• 699 Citations
  • 17 h-Index
20092020

Research output per year

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Research Output

  • 699 Citations
  • 17 h-Index
  • 44 Article
  • 2 Review article
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Article
2020

Synthesis and biological evaluation of 2-quinolineacrylamides

Wang, S. W., Lin, M. H., Hsu, F. C., Chen, M. C., Liou, J. P., Liu, Y. T., Chen, S. S. & Lee, H. Y., Feb 1 2020, In : Bioorganic and Medicinal Chemistry. 28, 3, p. 115250 115250.

Research output: Contribution to journalArticle

2019

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Structure-guided design of anti-cancer ribonucleotide reductase inhibitors

Misko, T. A., Liu, Y. T., Harris, M. E., Oleinick, N. L., Pink, J., Lee, H. Y. & Dealwis, C. G., Jan 1 2019, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 34, 1, p. 438-450 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo

Lee, H. Y., Nepali, K., Huang, F. I., Chang, C. Y., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Feb 8 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 905-917 13 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Jan 29 2018, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

15 Citations (Scopus)

A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo

Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., Mar 13 2018, In : Frontiers in Pharmacology. 9, MAR, 205.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Correction: 2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition (Org. Biomol. Chem. (2016) 14 (716-723))

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J. Y., Liou, J. P. & Lee, H. Y., Jan 1 2018, In : Organic and Biomolecular Chemistry. 16, 25, p. 4734 1 p.

Research output: Contribution to journalArticle

2017

3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity

Lee, H-Y., Lee, J. F., Kumar, S., Wu, Y. W., HuangFu, W-C., Lai, M-J., Li, Y-H., Huang, H. L., Kuo, F. C., Hsiao, C. J., Cheng, C. C., Yang, C. R. & Liou, J-P., Jan 5 2017, In : European Journal of Medicinal Chemistry. 125, p. 1268-1278 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells

Chao, M. W., Huang, H. L., HuangFu, W. C., Hsu, K. C., Liu, Y. M., Wu, Y. W., Lin, C. F., Chen, Y. L., Lai, M. J., Lee, H. Y., Liou, J. P., Teng, C. M. & Yang, C. R., 2017, In : Oncotarget. 8, 17, p. 27772-27785 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Ring-opened tetrahydro-γ-carbolines display cytotoxicity and selectivity with histone deacetylase isoforms

Nepali, K., Lee, H-Y., Lai, M-J., Ojha, R., Wu, T. Y., Wu, G. X., Chen, M-C. & Liou, J-P., Feb 15 2017, In : European Journal of Medicinal Chemistry. 127, p. 115-127 13 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
3 Citations (Scopus)
2016

2-(Phenylsulfonyl)quinoline N-hydroxyacrylamides as potent anticancer agents inhibiting histone deacetylase

Lee, H. Y., Chang, C. Y., Su, C. J., Huang, H. L., Mehndiratta, S., Chao, Y. H., Hsu, C. M., Kumar, S., Sung, T. Y., Huang, Y. Z., Li, Y. H., Yang, C. R. & Liou, J. P., Oct 21 2016, In : European Journal of Medicinal Chemistry. 122, p. 92-101 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Total Synthesis of Denbinobin

Lee, H. Y., Kumar, S., Lin, T. C. & Liou, J. P., Apr 22 2016, In : Journal of Natural Products. 79, 4, p. 1170-1173 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2015
16 Citations (Scopus)

2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J. Y., Liou, J. P. & Lee, H. Y., 2015, In : Organic and Biomolecular Chemistry. 14, 2, p. 716-723 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Antimitotic and antivascular activity of heteroaroyl-2-hydroxy-3,4,5-trimethoxybenzenes

Lee, H. Y., Chang, C-Y., Lai, M-J., Chuang, H-Y., Kuo, C-C., Chang, C-Y., Chang, J-Y. & Liou, J. P., Jul 23 2015, In : Bioorganic and Medicinal Chemistry. 23, 15, p. 4230-4236 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
10 Citations (Scopus)

N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling

Lai, M-J., Lee, H. Y., Chuang, H-Y., Chang, L-H., Tsai, A-C., Chen, M. C., Huang, H-L., Wu, Y-W., Teng, C-M., Pan, S. L., Liu, Y-M., Mehndiratta, S. & Liou, J. P., Aug 27 2015, In : Journal of Medicinal Chemistry. 58, 16, p. 6549-6558 10 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
9 Citations (Scopus)
2014

A novel action mechanism for MPT0g013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through upregulation of TIMP3 expression

Wang, C-Y., Liou, J. P., Tsai, A-C., Lai, M-J., Liu, Y-M., Lee, H. Y., Wang, J-C., Pan, S. L. & Teng, C-M., 2014, In : Oncotarget. 5, 20, p. 9838-9850 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Antimitotic and vascular disrupting agents: 2-Hydroxy-3,4,5- trimethoxybenzophenones

Chang, C. Y., Chuang, H. Y., Lee, H. Y., Yeh, T. K., Kuo, C. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., Apr 22 2014, In : European Journal of Medicinal Chemistry. 77, p. 306-314 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells

Lee, H. Y., Tsai, A. C., Chen, M. C., Shen, P. J., Cheng, Y. C., Kuo, C. C., Pan, S. L., Liu, Y. M., Liu, J. F., Yeh, T. K., Wang, J. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., May 22 2014, In : Journal of Medicinal Chemistry. 57, 10, p. 4009-4022 14 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents

Mehndiratta, S., Chiang, Y-F., Lai, M-J., Lee, H. Y., Chen, M. C., Kuo, C-C., Chang, C-Y., Chang, J-Y. & Liou, J. P., Sep 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 17, p. 4917-4923 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Denbinobin upregulates miR-146a expression and attenuates IL-1β-induced upregulation of ICAM-1 and VCAM-1 expressions in osteoarthritis fibroblast-like synoviocytes

Yang, C. R., Shih, K. S., Liou, J. P., Wu, Y. W., Hsieh, I. N., Lee, H. Y., Lin, T. C. & Wang, J. H., Oct 22 2014, In : Journal of Molecular Medicine. 92, 11, p. 1147-1158 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Effect of C7-substitution of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines on the selectivity towards a subclass of histone deacetylases

Lee, H. Y., Wang, L. T., Li, Y. H., Pan, S. L., Chen, Y. L., Teng, C. M. & Liou, J. P., Nov 28 2014, In : Organic and Biomolecular Chemistry. 12, 44, p. 8966-8976 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Indole-3-ethylsulfamoylphenylacrylamides: Potent histone deacetylase inhibitors with anti-inflammatory activity

Mehndiratta, S., Hsieh, Y. L., Liu, Y. M., Wang, A. W., Lee, H. Y., Liang, L. Y., Kumar, S., Teng, C. M., Yang, C. R. & Liou, J. P., Oct 6 2014, In : European Journal of Medicinal Chemistry. 85, p. 468-479 12 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Preclinical anti-arthritic study and pharmacokinetic properties of a potent histone deacetylase inhibitor MPT0G009

Hsieh, I-N., Liou, J. P., Lee, H. Y., Lai, M-J., Li, Y-H. & Yang, C-R., 2014, In : Cell Death and Disease. 5, 4, e1166.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Tubulin inhibitors: A patent review

Liu, Y. M., Chen, H. L., Lee, H. Y. & Liou, J. P., Jan 2014, In : Expert Opinion on Therapeutic Patents. 24, 1, p. 69-88 20 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)
2013

1-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors

Lee, H. Y., Yang, C-R., Lai, M-J., Huang, H-L., Hsieh, Y-L., Liu, Y-M., Yeh, T-K., Li, Y-H., Mehndiratta, S., Teng, C-M. & Liou, J. P., Jul 2013, In : ChemBioChem. 14, 10, p. 1248-1254 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Furanylazaindoles: Potent anticancer agents in vitro and in vivo

Lee, H. Y., Pan, S. L., Su, M-C., Liu, Y-M., Kuo, C-C., Chang, Y-T., Wu, J-S., Nien, C-Y., Mehndiratta, S., Chang, C-Y., Wu, S-Y., Lai, M-J., Chang, J-Y. & Liou, J. P., 2013, In : Journal of Medicinal Chemistry. 56, 20, p. 8008-8018 11 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Inside Cover: 1-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors (ChemBioChem 10/2013)

Lee, H. Y., Yang, C-R., Lai, M-J., Huang, H-L., Hsieh, Y-L., Liu, Y-M., Yeh, T-K., Li, Y-H., Mehndiratta, S., Teng, C-M. & Liou, J. P., Jul 2013, In : ChemBioChem. 14, 10, p. 1150 1 p.

Research output: Contribution to journalArticle

2012

Anticancer activity of MPT0E028, a novel potent histone deacetylase inhibitor, in human colorectal cancer HCT116 cells in vitro and in vivo

Huang, H-L., Lee, H. Y., Tsai, A-C., Peng, C-Y., Lai, M-J., Wang, J-C., Pan, S. L., Teng, C-M. & Liou, J. P., Aug 22 2012, In : PLoS One. 7, 8, e43645.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Application of Suzuki arylation, Sonogashira ethynylation and Rosenmund-von Braun cyanation in the exploration of substitution effects on the anticancer activity of 2-aroylquinolines

Lee, H. Y., Lee, L. W., Nien, C. Y., Kuo, C. C., Lin, P. Y., Chang, C. Y., Chang, J. Y. & Liou, J. P., 2012, In : Organic and Biomolecular Chemistry. 10, 48, p. 9593-9600 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Synthesis and biological evaluation of 1-arylsulfonyl-5-(N -hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo

Lai, M. J., Huang, H. L., Pan, S. L., Liu, Y. M., Peng, C. Y., Lee, H. Y., Yeh, T. K., Huang, P. H., Teng, C. M., Chen, C. S., Chuang, H. Y. & Liou, J. P., Apr 26 2012, In : Journal of Medicinal Chemistry. 55, 8, p. 3777-3791 15 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)
2011

2-Amino-3,4,5-Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors

Chuang, H-Y., Chang, J-Y., Lai, M-J., Kuo, C-C., Lee, H. Y., Hsieh, H-P., Chen, Y-J., Chen, L-T., Pan, W-Y. & Liou, J. P., Mar 7 2011, In : ChemMedChem. 6, 3, p. 450-456 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2

Lee, H. Y., Chang, J. Y., Nien, C. Y., Kuo, C. C., Shih, K. H., Wu, C. H., Chang, C. Y., Lai, W. Y. & Liou, J. P., Dec 22 2011, In : Journal of Medicinal Chemistry. 54, 24, p. 8517-8525 9 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents: Application of the copper-mediated Ullmann-type arylation

Lee, H. Y., Chang, J-Y., Chang, L-Y., Lai, W-Y., Lai, M-J., Shih, K-H., Kuo, C-C., Chang, C-Y. & Liou, J. P., May 7 2011, In : Organic and Biomolecular Chemistry. 9, 9, p. 3154-3157 4 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Synthesis and biological evaluation of 1-(4′-Indolyl and 6′-Quinolinyl) indoles as a new class of potent anticancer agents

Lai, M-J., Chang, J-Y., Lee, H. Y., Kuo, C-C., Lin, M. H., Hsieh, H-P., Chang, C-Y., Wu, J-S., Wu, S-Y., Shey, K-S. & Liou, J. P., Sep 2011, In : European Journal of Medicinal Chemistry. 46, 9, p. 3623-3629 7 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents

Hsieh, C. C., Lee, H. Y., Nien, C. Y., Kuo, C. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., Mar 2011, In : Molecules. 16, 3, p. 2274-2284 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2010

Efficient microwave-assisted synthesis of ellipticine through N-(1,4-dimethyl-9h-carbazol-3-ylmethyl)-n-tosylaminoacetaldehyde diethyl acetal

Lee, H. Y., Chen, G. S., Chen, C. S. & Cherna, J. W., Mar 2010, In : Journal of Heterocyclic Chemistry. 47, 2, p. 454-458 5 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Synthesis and biological evaluation of 7-arylindoline-1-benzenesulfonamides as a novel class of potent anticancer agents

Chang, J-Y., Lai, M-J., Chang, Y-T., Lee, H. Y., Cheng, Y-C., Kuo, C-C., Su, M-C., Chang, C-Y. & Liou, J. P., Aug 2010, In : MedChemComm. 1, 2, p. 152-155 4 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2009

An improved screening model to identify inhibitors targeting zinc-enhanced amyloid aggregation

Chang, P. T., Kung, F. L., Talekar, R. S., Chen, C. S., Lai, S. Y., Lee, H. Y. & Chern, J. W., Aug 15 2009, In : Analytical Chemistry. 81, 16, p. 6944-6951 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)