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Personal profile

Research Interests

  • Discovery and Development of small molecules towards IND
  • Structure optimization through rational drug design
  • Total Synthesis of natural products and its intelligent modification

Education

  • Ph.D. in Pharmaceutical Sciences, National Taiwan University

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 9 Similar Profiles
Tubulin Modulators Medicine & Life Sciences
Tubulin Medicine & Life Sciences
Histone Deacetylase Inhibitors Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Histone Deacetylases Medicine & Life Sciences
Antimitotic Agents Medicine & Life Sciences
Inhibitory Concentration 50 Medicine & Life Sciences
Antineoplastic Agents Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2013 2019

運用有機金屬偶聯反應於抗癌試劑合(2/2)

Liou, J.

8/1/187/31/19

Project: b - Ministry of Science and Technology

運用有機金屬偶聯反應於抗癌試劑合成(1/2)

Liou, J.

8/1/177/31/18

Project: b - Ministry of Science and Technology

Syntheses of Anti-Lung Cancer Agents(1/2)

Liou, J.

6/1/175/31/18

Project: b - Ministry of Science and Technology

105大專生計畫獎-劉景平

Liou, J.

8/1/167/31/17

Project: b - Ministry of Science and Technology

1,4-Benzoquinone之位向選擇性取代應用於抗癌試劑研發(3/3)

Liou, J.

8/1/167/31/17

Project: b - Ministry of Science and Technology

Research Output 1996 2019

  • 2277 Citations
  • 25 h-Index
  • 112 Article
  • 2 Review article
  • 1 Comment/debate

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

3 Citations

(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo

Lee, H. Y., Nepali, K., Huang, F. I., Chang, C. Y., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Feb 8 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 905-917 13 p.

Research output: Contribution to journalArticle

Quinolines
Histone Deacetylase Inhibitors
Multiple Myeloma
Growth
Hydroxamic Acids
2 Citations

1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC

Ojha, R., Huang, H. L., HuangFu, W. C., Wu, Y. W., Nepali, K., Lai, M. J., Su, C. J., Sung, T. Y., Chen, Y. L., Pan, S. L. & Liou, J. P., Apr 25 2018, In : European Journal of Medicinal Chemistry. 150, p. 667-677 11 p.

Research output: Contribution to journalArticle

Hydroxamic Acids
Histone Deacetylase Inhibitors
Antineoplastic Agents
Protein Isoforms
Cells

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Jan 29 2018, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

tau Proteins
Histone Deacetylase Inhibitors
Alzheimer Disease
Hydroxamic Acids
Phenotype

A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo

Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., Mar 13 2018, In : Frontiers in Pharmacology. 9, MAR, 205.

Research output: Contribution to journalArticle

Tubulin Modulators
Histone Deacetylases
Neoplasms
Tubulin
Molecular Docking Simulation