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Personal profile

Education

  • Ph.D. (Pharmaceutical Sciences), National Taiwan University

Research Interests

  • 藥物化學
  • 藥物合成開發
  • 藥物結構修飾
  • 有機化學合成
  • 天然物全合成

Fingerprint Dive into the research topics where Hsueh-Yun Lee is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 9 Similar Profiles
Histone Deacetylase Inhibitors Medicine & Life Sciences
Tubulin Medicine & Life Sciences
Histone Deacetylases Medicine & Life Sciences
Tubulin Modulators Medicine & Life Sciences
Inhibitory Concentration 50 Medicine & Life Sciences
Antineoplastic Agents Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Cells Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2019 2020

108大專生計畫獎-李學耘

Lee, H.

8/1/197/1/20

Project: A - Government Institutionb - Ministry of Science and Technology

開發1,3-二芳基取代之五元雜環作為抗胰臟癌劑(1/3)

Lee, H.

8/1/197/1/20

Project: A - Government Institutionb - Ministry of Science and Technology

設計與合成benzimidazole衍生物作為改善神經退化疾病之化合物

Lee, H.

7/1/192/1/20

Project: A - Government Institutionb - Ministry of Science and Technology

Research Output 2009 2019

  • 589 Citations
  • 15 h-Index
  • 41 Article
  • 2 Review article
5 Citations (Scopus)

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
27 Citations (Scopus)

Nitro-Group-Containing Drugs

Nepali, K., Lee, H. Y. & Liou, J. P., Mar 28 2019, In : Journal of Medicinal Chemistry. 62, 6, p. 2851-2893 43 p.

Research output: Contribution to journalReview article

Antitubercular Agents
Antiparasitic Agents
Pharmaceutical Chemistry
Prodrugs
Therapeutic Uses

Structure-guided design of anti-cancer ribonucleotide reductase inhibitors

Misko, T. A., Liu, Y. T., Harris, M. E., Oleinick, N. L., Pink, J., Lee, H. Y. & Dealwis, C. G., Jan 1 2019, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 34, 1, p. 438-450 13 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Hydrazones
Neoplasms
Pancreatic Neoplasms
Catalytic Domain
14 Citations (Scopus)

(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo

Lee, H. Y., Nepali, K., Huang, F. I., Chang, C. Y., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Feb 8 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 905-917 13 p.

Research output: Contribution to journalArticle

Quinolines
Histone Deacetylase Inhibitors
Multiple Myeloma
Growth
Hydroxamic Acids
10 Citations (Scopus)

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Jan 29 2018, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

tau Proteins
Histone Deacetylase Inhibitors
Alzheimer Disease
Hydroxamic Acids
Phenotype