Projects per year
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Histone Deacetylases
Medicine & Life Sciences
Proteins
Medicine & Life Sciences
Screening
Engineering & Materials Science
Neuraminidase
Medicine & Life Sciences
Ligands
Medicine & Life Sciences
Inhibitory Concentration 50
Medicine & Life Sciences
shikimate kinase
Medicine & Life Sciences
Autophagy
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2016 2019
藉由全方位探索新致病機制發現新的第2型糖尿病之肝臟治療靶點：基於慢性C型肝炎病毒感染模式到一般族群、連結基礎，生物信息學和臨床的系統性探討之轉譯研究－整合生物資訊方法研究C型肝炎誘發之第二型糖尿病的機轉與藥物開發(2/3)
8/1/18 → 7/31/19
Project: b - Ministry of Science and Technology
Discovery of multitarget inhibitors for colorectal cancer treatment using Pharmalogs
2/1/16 → 1/31/17
Project: b - Ministry of Science and Technology
Research Output 2008 2019
1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase
Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.Research output: Contribution to journal › Article
Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes
Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Jan 29 2018, (Accepted/In press) In : Journal of Medicinal Chemistry.Research output: Contribution to journal › Article
tau Proteins
Histone Deacetylase Inhibitors
Alzheimer Disease
Hydroxamic Acids
Phenotype
A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo
Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., Mar 13 2018, In : Frontiers in Pharmacology. 9, MAR, 205.Research output: Contribution to journal › Article
Tubulin Modulators
Histone Deacetylases
Neoplasms
Tubulin
Molecular Docking Simulation
Design of diarylheptanoid derivatives as dual inhibitors against class IIa histone deacetylase and β-amyloid aggregation
Chen, L. C., Tseng, H. J., Liu, C. Y., Huang, Y. Y., Yen, C. C., Weng, J. R., Lu, Y. L., Hou, W. C., Lin, T. E., Pan, I. H., Huang, K. K., Huang, W. J. & Hsu, K. C., Jul 3 2018, In : Frontiers in Pharmacology. 9, JUL, 708.Research output: Contribution to journal › Article
Diarylheptanoids
Histone Deacetylases
Amyloid
Alzheimer Disease
Pyrogallol
Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities
Chao, S. W., Chen, L. C., Yu, C. C., Liu, C. Y., Lin, T. E., Guh, J. H., Wang, C. Y., Chen, C. Y., Hsu, K. C. & Huang, W. J., Jan 1 2018, In : European Journal of Medicinal Chemistry. 143, p. 792-805 14 p.Research output: Contribution to journal › Article
Histone Deacetylases
Derivatives
Carbon
Molecular Docking Simulation
Cutaneous T-Cell Lymphoma