• 8285 Citations
  • 49 h-Index
1984 …2020

Research output per year

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Research Output

2020
Open Access
2019

Generation of induced pluripotent stem cell line-NTUHi001-A from a premature ovarian failure patient with Turner's syndrome mosaicism

Lu, C. Y., Chen, Y. A., Syu, S. H., Lu, H. E., Ho, H. N. & Chen, H. F., May 1 2019, In : Stem Cell Research. 37, 101422.

Research output: Contribution to journalArticle

Open Access

HSD3B1 gene polymorphism and female pattern hair loss in women with polycystic ovary syndrome

Tu, Y. A., Lin, S. J., Chen, P. L., Chou, C. H., Huang, C. C., Ho, H. N. & Chen, M. J., Aug 1 2019, In : Journal of the Formosan Medical Association. 118, 8, p. 1225-1231 7 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Hyperactive CREB signaling pathway involved in the pathogenesis of polycystic ovarian syndrome revealed by patient-specific induced pluripotent stem cell modeling

Huang, C. C., Chen, M. J., Lan, C. W., Wu, C. E., Huang, M. C., Kuo, H. C. & Ho, H. N., Jan 1 2019, In : Fertility and Sterility.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Increased platelet factor 4 and aberrant permeability of follicular fluid in PCOS

Huang, C. C., Chou, C. H., Chen, S. U., Ho, H. N., Yang, Y. S. & Chen, M. J., Jan 1 2019, In : Journal of the Formosan Medical Association. 118, 1P2, p. 249-259 11 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Mother-to-child transmission of HIV: An 11-year experience in a single center and HIV prevention effectiveness in Taiwan

Huang, K. Y., Li, Y. P., Shih, C. C., Lin, C. H., Kang, J., Lin, M. W., Hsu, W. W., Tai, Y. Y., Lin, S. Y. & Ho, H. N., Aug 1 2019, In : Journal of the Formosan Medical Association. 118, 8, p. 1211-1217 7 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

The spectrum of 45,X/46,XY mosaicism in Taiwanese children: The experience of a single center

Huang, Y. C., Lee, C. T., Wu, M. Z., Liu, S. Y., Tung, Y. C., Ho, H. N. & Tsai, W. Y., Jan 1 2019, In : Journal of the Formosan Medical Association. 118, 1P3, p. 450-456 7 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
2018

Allele-specific expression in a family quartet with autism reveals mono-to-biallelic switch and novel transcriptional processes of autism susceptibility genes

Lin, C. Y., Chang, K. W., Lin, C. Y., Wu, J. Y., Coon, H., Huang, P. H., Ho, H. N., Akbarian, S., Gau, S. S. F. & Huang, H. S., Dec 1 2018, In : Scientific Reports. 8, 1, 4277.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

IGF-1R Promotes Symmetric Self-Renewal and Migration of Alkaline Phosphatase+ Germ Stem Cells through HIF-2α-OCT4/CXCR4 Loop under Hypoxia

Kuo, Y. C., Au, H. K., Hsu, J. L., Wang, H. F., Lee, C. J., Peng, S. W., Lai, S. C., Wu, Y. C., Ho, H. N. & Huang, Y. H., Feb 13 2018, In : Stem Cell Reports. 10, 2, p. 524-537 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

M1 macrophages decrease in the deciduae from normal pregnancies but not from spontaneous abortions or unexplained recurrent spontaneous abortions

Tsao, F. Y., Wu, M. Y., Chang, Y. L., Wu, C. T. & Ho, H. N., Mar 1 2018, In : Journal of the Formosan Medical Association. 117, 3, p. 204-211 8 p.

Research output: Contribution to journalArticle

Open Access
18 Citations (Scopus)

Prospects of primary ovarian insufficiency patient-specific pluripotent stem cells for disease modeling and clinical impacts

Chen, H. F. & Ho, H. N., Mar 1 2018, In : Current Women's Health Reviews. 14, 1, p. 67-80 14 p.

Research output: Contribution to journalReview article

The efficacy of 24-month metformin for improving menses, hormones, and metabolic profiles in polycystic ovary syndrome

Yang, P. K., Hsu, C. Y., Chen, M. J., Lai, M. Y., Li, Z. R., Chen, C. H., Chen, S. U. & Ho, H. N., Jan 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 3, p. 890-899 10 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)
2017

Comparative global immune-related gene profiling of somatic cells, human pluripotent stem cells and their derivatives: Implication for human lymphocyte proliferation

Wu, C. E., Yu, C. W., Chang, K. W., Chou, W. H., Lu, C. Y., Ghelfi, E., Wu, F. C., Jan, P. S., Huang, M. C., Allard, P., Lin, S. P., Ho, H. N. & Chen, H. F., Sep 1 2017, In : Experimental and Molecular Medicine. 49, 9, e376.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Fluorescent nanodiamonds enable quantitative tracking of human mesenchymal stem cells in miniature pigs

Su, L. J., Wu, M. S., Hui, Y. Y., Chang, B. M., Pan, L., Hsu, P. C., Chen, Y. T., Ho, H. N., Huang, Y. H., Ling, T. Y., Hsu, H. H. & Chang, H. C., Mar 30 2017, In : Scientific Reports. 7, 45607.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Iron suppresses ovarian granulosa cell proliferation and arrests cell cycle through regulating p38 mitogen-activated protein kinase/p53/p21 pathway

Chen, M. J., Chou, C. H., Shun, C. T., Mao, T. L., Wen, W. F., Chen, C. D., Chen, S. U., Yang, Y. S. & Ho, H. N., Jan 1 2017, In : Biology of Reproduction. 97, 3, p. 438-448 11 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells

Hsieh, M. H., Chen, Y. T., Chen, Y. T., Lee, Y. H., Lu, J., Chien, C. L., Chen, H. F., Ho, H. N., Yu, C. J., Wang, Z. Q. & Teng, S. C., Oct 1 2017, In : Nucleic Acids Research. 45, 18, p. 10492-10503 12 p.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)
2016

Hepatic manifestations of women with polycystic ovary syndrome

Chen, M. J. & Ho, H. N., Nov 1 2016, In : Best Practice and Research: Clinical Obstetrics and Gynaecology. 37, p. 119-128 10 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)

Part 2: Making the "unproven" "proven"

Weiss, D. J., Rasko, J. E. J., Cuende, N., Ruiz, M. A., Ho, H. N., Nordon, R., Wilton, S., Dominici, M. & Srivastava, A., Jan 1 2016, In : Cytotherapy. 18, 1, p. 120-123 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2015

3D printing bioceramic porous scaffolds with good mechanical property and cell affinity

Chang, C. H., Lin, C. Y., Liu, F. H., Chen, M. H. C., Lin, C. P., Ho, H. N. & Liao, Y. S., Nov 1 2015, In : PLoS ONE. 10, 11, e0143713.

Research output: Contribution to journalArticle

Open Access
22 Citations (Scopus)

Activation of IL6/IGFIR confers poor prognosis of HBV-related hepatocellular carcinoma through induction of OCT4/NANOG expression

Chang, T. S., Wu, Y. C., Chi, C. C., Su, W. C., Chang, P. J., Lee, K. F., Tung, T. H., Wang, J., Liu, J-J., Tung, S. Y., Kuo, L. M., Ho, H. N., Ling, T. Y. & Huang, Y-H., Jan 1 2015, In : Clinical Cancer Research. 21, 1, p. 201-210 10 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Characteristic expression of major histocompatibility complex and immune privilege genes in human pluripotent stem cells and their derivatives

Chen, H. F., Yu, C. Y., Chen, M. J., Chou, S. H., Chiang, M. S., Chou, W. H., Ko, B. S., Huang, H. P., Kuo, H. C. & Ho, H. N., Jan 1 2015, In : Cell Transplantation. 24, 5, p. 845-864 20 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Concurrent exome-targeted next-generation sequencing and single nucleotide polymorphism array to identify the causative genetic aberrations of isolated Mayer-Rokitansky-Küster-Hauser syndrome

Chen, M. J., Wei, S. Y., Yang, W. S., Wu, T. T., Li, H. Y., Ho, H. N., Yang, Y. S. & Chen, P. L., Feb 2 2015, In : Human Reproduction. 30, 7, p. 1732-1742 11 p.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Functional microarray analysis of differentially expressed genes in granulosa cells from women with polycystic ovary syndrome related to MAPK/ERK signaling

Lan, C. W., Chen, M. J., Tai, K. Y., Yu, D. C., Yang, Y. C., Jan, P. S., Yang, Y. S., Chen, H. F. & Ho, H. N., Oct 13 2015, In : Scientific Reports. 5, 14994.

Research output: Contribution to journalArticle

Open Access
33 Citations (Scopus)

Granulosa cell-derived induced pluripotent stem cells exhibit pro-Trophoblastic differentiation potential

Chuang, C. Y., Huang, M. C., Chen, H. F., Tseng, L. H., Yu, C. Y., Stone, L., Huang, H. P., Ho, H. N. & Kuo, H. C., Feb 27 2015, In : Stem Cell Research and Therapy. 6, 1, 14.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Iron stores and obesity are negatively associated with ovarian volume and anti-Müllerian hormone levels in women with polycystic ovary syndrome

Yang, J. H., Chou, C. H., Yang, W. S., Ho, H. N., Yang, Y. S. & Chen, M. J., Dec 1 2015, In : Taiwanese Journal of Obstetrics and Gynecology. 54, 6, p. 686-692 7 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Loss of non-coding RNA expression from the DLK1-DIO3 imprinted locus correlates with reduced neural differentiation potential in human embryonic stem cell lines

Mo, C. F., Wu, F. C., Tai, K. Y., Chang, W. C., Chang, K. W., Kuo, H. C., Ho, H. N., Chen, H. F. & Lin, S. P., Jan 5 2015, In : Stem Cell Research and Therapy. 6, 1, 1.

Research output: Contribution to journalArticle

Open Access
36 Citations (Scopus)

Positioning a Scientific Community on Unproven Cellular Therapies: The 2015 International Society for Cellular Therapy Perspective

Dominici, M., Nichols, K., Srivastava, A., Weiss, D. J., Eldridge, P., Cuende, N., Deans, R. J., Rasko, J. E. J., Levine, A. D., Turner, L., Griffin, D. L., O'Donnell, L., Forte, M., Mason, C., Wagena, E., Janssen, W., Nordon, R., Wall, D., Ho, H. N., Ruiz, M. A. & 3 others, Wilton, S., Horwitz, E. M. & Gunter, K. C., Dec 1 2015, In : Cytotherapy. 17, 12, p. 1663-1666 4 p.

Research output: Contribution to journalEditorial

32 Citations (Scopus)

Symptom patterns and phenotypic subgrouping of women with polycystic ovary syndrome: Association between endocrine characteristics and metabolic aberrations

Huang, C. C., Tien, Y. J., Chen, M. J., Chen, C. H., Ho, H. N. & Yang, Y. S., Sep 30 2015, In : Human Reproduction. 30, 4, p. 937-946 10 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

The effect of androgens on ovarian follicle maturation: Dihydrotestosterone suppress FSH-stimulated granulosa cell proliferation by upregulating PPARÎ 3-dependent PTEN expression.

Chen, M. J., Chou, C. H., Chen, S. U., Yang, W. S., Yang, Y. S. & Ho, H. N., Dec 17 2015, In : Scientific Reports. 5, 18319.

Research output: Contribution to journalArticle

Open Access
33 Citations (Scopus)
2014

A nucleolus-predominant piggyBac transposase, NP-mPB, mediates elevated transposition efficiency in mammalian cells

Hong, J. B., Chou, F. J., Ku, A. T., Fan, H. H., Lee, T. L., Huang, Y. H., Yang, T. L., Su, I. C., Yu, I. S., Lin, S. W., Chien, C. L., Ho, H. N. & Chen, Y. T., Feb 24 2014, In : PLoS ONE. 9, 2, e89396.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Defects in the acquisition of tumor-killing capability of CD8+ cytotoxic T cells in streptozotocin-induced diabetic mice

Chen, S. C., Su, Y. C., Lu, Y. T., Ko, P. C. I., Chang, P. Y., Lin, H. J., Ho, H. N. & Lai, Y. P., Nov 12 2014, In : PLoS ONE. 9, 11, e109961.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Depressive symptoms, pain, and sexual dysfunction over the first year following vaginal or cesarean delivery: A prospective longitudinal study

Chang, S. R., Chen, K. H., Ho, H. N., Lai, Y. H., Lin, M. I., Lee, C. N. & Lin, W. A., Oct 1 2014, In : International Journal of Nursing Studies. 52, 9, p. 1433-1444 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

DNMT3L promotes quiescence in postnatal spermatogonial progenitor cells

Liao, H. F., Chen, W. S. C., Chen, Y. H., Kao, T. H., Tseng, Y. T., Lee, C. Y., Chiu, Y. C., Lee, P. L., Lin, Q. J., Ching, Y. H., Hata, K., Cheng, W. T. K., Tsai, M. H., Sasaki, H., Ho, H. N., Wu, S. C., Huang, Y-H., Yen, P. & Lin, S. P., 2014, In : Development. 141, 12, p. 2402-2413 12 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Granulosa cells and retinoic acid co-treatment enrich potential germ cells from manually selected Oct4-EGFP expressing human embryonic stem cells

Chen, H. F., Jan, P. S., Kuo, H. C., Wu, F. C., Lan, C. W., Huang, M. C., Chien, C. L. & Ho, H. N., Jan 1 2014, In : Reproductive BioMedicine Online. 29, 3, p. 319-332 14 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Hypoxia inducible factor 2α/insulin-like growth factor receptor signal loop supports the proliferation and Oct-4 maintenance of mouse germline stem cells

Huang, Y-H., Lin, M-H., Wang, P. C., Wu, Y. C., Chiang, H. L., Wang, Y. L., Chang, J. H., Huang, Y. K., Gu, S. Y., Ho, H. N. & Ling, T. Y., 2014, In : Molecular Human Reproduction. 20, 6, p. 526-537 12 p., gau016.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Suppression of the SOX2 neural effector gene by PRDM1 promotes human germ cell fate in embryonic stem cells

Lin, I. Y., Chiu, F. L., Yeang, C. H., Chen, H. F., Chuang, C. Y., Yang, S. Y., Hou, P. S., Sintupisut, N., Ho, H. N., Kuo, H. C. & Lin, K. I., Feb 11 2014, In : Stem Cell Reports. 2, 2, p. 189-204 16 p.

Research output: Contribution to journalArticle

Open Access
28 Citations (Scopus)
2013

Blastocyst morphology score as an indicator of embryo competence for women aged younger than 38 years in invitro fertilization cycles

Lee, T. H., Chen, C. D., Wu, M. Y., Chen, H. F., Chen, S. U., Ho, H. N. & Yang, Y. S., Sep 1 2013, In : Taiwanese Journal of Obstetrics and Gynecology. 52, 3, p. 374-380 7 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Differentiation of human embryonic stem cells into functional ovarian Granulosa-like cells

Lan, C. W., Chen, M. J., Jan, P. S., Chen, H. F. & Ho, H. N., Sep 1 2013, In : Journal of Clinical Endocrinology and Metabolism. 98, 9, p. 3713-3723 11 p.

Research output: Contribution to journalArticle

Open Access
21 Citations (Scopus)

LHX2 regulates the neural differentiation of human embryonic stem cells via transcriptional modulation of PAX6 and CER1

Hou, P. S., Chuang, C. Y., Kao, C. F., Chou, S. J., Stone, L., Ho, H. N., Chien, C. L. & Kuo, H. C., Sep 1 2013, In : Nucleic Acids Research. 41, 16, p. 7753-7770 18 p.

Research output: Contribution to journalArticle

Open Access
31 Citations (Scopus)

Nitric oxide modulates mitochondrial activity and apoptosis through protein S-nitrosylation for preimplantation embryo development

Lee, T. H., Lee, M. S., Huang, C. C., Tsao, H. M., Lin, P. M., Ho, H. N., Shew, J. Y. & Yang, Y. S., Aug 1 2013, In : Journal of Assisted Reproduction and Genetics. 30, 8, p. 1063-1072 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Optimal waiting period for subsequent fertility treatment after various hysteroscopic surgeries

Yang, J. H., Chen, M. J., Chen, C. D., Chen, S. U., Ho, H. N. & Yang, Y. S., Jan 1 2013, In : Fertility and Sterility. 99, 7

Research output: Contribution to journalArticle

58 Citations (Scopus)
2012

A whole genome methylation analysis of systemic lupus erythematosus: Hypomethylation of the IL10 and IL1R2 promoters is associated with disease activity

Lin, S. Y., Hsieh, S. C., Lin, Y. C., Lee, C. N., Tsai, M. H., Lai, L. C., Chuang, E. Y., Chen, P. C., Hung, C. C., Chen, L. Y., Hsieh, W. S., Niu, D. M., Su, Y. N. & Ho, H. N., Apr 1 2012, In : Genes and Immunity. 13, 3, p. 214-220 7 p.

Research output: Contribution to journalArticle

Open Access
54 Citations (Scopus)

Chemotherapeutic sensitivity of testicular germ cell tumors under hypoxic conditions is negatively regulated by SENP1-controlled sumoylation of OCT4

Wu, Y. C., Ling, T. Y., Lu, S. H., Kuo, H. C., Ho, H. N., Yeh, S. D., Shen, C. N. & Huang, Y. H., Oct 1 2012, In : Cancer Research. 72, 19, p. 4963-4973 11 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Depressive Symptoms as a Predictor of Sexual Function during Pregnancy

Chang, S. R., Ho, H. N., Chen, K. H., Shyu, M. K., Huang, L. H. & Lin, W. A., Jan 1 2012, In : Journal of Sexual Medicine. 9, 10, p. 2582-2589 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Functions of DNA methyltransferase 3-like in germ cells and beyond

Liao, H. F., Tai, K. Y., Chen, W. S. C., Cheng, L. C. W., Ho, H. N. & Lin, S. P., Oct 1 2012, In : Biology of the Cell. 104, 10, p. 571-587 17 p.

Research output: Contribution to journalReview article

17 Citations (Scopus)

Human pompe disease-induced pluripotent stem cells for pathogenesis modeling, drug testing and disease marker identification

Huang, H. P., Chen, P. H., Hwu, W. L., Chuang, C. Y., Chien, Y. H., Stone, L., Chien, C. L., Li, L. T., Chiang, S. C., Chen, H. F., Ho, H. N., Chen, C. H. & Kuo, H. C., Jun 1 2012, In : Human Molecular Genetics. 21, 11, 1 p., dds085.

Research output: Contribution to journalComment/debate

Open Access

Hypoadiponectinemia: A useful marker of dyslipidemia in women with polycystic ovary syndrome

Chang, C. Y., Chen, M. J., Yang, W. S., Yeh, C. Y., Ho, H. N., Chen, S. U. & Yang, Y. S., Dec 1 2012, In : Taiwanese Journal of Obstetrics and Gynecology. 51, 4, p. 583-590 8 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Myostatin and its association with abdominal obesity, androgen and follistatin levels in women with polycystic ovary syndrome

Chen, M. J., Han, D. S., Yang, J. H., Yang, Y. S., Ho, H. N. & Yang, W. S., Jan 1 2012, In : Human Reproduction. 27, 8, p. 2476-2483 8 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)
Open Access
2 Citations (Scopus)
2011

Carrier screening for spinal muscular atrophy (SMA) in 107,611 pregnant women during the period 2005-2009: A prospective population-based cohort study

Su, Y. N., Hung, C. C., Lin, S. Y., Chen, F. Y., Chern, J. P. S., Tsai, C., Chang, T. S., Yang, C. C., Li, H., Ho, H. N. & Lee, C. N., Mar 7 2011, In : PLoS ONE. 6, 2, e17067.

Research output: Contribution to journalArticle

Open Access
48 Citations (Scopus)