Kai-Cheng Hsu

Associate Professor, Master Program in Graduate Institute of Cancer Biology and Drug Discovery
Associate Professor, Ph.D. Program for Cancer Molecular Biology and Drug Discovery
Joint-Appointment Associate Professor, Ph.D. Program in Drug Discovery and Development Industry
Member, TMU Biomedical Commercialization Center

https://orcid.org/0000-0002-9022-6673

Emailpiki@tmu.edu.tw

Source: Scopus
Calculated based on no. of publications stored in Pure and citations from Scopus

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Personal profile

Education

2011 國立交通大學生物資訊及系統生物研究所博士
2007 國立交通大學生物資訊研究所碩士
2005 國立交通大學生物科技學系學士

Experience

2019- 臺北醫學大學癌症生物學與藥物研發研究所副教授
2019- 臺北醫學大學生技醫療產業研發博士學位學程副教授
2018- 臺北醫學大學癌症生物學與藥物研發研究所助理教授
2015- 臺北醫學大學癌症生物學與藥物研發博士學位學程助理教授
2013-2015 國立交通大學約聘助理研究員
2011-2013 國立交通大學博士後研究員

Research Interests

生物學之生化及分子生物
生物資訊與醫療資訊

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2 Active
9 Finished

電腦輔助設計與研發新穎DYRK1B抑制劑
Hsu, K.
1/1/21 → 12/31/21
Project: B - Project of TMU › h - Higher Education Sprout Project
針對癌症治療研發與活性最適化蛋白質激酶抑制劑(2/3)
Hsu, K.
8/1/20 → 7/1/21
Project: A - Government Institution › b - Ministry of Science and Technology
建立新興環境汙染物與藥物毒理預測平台之研究
Hsu, K.
7/1/20 → 2/1/21
Project: A - Government Institution › b - Ministry of Science and Technology
電腦輔助設計與研發新穎DYRK1B抑制劑
Hsu, K.
1/1/20 → 12/31/20
Project: A - Government Institution › d - Ministry of Education
Integrated Bioinformatics Approaches to Study the Mechanisms and Discover Drugs of Hcv-Induced Type 2 Diabetes Mellitus(3/3)
Hsu, K.
8/1/19 → 7/31/20
Project: A - Government Institution › b - Ministry of Science and Technology

789 Citations
16 h-Index
64 Article
4 Review article
3 Conference contribution
1 Comment/debate

A novel histone deacetylase inhibitor MPT0L184 dysregulates cell-cycle checkpoints and initiates unscheduled mitotic signaling
Chang, T. Y., Nepali, K., Chen, Y. Y., Yang, Y. C. S. H., Hsu, K. C., Yen, Y., Pan, S. L., Liou, J. P. & Lee, S. B., Jun 2021, In: Biomedicine and Pharmacotherapy. 138, 111485.
Research output: Contribution to journal › Article › peer-review

Open Access
CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition
Singh, A., Chang, T. Y., Kaur, N., Hsu, K. C., Yen, Y., Lin, T. E., Lai, M. J., Lee, S. B. & Liou, J. P., Apr 5 2021, In: European Journal of Medicinal Chemistry. 215, 113169.
Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus)
Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach
Chao, M. W., Lin, T. E., HuangFu, W. C., Chang, C. D., Tu, H. J., Chen, L. C., Yen, S. C., Sung, T. Y., Huang, W. J., Yang, C. R., Pan, S. L. & Hsu, K. C., Dec 2021, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 36, 1, p. 98-108 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia
Yen, S. C., Chen, L. C., Huang, H. L., Ngo, S. T., Wu, Y. W., Lin, T. E., Sung, T. Y., Lien, S. T., Tseng, H. J., Pan, S. L., Huang, W. J. & Hsu, K. C., Jan 22 2021, In: Journal of Natural Products. 84, 1, p. 1-10 10 p.
Research output: Contribution to journal › Article › peer-review
Pragmatic recruitment of memantine as the capping group for the design of HDAC inhibitors: A preliminary attempt to unravel the enigma of glioblastoma
Nepali, K., Hsu, T. I., Hsieh, C. M., Lo, W. L., Lai, M. J., Hsu, K. C., Lin, T. E., Chuang, J. Y. & Liou, J. P., May 5 2021, In: European Journal of Medicinal Chemistry. 217, 113338.
Research output: Contribution to journal › Article › peer-review

Investigating the potential effects of selective histone deacetylase 6 inhibitor ACY1215 on infarct size in rats with cardiac ischemia-reperfusion injury
Lin, C. (Contributor), Hsu, K. (Contributor), HuangFu, W. (Contributor), Lin, T. E. (Contributor), Huang, H. (Contributor) & Pan, S. (Contributor), Unknown Publisher, Mar 12 2020
DOI: 10.6084/m9.figshare.c.4896705.v1, https://doi.org/10.6084%2Fm9.figshare.c.4896705.v1
Dataset
Additional file 1 of Investigating the potential effects of selective histone deacetylase 6 inhibitor ACY1215 on infarct size in rats with cardiac ischemia-reperfusion injury
Lin, C. (Contributor), Hsu, K. (Contributor), HuangFu, W. (Contributor), Lin, T. E. (Contributor), Huang, H. (Contributor) & Pan, S. (Contributor), Unknown Publisher, Mar 12 2020
DOI: 10.6084/m9.figshare.11992497.v1, https://springernature.figshare.com/articles/Additional_file_1_of_Investigating_the_potential_effects_of_selective_histone_deacetylase_6_inhibitor_ACY1215_on_infarct_size_in_rats_with_cardiac_ischemia-reperfusion_injury/11992497/1
Dataset
CCDC 2000792: Experimental Crystal Structure Determination
Hsu, M. (Contributor), Hsieh, C. (Contributor), Kapoor, M. (Contributor), Chang, J. (Contributor), Chu, H. (Contributor), Cheng, T. (Contributor), Hsu, K. (Contributor), Lin, T. E. (Contributor), Tsai, F. (Contributor) & Horng, J. (Contributor), Unknown Publisher, May 1 2020
DOI: 10.5517/ccdc.csd.cc254zp0, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc254zp0&sid=DataCite
Dataset