Projects per year
Personal profile
Education
- 2010 Ph.D. (Pharmaceutical Sciences), National Taiwan University
- 2001 B.S., School of Pharmacy, Taipei Medical University
Experience
- 2018- 臺北醫學大學藥物科學學科副教授
- 2016-2017 臺北醫學大學生技醫療產業研發博士學位學程助理教授
- 2015-2018 臺北醫學大學藥物科學學科助理教授
- 2013-2015 臺北醫學大學藥物科學學科專案助理教授
- 2012-2013 臺北醫學大學藥物科學學科助理研究員
- 2011-2012 臺北醫學大學博士後研究
- 2010-2011 國立清華大學博士後研究
Research Interests
- 藥物化學
- 藥物合成開發
- 藥物結構修飾
- 有機化學合成
- 天然物全合成
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Projects
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開發1,3-二芳基取代之五元雜環作為抗胰臟癌劑(2/3)
8/1/20 → 7/1/21
Project: A - Government Institution › b - Ministry of Science and Technology
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Development of 1,3-Diaryl-Substituted Five-Membered Heterocycles as Anti-Pancreatic Cancer Agents(1/3)
8/1/19 → 7/31/20
Project: A - Government Institution › b - Ministry of Science and Technology
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設計與合成benzimidazole衍生物作為改善神經退化疾病之化合物
7/1/19 → 2/1/20
Project: A - Government Institution › b - Ministry of Science and Technology
Research output
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Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms
Mehndiratta, S., Chen, M. C., Chao, Y. H., Lee, C. H., Liou, J. P., Lai, M. J. & Lee, H. Y., Dec 2021, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 36, 1, p. 74-84 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
HDAC inhibitor protects chronic cerebral hypoperfusion and oxygen-glucose deprivation injuries via H3K14 and H4K5 acetylation-mediated BDNF expression
Fang, Y-C., Chan, L., Liou, J-P., Tu, Y-K., Lai, M-J., Chen, C-I., Vidyanti, A. N., Lee, H-Y. & Hu, C-J., Jun 1 2020, In: Journal of Cellular and Molecular Medicine. 24, 12, p. 6966-6977 12 p.Research output: Contribution to journal › Article › peer-review
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Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment
Kaur, N., Fang, Y. C., Lee, H. Y., Singh, A., Nepali, K., Lin, M. H., Yeh, T. K., Lai, M. J., Chan, L., Tu, Y. K., Banerjee, S., Hu, C. J. & Liou, J. P., Feb 1 2020, In: European Journal of Medicinal Chemistry. 187, 111915.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Synthesis and biological evaluation of 2-quinolineacrylamides
Wang, S. W., Lin, M. H., Hsu, F. C., Chen, M. C., Liou, J. P., Liu, Y. T., Chen, S. S. & Lee, H. Y., Feb 1 2020, In: Bioorganic and Medicinal Chemistry. 28, 3, p. 115250 115250.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase
Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In: European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus)
Datasets
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Structure-guided design of anti-cancer ribonucleotide reductase inhibitors
Misko, T. A. (Contributor), Liu, Y. (Contributor), Harris, M. E. (Contributor), Oleinick, N. L. (Contributor), Pink, J. (Contributor), Lee, H. (Contributor) & Dealwis, C. G. (Contributor), Unknown Publisher, Jan 1 2019
DOI: 10.6084/m9.figshare.7553114.v1, https://tandf.figshare.com/articles/Structure-guided_design_of_anti-cancer_ribonucleotide_reductase_inhibitors/7553114/1
Dataset
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Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms
Mehndiratta, S. (Contributor), Chen, M. (Contributor), Chao, Y. (Contributor), Lee, C. (Contributor), Liou, J. (Contributor), Lai, M. (Contributor) & Lee, H. (Contributor), Unknown Publisher, Jan 1 2020
DOI: 10.6084/m9.figshare.13207104.v1, https://tandf.figshare.com/articles/journal_contribution/Effect_of_3-subsitution_of_quinolinehydroxamic_acids_on_selectivity_of_histone_deacetylase_isoforms/13207104/1
Dataset