• 1129 Citations
  • 21 h-Index
20012019
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Research Output 2001 2019

  • 1129 Citations
  • 21 h-Index
  • 48 Article
  • 1 Chapter
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Article
2019

Alteration of mesenchymal stem cells polarity by laminar shear stimulation promoting β-catenin nuclear localization

Chen, W-T., Hsu, W-T., Yen, M-H., Changou, C. A., Han, C-L., Chen, Y-J., Cheng, J-Y., Chang, T-H., Lee, O. K-S. & Ho, J. H-C., Jan 1 2019, In : Biomaterials. 190-191, p. 1-10 10 p.

Research output: Contribution to journalArticle

Catenins
Cell Polarity
Stem cells
Mesenchymal Stromal Cells
Shear stress
Open Access
Spermatic Cord Torsion
Sperm Motility
Stem cells
Mesenchymal Stromal Cells
Metabolism
2017
2 Citations (Scopus)

Ankylosing spondylitis and the risk of cancer

Chang, C. C., Chang, C. W., Nguyen, P. A. A., Chang, T. H., Shih, Y. L., Chang, W. Y., Horng, J. T., Lee, O. K. S. & Ho, J. H. C., 2017, In : Oncology Letters. 14, 2, p. 1315-1322 8 p.

Research output: Contribution to journalArticle

Ankylosing Spondylitis
Neoplasms
Incidence
Confidence Intervals
Bone Neoplasms
6 Citations (Scopus)

DNA Methyltransferases Modulate Hepatogenic Lineage Plasticity of Mesenchymal Stromal Cells

Lee, C. W., Huang, W. C., Huang, H. D., Huang, Y. H., Ho, J. H., Yang, M. H., Yang, V. W. & Lee, O. K., 2017, In : Stem Cell Reports.

Research output: Contribution to journalArticle

Methyltransferases
Mesenchymal Stromal Cells
Plasticity
Hepatocytes
Transforming Growth Factors
10 Citations (Scopus)

Treatment of spinocerebellar ataxia with mesenchymal stem cells: A phase I/IIa clinical study

Tsai, Y. A., Liu, R. S., Lirng, J. F., Yang, B. H., Chang, C. H., Wang, Y. C., Wu, Y. S., Ho, J. H. C., Lee, O. K. & Soong, B. W., 2017, In : Cell Transplantation. 26, 3, p. 503-512 10 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Stem cells
Mesenchymal Stromal Cells
Machado-Joseph Disease
Intravenous Administration
2016
5 Citations (Scopus)

Detection of hepatic maturation by Raman spectroscopy in mesenchymal stromal cells undergoing hepatic differentiation

Wu, H. H., Ho, J. H. & Lee, O. K., Jan 11 2016, In : Stem Cell Research and Therapy. 7, 1, 6.

Research output: Contribution to journalArticle

Raman Spectrum Analysis
Mesenchymal Stromal Cells
Raman spectroscopy
Hepatocytes
Liver
7 Citations (Scopus)

Efficient generation of hepatic cells from mesenchymal stromal cells by an innovative bio-microfluidic cell culture device

Yen, M. H., Wu, Y. Y., Liu, Y. S., Rimando, M., Ho, J. H. C. & Lee, O. K. S., Aug 19 2016, In : Stem Cell Research and Therapy. 7, 1, 120.

Research output: Contribution to journalArticle

Lab-On-A-Chip Devices
Microfluidics
Mesenchymal Stromal Cells
Cell culture
Hepatocytes
2 Citations (Scopus)

Nasal dissemination of a single-clone IgH-rearranged conjunctival MALT lymphoma through the nasolacrimal duct: A case report

Hsieh, C. Y., Liao, Y. P., Wu, C. C., Yuan, S. P., Ho, J. H. C., Roan, R., Liew, P. L., Lai, M-T. & Lee, F., Aug 1 2016, In : Oncology Letters. 12, 2, p. 1007-1010 4 p.

Research output: Contribution to journalArticle

Nasolacrimal Duct
Marginal Zone B-Cell Lymphoma
Immunoglobulin Heavy Chains
Nose
Nasal Cavity
9 Citations (Scopus)

Stromal Tissue Rigidity Promotes Mesenchymal Stem Cell-Mediated Corneal Wound Healing Through the Transforming Growth Factor β Signaling Pathway

Yang, Y. H., Hsieh, T. L., Ji, A. T. Q., Hsu, W. T., Liu, C. Y., Lee, O. K. S. & Ho, J. H. C., Oct 1 2016, In : Stem Cells. 34, 10, p. 2525-2535 11 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Mesenchymal Stromal Cells
Wound Healing
Re-Epithelialization
Transforming Growth Factor beta
19 Citations (Scopus)

Three-dimensional spherical spatial boundary conditions differentially regulate osteogenic differentiation of mesenchymal stromal cells

Lo, Y. P., Liu, Y. S., Rimando, M. G., Ho, J. H. C., Lin, K. H. & Lee, O. K., Feb 17 2016, In : Scientific Reports. 6, 21253.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Cues
Integrins
Focal Adhesions
Aptitude
2015

Erratum: Oscillatory shear stress mediates directional reorganization of actin cytoskeleton and alters differentiation propensity of mesenchymal stem cells (Stem Cells (2015) 33:429 DOI: 10.1002/stem.1860)

Kuo, Y. C., Chang, T. H., Hsu, W. T., Zhou, J., Lee, H. H., Ho, J. H. C., Chien, S. & Lee, O. K. S., May 1 2015, In : Stem Cells. 33, 5, p. 1682 1 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Actin Cytoskeleton
Stem Cells
18 Citations (Scopus)

Local injection of mesenchymal stem cells protects testicular torsion-induced germ cell injury

Hsiao, C. H., Ji, A. T. Q., Chang, C-C., Cheng, C. J., Lee, L-M. & Ho, J. H. C., May 30 2015, (Accepted/In press) In : Stem Cell Research and Therapy.

Research output: Contribution to journalArticle

Spermatic Cord Torsion
Stem cells
Mesenchymal Stromal Cells
Germ Cells
Torsional stress
21 Citations (Scopus)

Niche-dependent regulations of metabolic balance in high-fat diet-induced diabetic mice by mesenchymal stromal cells

Ji, A. T. U. Q., Chang, Y. C., Fu, Y. J., Lee, O. K. & Ho, J. H., Mar 1 2015, In : Diabetes. 64, 3, p. 926-936 11 p.

Research output: Contribution to journalArticle

High Fat Diet
Mesenchymal Stromal Cells
Cell Transplantation
Homeostasis
Glucose
27 Citations (Scopus)

Oscillatory shear stress mediates directional reorganization of actin cytoskeleton and alters differentiation propensity of mesenchymal stem cells

Kuo, Y. C., Chang, T. H., Hsu, W. T., Zhou, J., Lee, H. H., Hui-Chun Ho, J., Chien, S. & Kuang-Sheng, O., Feb 1 2015, In : Stem Cells. 33, 2, p. 429-442 14 p.

Research output: Contribution to journalArticle

Catenins
Mesenchymal Stromal Cells
Actin Cytoskeleton
Actins
Wnt Signaling Pathway
12 Citations (Scopus)

Promotion of mesenchymal-to-epithelial transition by rac1 inhibition with small molecules accelerates hepatic differentiation of mesenchymal stromal cells

Teng, N. Y., Liu, Y. S., Wu, H. H., Liu, Y. A., Ho, J. H. & Lee, O. K. S., Apr 1 2015, In : Tissue Engineering - Part A. 21, 7-8, p. 1444-1454 11 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Mesenchymal Stromal Cells
rac1 GTP-Binding Protein
Cells
Molecules
7 Citations (Scopus)

Regulation of metastatic ability and drug resistance in pulmonary adenocarcinoma by matrix rigidity via activating c-Met and EGFR

Chang, C-C., Hsieh, T. L., Tiong, T. Y., Hsiao, C. H., Ji, A. T. Q., Hsu, W. T., Lee, O. K. & Ho, J. H., Aug 1 2015, In : Biomaterials. 60, p. 141-150 10 p.

Research output: Contribution to journalArticle

Aptitude
Epidermal Growth Factor Receptor
Drug Resistance
Rigidity
Lung
2014
10 Citations (Scopus)

The ability to suppress macrophage-mediated inflammation in orbital fat stem cells is controlled by miR-671-5p

Lien, G. S., Liu, J-F., Chien, M. H., Hsu, W. T., Chang, T. H., Ku, C. C., Ji, A. T. Q., Tan, P., Hsieh, T. L., Lee, L. M. & Ho, J. H., Aug 13 2014, In : Stem Cell Research and Therapy. 5, 4, 97.

Research output: Contribution to journalArticle

Macrophages
Stem cells
Adipocytes
Stem Cells
Fats
16 Citations (Scopus)

The effects of actin cytoskeleton perturbation on keratin intermediate filament formation in mesenchymal stem/stromal cells

Chang, T. H., Huang, H. D., Ong, W. K., Fu, Y. J., Lee, O. K., Chien, S. & Ho, J. H., Apr 2014, In : Biomaterials. 35, 13, p. 3934-3944 11 p.

Research output: Contribution to journalArticle

Keratin
Intermediate Filaments
Keratins
Stem cells
Mesenchymal Stromal Cells
2013
13 Citations (Scopus)

An iTRAQ proteomic study reveals an association between diet-induced enhanced fatty acid metabolism and the development of glucose intolerance in prediabetic mice

Ho, J. H., Lee, O. K., Fu, Y. J., Shih, H. T., Tseng, C. Y., Chung, C. C., Han, C. L. & Chen, Y. J., 2013, In : Journal of Proteome Research. 12, 3, p. 1120-1133 14 p.

Research output: Contribution to journalArticle

Glucose Intolerance
High Fat Diet
Nutrition
Metabolism
Proteomics
33 Citations (Scopus)

CD133-expressing thyroid cancer cells are undifferentiated, radioresistant and survive radioiodide therapy

Ke, C. C., Liu, R. S., Yang, A. H., Liu, C. S., Chi, C. W., Tseng, L. M., Tsai, Y. F., Ho, J. H., Lee, C. H. & Lee, O. K., Jan 2013, In : European Journal of Nuclear Medicine and Molecular Imaging. 40, 1, p. 61-71 11 p.

Research output: Contribution to journalArticle

Thyroid Neoplasms
Therapeutics
Cell Line
Recurrence
Neoplastic Stem Cells

Decrease in inner retinal thickness at para-and perifoveal areas before vascular retinopathy in patients with metabolic risk factors

Lin, K. J., Loi, M. X., Lei, S. Y., Shiau, C. C., Wu, C-L. & Ho, J. H. C., Sep 2013, In : Taiwan Journal of Ophthalmology. 3, 3, p. 108-115 8 p.

Research output: Contribution to journalArticle

Blood Vessels
Vision Disorders
Dyslipidemias
Hyperglycemia
Hypertension
27 Citations (Scopus)

In Vivo Fluorescence Imaging Reveals the Promotion of Mammary Tumorigenesis by Mesenchymal Stromal Cells

Ke, C. C., Liu, R. S., Suetsugu, A., Kimura, H., Ho, J. H., Lee, O. K. & Hoffman, R. M., Jul 25 2013, In : PLoS One. 8, 7, e69658.

Research output: Contribution to journalArticle

stromal cells
Optical Imaging
Mesenchymal Stromal Cells
carcinogenesis
breasts
25 Citations (Scopus)

The activation of directional stem cell motility by green light-emitting diode irradiation

Ong, W. K., Chen, H. F., Tsai, C. T., Fu, Y. J., Wong, Y. S., Yen, D. J., Chang, T. H., Huang, H. D., Kuang-Sheng Lee, O., Chien, S. & Hui-Chun Ho, J., Mar 2013, In : Biomaterials. 34, 8, p. 1911-1920 10 p.

Research output: Contribution to journalArticle

Methyl Green
Stem cells
Cell Movement
Light emitting diodes
Stem Cells
24 Citations (Scopus)

Topical administration of orbital fat-derived stem cells promotes corneal tissue regeneration

Lin, K. J., Loi, M. X., Lien, G. S., Cheng, C. F., Pao, H. Y., Chang, Y. C., Ji, A. T. Q. & Ho, J. H. C., 2013, In : Stem Cell Research and Therapy. 4, 3, 72.

Research output: Contribution to journalArticle

Topical Administration
Tissue regeneration
Stem cells
Regeneration
Stem Cells
2012
17 Citations (Scopus)

Ag/Au bi-metallic film based color surface plasmon resonance biosensor with enhanced sensitivity, color contrast and great linearity

Li, C. T., Lo, K. C., Chang, H. Y., Wu, H. T., Ho, J. H. & Yen, T. J., Jun 2012, In : Biosensors and Bioelectronics. 36, 1, p. 192-198 7 p.

Research output: Contribution to journalArticle

Metallic films
Contrast Sensitivity
Surface Plasmon Resonance
Surface plasmon resonance
Biosensing Techniques
44 Citations (Scopus)

Amine-surface-modified superparamagnetic iron oxide nanoparticles interfere with differentiation of human mesenchymal stem cells

Chang, Y. K., Liu, Y. P., Ho, J. H., Hsu, S. C. & Lee, O. K., Sep 2012, In : Journal of Orthopaedic Research. 30, 9, p. 1499-1506 8 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Nanoparticles
Amines
Cell Tracking
ferric oxide
1 Citation (Scopus)

Anterior Chamber Paracentesis Facilitates Laser Peripheral Iridotomy and Restores Vision in Mild-to-moderate Acute Primary Angle-closure Glaucoma

Cheng, C. F., Tsai, C. L., Lee, O. K. S., Feng, J. J. & Ho, J. H. C., Feb 2012, In : Journal of Experimental and Clinical Medicine(Taiwan). 4, 1, p. 52-57 6 p.

Research output: Contribution to journalArticle

Paracentesis
Angle Closure Glaucoma
Anterior Chamber
Mannitol
Lasers
19 Citations (Scopus)

Cardiovascular protection of magnolol: Cell-type specificity and dose-related effects

Ho, J. H. C. & Hong, C. Y., 2012, In : Journal of Biomedical Science. 19, 1, 70.

Research output: Contribution to journalArticle

Cytoprotection
Magnolia
Muscle
Platelets
Smooth Muscle Myocytes
121 Citations (Scopus)

Hypoxia promotes proliferation and osteogenic differentiation potentials of human mesenchymal stem cells

Hung, S. P., Ho, J. H., Shih, Y. R. V., Lo, T. & Lee, O. K., Feb 2012, In : Journal of Orthopaedic Research. 30, 2, p. 260-266 7 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Intercellular Signaling Peptides and Proteins
Osteogenesis
Bone Marrow
Oxygen
47 Citations (Scopus)

Multiple intravenous transplantations of mesenchymal stem cells effectively restore long-term blood glucose homeostasis by hepatic engraftment and β-cell differentiation in streptozocin-induced diabetic mice

Ho, J. H., Tseng, T. C., Ma, W. H., Ong, W. K., Chen, Y. F., Chen, M. H., Lin, M. W., Hong, C. Y. & Lee, O. K., 2012, In : Cell Transplantation. 21, 5, p. 997-1009 13 p.

Research output: Contribution to journalArticle

Mesenchymal Stem Cell Transplantation
Insulin
Streptozocin
Stem cells
Glucose
57 Citations (Scopus)

Regulation of the fate of human mesenchymal stem cells by mechanical and stereo-topographical cues provided by silicon nanowires

Kuo, S. W., Lin, H. I., Hui-Chun Ho, J., Shih, Y. R. V., Chen, H. F., Yen, T. J. & Lee, O. K., Jul 2012, In : Biomaterials. 33, 20, p. 5013-5022 10 p.

Research output: Contribution to journalArticle

Nanowires
Silicon
Stem cells
Mesenchymal Stromal Cells
Cues
36 Citations (Scopus)

Systemic human orbital fat-derived stem/stromal cell transplantation ameliorates acute inflammation in lipopolysaccharide-induced acute lung injury

Chien, M. H., Bien, M. Y., Ku, C. C., Chang, Y. C., Pao, H. Y., Yang, Y. L., Hsiao, M., Chen, C. L. & Ho, J. H., Apr 2012, In : Critical Care Medicine. 40, 4, p. 1245-1253 9 p.

Research output: Contribution to journalArticle

Acute Lung Injury
Stem Cell Transplantation
Stromal Cells
Lipopolysaccharides
Fats
2011
38 Citations (Scopus)

Cell contact accelerates replicative senescence of human mesenchymal stem cells independent of telomere shortening and p53 activation: Roles of ras and oxidative stress

Ho, J. H., Chen, Y. F., Ma, W. H., Tseng, T. C., Chen, M. H. & Lee, O. K., 2011, In : Cell Transplantation. 20, 8, p. 1209-1220 12 p.

Research output: Contribution to journalArticle

Telomere Shortening
Oxidative stress
Cell Aging
Stem cells
Mesenchymal Stromal Cells
24 Citations (Scopus)

Development of a surface plasmon resonance biosensor for Real-Time detection of osteogenic differentiation in live mesenchymal stem cells

Kuo, Y. C., Ho, J. H., Yen, T. J., Chen, H. F. & Lee, O. K. S., 2011, In : PLoS One. 6, 7, e22382.

Research output: Contribution to journalArticle

surface plasmon resonance
Surface Plasmon Resonance
biosensors
Surface plasmon resonance
Biosensing Techniques
37 Citations (Scopus)

Glucose reduction prevents replicative senescence and increases mitochondrial respiration in human mesenchymal stem cells

Lo, T., Ho, J. H., Yang, M. H. & Lee, O. K., 2011, In : Cell Transplantation. 20, 6, p. 813-825 13 p.

Research output: Contribution to journalArticle

Cell Aging
Stem cells
Mesenchymal Stromal Cells
Glucose
Respiration
50 Citations (Scopus)

Isolation and characterization of multi-potent stem cells from human orbital fat tissues

Ho, J. H. C., Ma, W. H., Tseng, T. C., Chen, Y. F., Chen, M. H. & Lee, O. K. S., Jan 1 2011, In : Tissue Engineering - Part A. 17, 1-2, p. 255-266 12 p.

Research output: Contribution to journalArticle

Oils and fats
Stem cells
Stem Cells
Epithelial Cells
Fats
44 Citations (Scopus)

Mesenchymal stem cell transplantation ameliorates motor function deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cells

Chang, Y. K., Chen, M. H., Chiang, Y. H., Chen, Y. F., Ma, W. H., Tseng, C. Y., Soong, B. W., Ho, J. H. & Lee, O. K., 2011, In : Journal of Biomedical Science. 18, 1, 54.

Research output: Contribution to journalArticle

Mesenchymal Stem Cell Transplantation
Spinocerebellar Ataxias
Purkinje Cells
Stem cells
Deterioration
135 Citations (Scopus)

Salvianolic acids: Small compounds with multiple mechanisms for cardiovascular protection

Ho, J. H. C. & Hong, C. Y., 2011, In : Journal of Biomedical Science. 18, 1, 30.

Research output: Contribution to journalArticle

Salvia miltiorrhiza
Smooth Muscle Myocytes
Muscle
Proteins
Cardiovascular Diseases
2010
13 Citations (Scopus)

Protection of thymosin beta-4 on corneal endothelial cells from UVB-induced apoptosis

Ho, J. H. C., Su, Y., Chen, K. H. & Lee, O. K. S., 2010, In : Chinese Journal of Physiology. 53, 3, p. 190-195 6 p.

Research output: Contribution to journalArticle

Endothelial Cells
Apoptosis
Caspase 9
Propidium
Annexin A5
21 Citations (Scopus)

Thymosin beta-4 directs cell fate determination of human mesenchymal stem cells through biophysical effects

Ho, J. H., Ma, W. H., Su, Y., Tseng, K. C., Kuo, T. K. & Lee, O. K. S., Jan 2010, In : Journal of Orthopaedic Research. 28, 1, p. 131-138 8 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Actins
Cytoskeleton
Osteoporosis
Coxsackie and Adenovirus Receptor-Like Membrane Protein
2009
48 Citations (Scopus)

Mesenchymal stem cell therapy for nonmusculoskeletal diseases: Emerging applications

Kuo, T. K., Ho, J. H. & Lee, O. K., 2009, In : Cell Transplantation. 18, 9, p. 1013-1028 16 p.

Research output: Contribution to journalArticle

Cell- and Tissue-Based Therapy
Stem cells
Mesenchymal Stromal Cells
Mesoderm
Stem Cells
2008
36 Citations (Scopus)

Thymosin beta-4 upregulates anti-oxidative enzymes and protects human cornea epithelial cells against oxidative damage

Ho, J. H. C., Tseng, K. C., Ma, W. H., Chen, K. H., Lee, K. S. & Su, Y., Jul 2008, In : British Journal of Ophthalmology. 92, 7, p. 992-997 6 p.

Research output: Contribution to journalArticle

Cornea
Up-Regulation
Epithelial Cells
Enzymes
Reactive Oxygen Species
2007
33 Citations (Scopus)

Internalization is essential for the antiapoptotic effects of exogenous thymosin β-4 on human corneal epithelial cells

Ho, J. H. C., Chuang, C. H., Ho, C. Y., Shih, Y. R. V., Lee, O. K. S. & Su, Y., Jan 2007, In : Investigative Ophthalmology and Visual Science. 48, 1, p. 27-33 7 p.

Research output: Contribution to journalArticle

Thymosin
Epithelial Cells
Fas Ligand Protein
T-Lymphocytes
Cytochalasin D
2006
4 Citations (Scopus)

Corneal injury by anti-misting agent in swim goggles: A case report

Peng, K. L., Chen, K. H., Hsu, W-M., Ho, H. C., Chiang, C. C., Lee, Y. C. & Lai, J. Y., Feb 2006, In : Cornea. 25, 2, p. 228-231 4 p.

Research output: Contribution to journalArticle

Eye Protective Devices
Cornea
Visual Acuity
Edema
Adrenal Cortex Hormones
2004
3 Citations (Scopus)

Linear-Long Incisions with a Small Optical Zone for the Correction of Astigmatism in Older Patients

Ho, H. C., Chen, K. H., Hsu, W-M., Lee, S. M., Chiang, C. C. & Li, Y. S., Jan 2004, In : Ophthalmology. 111, 1, p. 28-33 6 p.

Research output: Contribution to journalArticle

Astigmatism
Corneal Topography
Veterans Hospitals
Contact Lenses
General Hospitals
2002
6 Citations (Scopus)

Optic neuritis: A rare manisfestation of nasopharyngeal carcinoma [7]

Tsai, C. C., Ho, H. C., Kau, H. C., Kao, S. C. & Hsu, W-M., 2002, In : Eye. 16, 4, p. 501-503 3 p.

Research output: Contribution to journalArticle

Optic Neuritis
Nasopharyngeal carcinoma
2 Citations (Scopus)

T-cell lymphoma in the eyelid following intestinal B-cell lymphona [8]

Kau, H. C., Ho, H. C., Kao, S. C., Yang, C. F., Hsu, W. M. & Tsai, C. C., Nov 2002, In : Eye. 16, 6, p. 794-796 3 p.

Research output: Contribution to journalArticle

Cells
2001

FDP簡易視野計與Octopus電腦視野計於青光眼視野缺損上的比較

Translated title of the contribution: Comparison of the Results of the Glaucomatous Field Loss on Frequency Doubling Perimetry and Autoperimetry周清光(Joe C-K C & 何慧君(Hui-Chun H, 2001, In : 中華民國眼科醫學會雜誌. 40, 1, p. 36-41 6 p.

Research output: Contribution to journalArticle

octopuses