Projects per year
Personal profile
Experience
- 2014.08.01- 臺北醫學大學公共衛生暨營養學院副院長
- 2010.03.01-2014.02.19 臺北醫學大學健康食品研究中心主任
- 2009.08.01-2015.07.31 臺北醫學大學保健營養學系主任
- 2004.08.01- 臺北醫學大學保健營養學系教授
- 2002.08.01-2009.07.31 臺北醫學大學生涯發展與就業服務組組長
- 1996.08.01-2004.07.31 臺北醫學大學保健營養學系副教授
- 1995.08.07-1996.07.31 金車股份公司專員
Research Interests
- 大豆蛋白質對於血壓、血糖、脂質代謝之影響
- 大豆蛋白與酪蛋白對慢性腎衰竭模式動物殘存腎功能的影響
- β-conglycinin對糖尿病腎病變的影響
- 探討大豆蛋白對脂肪變性肝炎影響之機制
- 大豆蛋白對一氧化氮缺乏誘發高血壓之大白鼠血壓和組織損傷的影響
Education
- 1995 Ph.D., Tohoku University
- 1992 M.S., Tohoku University
- 1988 B.S., School of Nutrition and Health Sciences, Taipei Medical University
URL
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Network
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Projects
- 13 Finished
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本研究擬探討高度糖化終產物及其前驅物甲基乙二醛誘發腎臟與內皮功能損傷之負 面效應，並釐清該損傷機轉是否與活化發炎體有關；此外，另探討白藜蘆醇之介入是否對 於上述損傷具有保護作用。第一部分實驗以高度糖化終產物接受器抑制劑釐清腎臟中高度 糖化終產物接受器的表現是否和發炎體路徑的活化有關，此外評估不同種高度糖化終產物 對於小鼠腎功能之影響。第二部分實驗則以高度糖化終產物接受器抑制劑證實抑制受器和 高度糖化中產物之交互作用是否可達到減少自由基產生進而抑制發炎體的活化以減緩發 炎反應所造成的腎損傷。第三部實驗分則觀察白藜蘆醇對於以高度糖化終產物前驅物MG 誘發腎損傷之影響並釐清白藜蘆醇是否可透過影響發炎體的活化達到延緩腎臟受損的作 用。研究預期長期高度糖化終產物和其前驅物‐甲基乙二醇的投與會使高度糖化終產堆積 在腎臟，也可能經由與其接受器結合進入細胞中活化發炎體路徑使腎臟發炎，使腎臟和內 皮功能損傷。因此減少暴露於高度糖化終產物的環境下或是抑制其接受器的作用皆可抑制 發炎體的活化達到延緩腎損傷的作用，且白藜蘆醇的介入對於上述損傷可能具有保護作用。
8/1/16 → 7/31/17
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of Antrodia cinnamomea Extract on Fat Accumulation and Energy Expenditure
8/1/15 → 7/31/16
Project: A - Government Institution › b - Ministry of Science and Technology
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104年度「食品安全守護聯盟計畫」
1/1/15 → 12/31/15
Project: A - Government Institution › c - Ministry of Health and Welfare
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Evaluation on prevention for metabolic syndrome and diabetes mellitus through lifestyle modification intervention in pre-diabetic subjects (100-104)
Chiou, H., Bai, C., Tang, C., Yang, S., Su, C., Liou, T., Wang, S., Chen, J., Hsieh, A. & Huang, C.
12/24/14 → 12/5/15
Project: A - Government Institution › c - Ministry of Health and Welfare
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Effects of Antrodia Camphorate Extract on Diet-Induced Steatohepatitis
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
Research output
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Effects of coriandrum sativum seed extract on aging-induced memory impairment in samp8 mice
Mima, Y., Izumo, N., Chen, J. R., Yang, S. C., Furukawa, M. & Watanabe, Y., Feb 11 2020, In: Nutrients. 12, 2, 455.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Antroquinonol Attenuated Abdominal and Hepatic Fat Accumulation in Rats Fed an Obesogenic Diet
Chen, J. R., Yeh, W. J., Tan, H. Y. & Yang, H. Y., Sep 1 2019, In: Journal of Food Science. 84, 9, p. 2682-2687 6 p.Research output: Contribution to journal › Article › peer-review
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Camellia oleifera seed extract attenuated abdominal and hepatic fat accumulation in rats fed a high-fat diet
Yang, H. Y., Yeh, W. J., Ko, J. & Chen, J. R., Mar 2019, In: Applied Physiology, Nutrition and Metabolism. 44, 3, p. 320-325 6 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
Renoprotective Effects of Antroquinonol in Rats with Nω-Nitro-l-Arginine Methyl Ester-Induced Hypertension
Chen, J. R., Ko, J., Yeh, W. J., Huang, W. C. & Yang, H. Y., Oct 17 2018, In: Nutrients. 10, 10, 1521.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
Long-term administration of advanced glycation end-product stimulates the activation of NLRP3 inflammasome and sparking the development of renal injury
Yeh, W. J., Yang, H. Y., Pai, M-H., Wu, C-H. & Chen, J-R., Jan 1 2017, In: Journal of Nutritional Biochemistry. 39, p. 68-76 9 p.Research output: Contribution to journal › Article › peer-review
23 Citations (Scopus)