidative stress

Stuart, J. R., Kawai, H., Tsai, K. K. C., Chuang, E. Y. & Yuan, Z. M., Dec 8 2005, In : Oncogene. 24, 55, p. 8085-8092 8 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Cellular mechanisms for low-dose ionizing radiation-induced perturbation of the breast tissue microenvironment

Tsai, K. K. C., Chuang, Y. Y. E., Little, J. B. & Yuan, Z. M., Aug 1 2005, In : Cancer Research. 65, 15, p. 6734-6744 11 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)
2004

Leukocyte mitochondrial alterations after cardiac surgery involving cardiopulmonary bypass: clinical correlations.

Kong, C. W., Huang, C. H., Hsu, T. G., Tsai, K. K. C., Hsu, C. F., Huang, M. C. & Chen, C. L., Apr 2004, In : Shock. 21, 4, p. 315-319 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2003

c-Abl stabilizes p73 by a phosphorylation-augmented interaction

Tsai, K. K. C. & Yuan, Z. M., Jun 15 2003, In : Cancer Research. 63, 12, p. 3418-3424 7 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

DNA Damage-induced MDMX Degradation Is Mediated by MDM2

Kawai, H., Wiederschain, D., Kitao, H., Stuart, J., Tsai, K. K. C. & Yuan, Z. M., Nov 14 2003, In : Journal of Biological Chemistry. 278, 46, p. 45946-45953 8 p.

Research output: Contribution to journalArticle

138 Citations (Scopus)
2002

Effect of baicalein on apoptosis of the human Hep G2 cell line was induced by mitochondrial dysfunction

Chang, W. H., Chen, C. H., Gau, R. J., Lin, C. C., Tsai, C. L., Tsai, K. & Lu, F. J., 2002, In : Planta Medica. 68, 4, p. 302-306 5 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Leukocyte mitochondria alterations after aerobic exercise in trained human subjects

Hsu, T. G., Hsu, K. M., Kong, C. W., Lu, F. J., Cheng, H. & Tsai, K., 2002, In : Medicine and Science in Sports and Exercise. 34, 3, p. 438-442 5 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)
2001

Age-related changes in the mitochondrial depolarization induced by oxidative injury in human peripheral blood leukocytes

Tsai, K., Hsu, T. G., Lu, F. J., Hsu, C. F., Liu, T. Y. & Kong, C. W., 2001, In : Free Radical Research. 35, 4, p. 395-403 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Leukocyte mitochondria depolarization and apoptosis in advanced heart failure: Clinical correlations and effect of therapy

Kong, C. W., Hsu, T. G., Lu, F. J., Chan, W. L. & Tsai, K., Nov 15 2001, In : Journal of the American College of Cardiology. 38, 6, p. 1693-1700 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Oxidative DNA damage in human peripheral leukocytes induced by massive aerobic exercise

Tsai, K., Hsu, T. G., Hsu, K. M., Cheng, H., Liu, T. Y., Hsu, C. F. & Kong, C. W., Dec 1 2001, In : Free Radical Biology and Medicine. 31, 11, p. 1465-1472 8 p.

Research output: Contribution to journalArticle

178 Citations (Scopus)
2000

Is the endogenous peroxyl-radical scavenging capacity of plasma protective in systemic inflammatory disorders in humans?

Tsai, K., Hsu, T. G., Kong, C. W., Lin, K. C. & Fung-Jou, L. U., Mar 15 2000, In : Free Radical Biology and Medicine. 28, 6, p. 926-933 8 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Magnolol attenuates peroxidative damage and improves survival of rats with sepsis

Kong, C. W., Tsai, K., Chin, J. H., Chan, W. L. & Hong, C. Y., Jan 2000, In : Shock. 13, 1, p. 24-28 5 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)
1998

Oxidative stress: An important phenomenon with pathogenetic significance in the progression of acute pancreatitis

Tsai, K., Wang, S. S., Chen, T-G., Kong, C-W., Chang, F-Y., Lee, S-D. & Lu, F. J., 1998, In : Gut. 42, 6, p. 850-855 6 p.

Research output: Contribution to journalArticle

127 Citations (Scopus)