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Research Output

  • 629 Citations
  • 14 h-Index
  • 51 Article
  • 4 Review article
  • 3 Conference contribution
  • 1 Comment/debate
2020

A site-moiety map and virtual screening approach for discovery of novel 5-LOX inhibitors

Hsu, K. C., HuangFu, W. C., Lin, T. E., Chao, M. W., Sung, T. Y., Chen, Y. Y., Pan, S. L., Lee, J. C., Tzou, S. C., Sun, C. M. & Yang, J. M., Dec 1 2020, In : Scientific Reports. 10, 1, 10510.

Research output: Contribution to journalArticle

Open Access

Fluoropyrimidin-2,4-dihydroxy-5-isopropylbenzamides as antitumor agents against CRC and NSCLC cancer cells

Wu, W. C., Liu, Y. M., Liao, Y. H., Hsu, K. C., Lien, S. T., Chen, I. C., Lai, M. J., Li, Y. H., Pan, S. L., Chen, M. C. & Liou, J. P., Oct 1 2020, In : European Journal of Medicinal Chemistry. 203, 112540.

Research output: Contribution to journalArticle

Functional analysis of Clostridium difficile sortase B reveals key residues for catalytic activity and substrate specificity

Kang, C. Y., Huang, I. H., Chou, C. C., Wu, T. Y., Chang, J. C., Hsiao, Y. Y., Cheng, C. H., Tsai, W. J., Hsu, K. C. & Wang, S., Mar 13 2020, In : Journal of Biological Chemistry. 295, 11, p. 3734-3745 12 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Leucettamine B analogs and their carborane derivative as potential anti-cancer agents: Design, synthesis, and biological evaluation

Hsu, M. H., Hsieh, C. Y., Kapoor, M., Chang, J. H., Chu, H. L., Cheng, T. M., Hsu, K. C., Lin, T. E., Tsai, F. Y. & Horng, J. C., May 2020, In : Bioorganic Chemistry. 98, 103729.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Structural insight into the differential interactions between the DNA mimic protein SAUGI and two gamma herpesvirus uracil-DNA glycosylases

Liao, Y. T., Lin, S. J., Ko, T. P., Liu, C. Y., Hsu, K. C. & Wang, H. C., Oct 1 2020, In : International Journal of Biological Macromolecules. 160, p. 903-914 12 p.

Research output: Contribution to journalArticle

Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease

Tseng, H. J., Lin, M. H., Shiao, Y. J., Yang, Y. C., Chu, J. C., Chen, C. Y., Chen, Y. Y., Lin, T. E., Su, C. J., Pan, S. L., Chen, L. C., Wang, C. Y., Hsu, K. C. & Huang, W. J., Apr 15 2020, In : European Journal of Medicinal Chemistry. 192, p. 112193 112193.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2019

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Alternative splicing in human cancer cells is modulated by the amiloride derivative 3,5-diamino-6-chloro-N-(N-(2,6-dichlorobenzoyl)carbamimidoyl)pyrazine-2-carboxide

Lee, C. C., Chang, W. H., Chang, Y. S., Yang, J. M., Chang, C. S., Hsu, K. C., Chen, Y. T., Liu, T. Y., Chen, Y. C., Lin, S. Y., Wu, Y. C. & Chang, J. G., Jan 1 2019, In : Molecular Oncology. 13, 8, p. 1744-1762 19 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

New paradigm of functional regulation by DNA mimic proteins: Recent updates

Wang, H. C., Chou, C. C., Hsu, K. C., Lee, C. H. & Wang, A. H. J., May 1 2019, In : IUBMB Life. 71, 5, p. 539-548 10 p.

Research output: Contribution to journalReview article

5 Citations (Scopus)

Structural insights to the heterotetrameric interaction between the vibrio parahaemolyticus pirA vp and pirB vp toxins and activation of the cry-like pore-forming domain

Lin, S. J., Chen, Y. F., Hsu, K. C., Chen, Y. L., Ko, T. P., Lo, C. F., Wang, H. C. & Wang, H. C., Apr 1 2019, In : Toxins. 11, 4, 233.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

The role of ubiquitin-specific peptidases in cancer progression

Young, M. J., Hsu, K. C., Lin, T. E., Chang, W. C. & Hung, J. J., May 27 2019, In : Journal of Biomedical Science. 26, 1, 42.

Research output: Contribution to journalReview article

Open Access
4 Citations (Scopus)
2018

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Jan 29 2018, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

15 Citations (Scopus)

A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo

Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., Mar 13 2018, In : Frontiers in Pharmacology. 9, MAR, 205.

Research output: Contribution to journalArticle

3 Citations (Scopus)

A Novel Selective JAK2 Inhibitor Identified Using Pharmacological Interactions

Lin, T. E., HuangFu, W-C., Chao, M-W., Sung, T-Y., Chang, C-D., Chen, Y-Y., Hsieh, J-H., Tu, H-J., Huang, H-L., Pan, S-L. & Hsu, K-C., 2018, In : Frontiers in Pharmacology. 9, p. 1379

Research output: Contribution to journalArticle

Design of diarylheptanoid derivatives as dual inhibitors against class IIa histone deacetylase and β-amyloid aggregation

Chen, L. C., Tseng, H. J., Liu, C. Y., Huang, Y. Y., Yen, C. C., Weng, J. R., Lu, Y. L., Hou, W. C., Lin, T. E., Pan, I. H., Huang, K. K., Huang, W. J. & Hsu, K. C., Jul 3 2018, In : Frontiers in Pharmacology. 9, JUL, 708.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities

Chao, S. W., Chen, L. C., Yu, C. C., Liu, C. Y., Lin, T. E., Guh, J. H., Wang, C. Y., Chen, C. Y., Hsu, K. C. & Huang, W. J., Jan 1 2018, In : European Journal of Medicinal Chemistry. 143, p. 792-805 14 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Dual inhibition of PIK3C3 and FGFR as a new therapeutic approach to treat bladder cancer

Chen, C. H., Changou, C. A., Hsieh, T. H., Lee, Y. C., Chu, C. Y., Hsu, K. C., Wang, H. C., Lin, Y. C., Lo, Y. N., Liu, Y. R., Liou, J. P. & Yen, Y., Mar 1 2018, In : Clinical Cancer Research. 24, 5, p. 1176-1189 14 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

miR-211 regulates the expression of RRM2 in tumoral metastasis and recurrence in colorectal cancer patients with a k-ras gene mutation

Chang, C. C., Lin, C. C., Wang, C. H., Huang, C. C., Ke, T. W., Wei, P. L., Yeh, K. T., Hsu, K. C., Hsu, N. Y. & Cheng, Y. W., May 1 2018, In : Oncology Letters. 15, 5, p. 8107-8117 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2017

An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells

Chao, M. W., Huang, H. L., HuangFu, W. C., Hsu, K. C., Liu, Y. M., Wu, Y. W., Lin, C. F., Chen, Y. L., Lai, M. J., Lee, H. Y., Liou, J. P., Teng, C. M. & Yang, C. R., 2017, In : Oncotarget. 8, 17, p. 27772-27785 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Identification of neuraminidase inhibitors against dual H274Y/I222R mutant strains

Hsu, K. C., Hung, H. C., Huangfu, W. C., Sung, T. Y., Eight Lin, T., Fang, M. Y., Chen, I. J., Pathak, N., Hsu, J. T. A. & Yang, J. M., Dec 1 2017, In : Scientific Reports. 7, 1, 12336.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach

Hsu, K. C., Liu, C. Y., Lin, T. E., Hsieh, J. H., Sung, T. Y., Tseng, H. J., Yang, J. M. & Huang, W. J., Dec 1 2017, In : Scientific Reports. 7, 1, 3228.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Structural Insights into the Cytotoxic Mechanism of Vibrio parahaemolyticus PirAvp and PirBvp Toxins

Lin, S-J., Hsu, K-C. & Wang, H-C., Dec 1 2017, In : Marine Drugs. 15, 12

Research output: Contribution to journalReview article

15 Citations (Scopus)

The monomeric form of Neisseria DNA mimic protein DMP19 prevents DNA from binding to the histone-like HU protein

Huang, M. F., Lin, S. J., Ko, T. P., Liao, Y. T., Hsu, K. C. & Wang, H. C., Dec 1 2017, In : PLoS One. 12, 12, e0189461.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Total synthesis and metabolic stability of hispidulin and its d-labelled derivative

Chen, L. C., Hsu, K. C., Chiou, L. C., Tseng, H. J. & Huang, W. J., Nov 1 2017, In : Molecules. 22, 11, 1897.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2016

Design and synthesis of 1,2,3-triazole-containing N-acyl zanamivir analogs as potent neuraminidase inhibitors

Das, A., Adak, A. K., Ponnapalli, K., Lin, C. H., Hsu, K. C., Yang, J. M., Hsu, T. A. & Lin, C. C., Nov 10 2016, In : European Journal of Medicinal Chemistry. 123, p. 397-406 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate (MES)

Huang, K. W., Hsu, K. C., Chu, L. Y., Yang, J. M., Yuan, H. S. & Hsiao, Y. Y., Sep 8 2016, In : Journal of Medicinal Chemistry. 59, 17, p. 8019-8029 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Methyl Protodioscin, a Steroidal Saponin, Inhibits Neointima Formation in Vitro and in Vivo

Chung, Y. L., Pan, C. H., Wang, C. C. N., Hsu, K. C., Sheu, M. J., Chen, H. F. & Wu, C. H., Jun 24 2016, In : Journal of Natural Products. 79, 6, p. 1635-1644 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Novel lactulose and melibiose targeting autophagy to reduce polyQ aggregation in cell models of spinocerebellar ataxia

Lin, C. H., Wu, Y. R., Yang, J. M., Chen, W. L., Chao, C. Y., Chen, I. C., Lin, T. H., Wu, Y. C., Hsu, K. C., Chen, C. M., Lee, G. C., Hsieh-Li, H. M., Lee, C. M. & Lee-Chen, G. J., Apr 1 2016, In : CNS and Neurological Disorders - Drug Targets. 15, 3, p. 351-359 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Using structural-based protein engineering to modulate the differential inhibition effects of SAUGI on human and HSV uracil DNA glycosylase

Wang, H. C., Ho, C. H., Chou, C. C., Ko, T. P., Huang, M. F., Hsu, K. C. & Wang, A. H. J., May 19 2016, In : Nucleic Acids Research. 44, 9, p. 4440-4449 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2015

Anchor-based classification and type-C inhibitors for tyrosine kinases

Hsu, K. C., Sung, T. Y., Lin, C. T., Chiu, Y. Y., Hsu, J. T. A., Hung, H. C., Sun, C. M., Barve, I., Chen, W. L., Huang, W. C., Huang, C. T., Chen, C. H. & Yang, J. M., Jun 16 2015, In : Scientific Reports. 5, 10938.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The potential of lactulose and melibiose, two novel trehalase-indigestible and autophagy-inducing disaccharides, for polyQ-mediated neurodegenerative disease treatment

Lee, G. C., Lin, C. H., Tao, Y. C., Yang, J. M., Hsu, K. C., Huang, Y. J., Huang, S. H., Kung, P. J., Chen, W. L., Wang, C. M., Wu, Y. R., Chen, C. M., Lin, J. Y., Hsieh-Li, H. M. & Lee-Chen, G. J., May 1 2015, In : NeuroToxicology. 48, p. 120-130 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2014

5-Demethyltangeretin is more potent than tangeretin in inhibiting dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumorigenesis

Ma, N., Lai, C. S., Chung, C. H., Yang, J. M., Hsu, K. C., Chen, C. Y., Chung, T. S., Li, S., Ho, C. T. & Pan, M. H., 2014, In : Journal of Functional Foods. 11, C, p. 528-537 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Crowning proteins: Modulating the protein surface properties using crown ethers

Lee, C. C., Maestre-Reyna, M., Hsu, K. C., Wang, H. C., Liu, C. I., Jeng, W. Y., Lin, L. L., Wood, R., Chou, C. C., Yang, J. M. & Wang, A. H. J., Nov 24 2014, In : Angewandte Chemie - International Edition. 53, 48, p. 13054-13058 5 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

DNA mimic proteins: Functions, structures, and bioinformatic analysis

Wang, H. C., Ho, C. H., Hsu, K. C., Yang, J. M. & Wang, A. H. J., May 13 2014, In : Biochemistry. 53, 18, p. 2865-2874 10 p.

Research output: Contribution to journalReview article

23 Citations (Scopus)

Homopharma: A new concept for exploring the molecular binding mechanisms and drug repurposing

Chiu, Y. Y., Tseng, J. H., Liu, K. H., Lin, C. T., Hsu, K. C. & Yang, J. M., Dec 8 2014, In : BMC Genomics. 15, S8.

Research output: Contribution to journalArticle

8 Citations (Scopus)

KDM4B as a target for prostate cancer: Structural analysis and selective inhibition by a novel inhibitor

Chu, C. H., Wang, L. Y., Hsu, K. C., Chen, C. C., Cheng, H. H., Wang, S. M., Wu, C. M., Chen, T. J., Li, L. T., Liu, R., Hung, C. L., Yang, J. M., Kung, H. J. & Wang, W. C., Jul 24 2014, In : Journal of Medicinal Chemistry. 57, 14, p. 5975-5985 11 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Staphylococcus aureus protein SAUGI acts as a uracil-DNA glycosylase inhibitor

Wang, H. C., Hsu, K. C., Yang, J. M., Wu, M. L., Ko, T. P., Lin, S. R. & Wang, A. H. J., 2014, In : Nucleic Acids Research. 42, 2, p. 1354-1364 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2013

KIDFamMap: A database of kinase-inhibitor-disease family maps for kinase inhibitor selectivity and binding mechanisms

Chiu, Y. Y., Lin, C. T., Huang, J. W., Hsu, K. C., Tseng, J. H., You, S. R. & Yang, J. M., Jan 1 2013, In : Nucleic Acids Research. 41, D1

Research output: Contribution to journalArticle

15 Citations (Scopus)

Parallel Screening of Wild-Type and Drug-Resistant Targets for Anti-Resistance Neuraminidase Inhibitors

Hsu, K. C., Hung, H. C., Horng, J. T., Fang, M. Y., Chang, C. Y., Li, L. T., Chen, I. J., Chen, Y. C., Chou, D. L., Chang, C. W., Hsieh, H. P., Yang, J. M. & Hsu, J. T. A., Feb 20 2013, In : PLoS One. 8, 2, e56704.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Pathway-based Screening Strategy for Multitarget Inhibitors of Diverse Proteins in Metabolic Pathways

Hsu, K. C., Cheng, W. C., Chen, Y. F., Wang, W. C. & Yang, J. M., Jul 2013, In : PLoS Computational Biology. 9, 7, e1003127.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Rank-based interolog mapping for predicting proteinprotein interactions between genomes

Lo, Y. S., Chen, C. C., Hsu, K-C. & Yang, J. M., 2013, International Conference on Systems Biology, ISB. IEEE Computer Society, p. 55-62 8 p. 6623794

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-activities

Lin, C. H., Chang, T. C., Das, A., Fang, M. Y., Hung, H. C., Hsu, K. C., Yang, J. M., Von Itzstein, M., Mong, K. K. T., Hsu, T. A. & Lin, C. C., Jun 28 2013, In : Organic and Biomolecular Chemistry. 11, 24, p. 3943-3948 6 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2012

Core site-moiety maps reveal inhibitors and binding mechanisms of orthologous proteins by screening compound libraries

Hsu, K. C., Cheng, W. C., Chen, Y. F., Wang, H. J., Li, L. T., Wang, W. C. & Yang, J. M., Feb 29 2012, In : PLoS One. 7, 2, e32142.

Research output: Contribution to journalArticle

18 Citations (Scopus)

GemAffinity: A scoring function for predicting binding affinity and Virtual Screening

Hsu, K. C., Chen, Y. F. & Yang, J. M., Feb 2012, In : International Journal of Data Mining and Bioinformatics. 6, 1, p. 27-41 15 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Space-related pharma-motifs for fast search of protein binding motifs and polypharmacological targets.

Chiu, Y. Y., Lin, C. Y., Lin, C. T., Hsu, K. C., Chang, L. Z. & Yang, J. M., 2012, In : BMC Genomics. 13 Suppl 7, S21.

Research output: Contribution to journalArticle

2 Citations (Scopus)