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Research Output

  • 1069 Citations
  • 18 h-Index
  • 58 Article
  • 1 Conference contribution
2020

AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis

Chen, T. C., Chuang, J. Y., Ko, C. Y., Kao, T. J., Yang, P. Y., Yu, C. H., Liu, M. S., Hu, S. L., Tsai, Y. T., Chan, H., Chang, W. C. & Hsu, T. I., Feb 1 2020, In : Redox Biology. 30, p. 101413 101413.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Betulinic acid-mediated tuning of PERK/CHOP signaling by sp1 inhibition as a novel therapeutic strategy for glioblastoma

Lo, W. L., Hsu, T. I., Yang, W. B., Kao, T. J., Wu, M. H., Huang, Y. N., Yeh, S. H. & Chuang, J. Y., Apr 2020, In : Cancers. 12, 4, 981.

Research output: Contribution to journalArticle

Open Access

BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine

Chao, P. K., Chang, H. F., Chang, W. T., Yeh, T. K., Ou, L. C., Chuang, J. Y., Tsu-An Hsu, J., Tao, P. L., Loh, H. H., Shih, C., Ueng, S. H. & Yeh, S. H., Apr 1 2020, In : Neuropharmacology. 166, 107678.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Increased activation of HDAC1/2/6 and Sp1 underlies therapeutic resistance and tumor growth in glioblastoma

Yang, W-B., Hsu, C-C., Hsu, T-I., Liou, J-P., Chang, K-Y., Chen, P-Y., Liu, J-J., Yang, S-T., Wang, J-Y., Yeh, S-H., Chen, R-M., Chang, W-C. & Chuang, J-Y., Apr 24 2020, In : Neuro-Oncology.

Research output: Contribution to journalArticle

Morphine produces potent antinociception, sedation, and hypothermia in humanized mice expressing human mu-opioid receptor splice variants

Huang, Y-H., Wu, Y-W., Chuang, J-Y., Chang, Y-C., Chang, H-F., Tao, P-L., Loh, H. H. & Yeh, S-H., Feb 6 2020, In : Pain.

Research output: Contribution to journalArticle

Sp1 in Astrocyte Is Important for Neurite Outgrowth and Synaptogenesis

Hung, C. Y., Hsu, T. I., Chuang, J. Y., Su, T. P., Chang, W. C. & Hung, J. J., Jan 1 2020, In : Molecular Neurobiology. 57, 1

Research output: Contribution to journalArticle

2 Citations (Scopus)
2019
Open Access
3 Citations (Scopus)
Open Access
3 Citations (Scopus)

Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice

Chao, P. K., Chang, H. F., Ou, L. C., Chuang, J. Y., Lee, P. T., Chang, W. T., Chen, S. C., Ueng, S. H., Hsu, J. T. A., Tao, P. L., Law, P. Y., Loh, H. H. & Yeh, S. H., Dec 1 2019, In : Scientific Reports. 9, 1, 2405.

Research output: Contribution to journalArticle

2 Citations (Scopus)

CYP17A1 maintains the survival of glioblastomas by regulating SAR1-mediated endoplasmic reticulum health and redox homeostasis

Lin, H. Y., Ko, C. Y., Kao, T. J., Yang, W. B., Tsai, Y. T., Chuang, J. Y., Hu, S. L., Yang, P. Y., Lo, W. L. & Hsu, T. I., Sep 2019, In : Cancers. 11, 9, 1378.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
4 Citations (Scopus)

Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets

Chien, C. H., Chuang, J. Y., Yang, S. T., Yang, W. B., Chen, P. Y., Hsu, T. I., Huang, C. Y., Lo, W. L., Yang, K. Y., Liu, M. S., Chu, J. M., Chung, P. H., Liu, J. J., Chou, S. W., Chen, S. H. & Chang, K. Y., Oct 19 2019, In : Journal of Biomedical Science. 26, 1, 77.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2018

Ephexin1 is required for Eph-Mediated limb trajectory of spinal motor axons

Chang, C. J., Chang, M. Y., Chou, S. Y., Huang, C. C., Chuang, J. Y., Hsu, T. I., Chang, H. F., Wu, Y. H., Wu, C. C., Morales, D., Kania, A. & Kao, T. J., Feb 21 2018, In : Journal of Neuroscience. 38, 8, p. 2043-2056 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
14 Citations (Scopus)
6 Citations (Scopus)

Nck2 is essential for limb trajectory selection by spinal motor axons

Chang, C. J., Chang, M. Y., Lee, Y. C., Chen, K. Y., Hsu, T. I., Wu, Y. H., Chuang, J. Y. & Kao, T. J., Sep 1 2018, In : Developmental Dynamics. 247, 9, p. 1043-1056 14 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Upregulation of Znf179 acetylation by SAHA protects cells against oxidative stress

Wu, C. C., Lee, P. T., Kao, T. J., Chou, S. Y., Su, R. Y., Lee, Y. C., Yeh, S. H., Liou, J. P., Hsu, T. I., Su, T. P., Chuang, C. K., Chang, W. C. & Chuang, J. Y., Oct 1 2018, In : Redox Biology. 19, p. 74-80 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4 H -indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine

Chao, P. K., Ueng, S. H., Ou, L. C., Yeh, T. K., Chang, W. T., Chang, H. F., Chen, S. C., Tao, P. L., Law, P. Y., Loh, H. H., Cheng, M. F., Chuang, J. Y., Chen, C. T., Shih, C. & Yeh, S. H., May 1 2017, In : Anesthesiology. 126, 5, p. 952-966 15 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Mapping the naloxone binding sites on the mu-opioid receptor using cell-based photocrosslinkers

Ke, Y. Y., Huang, Y. H., Chien, W. C., Loh, H. H., Chuang, J. Y. & Yeh, S. H., Mar 1 2017, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1865, 3, p. 336-343 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Nm23-H1-stabilized hnRNPA2/B1 promotes internal ribosomal entry site (IRES)-mediated translation of Sp1 in the lung cancer progression

Hung, C. Y., Wang, Y. C., Chuang, J. Y., Young, M. J., Liaw, H., Chang, W. C. & Hung, J. J., Dec 1 2017, In : Scientific Reports. 7, 1, 9166.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma, which is independent of O6-methylguanine-DNA methyltransferase

Chang, K. Y., Hsu, T. I., Hsu, C. C., Tsai, S. Y., Liu, J. J., Chou, S. W., Liu, M. S., Liou, J. P., Ko, C. Y., Chen, K. Y., Hung, J. J., Chang, W. C., Chuang, C. K., Kao, T. J. & Chuang, J. Y., Oct 1 2017, In : Redox Biology. 13, p. 655-664 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Specificity protein 1-zinc finger protein 179 pathway is involved in the attenuation of oxidative stress following brain injury

Chuang, J-Y., Kao, T-J., Lin, S. H., Wu, A. C., Lee, P. T., Su, T. P., Yeh, S. H., Lee, Y-C., Wu, C-C. & Chang, W-C., Apr 1 2017, In : Redox Biology. 11, p. 135-143 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Stress stimuli induce cancer-stemness gene expression via Sp1 activation leading to therapeutic resistance in glioblastoma

Chang, K. Y., Huang, C. T., Hsu, T. I., Hsu, C. C., Liu, J. J., Chuang, C. K., Hung, J. J., Chang, W. C., Tsai, K. K. & Chuang, J. Y., Nov 4 2017, In : Biochemical and Biophysical Research Communications. 493, 1, p. 14-19 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2016

Experimental study on smoke propagation in titled underground tunnel fires

Li, J. M., Huang, Z. H., Chen, C., Chuang, J. & Li, Y., Jan 1 2016, Progress in Civil, Architectural and Hydraulic Engineering - Selected Papers of the 4th International Conference on Civil, Architectural and Hydraulic Engineering, ICCAHE 2015. Kim, Y-H. (ed.). CRC Press/Balkema, p. 1129-1132 4 p. (Progress in Civil, Architectural and Hydraulic Engineering - Selected Papers of the 4th International Conference on Civil, Architectural and Hydraulic Engineering, ICCAHE 2015).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Suberoylanilide hydroxamic acid represses glioma stem-like cells

Hsu, C. C., Chang, W-C., Hsu, T-I., Liu, J. J., Yeh, S. H., Wang, J-Y., Liou, J-P., Ko, C-Y., Chang, K. Y. & Chuang, J-Y., Nov 18 2016, In : Journal of Biomedical Science. 23, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

The sigma-1 receptor-zinc finger protein 179 pathway protects against hydrogen peroxide-induced cell injury

Su, T. C., Lin, S. H., Lee, P. T., Yeh, S. H., Hsieh, T. H., Chou, S. Y., Su, T. P., Hung, J. J., Chang, W. C., Lee, Y. C. & Chuang, J. Y., Jun 1 2016, In : Neuropharmacology. 105, p. 1-9 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2015
55 Citations (Scopus)
2014

Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling

Lee, P. T., Chao, P. K., Ou, L. C., Chuang, J. Y., Lin, Y. C., Chen, S. C., Chang, H. F., Law, P. Y., Loh, H. H., Chao, Y. S., Su, T. P. & Yeh, S. H., Dec 1 2014, In : Nucleic Acids Research. 42, 21, p. 13012-13025 14 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
18 Citations (Scopus)

Pin1-mediated Sp1 phosphorylation by CDK1 increases Sp1 stability and decreases its DNA-binding activity during mitosis

Yang, H. C., Chuang, J. Y., Jeng, W. Y., Liu, C. I., Wang, A. H. J., Lu, P. J., Chang, W. C. & Hung, J. J., Dec 16 2014, In : Nucleic Acids Research. 42, 22, p. 13573-13587 15 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Roles of testosterone and amygdaloid LTP induction in determining sex differences in fear memory magnitude

Chen, L. S., Tzeng, W. Y., Chuang, J. Y., Cherng, C. G., Gean, P. W. & Yu, L., 2014, In : Hormones and Behavior. 66, 3, p. 498-508 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2013

Companions reverse stressor-induced decreases in neurogenesis and cocaine conditioning possibly by restoring BDNF and NGF levels in dentate gyrus

Tzeng, W. Y., Chuang, J. Y., Lin, L. C., Cherng, C. G., Lin, K. Y., Chen, L. H., Su, C. C. & Yu, L., Mar 2013, In : Psychoneuroendocrinology. 38, 3, p. 425-437 13 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

D-cycloserine, sarcosine and D-serine diminish the expression of cocaine-induced conditioned place preference

Yang, F. Y., Lee, Y. S., Cherng, C. G., Cheng, L. Y., Chang, W. T., Chuang, J. Y., Kao, G. S. & Yu, L., Jun 2013, In : Journal of Psychopharmacology. 27, 6, p. 550-558 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine

Kourrich, S., Hayashi, T., Chuang, J. Y., Tsai, S. Y., Su, T. P. & Bonci, A., Jan 7 2013, In : Cell. 152, 1-2, p. 236-247 12 p.

Research output: Contribution to journalArticle

127 Citations (Scopus)
2012

Disruption of memory reconsolidation impairs storage of other, non-reactivated memory

Tzeng, W. Y., Chang, W. T., Chuang, J. Y., Lin, K. Y., Cherng, C. G. & Yu, L., Feb 2012, In : Neurobiology of Learning and Memory. 97, 2, p. 241-249 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Interactions between amyloid-β and hemoglobin: Implications for amyloid plaque formation in alzheimer's disease

Chuang, J. Y., Lee, C. W., Shih, Y. H., Yang, T., Yu, L. & Kuo, Y. M., Mar 6 2012, In : PLoS One. 7, 3, e33120.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Involvement of amygdaloid protein synthesis in early- and late-phase reconsolidation of emotion-related memories

Chuang, J. Y., Lin, K. Y., Cherng, C. G. & Yu, L., 2012, In : Chinese Journal of Physiology. 55, 5, p. 1-9 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Odors from proximal species reverse the stress-decreased neurogenesis via main olfactory processing

Cherng, C. F. G., Chang, C. P., Su, C. C., Tzeng, W. Y., Chuang, J. Y., Chen, L. H., Lin, K. Y. & Yu, L., Apr 1 2012, In : Behavioural Brain Research. 229, 1, p. 106-112 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells

Chuang, J. Y., Wang, S. A., Yang, W. B., Yang, H. C., Hung, C. Y., Su, T. P., Chang, W. C. & Hung, J. J., Nov 22 2012, In : Oncogene. 31, 47, p. 4946-4959 14 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2011

Accumbal 14-3-3ζ protein downregulation is associated with cocaine-conditioned memory

Kao, G. S., Chuang, J. Y., Cherng, C. F. G. & Yu, L., Dec 2011, In : NeuroSignals. 19, 4, p. 175-188 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
23 Citations (Scopus)

Overexpression of HDAC1 induces cellular senescence by Sp1/PP2A/pRb pathway

Chuang, J. Y. & Hung, J. J., Apr 15 2011, In : Biochemical and Biophysical Research Communications. 407, 3, p. 587-592 6 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Repeated co-administrations of alcohol- and ethamphetamine-produced anxiogenic effect could be associated with the neurotoxicity in the dentate gyrus

Chuang, J. Y., Chang, W. T., Cherng, C. G., Kao, G. S. & Yu, L., 2011, In : Journal of Neural Transmission. 118, 11, p. 1559-1569 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2010

MCAF1 and synergistic activation of the transcription of Epstein-Barr virus lytic genes by Rta and Zta

Chang, L. K., Chuang, J. Y., Nakao, M. & Liu, S. T., Apr 10 2010, In : Nucleic Acids Research. 38, 14, p. 4687-4700 14 p., gkq243.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Presence of conspecifics and their odor-impregnated objects reverse stress-decreased neurogenesis in mouse dentate gyrus

Cherng, C. G., Lin, P. S., Chuang, J. Y., Chang, W. T., Lee, Y. S., Kao, G. S., Lai, Y. T. & Yu, L., Mar 2010, In : Journal of Neurochemistry. 112, 5, p. 1138-1146 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2009

Chronic treatment with monoamine oxidase-B inhibitors decreases cocaine reward in mice

Ho, M. C., Cherng, C. G., Tsai, Y. P. N., Chiang, C. Y., Chuang, J. Y., Kao, S. F. & Yu, L., Jul 2009, In : Psychopharmacology. 205, 1, p. 141-149 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Heat Shock Protein 90 Is Important for Sp1 Stability during Mitosis

Wang, S. A., Chuang, J. Y., Yeh, S. H., Wang, Y. T., Liu, Y. W., Chang, W. C. & Hung, J. J., Apr 17 2009, In : Journal of Molecular Biology. 387, 5, p. 1106-1119 14 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)