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Research Output 1998 2020

  • 1539 Citations
  • 20 h-Index
  • 33 Article
  • 4 Review article
  • 2 Comment/debate
2020

A multicenter, phase I/II trial of biweekly S-1, leucovorin, oxaliplatin and gemcitabine in metastatic pancreatic adenocarcinoma–TCOG T1211 study

Chiang, N. J., Tsai, K. K., Hsiao, C. F., Yang, S. H., Hsiao, H. H., Shen, W. C., Hsu, C., Lin, Y. L., Chen, J. S., Shan, Y. S. & Chen, L. T., Jan 2020, In : European Journal of Cancer. 124, p. 123-130 8 p.

Research output: Contribution to journalArticle

oxaliplatin
gemcitabine
Leucovorin
Adenocarcinoma
irinotecan
2019
6 Citations (Scopus)

ASPM promotes prostate cancer stemness and progression by augmenting Wnt−Dvl-3−β-catenin signaling

Pai, V. C., Hsu, C. C., Chan, T. S., Liao, W. Y., Chuu, C. P., Chen, W-Y., Li, C. R., Lin, C. Y., Huang, S. P., Chen, L. T. & Tsai, K. K., Feb 21 2019, In : Oncogene. 38, 8, p. 1340-1353 14 p.

Research output: Contribution to journalArticle

Catenins
Microcephaly
Prostatic Neoplasms
Neoplastic Stem Cells
Neoplasms
3 Citations (Scopus)

Correction: ASPM promotes prostate cancer stemness and progression by augmenting Wnt−Dvl-3−β-catenin signaling (Oncogene, (2019), 38, 8, (1340-1353), 10.1038/s41388-018-0497-4)

Pai, V. C., Hsu, C. C., Chan, T. S., Liao, W. Y., Chuu, C. P., Chen, W-Y., Li, C. R., Lin, C. Y., Huang, S. P., Chen, L. T. & Tsai, K. K., Feb 21 2019, In : Oncogene. 38, 8, p. 1354 1 p.

Research output: Contribution to journalComment/debate

Catenins
Oncogenes
Prostatic Neoplasms

Histone demethylase KDM4C stimulates the proliferation of prostate cancer cells via activation of AKT and c-Myc

Lin, C. Y., Wang, B. J., Chen, B. C., Tseng, J. C., Jiang, S. S., Tsai, K. K., Shen, Y. Y., Yuh, C. H., Sie, Z. L., Wang, W. C., Kung, H. J. & Chuu, C. P., Nov 2019, In : Cancers. 11, 11, 1785.

Research output: Contribution to journalArticle

Open Access
Histone Demethylases
Prostatic Neoplasms
Prostate
Androgen Receptors
Cell Proliferation
Open Access
Neoplastic Stem Cells
Mesenchymal Stromal Cells
Fibroblasts
Carcinoma
Neoplasms
2 Citations (Scopus)

The differential distributions of ASPM isoforms and their roles in Wnt signaling, cell cycle progression, and pancreatic cancer prognosis

Hsu, C. C., Liao, W. Y., Chan, T. S., Chen, W. Y., Lee, C. T., Shan, Y. S., Huang, P. J., Hou, Y. C., Li, C. R. & Tsai, K. K., Dec 1 2019, In : Journal of Pathology. 249, 4, p. 498-508 11 p.

Research output: Contribution to journalArticle

Open Access
Microcephaly
Pancreatic Neoplasms
Cell Cycle
Protein Isoforms
Adenocarcinoma
6 Citations (Scopus)

The multifaceted role of mesenchymal stem cells in cancer

Timaner, M., Tsai, K. K. & Shaked, Y., Jan 1 2019, (Accepted/In press) In : Seminars in Cancer Biology.

Research output: Contribution to journalReview article

Mesenchymal Stromal Cells
Neoplasms
Multipotent Stem Cells
Epithelial-Mesenchymal Transition
Mesoderm
2018
16 Citations (Scopus)
Proton Pump Inhibitors
Hepatocellular Carcinoma
Confidence Intervals
Hepatitis C
Hepatitis B
2017
19 Citations (Scopus)

Metronomic Chemotherapy: Direct Targeting of Cancer Cells after all?

André, N., Tsai, K., Carré, M. & Pasquier, E., May 1 2017, In : Trends in Cancer. 3, 5, p. 319-325 7 p.

Research output: Contribution to journalReview article

Drug Therapy
Neoplasms
Immunotherapy
Immune System
Therapeutics
3 Citations (Scopus)

Stress stimuli induce cancer-stemness gene expression via Sp1 activation leading to therapeutic resistance in glioblastoma

Chang, K. Y., Huang, C. T., Hsu, T. I., Hsu, C. C., Liu, J. J., Chuang, C. K., Hung, J. J., Chang, W. C., Tsai, K. K. & Chuang, J. Y., Nov 4 2017, In : Biochemical and Biophysical Research Communications. 493, 1, p. 14-19 6 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Glioblastoma
Gene expression
Chemical activation
temozolomide

The novel roles of stromal fibroblasts in metronomic chemotherapy: Focusing on cancer stemness and immunity

Liao, W-Y., Chan, T-S. & Tsai, K. K., 2017, In : 台灣癌症醫學雜誌. 4, 4, p. 123-126 4 p.

Research output: Contribution to journalReview article

Immunity
Fibroblasts
Drug Therapy
Neoplasms
Carcinoma
2016
41 Citations (Scopus)

Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells

Chan, T. S., Hsu, C. C., Pai, V. C., Liao, W. Y., Huang, S. S., Tan, K. T., Yen, C. J., Hsu, S. C., Chen, W. Y., Shan, Y. S., Li, C. R., Lee, M. T., Jiang, K. Y., Chu, J. M., Lien, G. S., Weaver, V. M. & Tsai, K-C., 2016, In : Journal of Experimental Medicine. 213, 13, p. 2967-2988 22 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Drug Therapy
Neoplasms
Therapeutics
Chemokines
2015
22 Citations (Scopus)

Targeting chemotherapy-induced PTX3 in tumor stroma to prevent the progression of drug-resistant cancers

Chi, J. Y., Hsiao, Y. W., Li, C. F., Lo, Y. C., Lin, Z. Y., Hong, J. Y., Liu, Y. M., Han, X., Wang, S. M., Chen, B. K., Tsai, K-C. & Wang, J. M., 2015, In : Oncotarget. 6, 27, p. 23987-24001 15 p.

Research output: Contribution to journalArticle

Drug Therapy
CCAAT-Enhancer-Binding Protein-delta
Pharmaceutical Preparations
Neoplasms
Tumor Microenvironment
2014
58 Citations (Scopus)

Cancer/stroma interplay via cyclooxygenase-2 and indoleamine 2,3-dioxygenase promotes breast cancer progression

Chen, J. Y., Li, C. F., Kuo, C. C., Tsai, K. K., Hou, M. F. & Hung, W. C., Jul 25 2014, In : Breast Cancer Research. 16, 4, 410.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Cyclooxygenase 2
Breast Neoplasms
Neoplasms
Fibroblasts
2013
28 Citations (Scopus)

A gene expression signature of epithelial tubulogenesis and a role for ASPM in pancreatic tumor progression

Wang, W. Y., Hsu, C. C., Wang, T. Y., Li, C. R., Hou, Y. C., Chu, J. M., Lee, C. T., Liu, M. S., Su, J. J. M., Jian, K. Y., Huang, S. S., Jiang, S. S., Shan, Y. S., Lin, P. W., Shen, Y. Y., Lee, M. T. L., Chan, T. S., Chang, C. C., Chen, C. H., Chang, I. S. & 3 others, Lee, Y. L., Chen, L. T. & Tsai, K-C., Nov 2013, In : Gastroenterology. 145, 5, p. 1110-1120 11 p.

Research output: Contribution to journalArticle

Morphogenesis
Transcriptome
Adenocarcinoma
Neoplasms
Gene Expression
30 Citations (Scopus)

Cholestane-3β, 5α, 6β-triol Suppresses Proliferation, Migration, and Invasion of Human Prostate Cancer Cells

Lin, C. Y., Huo, C., Kuo, L. K., Hiipakka, R. A., Jones, R. B., Lin, H. P., Hung, Y., Su, L. C., Tseng, J. C., Kuo, Y. Y., Wang, L. Y., Fukui, Y., Kao, Y. H., Kokontis, J. M., Yeh, C. C., Chen, L., Yang, S. D., Fu, H. H., Chen, Y. W., Tsai, K-C. & 2 others, Chang, J. Y. & Chuu, C. P., Jun 13 2013, In : PLoS One. 8, 6, e65734.

Research output: Contribution to journalArticle

prostatic neoplasms
Prostatic Neoplasms
Cells
cadherins
cells
7 Citations (Scopus)

Complete microscale profiling of tumor microangiogenesis. A microradiological methodology reveals fundamental aspects of tumor angiogenesis and yields an array of quantitative parameters for its characterization.

Chien, C. C., Kempson, I. M., Wang, C. L., Chen, H., Hwu, Y., Chen, Y. N., Lee, T-K., Tsai, K. K. C., Liu, M. S., Chang, K. Y., Yang, C. S. & Margaritondo, G., May 2013, In : Biotechnology Advances. 31, 3, p. 396-401 6 p.

Research output: Contribution to journalArticle

Tumors
Neoplasms
Angiogenesis Inhibitors
Oncology
Microanalysis
11 Citations (Scopus)

Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer

Li, C. R., Su, J. J. M., Wang, W. Y., Lee, M. T. L., Wang, T. Y., Jiang, K. Y., Li, C. F., Hsu, J. M., Chen, C. K., Chen, M., Jiang, S. S., Weaver, V. M. & Tsai, K. K. C., Feb 2013, In : American Journal of Pathology. 182, 2, p. 363-374 12 p.

Research output: Contribution to journalArticle

Apoptosis Regulatory Proteins
Morphogenesis
Prostatic Neoplasms
Prostate
Neoplasms
2012
38 Citations (Scopus)

Control of cyclooxygenase-2 expression and tumorigenesis by endogenous 5-methoxytryptophan

Cheng, H. H., Kuo, C. C., Yan, J. L., Chen, H. L., Lin, W. C., Wang, K. H., Tsai, K. K. C., Guvén, H., Flaberg, E., Szekelyd, L., Klein, G. & Wu, K. K., Aug 14 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 33, p. 13231-13236 6 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Carcinogenesis
Neoplasms
Tryptophan
Acetylserotonin O-Methyltransferase
8 Citations (Scopus)

Effects of intravenous iron saccharate on improving severe anemia in rheumatoid arthritis patients

Chen, W. S., Liu, C. Y., Lee, H. T., Tsai, K., Lin, Y. C., Tarng, D. C., Ho, C. H. & Lin, H. Y., Mar 1 2012, In : Clinical Rheumatology. 31, 3, p. 469-477 9 p.

Research output: Contribution to journalArticle

saccharated ferric oxide
Anemia
Rheumatoid Arthritis
Iron
Hemoglobins
4 Citations (Scopus)

Erratum: The Skp2-SCF E3 ligase regulates akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis (Cell (2012) 149 (1098-1111))

Chan, C. H., Li, C. F., Yang, W. L., Gao, Y., Lee, S. W., Feng, Z., Huang, H. Y., Tsai, K. K. C., Flores, L. G., Shao, Y., Hazle, J. D., Yu, D., Wei, W., Sarbassov, D., Hung, M. C., Nakayama, K. I. & Lin, H. K., Nov 9 2012, In : Cell. 151, 4, p. 913-914 2 p.

Research output: Contribution to journalComment/debate

18 Citations (Scopus)

Krüppel-like factor 10 expression as a prognostic indicator for pancreatic adenocarcinoma

Chang, V. H. S., Chu, P. Y., Peng, S. L., Mao, T. L., Shan, Y. S., Hsu, C. F., Lin, C. Y., Tsai, K-C., Yu, W. C. Y. & Ch'Ang, H. J., Aug 2012, In : American Journal of Pathology. 181, 2, p. 423-430 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Transforming Growth Factors
Methylation
Methyltransferases
197 Citations (Scopus)

The Skp2-SCF E3 ligase regulates akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis

Chan, C. H., Li, C. F., Yang, W. L., Gao, Y., Lee, S. W., Feng, Z., Huang, H. Y., Tsai, K. K. C., Flores, L. G., Shao, Y., Hazle, J. D., Yu, D., Wei, W., Sarbassov, D. D., Hung, M. C., Nakayama, K. I. & Lin, H. K., May 25 2012, In : Cell. 149, 5, p. 1098-1111 14 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Ubiquitination
Glycolysis
TNF Receptor-Associated Factor 6
Carcinogenesis
2010
71 Citations (Scopus)

HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype

Gilbert, P. M., Mouw, J. K., Unger, M. A., Lakins, J. N., Gbegnon, M. K., Clemmer, V. B., Benezra, M., Licht, J. D., Boudreau, N. J., Tsai, K. K. C., Welm, A. L., Feldman, M. D., Weber, B. L. & Weaver, V. M., May 3 2010, In : Journal of Clinical Investigation. 120, 5, p. 1535-1550 16 p.

Research output: Contribution to journalArticle

Open Access
Homeobox Genes
Breast Neoplasms
Phenotype
Aggression
Breast
2009
30 Citations (Scopus)

Low-dose radiation-induced senescent stromal fibroblasts render nearby breast cancer cells radioresistant

Tsai, K. K. C., Stuart, J., Chuang, Y. Y. E., Little, J. B. & Yuan, Z. M., Sep 2009, In : Radiation Research. 172, 3, p. 306-313 8 p.

Research output: Contribution to journalArticle

fibroblasts
breast
Fibroblasts
cancer
Radiation
2008
51 Citations (Scopus)

Deleterious effects of short-term, high-intensity exercise on immune function: Evidence from leucocyte mitochondrial alterations and apoptosis

Tuan, T. C., Hsu, T. G., Fong, M. C., Hsu, C. F., Tsai, K. K. C., Lee, C. Y. & Kong, C. W., Jan 2008, In : British Journal of Sports Medicine. 42, 1, p. 11-15 5 p.

Research output: Contribution to journalArticle

Leukocytes
Exercise
Apoptosis
Membrane Potentials
Neutrophils
2005
23 Citations (Scopus)

c-Abl regulates Early Growth Response Protein (EGR1) in response to oxidative stress

Stuart, J. R., Kawai, H., Tsai, K. K. C., Chuang, E. Y. & Yuan, Z. M., Dec 8 2005, In : Oncogene. 24, 55, p. 8085-8092 8 p.

Research output: Contribution to journalArticle

Early Growth Response Protein 1
Oxidative Stress
Growth
Phosphotransferases
Apoptosis
81 Citations (Scopus)

Cellular mechanisms for low-dose ionizing radiation-induced perturbation of the breast tissue microenvironment

Tsai, K. K. C., Chuang, Y. Y. E., Little, J. B. & Yuan, Z. M., Aug 1 2005, In : Cancer Research. 65, 15, p. 6734-6744 11 p.

Research output: Contribution to journalArticle

Ionizing Radiation
Breast
Fibroblasts
Secreted Matrix Metalloproteinases
Carcinogenesis
2004
6 Citations (Scopus)

Leukocyte mitochondrial alterations after cardiac surgery involving cardiopulmonary bypass: clinical correlations.

Kong, C. W., Huang, C. H., Hsu, T. G., Tsai, K. K. C., Hsu, C. F., Huang, M. C. & Chen, C. L., Apr 2004, In : Shock. 21, 4, p. 315-319 5 p.

Research output: Contribution to journalArticle

Cardiopulmonary Bypass
Membrane Potentials
Thoracic Surgery
Leukocytes
Oxidants
2003
83 Citations (Scopus)

c-Abl stabilizes p73 by a phosphorylation-augmented interaction

Tsai, K. K. C. & Yuan, Z. M., Jun 15 2003, In : Cancer Research. 63, 12, p. 3418-3424 7 p.

Research output: Contribution to journalArticle

Phosphorylation
Protein Isoforms
Cisplatin
DNA Damage
Tyrosine
136 Citations (Scopus)

DNA Damage-induced MDMX Degradation Is Mediated by MDM2

Kawai, H., Wiederschain, D., Kitao, H., Stuart, J., Tsai, K. K. C. & Yuan, Z. M., Nov 14 2003, In : Journal of Biological Chemistry. 278, 46, p. 45946-45953 8 p.

Research output: Contribution to journalArticle

DNA Damage
Chemical activation
Degradation
DNA
Proto-Oncogene Proteins c-mdm2
2002
54 Citations (Scopus)

Effect of baicalein on apoptosis of the human Hep G2 cell line was induced by mitochondrial dysfunction

Chang, W. H., Chen, C. H., Gau, R. J., Lin, C. C., Tsai, C. L., Tsai, K. & Lu, F. J., 2002, In : Planta Medica. 68, 4, p. 302-306 5 p.

Research output: Contribution to journalArticle

Hep G2 Cells
Cells
Apoptosis
Mitochondria
Mitochondrial Membrane Potential
53 Citations (Scopus)

Leukocyte mitochondria alterations after aerobic exercise in trained human subjects

Hsu, T. G., Hsu, K. M., Kong, C. W., Lu, F. J., Cheng, H. & Tsai, K., 2002, In : Medicine and Science in Sports and Exercise. 34, 3, p. 438-442 5 p.

Research output: Contribution to journalArticle

Mitochondria
Leukocytes
Exercise
Membrane Potentials
Apoptosis
2001
9 Citations (Scopus)

Age-related changes in the mitochondrial depolarization induced by oxidative injury in human peripheral blood leukocytes

Tsai, K., Hsu, T. G., Lu, F. J., Hsu, C. F., Liu, T. Y. & Kong, C. W., 2001, In : Free Radical Research. 35, 4, p. 395-403 9 p.

Research output: Contribution to journalArticle

tert-Butylhydroperoxide
Mitochondria
Depolarization
Oxidants
Leukocytes
14 Citations (Scopus)

Leukocyte mitochondria depolarization and apoptosis in advanced heart failure: Clinical correlations and effect of therapy

Kong, C. W., Hsu, T. G., Lu, F. J., Chan, W. L. & Tsai, K., Nov 15 2001, In : Journal of the American College of Cardiology. 38, 6, p. 1693-1700 8 p.

Research output: Contribution to journalArticle

Mitochondria
Leukocytes
Heart Failure
Apoptosis
Membrane Potentials
174 Citations (Scopus)

Oxidative DNA damage in human peripheral leukocytes induced by massive aerobic exercise

Tsai, K., Hsu, T. G., Hsu, K. M., Cheng, H., Liu, T. Y., Hsu, C. F. & Kong, C. W., Dec 1 2001, In : Free Radical Biology and Medicine. 31, 11, p. 1465-1472 8 p.

Research output: Contribution to journalArticle

DNA Damage
Leukocytes
Endonucleases
Exercise
DNA
2000
54 Citations (Scopus)

Is the endogenous peroxyl-radical scavenging capacity of plasma protective in systemic inflammatory disorders in humans?

Tsai, K., Hsu, T. G., Kong, C. W., Lin, K. C. & Fung-Jou, L. U., Mar 15 2000, In : Free Radical Biology and Medicine. 28, 6, p. 926-933 8 p.

Research output: Contribution to journalArticle

Systemic Inflammatory Response Syndrome
Scavenging
Plasmas
Antioxidants
Oxidative stress
58 Citations (Scopus)

Magnolol attenuates peroxidative damage and improves survival of rats with sepsis

Kong, C. W., Tsai, K., Chin, J. H., Chan, W. L. & Hong, C. Y., Jan 2000, In : Shock. 13, 1, p. 24-28 5 p.

Research output: Contribution to journalArticle

Sepsis
Punctures
Antioxidants
Magnolia
magnolol
1998
125 Citations (Scopus)

Oxidative stress: An important phenomenon with pathogenetic significance in the progression of acute pancreatitis

Tsai, K., Wang, S. S., Chen, T-G., Kong, C-W., Chang, F-Y., Lee, S-D. & Lu, F. J., 1998, In : Gut. 42, 6, p. 850-855 6 p.

Research output: Contribution to journalArticle

Pancreatitis
Oxidative Stress
Dehydroascorbic Acid
Superoxides
Tocopherols