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Research Output 1991 2020

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Article
2020

Biomass and Lipid Production Potential of an Indian Marine Algal Isolate Tetraselmis striata BBRR1

Boopathy, A. B., Jayakumar, T., Chinnasamy, S., Rajaram, M. G., Mohan, N., Nagaraj, S., Rengasamy, R., Manubolu, M., Sheu, J. R. & Chang, C. C., Jan 1 2020, In : Energies. 13, 2, 341.

Research output: Contribution to journalArticle

Open Access

Ruthenium derivatives attenuate LPS-induced inflammatory responses and liver injury via suppressing NF-κB signaling and free radical production

Jayakumar, T., Huang, H. C., Hsia, C. W., Fong, T. H., Khamrang, T., Velusamy, M., Manubolu, M., Sheu, J. R. & Hsia, C. H., Mar 2020, In : Bioorganic Chemistry. 96, 103639.

Research output: Contribution to journalArticle

2019

A critical period for the development of schizophrenia-like pathology by aberrant postnatal neurogenesis

Sheu, J. R., Hsieh, C. Y., Jayakumar, T., Tseng, M. F., Lee, H. N., Huang, S. W., Manubolu, M. & Yang, C. H., Jan 1 2019, In : Frontiers in Neuroscience. 13, JUN, 635.

Research output: Contribution to journalArticle

Open Access
Neurogenesis
Schizophrenia
Pathology
Critical Period (Psychology)
Hallucinations
1 Citation (Scopus)

Esculetin, A coumarin derivative, prevents thrombosis: Inhibitory signaling on PLCγ2-PKC-AKT activation in human platelets

Hsia, C. W., Lin, K. C., Lee, T. Y., Hsia, C. H., Chou, D. S., Jayakumar, T., Velusamy, M. & Sheu, J. R., Jun 1 2019, In : International Journal of Molecular Sciences. 20, 11, 2731.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

HDAC6 dysfunction contributes to impaired maturation of adult neurogenesis in vivo: vital role on functional recovery after ischemic stroke

Sheu, J-R., Hsieh, C-Y., Jayakumar, T., Lin, G-Y., Lee, H-N., Huang, S-W. & Yang, C-H., Apr 18 2019, In : Journal of Biomedical Science. 26, 1, 27.

Research output: Contribution to journalArticle

Neurogenesis
Neurons
Stroke
Recovery
Patient rehabilitation

New therapeutic strategy of hinokitiol in haemorrhagic shock-induced liver injury

Lu, W-J., Lin, K-H., Tseng, M-F., Yuan, K-C., Huang, H-C., Sheu, J-R. & Chen, R-J., Mar 1 2019, In : Journal of Cellular and Molecular Medicine. 23, 3, p. 1723-1734 12 p.

Research output: Contribution to journalArticle

Hemorrhagic Shock
Liver
Wounds and Injuries
Resuscitation
Therapeutics
7 Citations (Scopus)

Protective effects of ammannia baccifera against ccl4-induced oxidative stress in rats

Goodla, L., Manubolu, M., Pathakoti, K., Jayakumar, T., Sheu, J. R., Fraker, M., Tchounwou, P. B. & Poondamalli, P. R., Apr 2 2019, In : International Journal of Environmental Research and Public Health. 16, 8, 1440.

Research output: Contribution to journalArticle

Open Access

Suppression of human platelet activation via integrin αiibβ3 outside-in independent signal and reduction of the mortality in pulmonary thrombosis by auraptene

Hsia, C. W., Tsai, C. L., Sheu, J. R., Lu, W. J., Hsia, C. H., Velusamy, M., Jayakumar, T. & Li, J. Y., Nov 2 2019, In : International Journal of Molecular Sciences. 20, 22, 5585.

Research output: Contribution to journalArticle

Open Access
2018

Analysis of Titin in Red and White Muscles: Crucial Role on Muscle Contractions Using a Fish Model

Wu, M. P., Chang, N. C., Chung, C. L., Chiu, W. C., Hsu, C. C., Chen, H. M., Sheu, J. R., Jayakumar, T., Chou, D. S. & Fong, T. H., Nov 18 2018, In : BioMed Research International. 2018, p. 5816875 11 p., 5816875.

Research output: Contribution to journalArticle

Connectin
Muscle Contraction
Fish
Muscle
Muscles

An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets

Lu, W. J., Chung, C. L., Chen, R. J., Huang, L. T., Lien, L. M., Chang, C. C., Lin, K. H. & Sheu, J. R., Nov 14 2018, In : Journal of Clinical Medicine. 7, 11

Research output: Contribution to journalArticle

Phospholipase D
Blood Platelets
Platelet Activation
Platelet Aggregation
Thrombosis

Biofuel and biochemical analysis of amphora coffeaeformis RR03, a novel marine diatom, cultivated in an open raceway pond

Rajaram, M. G., Nagaraj, S., Manjunath, M., Boopathy, A. B., Kurinjimalar, C., Rengasamy, R., Jayakumar, T., Sheu, J. R. & Li, J. Y., Jun 1 2018, In : Energies. 11, 6, en11061341.

Research output: Contribution to journalArticle

Diatoms
Ponds
Biofuels
Biomass
Fatty Acids
8 Citations (Scopus)

CME-1, a novel polysaccharide, suppresses iNOS expression in lipopolysaccharide-stimulated macrophages through ceramide-initiated protein phosphatase 2A activation

Sheu, J. R., Chen, Z. C., Hsu, M. J., Wang, S. H., Jung, K. W., Wu, W. F., Pan, S. H., Teng, R. D., Yang, C. H. & Hsieh, C. Y., Feb 1 2018, In : Journal of Cellular and Molecular Medicine. 22, 2, p. 999-1013 15 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Ceramides
Nitric Oxide Synthase Type II
Polysaccharides
Lipopolysaccharides
6 Citations (Scopus)

Hinokitiol inhibits migration of A549 lung cancer cells via suppression of MMPs and induction of antioxidant enzymes and apoptosis

Jayakumar, T., Liu, C. H., Wu, G. Y., Lee, T. Y., Manubolu, M., Hsieh, C. Y., Yang, C. H. & Sheu, J. R., Mar 22 2018, In : International Journal of Molecular Sciences. 19, 4, 939.

Research output: Contribution to journalArticle

Enzyme Induction
antioxidants
apoptosis
Cell death
Antioxidants
2 Citations (Scopus)

Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation

Shyu, R. S., Khamrang, T., Sheu, J. R., Hsia, C. W., Velusamy, M., Hsia, C. H., Chou, D. S. & Chang, C. C., Jan 1 2018, In : Bioinorganic Chemistry and Applications. 2018, p. 8291393 8291393.

Research output: Contribution to journalArticle

Iridium
Platelet Activation
Organometallics
Platelets
Collagen
1 Citation (Scopus)

Mechanism of free radical generation in platelets and primary hepatocytes: A novel electron spin resonance study

Wang, C. L., Yang, P. S., Tsao, J. T., Jayakumar, T., Wang, M. J., Sheu, J. R. & Chou, D. S., Jan 1 2018, In : Molecular Medicine Reports. 17, 1, p. 2061-2069 9 p.

Research output: Contribution to journalArticle

Electron Spin Resonance Spectroscopy
Platelets
Free Radicals
Paramagnetic resonance
Hepatocytes

Mechanisms of TQ-6, a Novel Ruthenium-Derivative Compound, against Lipopolysaccharide-Induced In Vitro Macrophage Activation and Liver Injury in Experimental Mice: The Crucial Role of p38 MAPK and NF-κB Signaling

Hsia, C-H., Velusamy, M., Jayakumar, T., Chen, Y-J., Hsia, C-W., Tsai, J-H., Teng, R-D. & Sheu, J-R., Nov 19 2018, In : Cells. 7, 11

Research output: Contribution to journalArticle

Ruthenium Compounds
Ruthenium
Macrophage Activation
Macrophages
p38 Mitogen-Activated Protein Kinases
2 Citations (Scopus)
norcantharidin
Integrins
Fibrinogen
Blood Platelets
Clot Retraction
5 Citations (Scopus)

Novel iridium (III)-derived organometallic compound for the inhibition of human platelet activation

Shyu, K. G., Velusamy, M., Hsia, C. W., Yang, C. H., Hsia, C. H., Chou, D. S., Jayakumar, T., Sheu, J. R. & Li, J. Y., May 1 2018, In : International Journal of Molecular Medicine. 41, 5, p. 2589-2600 12 p.

Research output: Contribution to journalArticle

Organometallic Compounds
Iridium
Platelet Activation
Platelet Aggregation
Collagen
2 Citations (Scopus)

Novel therapeutic agent against platelet activation in vitro and arterial thrombosis in vivo by morin hydrate

Hsia, C. W., Wu, M. P., Velusamy, M., Hsia, C. H., Chou, D. S., Tsai, C. L., Hsu, C. Y., Jayakumar, T., Chung, C. L. & Sheu, J. R., Aug 13 2018, In : International Journal of Molecular Sciences. 19, 8, 2386.

Research output: Contribution to journalArticle

thrombosis
Platelet Activation
Platelets
platelets
Hydrates
3 Citations (Scopus)

Structure-antiplatelet activity relationships of novel ruthenium (ii) complexes: Investigation of its molecular targets

Hsia, C. H., Jayakumar, T., Sheu, J. R., Tsao, S. Y., Velusamy, M., Hsia, C. W., Chou, D. S., Chang, C. C., Chung, C. L., Khamrang, T. & Lin, K. C., Feb 22 2018, In : Molecules. 23, 2, 477.

Research output: Contribution to journalArticle

Ruthenium
Structure-Activity Relationship
Platelets
platelets
ruthenium
1 Citation (Scopus)

Structure⁻Activity Relationship Study of Newly Synthesized Iridium-III Complexes as Potential Series for Treating Thrombotic Diseases

Yang, C. H., Hsia, C. W., Jayakumar, T., Sheu, J. R., Hsia, C. H., Khamrang, T., Chen, Y. J., Manubolu, M. & Chang, Y., Nov 19 2018, In : International Journal of Molecular Sciences. 19, 11

Research output: Contribution to journalArticle

Iridium
iridium
collagens
Collagen
Iridium compounds
2017
6 Citations (Scopus)

A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice

Sheu, J. R., Chen, Z. C., Jayakumar, T., Chou, D. S., Yen, T. L., Lee, H. N., Pan, S. H., Hsia, C. H., Yang, C. H. & Hsieh, C. Y., Feb 6 2017, In : Scientific Reports. 7, 42277.

Research output: Contribution to journalArticle

Stroke
Medicine
Middle Cerebral Artery Infarction
Therapeutics
JNK Mitogen-Activated Protein Kinases
3 Citations (Scopus)

A novel ruthenium (II)-derived organometallic compound, TQ-6, potently inhibits platelet aggregation: Ex vivo and in vivo studies

Hsia, C. H., Velusamy, M., Sheu, J. R., Khamrang, T., Jayakumar, T., Lu, W. J., Lin, K. H. & Chang, C. C., Dec 1 2017, In : Scientific Reports. 7, 1, 9556.

Research output: Contribution to journalArticle

Organometallic Compounds
Ruthenium
Fluorescein-5-isothiocyanate
Platelet Aggregation
Blood Platelets
3 Citations (Scopus)

Antiplatelet activity of a newly synthesized novel ruthenium (II): A potential role for Akt/JNK signaling

Khamrang, T., Hung, K. C., Hsia, C. H., Hsieh, C. Y., Velusamy, M., Jayakumar, T. & Sheu, J. R., May 1 2017, In : International Journal of Molecular Sciences. 18, 5, 916.

Research output: Contribution to journalArticle

Ruthenium
Platelets
platelets
Platelet Aggregation
ruthenium
1 Citation (Scopus)

Development of benzimidazole derivatives as novel anti-platelet drugs

Yao, W. C., Yuan, L. T., Yang, W. B., Hsia, C. H., Huang, L. T., Lee, T. Y., Sheu, J. R., Lu, W-J., Jayakumar, T. & Chen, R. J., Jan 1 2017, In : Current Pharmaceutical Biotechnology. 18, 7, p. 594-605 12 p.

Research output: Contribution to journalArticle

Thrombin
Blood Platelets
Platelet Aggregation
Pharmaceutical Preparations
Epinephrine
7 Citations (Scopus)

Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies

Lee, T. Y., Chang, C. C., Lu, W-J., Yen, T. L., Lin, K. H., Geraldine, P., Li, J. Y. & Sheu, J-R., Jan 5 2017, In : Scientific Reports. 7, 40002.

Research output: Contribution to journalArticle

Collagen Receptors
Glycoproteins
Blood Platelets
Collagen
Platelet Activation
8 Citations (Scopus)

In vitro antioxidant and anticataractogenic potential of silver nanoparticles biosynthesized using an ethanolic extract of Tabernaemontana divaricata leaves

Anbukkarasi, M., Thomas, P. A., Sheu, J. R. & Geraldine, P., Jul 1 2017, In : Biomedicine and Pharmacotherapy. 91, p. 467-475 9 p.

Research output: Contribution to journalArticle

Tabernaemontana
Silver
Nanoparticles
Lenses
Antioxidants
5 Citations (Scopus)

Ketamine, a clinically used anesthetic, inhibits vascular smooth muscle cell proliferation via PP2A-activated PI3K/Akt/ERK inhibition

Chang, Y., Li, J. Y., Jayakumar, T., Hung, S. H., Lee, W. C., Manubolu, M., Sheu, J. R. & Hsu, M. J., Dec 1 2017, In : International Journal of Molecular Sciences. 18, 12, 2545.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
anesthetics
Enzyme inhibition
smooth muscle
Protein Phosphatase 2
4 Citations (Scopus)

New therapeutic agent against arterial thrombosis: An iridium(III)-derived organometallic compound

Hsia, C. W., Velusamy, M., Tsao, J. T., Hsia, C. H., Chou, D. S., Jayakumar, T., Lee, L. W., Li, J. Y. & Sheu, J. R., Dec 5 2017, In : International Journal of Molecular Sciences. 18, 12, 2616.

Research output: Contribution to journalArticle

Organometallic Compounds
thrombosis
Iridium
organometallic compounds
Organometallics
5 Citations (Scopus)

Nobiletin, a citrus flavonoid, activates Vasodilator-stimulated phosphoprotein in human platelets through non-cyclic nucleotide-related mechanisms

Jayakumar, T., Lin, K. C., Lu, W-J., Lin, C. Y., Pitchairaj, G., Li, J. Y. & Sheu, J-R., Jan 1 2017, In : International Journal of Molecular Medicine. 39, 1, p. 174-182 9 p.

Research output: Contribution to journalArticle

Citrus
Flavonoids
Blood Platelets
Nucleotides
Phosphorylation

Structure-activity relationship of three synthesized benzimidazole-based oligosaccharides in human platelet activation

Chang, Y., Hsu, W. H., Yang, W. B., Jayakumar, T., Lee, T. Y., Sheu, J. R., Lu, W. J. & Li, J. Y., Nov 1 2017, In : International Journal of Molecular Medicine. 40, 5, p. 1520-1528 9 p.

Research output: Contribution to journalArticle

Platelet Activation
Structure-Activity Relationship
Oligosaccharides
Collagen
p38 Mitogen-Activated Protein Kinases
1 Citation (Scopus)

The neuroprotective effects of Tao-Ren-Cheng-Qi Tang against embolic stroke in rats

Hsu, L. W., Shiao, W. C., Chang, N. C., Yu, M. C., Yen, T. L., Thomas, P. A., Jayakumar, T. & Sheu, J. R., Jan 31 2017, In : Chinese Medicine (United Kingdom). 12, 1, 7.

Research output: Contribution to journalArticle

Qi
Neuroprotective Agents
Stroke
Aspirin
Middle Cerebral Artery Infarction
2016
29 Citations (Scopus)
Heme Oxygenase-1
Cytoprotection
Endothelial cells
p38 Mitogen-Activated Protein Kinases
Rats
25 Citations (Scopus)

Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways

Lien, L. M., Wang, M. J., Chen, R. J., Chiu, H. C., Wu, J. L., Shen, M. Y., Chou, D. S., Sheu, J. R., Lin, K. H. & Lu, W-J., Feb 1 2016, In : Phytotherapy Research. 30, 2, p. 214-221 8 p.

Research output: Contribution to journalArticle

flavone
Glioma
Cell Movement
Cell Cycle
Growth
3 Citations (Scopus)

Novel synthetic benzimidazole-derived oligosaccharide, M3BIM, prevents ex vivo platelet aggregation and in vivo thromboembolism

Yen, T. L., Wu, M. P., Chung, C. L., Yang, W. B., Jayakumar, T., Geraldine, P., Chou, C. M., Chang, C. Y., Lu, W-J. & Sheu, J. R., Feb 17 2016, In : Journal of Biomedical Science. 23, 1, 26.

Research output: Contribution to journalArticle

Thromboembolism
Platelets
Oligosaccharides
Platelet Aggregation
Collagen
24 Citations (Scopus)

Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation

Shen, M. Y., Chen, F. Y., Hsu, J. F., Fu, R. H., Chang, C. M., Chang, C. T., Liu, C. H., Wu, J. R., Lee, A. S., Chan, H. C., Sheu, J. R., Lin, S. Z., Shyu, W. C., Sawamura, T., Chang, K. C., Hsu, C. Y. & Chen, C. H., Mar 10 2016, In : Blood. 127, 10, p. 1336-1345 10 p.

Research output: Contribution to journalArticle

Platelets
Platelet Aggregation
Oxidized LDL Receptors
LDL Lipoproteins
Agglomeration
17 Citations (Scopus)

Prevention of arterial thrombosis by nobiletin: In vitro and in vivo studies

Lu, W-J., Lin, K. C., Liu, C. P., Lin, C. Y., Wu, H. C., Chou, D. S., Geraldine, P., Huang, S. Y., Hsieh, C. Y. & Sheu, J. R., Feb 1 2016, In : Journal of Nutritional Biochemistry. 28, p. 1-8 8 p.

Research output: Contribution to journalArticle

Platelets
Thrombosis
Platelet Aggregation
Platelet Activation
Blood Platelets
2015
17 Citations (Scopus)

Astaxanthin, a carotenoid, stimulates immune responses by enhancing IFN-γ and Il-2 secretion in primary cultured lymphocytes in Vitro and ex Vivo

Lin, K. H., Lin, K. C., Lu, W-J., Thomas, P. A., Jayakumar, T. & Sheu, J. R., Dec 29 2015, In : International Journal of Molecular Sciences. 17, 1, 44.

Research output: Contribution to journalArticle

carotenoids
secretions
Lymphocytes
lymphocytes
Carotenoids
Cerebrovascular Disorders
Herbal Medicine
Traditional Medicine
Cardiovascular Diseases
Therapeutics
12 Citations (Scopus)

Cepharanthine mitigates lung injury in lower limb ischemia-reperfusion

Kao, M. C., Yang, C. H., Chou, W. C., Sheu, J. R. & Huang, C. J., Dec 1 2015, In : The Journal of surgical research. 199, 2, p. 647-656 10 p.

Research output: Contribution to journalArticle

Lung Injury
Reperfusion
Lower Extremity
Ischemia
Heme Oxygenase-1
7 Citations (Scopus)

Cepharanthine mitigates pro-inflammatory cytokine response in lung injury induced by hemorrhagic shock/resuscitation in rats

Kao, M. C., Yang, C. H., Sheu, J. R. & Huang, C. J., Dec 1 2015, In : Cytokine. 76, 2, p. 442-448 7 p.

Research output: Contribution to journalArticle

Resuscitation
Hemorrhagic Shock
Lung Injury
Rats
Cytokines
9 Citations (Scopus)

Hinokitiol exerts anticancer activity through downregulation of MMPs 9/2 and enhancement of catalase and SOD enzymes: In vivo augmentation of lung histoarchitecture

Huang, C. H., Jayakumar, T., Chang, C. C., Fong, T. H., Lu, S. H., Thomas, P. A., Choy, C-S. & Sheu, J. R., Sep 25 2015, In : Molecules. 20, 10, p. 17720-17734 15 p.

Research output: Contribution to journalArticle

catalase
inorganic peroxides
antioxidants
Matrix Metalloproteinases
Catalase
3 Citations (Scopus)
Concanavalin A
Cell Cycle Checkpoints
Lymphocytes
T-Lymphocytes
Cell Cycle Resting Phase
11 Citations (Scopus)

Inhibitory mechanisms of cme-1, a novel polysaccharide from the mycelia of cordyceps sinensis, in platelet activation

Chang, Y., Hsu, W. H., Lu, W. J., Jayakumar, T., Liao, J. C., Lin, M. J., Wang, S. H., Geraldine, P., Lin, K. H. & Sheu, J. R., 2015, In : Current Pharmaceutical Biotechnology. 16, 5, p. 451-461 11 p.

Research output: Contribution to journalArticle

Cordyceps
Mycelium
Platelet Activation
Polysaccharides
Platelet Aggregation

Innovative targeting strategies in drug therapy for inflammatory diseases: Mechanistic approaches

Chou, D. S., Sheu, J. R., Thomas, P. A. & Sakthivel, M., 2015, In : Scientific World Journal. 2015, 891676.

Research output: Contribution to journalArticle

Molecular Targeted Therapy
targeting
drug
Anti-Inflammatory Agents
Inflammation
16 Citations (Scopus)
interstitial collagenase
Matrix Metalloproteinase 1
gelatinase B
tumor necrosis factors
Matrix Metalloproteinase 9
2 Citations (Scopus)

Research performance of biomarkers from biofluids in periodontal disease publications

Lin, P. H., Yeh, S. K., Huang, W. C., Chen, H. Y., Chen, C. H., Sheu, J. R., Lin, C. T. & Huang, Y. K., Mar 1 2015, In : Journal of Dental Sciences. 10, 1, p. 61-67 7 p.

Research output: Contribution to journalArticle

Periodontal Diseases
Saliva
Publications
Biomarkers
Serum
5 Citations (Scopus)

Salutary effects of cepharanthine against skeletal muscle and kidney injuries following limb ischemia/reperfusion

Kao, M. C., Chung, C. Y., Chang, Y. Y., Lin, C. K., Sheu, J. R. & Huang, C. J., 2015, In : Evidence-based Complementary and Alternative Medicine. 2015, 504061.

Research output: Contribution to journalArticle

Reperfusion
Skeletal Muscle
Ischemia
Extremities
Kidney
12 Citations (Scopus)

Sesamol reduces the atherogenicity of electronegative L5 LDL in vivo and in vitro

Chen, W. Y., Chen, F. Y., Lee, A. S., Ting, K. H., Chang, C. M., Hsu, J. F., Lee, W. S., Sheu, J. R., Chen, C. H. & Shen, M. Y., Feb 27 2015, In : Journal of Natural Products. 78, 2, p. 225-233 9 p.

Research output: Contribution to journalArticle

High Fat Diet
Nutrition
LDL Lipoproteins
Fats
Atherosclerosis