Projects per year
Personal profile
Education
- 2000 Ph.D., Graduate Institute of Pharmaceutical Sciences, National Taiwan University
- 1996 M.S., Graduate Institute of Pharmaceutical Sciences, National Taiwan University
- 1994 B.S., School of Pharmacy, Taipei Medical University
Experience
- 2018- Dean, College of Pharmacy, Taipei Medical University
- 2017- Director, Biomedical Commercialization Center, Taipei Medical University
- 2015- Director, Research Center of Pharmaceutical Sciences and Biotechnology, College of Pharmacy, Taipei Medical University
- 2013-2017 Associate Dean, College of Pharmacy, Taipei Medical University
- 2012-2016 Director, Core Laboratory of Drug Organic Synthesis, Taipei Medical University
- 2013- Jointly Appointed Professor, Ph.D. Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University
- 2013- Jointly Appointed Professor, Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University
- 2012- Professor, School of Pharmacy, College of Pharmacy, Taipei Medical University
- 2008-2012 Associate Professor, School of Pharmacy, College of Pharmacy, Taipei Medical University
- 2004-2008 Assistant Professor, School of Pharmacy, College of Pharmacy, Taipei Medical University
- 2000-2004 Postdoctoral Research, Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes
Awards
- 2019 Total Research project Budget Award - Excellence Award, Taipei Medical University
- 2019 Excellent Industry-Academia Collaboration Award, Taipei Medical University
1. EDITORIAL ADVISORY BOARD members, Journal of Medicinal Chemistry (IF = 6.259, CHEMISTRY/MEDICINAL)
2. 2015 Taipei Medical University Teaching Award
3. 2014 Taipei Biotech Awards, Gold “Industry-University Cooperation Award”
4. 2014 TienTe Lee Award, Young Scientist Award
5. 2011 Young scientist award, Ching-Kang Foundation for Pharmacy Promotion
Research Interests
- Discovery and Development of small molecular compounds towards IND
- Structure optimization through rational drug design and intelligent modification
- Medicinal Chemistry
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Projects
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開發阻斷神經類固醇生合成與雄性素接受器活性的新穎藥物以避免癌症抗藥性
1/1/21 → 12/31/21
Project: B - Project of TMU › h - Higher Education Sprout Project
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有機金屬催化反應於合成化學和藥物化學之抗癌表觀遺傳學抑制劑研究(2/2)
8/1/20 → 7/1/21
Project: A - Government Institution › b - Ministry of Science and Technology
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Lysine-specific histone demethylase 1 抑制劑的研發
2/1/20 → 1/31/21
Project: A - Government Institution › b - Ministry of Science and Technology
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開發阻斷神經類固醇生合成與雄性素接受器活性的新穎藥物以避免癌症抗藥性
1/1/20 → 12/31/20
Project: A - Government Institution › d - Ministry of Education
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Synthetic and Medicinal Utility of Organometallics in the Development of Anticancer Epigenetic Inhibitors: Applications and Explorations( I )( I )(1/2)
8/1/19 → 7/31/20
Project: A - Government Institution › b - Ministry of Science and Technology
Research output
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A novel histone deacetylase inhibitor MPT0L184 dysregulates cell-cycle checkpoints and initiates unscheduled mitotic signaling
Chang, T. Y., Nepali, K., Chen, Y. Y., Yang, Y. C. S. H., Hsu, K. C., Yen, Y., Pan, S. L., Liou, J. P. & Lee, S. B., Jun 2021, In: Biomedicine and Pharmacotherapy. 138, 111485.Research output: Contribution to journal › Article › peer-review
Open Access -
CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition
Singh, A., Chang, T. Y., Kaur, N., Hsu, K. C., Yen, Y., Lin, T. E., Lai, M. J., Lee, S. B. & Liou, J. P., Apr 5 2021, In: European Journal of Medicinal Chemistry. 215, 113169.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms
Mehndiratta, S., Chen, M. C., Chao, Y. H., Lee, C. H., Liou, J. P., Lai, M. J. & Lee, H. Y., Dec 2021, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 36, 1, p. 74-84 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Erratum: TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis (Theranostics (2019) 9:22 (6676-6689) DOI: 10.7150/thno.34020)
Huang, H. L., Liu, Y. M., Sung, T. Y., Huang, T. C., Cheng, Y. W., Liou, J. P. & Pan, S. L., Jan 1 2021, In: Theranostics. 11, 5, p. 2079 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Pragmatic recruitment of memantine as the capping group for the design of HDAC inhibitors: A preliminary attempt to unravel the enigma of glioblastoma
Nepali, K., Hsu, T. I., Hsieh, C. M., Lo, W. L., Lai, M. J., Hsu, K. C., Lin, T. E., Chuang, J. Y. & Liou, J. P., May 5 2021, In: European Journal of Medicinal Chemistry. 217, 113338.Research output: Contribution to journal › Article › peer-review
Datasets
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Additional file 5: of Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status
Chao, M. (Contributor), Chang, L. (Contributor), Tu, H. (Contributor), Chang, C. (Contributor), Lai, M. (Contributor), Chen, Y. (Contributor), Liou, J. (Contributor), Teng, C. (Contributor) & Pan, S. (Contributor), Unknown Publisher, May 29 2019
DOI: 10.6084/m9.figshare.8202902.v1, https://springernature.figshare.com/articles/Additional_file_5_of_Combination_treatment_strategy_for_pancreatic_cancer_involving_the_novel_HDAC_inhibitor_MPT0E028_with_a_MEK_inhibitor_beyond_K-Ras_status/8202902/1
Dataset
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Additional file 1: of Novel microtubule inhibitor MPT0B098 inhibits hypoxia-induced epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma
Tsai, I. (Contributor), Kuo, C. (Contributor), Liou, J. (Contributor) & Chang, J. (Contributor), Unknown Publisher, Mar 28 2018
DOI: 10.6084/m9.figshare.6061133.v1, https://springernature.figshare.com/articles/Additional_file_1_of_Novel_microtubule_inhibitor_MPT0B098_inhibits_hypoxia-induced_epithelial-to-mesenchymal_transition_in_head_and_neck_squamous_cell_carcinoma/6061133/1
Dataset
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Additional file 4: of Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status
Chao, M. (Contributor), Chang, L. (Contributor), Tu, H. (Contributor), Chang, C. (Contributor), Lai, M. (Contributor), Chen, Y. (Contributor), Liou, J. (Contributor), Teng, C. (Contributor) & Pan, S. (Contributor), Unknown Publisher, May 29 2019
DOI: 10.6084/m9.figshare.8202896.v1, https://springernature.figshare.com/articles/Additional_file_4_of_Combination_treatment_strategy_for_pancreatic_cancer_involving_the_novel_HDAC_inhibitor_MPT0E028_with_a_MEK_inhibitor_beyond_K-Ras_status/8202896/1
Dataset
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Additional file 1: of The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells
Tu, H. (Contributor), Lin, Y. (Contributor), Chao, M. (Contributor), Sung, T. (Contributor), Wu, Y. (Contributor), Chen, Y. (Contributor), Lin, M. (Contributor), Liou, J. (Contributor), Pan, S. (Contributor) & Yang, C. (Contributor), Unknown Publisher, Dec 29 2018
DOI: 10.6084/m9.figshare.7531874.v1, https://springernature.figshare.com/articles/Additional_file_1_of_The_anticancer_effects_of_MPT0G211_a_novel_HDAC6_inhibitor_combined_with_chemotherapeutic_agents_in_human_acute_leukemia_cells/7531874/1
Dataset
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Suberoylanilide hydroxamic acid represses glioma stem-like cells
Hsu, C. (Contributor), Chang, W. (Contributor), Hsu, T. (Contributor), Liu, J. (Contributor), Yeh, S. (Contributor), Wang, J. (Contributor), Liou, J. (Contributor), Ko, C. (Contributor), Chang, K. (Contributor) & Chuang, J. (Contributor), Unknown Publisher, Nov 18 2016
DOI: 10.6084/m9.figshare.c.3596465.v1, https://figshare.com/collections/Suberoylanilide_hydroxamic_acid_represses_glioma_stem-like_cells/3596465/1
Dataset