Hsueh-Yun Lee

Associate Professor, Department of Pharmaceutical Sciences
Joint-Appointment Associate Professor, Ph.D. Program in Drug Discovery and Development Industry
Joint-Appointment Associate Professor, Master Program in Clinical Pharmacogenomics and Pharmacoproteomics
Member, TMU Biomedical Commercialization Center

https://orcid.org/0000-0001-6683-0726

Emailhyl@tmu.edu.tw

Source: Scopus
Calculated based on no. of publications stored in Pure and citations from Scopus

Research activity per year

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Personal profile

Education

2010 Ph.D. (Pharmaceutical Sciences), National Taiwan University
2001 B.S., School of Pharmacy, Taipei Medical University

Experience

2020- Associate Professor, Master Program in Clinical Pharmacogenomics and Pharmacoproteomics, Taipei Medical University
2018- Associate Professor, Department of Pharmaceutical Sciences, Taipei Medical University
2016-2017 Assistant Professor, Ph.D. Program in Drug Discovery and Development Industry, Taipei Medical University
2015-2018 Assistant Professor, Department of Pharmaceutical Sciences, Taipei Medical University
2013-2015 Project Assistant Research Fellow, Department of Pharmaceutical Sciences, Taipei Medical University
2012-2013 Assistant Researcher, Department of Pharmaceutical Sciences, Taipei Medical University

Research Interests

藥物化學
藥物合成開發
藥物結構修飾
有機化學合成
天然物全合成

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2 Active
3 Finished

結構優化以開發DYRK1B抑制劑
Lee, H.
1/1/21 → 12/31/21
Project: B - Project of TMU › h - Higher Education Sprout Project
開發1,3-二芳基取代之五元雜環作為抗胰臟癌劑(2/3)
Lee, H.
8/1/20 → 7/1/21
Project: A - Government Institution › b - Ministry of Science and Technology
結構優化以開發DYRK1B抑制劑
Lee, H.
1/1/20 → 12/31/20
Project: A - Government Institution › d - Ministry of Education
Development of 1,3-Diaryl-Substituted Five-Membered Heterocycles as Anti-Pancreatic Cancer Agents(1/3)
Lee, H.
8/1/19 → 7/31/20
Project: A - Government Institution › b - Ministry of Science and Technology
設計與合成benzimidazole衍生物作為改善神經退化疾病之化合物
Lee, H.
7/1/19 → 2/1/20
Project: A - Government Institution › b - Ministry of Science and Technology

862 Citations
18 h-Index
45 Article
2 Review article

Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms
Mehndiratta, S., Chen, M. C., Chao, Y. H., Lee, C. H., Liou, J. P., Lai, M. J. & Lee, H. Y., Dec 2021, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 36, 1, p. 74-84 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
HDAC inhibitor protects chronic cerebral hypoperfusion and oxygen-glucose deprivation injuries via H3K14 and H4K5 acetylation-mediated BDNF expression
Fang, Y-C., Chan, L., Liou, J-P., Tu, Y-K., Lai, M-J., Chen, C-I., Vidyanti, A. N., Lee, H-Y. & Hu, C-J., Jun 1 2020, In: Journal of Cellular and Molecular Medicine. 24, 12, p. 6966-6977 12 p.
Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus)
Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment
Kaur, N., Fang, Y. C., Lee, H. Y., Singh, A., Nepali, K., Lin, M. H., Yeh, T. K., Lai, M. J., Chan, L., Tu, Y. K., Banerjee, S., Hu, C. J. & Liou, J. P., Feb 1 2020, In: European Journal of Medicinal Chemistry. 187, 111915.
Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus)
Synthesis and biological evaluation of 2-quinolineacrylamides
Wang, S. W., Lin, M. H., Hsu, F. C., Chen, M. C., Liou, J. P., Liu, Y. T., Chen, S. S. & Lee, H. Y., Feb 1 2020, In: Bioorganic and Medicinal Chemistry. 28, 3, p. 115250 115250.
Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus)
1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase
Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In: European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.
Research output: Contribution to journal › Article › peer-review
12 Citations (Scopus)

Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms
Mehndiratta, S. (Contributor), Chen, M. (Contributor), Chao, Y. (Contributor), Lee, C. (Contributor), Liou, J. (Contributor), Lai, M. (Contributor) & Lee, H. (Contributor), Unknown Publisher, Jan 1 2020
DOI: 10.6084/m9.figshare.13207104.v1, https://tandf.figshare.com/articles/journal_contribution/Effect_of_3-subsitution_of_quinolinehydroxamic_acids_on_selectivity_of_histone_deacetylase_isoforms/13207104/1
Dataset
Structure-guided design of anti-cancer ribonucleotide reductase inhibitors
Misko, T. A. (Contributor), Liu, Y. (Contributor), Harris, M. E. (Contributor), Oleinick, N. L. (Contributor), Pink, J. (Contributor), Lee, H. (Contributor) & Dealwis, C. G. (Contributor), Unknown Publisher, Jan 1 2019
DOI: 10.6084/m9.figshare.7553114.v1, https://tandf.figshare.com/articles/Structure-guided_design_of_anti-cancer_ribonucleotide_reductase_inhibitors/7553114/1
Dataset