• 2384 Citations
  • 30 h-Index
20072020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 2384 Citations
  • 30 h-Index
  • 74 Article
  • 3 Comment/debate
  • 2 Review article
2020

Glycofullerenes inhibit particulate matter induced inflammation and loss of barrier proteins in HaCaT human keratinocytes

Lee, C. W., Su, Y. H., Chiang, Y. C., Lee, I. T., Li, S. Y., Lee, H. C., Hsu, L. F., Yan, Y. L., Li, H. Y., Chen, M. C., Peng, K. T. & Lai, C. H., Apr 2020, In : Biomolecules. 10, 4, 514.

Research output: Contribution to journalArticle

Open Access

Nrf2/HO-1 partially regulates cytoprotective effects of carbon monoxide against urban particulate matter-induced inflammatory responses in oral keratinocytes

Cheng, C. Y., Vo, T. T. T., Lin, W. N., Huang, H. W., Chuang, C. C., Chu, P. M. & Lee, I. T., Sep 2020, In : Cytokine. 133, 155185.

Research output: Contribution to journalArticle

Surfactin from Bacillus subtilis attenuates ambient air particulate matter-promoted human oral cancer cells metastatic potential

Vo, T. T. T., Lee, C-W., Wu, C-Z., Liu, J-F., Lin, W-N., Chen, Y-L., Hsu, L-F., Tsai, M-H. & Lee, I-T., 2020, In : Journal of Cancer. 11, 20, p. 6038-6049 12 p.

Research output: Contribution to journalArticle

Urban Particulate Matter Enhances ROS/IL-6/COX-II Production by Inhibiting MicroRNA-137 in Synovial Fibroblast of Rheumatoid Arthritis

Tsai, M. H., Chi, M. C., Hsu, J. F., Lee, I. T., Lin, K. M., Fang, M. L., Lee, M. H., Lee, C. W. & Liu, J. F., Jun 2 2020, In : Cells. 9, 6

Research output: Contribution to journalArticle

Open Access
2019

Carbon monoxide releasing molecule-2 protects against particulate matter-induced lung inflammation by inhibiting TLR2 and 4/ROS/NLRP3 inflammasome activation

Lee, C. W., Chi, M. C., Hsu, L. F., Yang, C. M., Hsu, T. H., Chuang, C. C., Lin, W. N., Chu, P. M. & Lee, I. T., Aug 1 2019, In : Molecular Immunology. 112, p. 163-174 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Participation of NADPH Oxidase-Related Reactive Oxygen Species in Leptin-Promoted Pulmonary Inflammation: Regulation of cPLA2α and COX-2 Expression

Hsu, P. S., Lin, C. M., Chang, J. F., Wu, C. S., Sia, K. C., Lee, I. T., Huang, K. Y. & Lin, W. N., Mar 1 2019, In : International Journal of Molecular Sciences. 20, 5, p. 1078 1078.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Protective mechanisms of resveratrol derivatives against TNF-α-induced inflammatory responses in rat mesangial cells

Lee, I-T., Lin, C. F., Huang, Y. L., Chong, K. Y., Hsieh, M. F., Huang, T. H. & Cheng, C. Y., Jan 1 2019, In : Cytokine. 113, p. 380-392 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Targeting ROS and cPLA2/COX2 Expressions Ameliorated Renal Damage in Obese Mice with Endotoxemia

Chang, J. F., Yeh, J. C., Ho, C. T., Liu, S. H., Hsieh, C. Y., Wang, T. M., Chang, S. W., Lee, I. T., Huang, K. Y., Wang, J. Y. & Lin, W. N., Sep 6 2019, In : International Journal of Molecular Sciences. 20, 18

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Water-Soluble Fullerenol C60(OH)36 toward Effective Anti-Air Pollution Induced by Urban Particulate Matter in HaCaT Cell

Lee, C. W., Chi, M. C., Peng, K. T., Chiang, Y. C., Hsu, L. F., Yan, Y. L., Li, H. Y., Chen, M. C., Lee, I. T. & Lai, C. H., Aug 30 2019, In : International Journal of Molecular Sciences. 20, 17

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2018

Carbon monoxide ameliorates Staphylococcus aureus-elicited COX-2/IL-6/MMP-9-dependent human aortic endothelial cell migration and inflammatory responses

Tsai, M. H., Yang, C. M., Chang, K. T., Chuang, C. C., Lin, W. N., Jiang, R. S., Wu, C. H. & Lee, I. T., Nov 1 2018, In : Immunology Letters. 203, p. 40-49 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Carbon monoxide releasing molecule-2 attenuates Pseudomonas aeruginosa-induced ROS-dependent ICAM-1 expression in human pulmonary alveolar epithelial cells

Lee, C. W., Wu, C. H., Chiang, Y. C., Chen, Y. L., Chang, K. T., Chuang, C. C. & Lee, I. T., Sep 1 2018, In : Redox Biology. 18, p. 93-103 11 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Comparison of the incidence, clinical features and outcomes of invasive candidiasis in children and neonates

Hsu, J. F., Lai, M. Y., Lee, C. W., Chu, S. M., Wu, I. H., Huang, H. R., Lee, I-T., Chiang, M. C., Fu, R. H. & Tsai, M. H., Apr 24 2018, In : BMC Infectious Diseases. 18, 1, 194.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Corrigendum to “CO-releasing molecules CORM2 attenuates angiotensin II-induced human aortic smooth muscle cell migration through inhibition of ROS/IL-6 generation and matrix metalloproteinases-9 expression” [Redox Biol. 12 (2017) 377–388]

Tsai, M. H., Lee, C. W., Hsu, L. F., Li, S. Y., Chiang, Y. C., Lee, M. H., Chen, C. H., Liang, H. F., How, J. M., Chang, P. J., Wu, C. M. & Lee, I. T., Jan 1 2018, (Accepted/In press) In : Redox Biology. 28, 101005.

Research output: Contribution to journalArticle

Open Access

Erratum: Magnolol nanoparticles exhibit improved water solubility and suppress TNF-α-induced VCAM-1 expression in endothelial cells (Journal of Biomedical Nanotechnology (2017) 13:3 (225-268) DOI: 10.1166/jbn.2017.2342)

Lee, C. W., Hu, S. C. S., Yen, F. L., Hsu, L. F., Lee, I-T., Lin, Z. C., Tsai, M. H., Huang, C. L., Liang, C. J. & Chiang, Y. C., Dec 1 2018, In : Journal of Biomedical Nanotechnology. 14, 12, 1 p.

Research output: Contribution to journalComment/debate

Extracts of Artocarpus communis induce mitochondria-associated apoptosis via pro-oxidative activity in human glioblastoma cells

Lee, C. W., Hsu, L. F., Lee, M. H., Lee, I. T., Liu, J. F., Chiang, Y. C. & Tsai, M. H., May 2 2018, In : Frontiers in Pharmacology. 9, MAY, 411.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Infection with Staphylococcus aureus elicits COX-2/PGE 2 /IL-6/MMP-9-dependent aorta inflammation via the inhibition of intracellular ROS production

Tsai, M. H., Wu, C. H., Lin, W. N., Cheng, C. Y., Chuang, C. C., Chang, K. T., Jiang, R. S., Hsu, J. F. & Lee, I. T., Nov 1 2018, In : Biomedicine and Pharmacotherapy. 107, p. 889-900 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Resveratrol attenuates staphylococcus aureus-induced monocyte adhesion through downregulating pdgfr/ap-1 activation in human lung epithelial cells

Lee, I-T., Lin, C. C., Yang, C. C., Hsiao, L. D., Wu, M. Y. & Yang, C. M., Jan 1 2018, In : International Journal of Molecular Sciences. 19, 10, 3058.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
2017

Aliskiren improves Ischemia- and oxygen glucose deprivation-induced cardiac injury through activation of autophagy and AMP-activated protein kinase

Chiang, M. H., Liang, C. J., Liu, C. W., Pan, B. J., Chen, W. P., Yang, Y. F., Lee, I-T., Tsai, J. S., Lee, C. W. & Chen, Y. L., Nov 14 2017, In : Frontiers in Pharmacology. 8, NOV, 819.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Breakthrough candidemia in children: Clinical and microbiological characteristics, therapeutic strategies and impact on outcomes

Lai, M. Y., Hsu, J. F., Chu, S. M., Wu, I. H., Huang, H. R., Lin, C. C., Lee, I-T., Chiang, M. C., Fu, R. H. & Tsai, M. H., Jun 1 2017, In : Future Microbiology. 12, 8, p. 695-705 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

CO-releasing molecules CORM2 attenuates angiotensin II-induced human aortic smooth muscle cell migration through inhibition of ROS/IL-6 generation and matrix metalloproteinases-9 expression

Tsai, M. H., Lee, C. W., Hsu, L. F., Li, S. Y., Chiang, Y. C., Lee, M. H., Chen, C. H., Liang, H. F., How, J. M., Chang, P. J., Wu, C. M. & Lee, I-T., Aug 1 2017, In : Redox Biology. 12, p. 377-388 12 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Magnolol nanoparticles exhibit improved water solubility and suppress TNF-α-induced VCAM-1 expression in endothelial cells

Lee, C. W., Hu, S. C. S., Yen, F. L., Hsu, L. F., Lee, I-T., Lin, Z. C., Tsai, M. H., Huang, C. L., Liang, C. J. & Chiang, Y. C., Mar 1 2017, In : Journal of Biomedical Nanotechnology. 13, 3, p. 255-268 14 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Resveratrol attenuates ICAM-1 expression and monocyte adhesiveness to TNF-α-treated endothelial cells: Evidence for an anti-inflammatory cascade mediated by the MIR-221/222/AMPK/p38/NF-7kappa;B pathway

Liu, C. W., Sung, H. C., Lin, S. R., Wu, C. W., Lee, C. W., Lee, I-T., Yang, Y. F., Yu, I. S., Lin, S. W., Chiang, M. H., Liang, C. J. & Chen, Y. L., Mar 24 2017, In : Scientific Reports. 7, 44689.

Research output: Contribution to journalArticle

Open Access
30 Citations (Scopus)

Resveratrol inhibits urban particulate matter-induced COX-2/PGE2 release in human fibroblast-like synoviocytes via the inhibition of activation of NADPH oxidase/ROS/NF-κB

Tsai, M. H., Hsu, L. F., Lee, C. W., Chiang, Y. C., Lee, M. H., How, J. M., Wu, C. M., Huang, C. L. & Lee, I-T., Jul 1 2017, In : International Journal of Biochemistry and Cell Biology. 88, p. 113-123 11 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2016

Anti-melanoma activity of Bupleurum chinense, Bupleurum kaoi and nanoparticle formulation of their major bioactive compound saikosaponin-d

Hu, S. C. S., Lee, I-T., Yen, M. H., Lin, C. C., Lee, C. W. & Yen, F. L., Feb 17 2016, In : Journal of Ethnopharmacology. 179, p. 432-442 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Clinical and molecular characteristics of neonatal extended-spectrum β-lactamase-producing gram-negative bacteremia: A 12-year case-control-control study of a referral center in Taiwan

Tsai, M. H., Lee, I-T., Chu, S. M., Lien, R., Huang, H. R., Chiang, M. C., Fu, R. H., Hsu, J. F. & Huang, Y. C., Aug 1 2016, In : PLoS One. 11, 8, e0159744.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Eupafolin ameliorates COX-2 expression and PGE 2 production in particulate pollutants-exposed human keratinocytes through ROS/MAPKs pathways

Lee, C. W., Lin, Z. C., Hsu, L. F., Fang, J. Y., Chiang, Y. C., Tsai, M. H., Lee, M. H., Li, S. Y., Hu, S. C. S., Lee, I-T. & Yen, F. L., Aug 2 2016, In : Journal of Ethnopharmacology. 189, p. 300-309 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Infectious complications and morbidities after neonatal bloodstream infections: An observational cohort study

Tsai, M. H., Lee, C. W., Chu, S. M., Lee, I-T., Lien, R., Huang, H. R., Chiang, M. C., Fu, R. H., Hsu, J. F. & Huang, Y. C., Jan 1 2016, In : Medicine (United States). 95, 11, e3078.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Lipopolysaccharide induces ICAM-1 expression via a c-Src/NADPH oxidase/ROS-dependent NF-κB pathway in human pulmonary alveolar epithelial cells

Cho, R. L., Yang, C. C., Lee, I-T., Lin, C. C., Chi, P. L., Hsiao, L. D. & Yang, C. M., Apr 1 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 310, 7, p. L639-L657

Research output: Contribution to journalArticle

36 Citations (Scopus)

Urban particulate matter down-regulates filaggrin via COX2 expression/PGE2 production leading to skin barrier dysfunction

Lee, C. W., Lin, Z. C., Hu, S. C. S., Chiang, Y. C., Hsu, L. F., Lin, Y. C., Lee, I-T., Tsai, M. H. & Fang, J. Y., Jun 17 2016, In : Scientific Reports. 6, 27995.

Research output: Contribution to journalArticle

Open Access
63 Citations (Scopus)
2015

c-Src-dependent transactivation of EGFR mediates CORM-2-induced HO-1 expression in human tracheal smooth muscle cells

Yang, C. M., Lin, C. C., Lee, I-T., Hsu, C. K., Tai, Y. C., Hsieh, H. L., Chi, P. L. & Hsiao, L. D., Oct 1 2015, In : Journal of Cellular Physiology. 230, 10, p. 2351-2361 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Incidence, prevalence, and medical expenditures of classical amyotrophic lateral sclerosis in Taiwan, 1999-2008

Tsai, C. P., Wang, K. C., Hwang, C. S., Lee, I-T. & Lee, C. T. C., Jul 1 2015, In : Journal of the Formosan Medical Association. 114, 7, p. 612-619 8 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Sphingosine-1-phosphate mediates COX-2 expression and PGE2/IL-6 secretion via c-Src-Dependent AP-1 activation

Hsu, C. K., Lee, I-T., Lin, C. C., Hsiao, L. D. & Yang, C. M., Mar 1 2015, In : Journal of Cellular Physiology. 230, 3, p. 702-715 14 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Sphingosine-1-phosphate mediates ICAM-1-dependent monocyte adhesion through p38 MAPK and p42/p44 MAPK-dependent akt activation

Lin, C. C., Lee, I-T., Hsu, C. H., Hsu, C. K., Chi, P. L., Hsiao, L. D. & Yang, C. M., Mar 3 2015, In : PLoS One. 10, 3, e0118473.

Research output: Contribution to journalArticle

Open Access
18 Citations (Scopus)

TNF-α mediates PKCδ/JNK1/2/c-Jun-dependent monocyte adhesion via ICAM-1 induction in human retinal pigment epithelial cells

Lee, I-T., Liu, S. W., Chi, P. L., Lin, C. C., Hsiao, L. D. & Yang, C. M., Feb 12 2015, In : PLoS One. 10, 2, e0117911.

Research output: Contribution to journalArticle

Open Access
23 Citations (Scopus)
2014

c-Src/Jak2/PDGFR/PKCδ-dependent MMP-9 induction is required for thrombin-stimulated rat brain astrocytes migration

Lin, C. C., Lee, I-T., Chi, P. L., Hsieh, H. L., Cheng, S. E., Hsiao, L. D., Liu, C. J. & Yang, C. M., Jan 1 2014, In : Molecular Neurobiology. 49, 2, p. 658-672 15 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

C-Src-dependent transactivation of PDGFR contributes to TNF-α-induced MMP-9 expression and functional impairment in osteoblasts

Tsai, C. L., Chen, W. C., Lee, I-T., Chi, P. L., Cheng, S. E. & Yang, C. M., Mar 1 2014, In : Bone. 60, p. 186-197 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Erratum: Lung inflammation caused by adenosine-5′-triphosphate is mediated via Ca2+/PKCs-dependent COX-2/PGE2 induction (Int. J. Biochem. Cell Biol. (2013) 45 (1657-1668))

Lee, I-T., Lin, C. C., Lin, W. N., Wu, W. L., Hsiao, L. D. & Yang, C. M., Jan 1 2014, In : International Journal of Biochemistry and Cell Biology. 46, 1, p. 162-163 2 p.

Research output: Contribution to journalComment/debate

HO-1 induction by CO-RM2 attenuates TNF- α -induced cytosolic phospholipase A2 expression via inhibition of PKC α -dependent NADPH oxidase/ROS and NF- B

Chi, P. L., Liu, C. J., Lee, I-T., Chen, Y. W., Hsiao, L. D. & Yang, C. M., Mar 5 2014, In : Mediators of Inflammation. 2014, 279171.

Research output: Contribution to journalArticle

Open Access
23 Citations (Scopus)
11 Citations (Scopus)

Resveratrol inhibits Staphylococcus aureus-induced TLR2/MyD88/NF-κB-dependent VCAM-1 expression in human lung epithelial cells.

Lee, I-T., Lin, C. C., Hsu, C. K., Wu, M. Y., Cho, R. L. & Yang, C. M., Jan 1 2014, In : Clinical science (London, England : 1979). 127, 6, p. 375-390 16 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Thrombin induces ICAM-1 expression in human lung epithelial cells via c-Src/PDGFR/PI3K/ Akt-dependent NF-κB/p300 activation

Cheng, S. E., Lee, I-T., Lin, C. C., Hsiao, L. D. & Yang, C. M., Jan 1 2014, In : Clinical Science. 127, 3, p. 171-183 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

TNF-α induces cytosolic phospholipase A2 expression via Jak2/PDGFR-dependent Elk-1/p300 activation in human lung epithelial cells

Yang, C. M., Lee, I-T., Chi, P. L., Cheng, S. E., Hsiao, L. D. & Hsu, C. K., Mar 15 2014, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 306, 6

Research output: Contribution to journalArticle

13 Citations (Scopus)
2013

ATP Mediates NADPH Oxidase/ROS Generation and COX-2/PGE2 Expression in A549 Cells: Role of P2 Receptor-Dependent STAT3 Activation

Cheng, S. E., Lee, I-T., Lin, C. C., Wu, W. L., Hsiao, L. D. & Yang, C. M., Jan 17 2013, In : PLoS One. 8, 1, e54125.

Research output: Contribution to journalArticle

Open Access
37 Citations (Scopus)

ATP stimulates PGE2/cyclin D1-dependent VSMCs proliferation via STAT3 activation: Role of PKCs-dependent NADPH oxidase/ROS generation

Lee, I-T., Lin, C. C., Wang, C. H., Cherng, W. J., Wang, J. S. & Yang, C. M., Apr 1 2013, In : Biochemical Pharmacology. 85, 7, p. 954-964 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

C-Src-dependent MAPKs/AP-1 activation is involved in TNF-α-induced matrix metalloproteinase-9 expression in rat heart-derived H9c2 cells

Yang, C. M., Lee, I-T., Lin, C. C., Wang, C. H., Cherng, W. J. & Hsiao, L. D., Apr 15 2013, In : Biochemical Pharmacology. 85, 8, p. 1115-1123 9 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

IL-1β Promotes Corneal Epithelial Cell Migration by Increasing MMP-9 Expression through NF-κB- and AP-1-Dependent Pathways

Tseng, H. C., Lee, I-T., Lin, C. C., Chi, P. L., Cheng, S. E., Shih, R. H., Hsiao, L. D. & Yang, C. M., Mar 7 2013, In : PLoS One. 8, 3, e57955.

Research output: Contribution to journalArticle

Open Access
44 Citations (Scopus)

Inflammatory signalings involved in airway and pulmonary diseases

Lee, I-T. & Yang, C. M., May 13 2013, In : Mediators of Inflammation. 2013, 791231.

Research output: Contribution to journalReview article

Open Access
138 Citations (Scopus)

Lung inflammation caused by adenosine-5'-triphosphate is mediatedvia Ca2+/PKCs-dependent COX-2/PGE2induction

Leea, I-T., Lin, C. C., Lin, W. N., Wu, W. L., Hsiao, L. D. & Yang, C. M., Jan 1 2013, In : International Journal of Biochemistry and Cell Biology. 45, 8, p. 1657-1668 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

NADPH oxidase/ROS-dependent PYK2 activation is involved in TNF-α-induced matrix metalloproteinase-9 expression in rat heart-derived H9c2 cells

Yang, C. M., Lee, I-T., Hsu, R. C., Chi, P. L. & Hsiao, L. D., Oct 15 2013, In : Toxicology and Applied Pharmacology. 272, 2, p. 431-442 12 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Protective effects of (-)-epigallocatechin-3-gallate against TNF-α-induced lung inflammation via ROS-dependent ICAM-1 inhibition

Lee, I-T., Lin, C. C., Lee, C. Y., Hsieh, P. W. & Yang, C. M., Jan 1 2013, In : Journal of Nutritional Biochemistry. 24, 1, p. 124-136 13 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)