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Research Output

2020
Open Access

Biomass and Lipid Production Potential of an Indian Marine Algal Isolate Tetraselmis striata BBRR1

Boopathy, A. B., Jayakumar, T., Chinnasamy, S., Rajaram, M. G., Mohan, N., Nagaraj, S., Rengasamy, R., Manubolu, M., Sheu, J. R. & Chang, C. C., Jan 1 2020, In : Energies. 13, 2, 341.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
Open Access

Modulation of human platelet activation and in vivo vascular thrombosis by columbianadin: Regulation by integrin αiIbβ3 inside-out but not outside-in signals

Hou, S. M., Hsia, C. W., Tsai, C. L., Hsia, C. H., Jayakumar, T., Velusamy, M. & Sheu, J. R., May 6 2020, In : Journal of Biomedical Science. 27, 1, 60.

Research output: Contribution to journalArticle

Open Access

Ruthenium derivatives attenuate LPS-induced inflammatory responses and liver injury via suppressing NF-κB signaling and free radical production

Jayakumar, T., Huang, H. C., Hsia, C. W., Fong, T. H., Khamrang, T., Velusamy, M., Manubolu, M., Sheu, J. R. & Hsia, C. H., Mar 2020, In : Bioorganic Chemistry. 96, 103639.

Research output: Contribution to journalArticle

2019

A critical period for the development of schizophrenia-like pathology by aberrant postnatal neurogenesis

Sheu, J. R., Hsieh, C. Y., Jayakumar, T., Tseng, M. F., Lee, H. N., Huang, S. W., Manubolu, M. & Yang, C. H., Jan 1 2019, In : Frontiers in Neuroscience. 13, JUN, 635.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Esculetin, A coumarin derivative, prevents thrombosis: Inhibitory signaling on PLCγ2-PKC-AKT activation in human platelets

Hsia, C. W., Lin, K. C., Lee, T. Y., Hsia, C. H., Chou, D. S., Jayakumar, T., Velusamy, M. & Sheu, J. R., Jun 1 2019, In : International Journal of Molecular Sciences. 20, 11, 2731.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

HDAC6 dysfunction contributes to impaired maturation of adult neurogenesis in vivo: vital role on functional recovery after ischemic stroke

Sheu, J-R., Hsieh, C-Y., Jayakumar, T., Lin, G-Y., Lee, H-N., Huang, S-W. & Yang, C-H., Apr 18 2019, In : Journal of Biomedical Science. 26, 1, 27.

Research output: Contribution to journalArticle

6 Citations (Scopus)

New therapeutic strategy of hinokitiol in haemorrhagic shock-induced liver injury

Lu, W-J., Lin, K-H., Tseng, M-F., Yuan, K-C., Huang, H-C., Sheu, J-R. & Chen, R-J., Mar 1 2019, In : Journal of Cellular and Molecular Medicine. 23, 3, p. 1723-1734 12 p.

Research output: Contribution to journalArticle

Protective effects of ammannia baccifera against ccl4-induced oxidative stress in rats

Goodla, L., Manubolu, M., Pathakoti, K., Jayakumar, T., Sheu, J. R., Fraker, M., Tchounwou, P. B. & Poondamalli, P. R., Apr 2 2019, In : International Journal of Environmental Research and Public Health. 16, 8, 1440.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Suppression of human platelet activation via integrin αiibβ3 outside-in independent signal and reduction of the mortality in pulmonary thrombosis by auraptene

Hsia, C. W., Tsai, C. L., Sheu, J. R., Lu, W. J., Hsia, C. H., Velusamy, M., Jayakumar, T. & Li, J. Y., Nov 2 2019, In : International Journal of Molecular Sciences. 20, 22, 5585.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
Open Access
1 Citation (Scopus)
2018

Analysis of Titin in Red and White Muscles: Crucial Role on Muscle Contractions Using a Fish Model

Wu, M. P., Chang, N. C., Chung, C. L., Chiu, W. C., Hsu, C. C., Chen, H. M., Sheu, J. R., Jayakumar, T., Chou, D. S. & Fong, T. H., Nov 18 2018, In : BioMed Research International. 2018, p. 5816875 11 p., 5816875.

Research output: Contribution to journalArticle

2 Citations (Scopus)

An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets

Lu, W. J., Chung, C. L., Chen, R. J., Huang, L. T., Lien, L. M., Chang, C. C., Lin, K. H. & Sheu, J. R., Nov 14 2018, In : Journal of Clinical Medicine. 7, 11

Research output: Contribution to journalArticle

Biofuel and biochemical analysis of amphora coffeaeformis RR03, a novel marine diatom, cultivated in an open raceway pond

Rajaram, M. G., Nagaraj, S., Manjunath, M., Boopathy, A. B., Kurinjimalar, C., Rengasamy, R., Jayakumar, T., Sheu, J. R. & Li, J. Y., Jun 1 2018, In : Energies. 11, 6, en11061341.

Research output: Contribution to journalArticle

1 Citation (Scopus)

CME-1, a novel polysaccharide, suppresses iNOS expression in lipopolysaccharide-stimulated macrophages through ceramide-initiated protein phosphatase 2A activation

Sheu, J. R., Chen, Z. C., Hsu, M. J., Wang, S. H., Jung, K. W., Wu, W. F., Pan, S. H., Teng, R. D., Yang, C. H. & Hsieh, C. Y., Feb 1 2018, In : Journal of Cellular and Molecular Medicine. 22, 2, p. 999-1013 15 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
Open Access

Hinokitiol inhibits migration of A549 lung cancer cells via suppression of MMPs and induction of antioxidant enzymes and apoptosis

Jayakumar, T., Liu, C. H., Wu, G. Y., Lee, T. Y., Manubolu, M., Hsieh, C. Y., Yang, C. H. & Sheu, J. R., Mar 22 2018, In : International Journal of Molecular Sciences. 19, 4, 939.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation

Shyu, R. S., Khamrang, T., Sheu, J. R., Hsia, C. W., Velusamy, M., Hsia, C. H., Chou, D. S. & Chang, C. C., Jan 1 2018, In : Bioinorganic Chemistry and Applications. 2018, p. 8291393 8291393.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Mechanism of free radical generation in platelets and primary hepatocytes: A novel electron spin resonance study

Wang, C. L., Yang, P. S., Tsao, J. T., Jayakumar, T., Wang, M. J., Sheu, J. R. & Chou, D. S., Jan 1 2018, In : Molecular Medicine Reports. 17, 1, p. 2061-2069 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Mechanisms of TQ-6, a Novel Ruthenium-Derivative Compound, against Lipopolysaccharide-Induced In Vitro Macrophage Activation and Liver Injury in Experimental Mice: The Crucial Role of p38 MAPK and NF-κB Signaling

Hsia, C-H., Velusamy, M., Jayakumar, T., Chen, Y-J., Hsia, C-W., Tsai, J-H., Teng, R-D. & Sheu, J-R., Nov 19 2018, In : Cells. 7, 11

Research output: Contribution to journalArticle

Molecular pharmacology and pathology of strokes

Sheu, J. R., Jan 1 2018, In : International Journal of Molecular Sciences. 19, 12, 4103.

Research output: Contribution to journalEditorial

4 Citations (Scopus)

Novel iridium (III)-derived organometallic compound for the inhibition of human platelet activation

Shyu, K. G., Velusamy, M., Hsia, C. W., Yang, C. H., Hsia, C. H., Chou, D. S., Jayakumar, T., Sheu, J. R. & Li, J. Y., May 1 2018, In : International Journal of Molecular Medicine. 41, 5, p. 2589-2600 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Novel therapeutic agent against platelet activation in vitro and arterial thrombosis in vivo by morin hydrate

Hsia, C. W., Wu, M. P., Velusamy, M., Hsia, C. H., Chou, D. S., Tsai, C. L., Hsu, C. Y., Jayakumar, T., Chung, C. L. & Sheu, J. R., Aug 13 2018, In : International Journal of Molecular Sciences. 19, 8, 2386.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Possible molecular targets of novel ruthenium complexes in antiplatelet therapy

Jayakumar, T., Hsu, C. Y., Khamrang, T., Hsia, C. H., Hsia, C. W., Manubolu, M. & Sheu, J. R., Jun 20 2018, In : International Journal of Molecular Sciences. 19, 6, 1818.

Research output: Contribution to journalReview article

5 Citations (Scopus)

Structure-antiplatelet activity relationships of novel ruthenium (ii) complexes: Investigation of its molecular targets

Hsia, C. H., Jayakumar, T., Sheu, J. R., Tsao, S. Y., Velusamy, M., Hsia, C. W., Chou, D. S., Chang, C. C., Chung, C. L., Khamrang, T. & Lin, K. C., Feb 22 2018, In : Molecules. 23, 2, 477.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Structure⁻Activity Relationship Study of Newly Synthesized Iridium-III Complexes as Potential Series for Treating Thrombotic Diseases

Yang, C. H., Hsia, C. W., Jayakumar, T., Sheu, J. R., Hsia, C. H., Khamrang, T., Chen, Y. J., Manubolu, M. & Chang, Y., Nov 19 2018, In : International Journal of Molecular Sciences. 19, 11

Research output: Contribution to journalArticle

1 Citation (Scopus)
2017

A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice

Sheu, J. R., Chen, Z. C., Jayakumar, T., Chou, D. S., Yen, T. L., Lee, H. N., Pan, S. H., Hsia, C. H., Yang, C. H. & Hsieh, C. Y., Feb 6 2017, In : Scientific Reports. 7, 42277.

Research output: Contribution to journalArticle

7 Citations (Scopus)

A novel ruthenium (II)-derived organometallic compound, TQ-6, potently inhibits platelet aggregation: Ex vivo and in vivo studies

Hsia, C. H., Velusamy, M., Sheu, J. R., Khamrang, T., Jayakumar, T., Lu, W. J., Lin, K. H. & Chang, C. C., Dec 1 2017, In : Scientific Reports. 7, 1, 9556.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Antiplatelet activity of a newly synthesized novel ruthenium (II): A potential role for Akt/JNK signaling

Khamrang, T., Hung, K. C., Hsia, C. H., Hsieh, C. Y., Velusamy, M., Jayakumar, T. & Sheu, J. R., May 1 2017, In : International Journal of Molecular Sciences. 18, 5, 916.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Development of benzimidazole derivatives as novel anti-platelet drugs

Yao, W. C., Yuan, L. T., Yang, W. B., Hsia, C. H., Huang, L. T., Lee, T. Y., Sheu, J. R., Lu, W-J., Jayakumar, T. & Chen, R. J., Jan 1 2017, In : Current Pharmaceutical Biotechnology. 18, 7, p. 594-605 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Open Access

Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies

Lee, T. Y., Chang, C. C., Lu, W-J., Yen, T. L., Lin, K. H., Geraldine, P., Li, J. Y. & Sheu, J-R., Jan 5 2017, In : Scientific Reports. 7, 40002.

Research output: Contribution to journalArticle

11 Citations (Scopus)

In vitro antioxidant and anticataractogenic potential of silver nanoparticles biosynthesized using an ethanolic extract of Tabernaemontana divaricata leaves

Anbukkarasi, M., Thomas, P. A., Sheu, J. R. & Geraldine, P., Jul 1 2017, In : Biomedicine and Pharmacotherapy. 91, p. 467-475 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Ketamine, a clinically used anesthetic, inhibits vascular smooth muscle cell proliferation via PP2A-activated PI3K/Akt/ERK inhibition

Chang, Y., Li, J. Y., Jayakumar, T., Hung, S. H., Lee, W. C., Manubolu, M., Sheu, J. R. & Hsu, M. J., Dec 1 2017, In : International Journal of Molecular Sciences. 18, 12, 2545.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Multi-targeting andrographolide, a novel NF-κB inhibitor, as a potential therapeutic agent for stroke

Yang, C. H., Yen, T. L., Hsu, C. Y., Thomas, P. A., Sheu, J. R. & Jayakumar, T., Aug 1 2017, In : International Journal of Molecular Sciences. 18, 8, 1638.

Research output: Contribution to journalReview article

43 Citations (Scopus)

New therapeutic agent against arterial thrombosis: An iridium(III)-derived organometallic compound

Hsia, C. W., Velusamy, M., Tsao, J. T., Hsia, C. H., Chou, D. S., Jayakumar, T., Lee, L. W., Li, J. Y. & Sheu, J. R., Dec 5 2017, In : International Journal of Molecular Sciences. 18, 12, 2616.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Nobiletin, a citrus flavonoid, activates Vasodilator-stimulated phosphoprotein in human platelets through non-cyclic nucleotide-related mechanisms

Jayakumar, T., Lin, K. C., Lu, W-J., Lin, C. Y., Pitchairaj, G., Li, J. Y. & Sheu, J-R., Jan 1 2017, In : International Journal of Molecular Medicine. 39, 1, p. 174-182 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Structure-activity relationship of three synthesized benzimidazole-based oligosaccharides in human platelet activation

Chang, Y., Hsu, W. H., Yang, W. B., Jayakumar, T., Lee, T. Y., Sheu, J. R., Lu, W. J. & Li, J. Y., Nov 1 2017, In : International Journal of Molecular Medicine. 40, 5, p. 1520-1528 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The neuroprotective effects of Tao-Ren-Cheng-Qi Tang against embolic stroke in rats

Hsu, L. W., Shiao, W. C., Chang, N. C., Yu, M. C., Yen, T. L., Thomas, P. A., Jayakumar, T. & Sheu, J. R., Jan 31 2017, In : Chinese Medicine (United Kingdom). 12, 1, 7.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2016
34 Citations (Scopus)

Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways

Lien, L. M., Wang, M. J., Chen, R. J., Chiu, H. C., Wu, J. L., Shen, M. Y., Chou, D. S., Sheu, J. R., Lin, K. H. & Lu, W-J., Feb 1 2016, In : Phytotherapy Research. 30, 2, p. 214-221 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Novel synthetic benzimidazole-derived oligosaccharide, M3BIM, prevents ex vivo platelet aggregation and in vivo thromboembolism

Yen, T. L., Wu, M. P., Chung, C. L., Yang, W. B., Jayakumar, T., Geraldine, P., Chou, C. M., Chang, C. Y., Lu, W-J. & Sheu, J. R., Feb 17 2016, In : Journal of Biomedical Science. 23, 1, 26.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation

Shen, M. Y., Chen, F. Y., Hsu, J. F., Fu, R. H., Chang, C. M., Chang, C. T., Liu, C. H., Wu, J. R., Lee, A. S., Chan, H. C., Sheu, J. R., Lin, S. Z., Shyu, W. C., Sawamura, T., Chang, K. C., Hsu, C. Y. & Chen, C. H., Mar 10 2016, In : Blood. 127, 10, p. 1336-1345 10 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Prevention of arterial thrombosis by nobiletin: In vitro and in vivo studies

Lu, W-J., Lin, K. C., Liu, C. P., Lin, C. Y., Wu, H. C., Chou, D. S., Geraldine, P., Huang, S. Y., Hsieh, C. Y. & Sheu, J. R., Feb 1 2016, In : Journal of Nutritional Biochemistry. 28, p. 1-8 8 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

The pharmacodynamics of antiplatelet compounds in thrombosis treatment

Jayakumar, T., Yang, C. H., Geraldine, P., Yen, T. L. & Sheu, J. R., Jun 2 2016, In : Expert Opinion on Drug Metabolism and Toxicology. 12, 6, p. 615-632 18 p.

Research output: Contribution to journalReview article

10 Citations (Scopus)
2015

Astaxanthin, a carotenoid, stimulates immune responses by enhancing IFN-γ and Il-2 secretion in primary cultured lymphocytes in Vitro and ex Vivo

Lin, K. H., Lin, K. C., Lu, W-J., Thomas, P. A., Jayakumar, T. & Sheu, J. R., Dec 29 2015, In : International Journal of Molecular Sciences. 17, 1, 44.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Cepharanthine mitigates lung injury in lower limb ischemia-reperfusion

Kao, M. C., Yang, C. H., Chou, W. C., Sheu, J. R. & Huang, C. J., Dec 1 2015, In : The Journal of surgical research. 199, 2, p. 647-656 10 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)