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Research Output 1988 2019

  • 924 Citations
  • 17 h-Index
  • 50 Article
  • 1 Conference contribution
2019

BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine

Chao, P. K., Chang, H. F., Chang, W. T., Yeh, T. K., Ou, L. C., Chuang, J. Y., Tsu-An Hsu, J., Tao, P. L., Loh, H. H., Shih, C., Ueng, S. H. & Yeh, S. H., Jan 1 2019, In : Neuropharmacology. 107678.

Research output: Contribution to journalArticle

Peptide Receptors
mu Opioid Receptor
Morphine
Naloxone
Arrestin
Open Access
CCAAT-Enhancer-Binding Protein-delta
Platelet-Derived Growth Factor
Glioma
Stem Cells
Interleukin-1

Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice

Chao, P. K., Chang, H. F., Ou, L. C., Chuang, J. Y., Lee, P. T., Chang, W. T., Chen, S. C., Ueng, S. H., Hsu, J. T. A., Tao, P. L., Law, P. Y., Loh, H. H. & Yeh, S. H., Dec 1 2019, In : Scientific Reports. 9, 1, 2405.

Research output: Contribution to journalArticle

mu Opioid Receptor
Endocytosis
Morphine
Ligands
Morphine Dependence
temozolomide
Dehydroepiandrosterone
Glioblastoma
Acetylation
Phosphorylation

Sp1 in Astrocyte Is Important for Neurite Outgrowth and Synaptogenesis

Hung, C. Y., Hsu, T. I., Chuang, J. Y., Su, T. P., Chang, W. C. & Hung, J. J., Jan 1 2019, In : Molecular Neurobiology.

Research output: Contribution to journalArticle

Astrocytes
Synapses
Hippocampus
Neurons
Toll-Like Receptor 2
2018
1 Citation (Scopus)

Ephexin1 is required for Eph-Mediated limb trajectory of spinal motor axons

Chang, C. J., Chang, M. Y., Chou, S. Y., Huang, C. C., Chuang, J. Y., Hsu, T. I., Chang, H. F., Wu, Y. H., Wu, C. C., Morales, D., Kania, A. & Kao, T. J., Feb 21 2018, In : Journal of Neuroscience. 38, 8, p. 2043-2056 14 p.

Research output: Contribution to journalArticle

Axons
Extremities
Ephrins
Growth Cones
Motor Neurons
5 Citations (Scopus)
temozolomide
Autophagy
Glioma
Apoptosis
Pharmaceutical Preparations
5 Citations (Scopus)
Ubiquitination
Glioma
Glioblastoma
Stem Cells
temozolomide

Nck2 is essential for limb trajectory selection by spinal motor axons

Chang, C. J., Chang, M. Y., Lee, Y. C., Chen, K. Y., Hsu, T. I., Wu, Y. H., Chuang, J. Y. & Kao, T. J., Sep 1 2018, In : Developmental Dynamics. 247, 9, p. 1043-1056 14 p.

Research output: Contribution to journalArticle

Axons
Extremities
Motor Neurons
Ephrins
Neurites
4 Citations (Scopus)
Glioblastoma
Amyloid
Integrins
Serum
Glioma
1 Citation (Scopus)

Upregulation of Znf179 acetylation by SAHA protects cells against oxidative stress

Wu, C. C., Lee, P. T., Kao, T. J., Chou, S. Y., Su, R. Y., Lee, Y. C., Yeh, S. H., Liou, J. P., Hsu, T. I., Su, T. P., Chuang, C. K., Chang, W. C. & Chuang, J. Y., Oct 1 2018, In : Redox Biology. 19, p. 74-80 7 p.

Research output: Contribution to journalArticle

Acetylation
Oxidative stress
Zinc Fingers
Zinc
Oxidative Stress
2017
3 Citations (Scopus)

1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4 H -indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine

Chao, P. K., Ueng, S. H., Ou, L. C., Yeh, T. K., Chang, W. T., Chang, H. F., Chen, S. C., Tao, P. L., Law, P. Y., Loh, H. H., Cheng, M. F., Chuang, J. Y., Chen, C. T., Shih, C. & Yeh, S. H., May 1 2017, In : Anesthesiology. 126, 5, p. 952-966 15 p.

Research output: Contribution to journalArticle

Opioid Receptors
Morphine
Opioid Analgesics
Charcoal
Surgical Instruments
2 Citations (Scopus)

Mapping the naloxone binding sites on the mu-opioid receptor using cell-based photocrosslinkers

Ke, Y. Y., Huang, Y. H., Chien, W. C., Loh, H. H., Chuang, J. Y. & Yeh, S. H., Mar 1 2017, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1865, 3, p. 336-343 8 p.

Research output: Contribution to journalArticle

mu Opioid Receptor
Naloxone
Binding Sites
Morphine
Amber
1 Citation (Scopus)

Nm23-H1-stabilized hnRNPA2/B1 promotes internal ribosomal entry site (IRES)-mediated translation of Sp1 in the lung cancer progression

Hung, C. Y., Wang, Y. C., Chuang, J. Y., Young, M. J., Liaw, H., Chang, W. C. & Hung, J. J., Dec 1 2017, In : Scientific Reports. 7, 1, 9166.

Research output: Contribution to journalArticle

Protein Biosynthesis
Lung Neoplasms
Proteins
Messenger RNA
Protein Stability
5 Citations (Scopus)

Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma, which is independent of O6-methylguanine-DNA methyltransferase

Chang, K. Y., Hsu, T. I., Hsu, C. C., Tsai, S. Y., Liu, J. J., Chou, S. W., Liu, M. S., Liou, J. P., Ko, C. Y., Chen, K. Y., Hung, J. J., Chang, W. C., Chuang, C. K., Kao, T. J. & Chuang, J. Y., Oct 1 2017, In : Redox Biology. 13, p. 655-664 10 p.

Research output: Contribution to journalArticle

temozolomide
Methyltransferases
Glioblastoma
DNA
Proteins
13 Citations (Scopus)

Specificity protein 1-zinc finger protein 179 pathway is involved in the attenuation of oxidative stress following brain injury

Chuang, J-Y., Kao, T-J., Lin, S. H., Wu, A. C., Lee, P. T., Su, T. P., Yeh, S. H., Lee, Y-C., Wu, C-C. & Chang, W-C., Apr 1 2017, In : Redox Biology. 11, p. 135-143 9 p.

Research output: Contribution to journalArticle

Oxidative stress
Zinc Fingers
Brain Injuries
Zinc
Brain
2 Citations (Scopus)

Stress stimuli induce cancer-stemness gene expression via Sp1 activation leading to therapeutic resistance in glioblastoma

Chang, K. Y., Huang, C. T., Hsu, T. I., Hsu, C. C., Liu, J. J., Chuang, C. K., Hung, J. J., Chang, W. C., Tsai, K. K. & Chuang, J. Y., Nov 4 2017, In : Biochemical and Biophysical Research Communications. 493, 1, p. 14-19 6 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Glioblastoma
Gene expression
Chemical activation
temozolomide
temozolomide
Dehydroepiandrosterone
Glioma
Cytochrome P-450 Enzyme System
Up-Regulation
2016

Experimental study on smoke propagation in titled underground tunnel fires

Li, J. M., Huang, Z. H., Chen, C., Chuang, J. & Li, Y., Jan 1 2016, Progress in Civil, Architectural and Hydraulic Engineering - Selected Papers of the 4th International Conference on Civil, Architectural and Hydraulic Engineering, ICCAHE 2015. Kim, Y-H. (ed.). CRC Press/Balkema, p. 1129-1132 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Smoke
smoke
Tunnels
Fires
tunnel
7 Citations (Scopus)

Suberoylanilide hydroxamic acid represses glioma stem-like cells

Hsu, C. C., Chang, W-C., Hsu, T-I., Liu, J. J., Yeh, S. H., Wang, J-Y., Liou, J-P., Ko, C-Y., Chang, K. Y. & Chuang, J-Y., Nov 18 2016, In : Journal of Biomedical Science. 23, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Glioma
Stem Cells
Glioblastoma
Cells
Histone Deacetylases
9 Citations (Scopus)

The sigma-1 receptor-zinc finger protein 179 pathway protects against hydrogen peroxide-induced cell injury

Su, T. C., Lin, S. H., Lee, P. T., Yeh, S. H., Hsieh, T. H., Chou, S. Y., Su, T. P., Hung, J. J., Chang, W. C., Lee, Y. C. & Chuang, J. Y., Jun 1 2016, In : Neuropharmacology. 105, p. 1-9 9 p.

Research output: Contribution to journalArticle

Zinc Fingers
Hydrogen Peroxide
Reactive Oxygen Species
Wounds and Injuries
Dehydroepiandrosterone Sulfate
2015
45 Citations (Scopus)
Chromatin Assembly and Disassembly
Nuclear Envelope
Cocaine
Monoamine Oxidase
Endoplasmic Reticulum
2014
13 Citations (Scopus)

Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling

Lee, P. T., Chao, P. K., Ou, L. C., Chuang, J. Y., Lin, Y. C., Chen, S. C., Chang, H. F., Law, P. Y., Loh, H. H., Chao, Y. S., Su, T. P. & Yeh, S. H., Dec 1 2014, In : Nucleic Acids Research. 42, 21, p. 13012-13025 14 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoprotein K
Opioid Receptors
Morphine
Neurons
mu Opioid Receptor
17 Citations (Scopus)
Proteolysis
Lung Neoplasms
Carcinogenesis
Phosphorylation
Acetylation
9 Citations (Scopus)

Pin1-mediated Sp1 phosphorylation by CDK1 increases Sp1 stability and decreases its DNA-binding activity during mitosis

Yang, H. C., Chuang, J. Y., Jeng, W. Y., Liu, C. I., Wang, A. H. J., Lu, P. J., Chang, W. C. & Hung, J. J., Dec 16 2014, In : Nucleic Acids Research. 42, 22, p. 13573-13587 15 p.

Research output: Contribution to journalArticle

Mitosis
Phosphorylation
DNA
Peptides
Cell Cycle
17 Citations (Scopus)

Roles of testosterone and amygdaloid LTP induction in determining sex differences in fear memory magnitude

Chen, L. S., Tzeng, W. Y., Chuang, J. Y., Cherng, C. G., Gean, P. W. & Yu, L., 2014, In : Hormones and Behavior. 66, 3, p. 498-508 11 p.

Research output: Contribution to journalArticle

Long-Term Potentiation
Sex Characteristics
Fear
Testosterone
Freezing
2013
21 Citations (Scopus)

Companions reverse stressor-induced decreases in neurogenesis and cocaine conditioning possibly by restoring BDNF and NGF levels in dentate gyrus

Tzeng, W. Y., Chuang, J. Y., Lin, L. C., Cherng, C. G., Lin, K. Y., Chen, L. H., Su, C. C. & Yu, L., Mar 2013, In : Psychoneuroendocrinology. 38, 3, p. 425-437 13 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Neurogenesis
Dentate Gyrus
Nerve Growth Factor
Cocaine
16 Citations (Scopus)

D-cycloserine, sarcosine and D-serine diminish the expression of cocaine-induced conditioned place preference

Yang, F. Y., Lee, Y. S., Cherng, C. G., Cheng, L. Y., Chang, W. T., Chuang, J. Y., Kao, G. S. & Yu, L., Jun 2013, In : Journal of Psychopharmacology. 27, 6, p. 550-558 9 p.

Research output: Contribution to journalArticle

Sarcosine
Cycloserine
Cocaine
Serine
N-Methyl-D-Aspartate Receptors
110 Citations (Scopus)

Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine

Kourrich, S., Hayashi, T., Chuang, J. Y., Tsai, S. Y., Su, T. P. & Bonci, A., Jan 7 2013, In : Cell. 152, 1-2, p. 236-247 12 p.

Research output: Contribution to journalArticle

Cocaine
Kv1.2 Potassium Channel
Proteins
Drug-Seeking Behavior
Nucleus Accumbens
2012
8 Citations (Scopus)

Disruption of memory reconsolidation impairs storage of other, non-reactivated memory

Tzeng, W. Y., Chang, W. T., Chuang, J. Y., Lin, K. Y., Cherng, C. G. & Yu, L., Feb 2012, In : Neurobiology of Learning and Memory. 97, 2, p. 241-249 9 p.

Research output: Contribution to journalArticle

Amygdala
Lidocaine
Cocaine
Emotions
Basolateral Nuclear Complex
45 Citations (Scopus)

Interactions between amyloid-β and hemoglobin: Implications for amyloid plaque formation in alzheimer's disease

Chuang, J. Y., Lee, C. W., Shih, Y. H., Yang, T., Yu, L. & Kuo, Y. M., Mar 6 2012, In : PLoS One. 7, 3, e33120.

Research output: Contribution to journalArticle

Amyloid Plaques
amyloid
Alzheimer disease
Amyloid
hemoglobin
2 Citations (Scopus)

Involvement of amygdaloid protein synthesis in early- and late-phase reconsolidation of emotion-related memories

Chuang, J. Y., Lin, K. Y., Cherng, C. G. & Yu, L., 2012, In : Chinese Journal of Physiology. 55, 5, p. 1-9 9 p.

Research output: Contribution to journalArticle

Anisomycin
Cocaine
Emotions
Proteins
Amygdala
6 Citations (Scopus)

Odors from proximal species reverse the stress-decreased neurogenesis via main olfactory processing

Cherng, C. F. G., Chang, C. P., Su, C. C., Tzeng, W. Y., Chuang, J. Y., Chen, L. H., Lin, K. Y. & Yu, L., Apr 1 2012, In : Behavioural Brain Research. 229, 1, p. 106-112 7 p.

Research output: Contribution to journalArticle

Neurogenesis
Cell Proliferation
Dentate Gyrus
Odorants
Zinc Sulfate
23 Citations (Scopus)

Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells

Chuang, J. Y., Wang, S. A., Yang, W. B., Yang, H. C., Hung, C. Y., Su, T. P., Chang, W. C. & Hung, J. J., Nov 22 2012, In : Oncogene. 31, 47, p. 4946-4959 14 p.

Research output: Contribution to journalArticle

CDC2 Protein Kinase
Cyclin B1
Mitosis
Phosphorylation
DNA
2011
1 Citation (Scopus)

Accumbal 14-3-3ζ protein downregulation is associated with cocaine-conditioned memory

Kao, G. S., Chuang, J. Y., Cherng, C. F. G. & Yu, L., Dec 2011, In : NeuroSignals. 19, 4, p. 175-188 14 p.

Research output: Contribution to journalArticle

14-3-3 Proteins
Cocaine
Down-Regulation
Cues
Recurrence
21 Citations (Scopus)
Histone Deacetylase 1
Cyclin B1
Methylation
Hydrogen Peroxide
Cells
19 Citations (Scopus)

Overexpression of HDAC1 induces cellular senescence by Sp1/PP2A/pRb pathway

Chuang, J. Y. & Hung, J. J., Apr 15 2011, In : Biochemical and Biophysical Research Communications. 407, 3, p. 587-592 6 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Cell Aging
Catalytic Domain
Histone Deacetylase 1
Cells
9 Citations (Scopus)

Repeated co-administrations of alcohol- and ethamphetamine-produced anxiogenic effect could be associated with the neurotoxicity in the dentate gyrus

Chuang, J. Y., Chang, W. T., Cherng, C. G., Kao, G. S. & Yu, L., 2011, In : Journal of Neural Transmission. 118, 11, p. 1559-1569 11 p.

Research output: Contribution to journalArticle

Dentate Gyrus
Alcohols
Lateral Ventricles
Amygdala
Prefrontal Cortex
2010
20 Citations (Scopus)

MCAF1 and synergistic activation of the transcription of Epstein-Barr virus lytic genes by Rta and Zta

Chang, L. K., Chuang, J. Y., Nakao, M. & Liu, S. T., Apr 10 2010, In : Nucleic Acids Research. 38, 14, p. 4687-4700 14 p., gkq243.

Research output: Contribution to journalArticle

Response Elements
Human Herpesvirus 4
Transcriptional Activation
Genes
Proteins
17 Citations (Scopus)

Presence of conspecifics and their odor-impregnated objects reverse stress-decreased neurogenesis in mouse dentate gyrus

Cherng, C. G., Lin, P. S., Chuang, J. Y., Chang, W. T., Lee, Y. S., Kao, G. S., Lai, Y. T. & Yu, L., Mar 2010, In : Journal of Neurochemistry. 112, 5, p. 1138-1146 9 p.

Research output: Contribution to journalArticle

Neurogenesis
Dentate Gyrus
Odors
Bromodeoxyuridine
Social Support
2009
13 Citations (Scopus)

Chronic treatment with monoamine oxidase-B inhibitors decreases cocaine reward in mice

Ho, M. C., Cherng, C. G., Tsai, Y. P. N., Chiang, C. Y., Chuang, J. Y., Kao, S. F. & Yu, L., Jul 2009, In : Psychopharmacology. 205, 1, p. 141-149 9 p.

Research output: Contribution to journalArticle

Clorgyline
Monoamine Oxidase Inhibitors
Monoamine Oxidase
Reward
Cocaine
30 Citations (Scopus)

Heat Shock Protein 90 Is Important for Sp1 Stability during Mitosis

Wang, S. A., Chuang, J. Y., Yeh, S. H., Wang, Y. T., Liu, Y. W., Chang, W. C. & Hung, J. J., Apr 17 2009, In : Journal of Molecular Biology. 387, 5, p. 1106-1119 14 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 8
HSP90 Heat-Shock Proteins
Mitosis
Arachidonate 12-Lipoxygenase
Interphase
10 Citations (Scopus)

Medial prefrontal cortex and nucleus accumbens core are involved in retrieval of the methamphetamine-associated memory

Chiang, C. Y., Cherng, C. G., Lai, Y. T., Fan, H. Y., Chuang, J. Y., Kao, G. S., Chang, W. T. & Yu, L., Jan 30 2009, In : Behavioural Brain Research. 197, 1, p. 24-30 7 p.

Research output: Contribution to journalArticle

Methamphetamine
Nucleus Accumbens
Prefrontal Cortex
Cues
Neurons
56 Citations (Scopus)

Overexpression of Sp1 leads to p53-dependent apoptosis in cancer cells

Chuang, J. Y., Wu, C. H., Lai, M. D., Chang, W. C. & Hung, J. J., Nov 1 2009, In : International Journal of Cancer. 125, 9, p. 2066-2076 11 p.

Research output: Contribution to journalArticle

Apoptosis
Neoplasms
Cell Line
Annexin A5
Product Packaging
2008
32 Citations (Scopus)

Enhancement of Transactivation Activity of Rta of Epstein-Barr Virus by RanBPM

Chang, L. K., Liu, S. T., Kuo, C. W., Wang, W. H., Chuang, J. Y., Bianchi, E. & Hong, Y. R., May 29 2008, In : Journal of Molecular Biology. 379, 2, p. 231-242 12 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4
Transcriptional Activation
Immediate-Early Proteins
Sumoylation
Virus Activation
83 Citations (Scopus)

Phosphorylation by c-Jun NH2-terminal kinase 1 regulates the stability of transcription factor Sp1 during mitosis

Chuang, J. Y., Wang, Y. T., Yeh, S. H., Liu, Y. W., Chang, W. C. & Hung, J. J., Mar 2008, In : Molecular Biology of the Cell. 19, 3, p. 1139-1151 13 p.

Research output: Contribution to journalArticle

Sp1 Transcription Factor
JNK Mitogen-Activated Protein Kinases
Mitosis
Phosphorylation
Tumor Cell Line
63 Citations (Scopus)

Sumoylation of Specificity Protein 1 Augments Its Degradation by Changing the Localization and Increasing the Specificity Protein 1 Proteolytic Process

Wang, Y. T., Chuang, J. Y., Shen, M. R., Yang, W. B., Chang, W. C. & Hung, J. J., Jul 25 2008, In : Journal of Molecular Biology. 380, 5, p. 869-885 17 p.

Research output: Contribution to journalArticle

Sumoylation
SUMO-1 Protein
Proteins
Proteolysis
Ubiquitination
2006
18 Citations (Scopus)

Sumoylation of Rta of Epstein-Barr virus is preferentially enhanced by PIASxβ

Liu, S. T., Wang, W. H., Hong, Y. R., Chuang, J. Y., Lu, P. J. & Chang, L. K., Aug 2006, In : Virus Research. 119, 2, p. 163-170 8 p.

Research output: Contribution to journalArticle

Sumoylation
Human Herpesvirus 4
Immediate-Early Proteins
Ubiquitin-Protein Ligases
Response Elements
2005
51 Citations (Scopus)

Activation of Sp1-mediated transcription by Rta of Epstein-Barr virus via an interaction with MCAF1

Chang, L. K., Chung, J. Y., Hong, Y. R., Ichimura, T., Nakao, M. & Liu, S. T., 2005, In : Nucleic Acids Research. 33, 20, p. 6528-6539 12 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4
Chromatin
Response Elements
Transcriptional Activation
snRNP Core Proteins
2003
75 Citations (Scopus)

Inhibition of Epstein-Barr virus lytic cycle by (-)-epigallocatechin gallate

Chang, L. K., Wei, T. T., Chiu, Y. F., Tung, C. P., Chuang, J. Y., Hung, S. K., Li, C. & Liu, S. T., Feb 21 2003, In : Biochemical and Biophysical Research Communications. 301, 4, p. 1062-1068 7 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4
Viruses
Microarrays
Immediate-Early Genes
Flow cytometry