Projects per year
Personal profile
Research Interests
- Discovery and Development of small molecules towards IND
- Structure optimization through rational drug design
- Total Synthesis of natural products and its intelligent modification
Education
- Ph.D. in Pharmaceutical Sciences, National Taiwan University
Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
- 9 Similar Profiles
Tubulin Modulators
Medicine & Life Sciences
Tubulin
Medicine & Life Sciences
Histone Deacetylase Inhibitors
Medicine & Life Sciences
Neoplasms
Medicine & Life Sciences
Histone Deacetylases
Medicine & Life Sciences
Antimitotic Agents
Medicine & Life Sciences
Inhibitory Concentration 50
Medicine & Life Sciences
Antineoplastic Agents
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2013 2019
Syntheses of Anti-Lung Cancer Agents(1/2)
6/1/17 → 5/31/18
Project: b - Ministry of Science and Technology
1,4-Benzoquinone之位向選擇性取代應用於抗癌試劑研發(3/3)
8/1/16 → 7/31/17
Project: b - Ministry of Science and Technology
Research Output 1996 2019
1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase
Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.Research output: Contribution to journal › Article
(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo
Lee, H. Y., Nepali, K., Huang, F. I., Chang, C. Y., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Feb 8 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 905-917 13 p.Research output: Contribution to journal › Article
Quinolines
Histone Deacetylase Inhibitors
Multiple Myeloma
Growth
Hydroxamic Acids
1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC
Ojha, R., Huang, H. L., HuangFu, W. C., Wu, Y. W., Nepali, K., Lai, M. J., Su, C. J., Sung, T. Y., Chen, Y. L., Pan, S. L. & Liou, J. P., Apr 25 2018, In : European Journal of Medicinal Chemistry. 150, p. 667-677 11 p.Research output: Contribution to journal › Article
Hydroxamic Acids
Histone Deacetylase Inhibitors
Antineoplastic Agents
Protein Isoforms
Cells
5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes
Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Jan 29 2018, (Accepted/In press) In : Journal of Medicinal Chemistry.Research output: Contribution to journal › Article
tau Proteins
Histone Deacetylase Inhibitors
Alzheimer Disease
Hydroxamic Acids
Phenotype
A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo
Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., Mar 13 2018, In : Frontiers in Pharmacology. 9, MAR, 205.Research output: Contribution to journal › Article
Tubulin Modulators
Histone Deacetylases
Neoplasms
Tubulin
Molecular Docking Simulation