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Research Output 1986 2019

  • 2615 Citations
  • 27 h-Index
  • 61 Article
  • 3 Chapter
  • 1 Comment/debate
1 Citation (Scopus)

Weekly CAF chemotherapy for advanced breast cancer patients

Hwang, W. S., Hsiung, C. A., Ko, W. S., Wang, C. C., Chang, J. Y., Lai, G. M., Hsieh, R. K., Tsao, C. J., Chen, L. T., Law, C. K., Cheng, A. L., Fan, S. F., Tzeng, C. H., Chiou, T. J. & Whang-Peng, J., Jul 1997, In : Oncology. 54, 4, p. 293-297 5 p.

Research output: Contribution to journalArticle

Fluorouracil
Doxorubicin
Cyclophosphamide
Breast Neoplasms
Drug Therapy
31 Citations (Scopus)

The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells

Yan, K. H., Yao, C. J., Chang, H. Y., Lai, G. M., Cheng, A. L. & Chuang, S. E., Mar 2010, In : Molecular Carcinogenesis. 49, 3, p. 235-246 12 p.

Research output: Contribution to journalArticle

troglitazone
Cell Cycle Checkpoints
Aspirin
Lung Neoplasms
Apoptosis
10 Citations (Scopus)

Targeting PML-RARα and oncogenic signaling pathways by Chinese herbal mixture Tien-Hsien liquid in acute promyelocytic leukemia NB4 cells

Lai, T-I., Yao, C. J., Yang, C. M., Chuang, S. E., Yan, J. L., Liu, C. Y., Chen, S. W., Yan, K. H. & Lai, G. M., 2011, In : Evidence-based Complementary and Alternative Medicine. 2011, 984154.

Research output: Contribution to journalArticle

Acute Promyelocytic Leukemia
Apoptosis
tien-hsien liquid
Cyclin B1
Cyclin A
69 Citations (Scopus)

Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinoma cells expressing AXL

Lay, J. D., Hong, C. C., Huang, J. S., Yang, Y. Y., Pao, C. Y., Liu, C. H., Lai, Y. P., Lai, G. M., Cheng, A. L., Su, I. J. & Chuang, S. E., Apr 15 2007, In : Cancer Research. 67, 8, p. 3878-3887 10 p.

Research output: Contribution to journalArticle

Sulfasalazine
Drug Resistance
Non-Small Cell Lung Carcinoma
Receptor Protein-Tyrosine Kinases
Doxorubicin
9 Citations (Scopus)

RPS12 increases the invasiveness in cervical cancer activated by c-Myc and inhibited by the dietary flavonoids luteolin and quercetin

Lin, C. W., Lai, G. M., Chen, K. C., Lin, T. H., Fan, J. J., Hsu, R. L., Chou, C. M., Lin, C. M., Kandaswami, C. C., Lee, M. T. & Cheng, C. H., Dec 1 2015, In : Journal of Functional Foods. 19, p. 236-247 12 p.

Research output: Contribution to journalArticle

Luteolin
uterine cervical neoplasms
luteolin
Quercetin
Flavonoids
27 Citations (Scopus)

Resistance of a human ovarian cancer line to 5-fluorouracil associated with decreased levels of 5-fluorouracil in DNA

Chu, E., Lai, G. M., Zinn, S. & Allegra, C. J., 1990, In : Molecular Pharmacology. 38, 3, p. 410-417 8 p.

Research output: Contribution to journalArticle

Fluorouracil
Ovarian Neoplasms
DNA
Fluorodeoxyuridylate
Cell Line
124 Citations (Scopus)

Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia

Hong, C. C., Lay, J. D., Huang, J. S., Cheng, A. L., Tang, J. L., Lin, M. T., Lai, G. M. & Chuang, S. E., Sep 18 2008, In : Cancer Letters. 268, 2, p. 314-324 11 p.

Research output: Contribution to journalArticle

U937 Cells
Receptor Protein-Tyrosine Kinases
Drug Resistance
Acute Myeloid Leukemia
Leukemia
1 Citation (Scopus)

Protective effect of Antrodia cinnamomea extract against irradiation-induced acute hepatitis

Kuo, T. H., Kuo, Y. H., Cho, C. Y., Yao, C. J., Lai, G. M. & Chuang, S. E., Feb 2 2019, In : International Journal of Molecular Sciences. 20, 4, 846.

Research output: Contribution to journalArticle

Open Access
Antrodia
Bearings (structural)
hepatitis
Radiotherapy
Free radicals
2 Citations (Scopus)
Open Access
Fear
Fatigue
Survivors
Rehabilitation
Qigong
47 Citations (Scopus)

Prognostic factors of locoregionally recurrent nasopharyngeal carcinoma - A retrospective review of 182 cases

Yang, T. S., Ng, K. T., Wang, H. M., Wang, C. H., Liaw, C. C. & Lai, G. M., 1996, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 19, 4, p. 337-343 7 p.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Recurrence
Retreatment
Drug Therapy
Nasopharyngeal carcinoma
24 Citations (Scopus)

Prognosis of thymic carcinoma: Analysis of 16 cases

Chang, H. K., Wang, C. H., Liaw, C. C., Ng, K. T., Chang, J. P., Chen, M. S., Kuo, T. & Lai, G. M., 1992, In : Journal of the Formosan Medical Association = Taiwan yi zhi. 91, 8, p. 764-769 6 p.

Research output: Contribution to journalArticle

Thymus Neoplasms
Thymoma
Radiotherapy
Neoplasm Metastasis
Carcinoma
128 Citations (Scopus)

P‐glycoprotein expression and schedule dependence of adriamycin cytotoxicity in human colon carcinoma cell lines

Lai, G. M., Chen, Y. N., Mickley, L. A., Fojo, A. T. & Bates, S. E., 1991, In : International Journal of Cancer. 49, 5, p. 696-703 8 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Doxorubicin
Appointments and Schedules
Colon
Carcinoma
27 Citations (Scopus)

Oxidative stress enhances Axl-mediated cell migration through an Akt1/Rac1-dependent mechanism

Huang, J. S., Cho, C. Y., Hong, C. C., Yan, M. D., Hsieh, M-C., Lay, J. D., Lai, G. M., Cheng, A. L. & Chuang, S. E., 2013, In : Free Radical Biology and Medicine. 65, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

Oxidative stress
Cell Movement
Reactive Oxygen Species
Oxidative Stress
Phosphatidylinositol 3-Kinases
1 Citation (Scopus)

Opposite regulation of CHOP and GRP78 and synergistic apoptosis induction by selenium yeast and fish oil via AMPK activation in lung adenocarcinoma cells

Kao, R. H., Lai, G. M., Chow, J. M., Liao, C. H., Zheng, Y. M., Tsai, W. L., Hsia, S., Lai, I. C., Lee, H. L., Chuang, S. E., Whang-Peng, J. & Yao, C. J., Oct 8 2018, In : Nutrients. 10, 10, 1458.

Research output: Contribution to journalArticle

AMP-activated protein kinase
AMP-Activated Protein Kinases
Fish Oils
Selenium
adenocarcinoma
32 Citations (Scopus)
Endoplasmic Reticulum Stress
Curcumin
Reactive Oxygen Species
Prostatic Neoplasms
Cell Death
22 Citations (Scopus)

Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cells

Hsiao, P. C., Lee, W-J., Yang, S. F., Tan, P., Chen, H. Y., Lee, L-M., Chang, J. L., Lai, G-M., Chow, J-M. & Chien, M-H., Dec 1 2014, In : Tumor Biology. 35, 12, p. 11903-11911 9 p.

Research output: Contribution to journalArticle

Caspase 9
Caspase 8
Myeloid Cells
Acute Myeloid Leukemia
Apoptosis
21 Citations (Scopus)

Newly established MST-1 tumour cell line and tumour-infiltrating lymphocyte culture from a patient with soft tissue melanoma (clear cell sarcoma) and their potential applications to patient immunotherapy

Liao, S. K., Perng, Y. P., Lee, L. A., Chang, K. S. S., Lai, G. M., Wong, E. & Ho, Y. S., Feb 1996, In : European Journal of Cancer. 32, 2, p. 346-356 11 p.

Research output: Contribution to journalArticle

Clear Cell Sarcoma
Tumor-Infiltrating Lymphocytes
Tumor Cell Line
Immunotherapy
Melanoma
18 Citations (Scopus)

Negative feedback regulation of AXL by miR-34a modulates apoptosis in lung cancer cells

Cho, C. Y., Huang, J. S., Shiah, S. G., Chung, S. Y., Lay, J. D., Yang, Y. Y., Lai, G. M., Cheng, A. L., Chen, L. T. & Chuang, S. E., Feb 1 2016, In : RNA. 22, 2, p. 303-315 13 p.

Research output: Contribution to journalArticle

MicroRNAs
Lung Neoplasms
Activating Transcription Factors
Apoptosis
MAP Kinase Signaling System
34 Citations (Scopus)

Meningeal carcinomatosis from solid tumors: clinical analysis of 42 cases.

Liaw, C. C., Ng, K. T., Huang, J. S., Wang, C. H., Kiu, M. C. & Lai, G. M., Mar 1992, In : Journal of the Formosan Medical Association = Taiwan yi zhi. 91, 3, p. 299-303 5 p.

Research output: Contribution to journalArticle

Meningeal Carcinomatosis
Radiotherapy
Methotrexate
Breast Neoplasms
Neoplasms
13 Citations (Scopus)

Mefloquine induces cell death in prostate cancer cells and provides a potential novel treatment strategy in vivo

Yan, K. H., Lin, Y. W., Hsiao, C. H., Wen, Y-C., Lin, K. H., Liu, C. C., Hsieh, M-C., Yao, C. J., Yan, M. D., Lai, G. M., Chuang, S. E. & Lee, L. M., Oct 2013, In : Oncology Letters. 5, 5, p. 1567-1571 5 p.

Research output: Contribution to journalArticle

Mefloquine
Prostatic Neoplasms
Cell Death
lissamine rhodamine B
Reactive Oxygen Species
15 Citations (Scopus)

Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt, ERK, JNK and AMPK signaling

Yan, K. H., Yao, C. J., Hsiao, C. H., Lin, K. H., Lin, Y. W., Wen, Y-C., Liu, C. C., Yan, M. D., Chuang, S. E., Lai, G. M. & Lee, L. M., Oct 2013, In : Oncology Letters. 5, 5, p. 1541-1545 5 p.

Research output: Contribution to journalArticle

Mefloquine
Extracellular Signal-Regulated MAP Kinases
Adenosine Monophosphate
Protein Kinases
Reactive Oxygen Species
58 Citations (Scopus)

Mechanisms of resistance to cisplatin and alkylating agents.

Hamilton, T. C., Lai, G. M., Rothenberg, M. L., Fojo, A. T., Young, R. C. & Ozols, R. F., 1989, In : Cancer Treatment and Research. 48, p. 151-169 19 p.

Research output: Contribution to journalArticle

Alkylating Agents
Drug Resistance
Ovarian Neoplasms
Cisplatin
12 Citations (Scopus)

Malignant thyroid teratoma of an adult: A long-term survival after chemotherapy

Chen, J. S., Lai, G. M. & Hsueh, S., Apr 1998, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 21, 2, p. 212-214 3 p.

Research output: Contribution to journalArticle

Teratoma
Thyroid Gland
Drug Therapy
Survival
Neoplasms

Malignant germ cell tumors in adults and adolescents--analysis of 36 cases including testis, mediastinum and retroperitoneum origins

Liaw, C. C., Ng, K. T., Lai, G. M., Chen, M. H., Lin, F. J. & Huang, M. H., Sep 20 1986, Changgeng yi xue za zhi / Changgeng ji nian yi yuan = Chang Gung medical journal / Chang Gung Memorial Hospital. 3 ed. Vol. 9. p. 194-203 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mesonephroma
Retroperitoneal Neoplasms
Mediastinal Neoplasms
Dysgerminoma
Germ Cell and Embryonal Neoplasms
52 Citations (Scopus)

Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells

Chen, C. N., Huang, H. H., Wu, C. L., Lin, C. P. C., Hsu, J. T. A., Hsieh, H. P., Chuang, S. E. & Lai, G. M., Feb 8 2007, In : Cancer Letters. 246, 1-2, p. 237-252 16 p.

Research output: Contribution to journalArticle

Sesquiterpenes
Mitochondrial Membranes
Lactones
Caspases
Melanoma
4 Citations (Scopus)

Intensive Chemotherapy plus Recombinant Human Granulocyte Colony Stimulating Factor Support for Distant Metastatic Nasopharyngeal Carcinoma

Wang, C. H., Wang, H. M., Chen, J. S., Chang, W. J. & Lai, G. M., Jan 1997, In : Oncology. 54, SUPPL. 1, p. 34-37 4 p.

Research output: Contribution to journalArticle

Granulocyte Colony-Stimulating Factor
Drug Therapy
Nasopharyngeal carcinoma
Bone Marrow
Epirubicin
13 Citations (Scopus)
Ginsenosides
autophagy
Autophagy
lung neoplasms
Lung Neoplasms
295 Citations (Scopus)

Increased DNA repair as a mechanism of acquired resistance to cis-diamminedichloroplatinum(II) in human ovarian cancer cell lines

Masuda, H., Ozols, R. F., Lai, G. M., Fojo, A., Rothenberg, M. & Hamilton, T. C., 1988, In : Cancer Research. 48, 20, p. 5713-5716 4 p.

Research output: Contribution to journalArticle

DNA Repair
Ovarian Neoplasms
Cisplatin
Cell Line
DNA
5 Citations (Scopus)

Identification of novel anti-liver cancer small molecules with better therapeutic index than sorafenib via zebrafish drug screening platform

Lin, H. S., Huang, Y. L., Wang, Y. R., Hsiao, E., Hsu, T. A., Shiao, H. Y., Jiaang, W. T., Sampurna, B. P., Lin, K. H., Wu, M. S., Lai, G. M. & Yuh, C. H., Jun 1 2019, In : Cancers. 11, 6, 739.

Research output: Contribution to journalArticle

Open Access
Preclinical Drug Evaluations
Zebrafish
Liver Neoplasms
Hepatocellular Carcinoma
Inhibitory Concentration 50
72 Citations (Scopus)

Identification and characterization of a novel gene Saf transcribed from the opposite strand of Fas

Yan, M. D., Hong, C. C., Lai, G. M., Cheng, A. L., Lin, Y. W. & Chuang, S. E., Jun 1 2005, In : Human Molecular Genetics. 14, 11, p. 1465-1474 10 p.

Research output: Contribution to journalArticle

Apoptosis
Genes
Physiological Phenomena
Antisense RNA
Jurkat Cells
PC12 Cells
Extracellular Signal-Regulated MAP Kinases
Cell Differentiation
Urine
Apoptosis
68 Citations (Scopus)
Caspases
Cytochromes c
Blood-Brain Barrier
Neuroblastoma
Mitochondria
18 Citations (Scopus)
Side-Population Cells
Mouth Neoplasms
Heterografts
Neoplastic Stem Cells
Apoptosis
43 Citations (Scopus)

Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells

Chang, K. H., Yan, M. D., Yao, C. J., Lin, P. C. & Lai, G. M., Nov 2013, In : Oncology Letters. 6, 5, p. 1435-1438 4 p.

Research output: Contribution to journalArticle

Autophagy
Glioblastoma
Apoptosis
lissamine rhodamine B
Cell Line
29 Citations (Scopus)
Catenins
Neoplastic Stem Cells
Mouth Neoplasms
Side-Population Cells
Apoptosis
41 Citations (Scopus)

Fucoidan elevates MicroRNA-29b to regulate DNMT3B-MTSS1 axis and inhibit EMT in human hepatocellular carcinoma cells

Yan, M. D., Yao, C. J., Chow, J. M., Chang, C. L., Hwang, P. A., Chuang, S. E., Whang-Peng, J. & Lai, G. M., Oct 1 2015, In : Marine Drugs. 13, 10, p. 6099-6116 18 p.

Research output: Contribution to journalArticle

MicroRNAs
Hepatocellular Carcinoma
Neoplasm Metastasis
Cadherins
Tumor Suppressor Proteins
61 Citations (Scopus)

Expression of epidermal growth factor receptor in head and neck cancers correlates with clinical progression: A multicentre immunohistochemical study in the Asia-Pacific region

Putti, T. C., To, K. F., Hsu, H. C., Chan, A. T. C., Lai, G. M., Tse, G., Lee, Y. S., Whang-Peng, J., Millward, M., Lin, L., Lin, X. & Lee, C. S., 2002, In : Histopathology. 41, 2, p. 144-151 8 p.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Epidermal Growth Factor Receptor
Multicenter Studies
Neoplasms
Hypopharynx

Erratum: Oxidative stress enhances AXL-mediated cell migration through AKT1/Rac1-dependent mechanism (Free Radical Biology and Medicine (2013) 65 (1246-1256))

Huang, J. S., Cho, C. Y., Hong, C. C., Yan, M. D., Hsieh, M-C., Lay, J. D., Lai, G. M., Ann-Lii, C. & Chuang, S. E., Feb 2014, In : Free Radical Biology and Medicine. 67, p. 416 1 p.

Research output: Contribution to journalArticle

Oxidative stress
Medicine
Free Radicals
75 Citations (Scopus)

Epidemiologic characteristics and multiple risk factors of lung cancer in Taiwan

Chen, C. J., Wu, H. Y., Chuang, Y. C., Chang, A. S., Luh, K. T., Chao, H. H., Chen, K. Y., Chen, S. G., Lai, G. M., Huang, H. H. & Lee, H. H., 1990, In : Anticancer Research. 10, 4, p. 971-976 6 p.

Research output: Contribution to journalArticle

Taiwan
Lung Neoplasms
Mortality
Smoking
Indoor Air Pollution
95 Citations (Scopus)

Epidemiological characteristics and multiple risk factors of stomach cancer in Taiwan

Lee, H. H., Wu, H. Y., Chuang, Y. C., Chang, A. S., Chao, H. H., Chen, K. Y., Chen, H. K., Lai, G. M., Huang, H. H. & Chen, C. J., 1990, In : Anticancer Research. 10, 4, p. 875-882 8 p.

Research output: Contribution to journalArticle

Taiwan
Stomach Neoplasms
Meat
Stomach Diseases
Food
149 Citations (Scopus)

Enhanced DNA repair and resistance to cisplatin in human ovarian cancer

Lai, G. M., Ozols, R. F., Smyth, J. F., Young, R. C. & Hamilton, T. C., Dec 15 1988, In : Biochemical Pharmacology. 37, 24, p. 4597-4600 4 p.

Research output: Contribution to journalArticle

Aphidicolin
Diterpenes
Cisplatin
Repair
DNA
5 Citations (Scopus)

Elimination of cancer stem-like side population in human glioblastoma cells accompanied with stemness gene suppression by Korean herbal recipe MSC500

Yao, C. J., Han, T. Y., Shih, P. H., Yi, T. Y., Lai, I. C., Chang, K. H., Lai, T-I., Chang, C. L. & Lai, G. M., Nov 19 2014, In : Integrative Cancer Therapies. 13, 6, p. 541-554 14 p.

Research output: Contribution to journalArticle

Glioblastoma
Side-Population Cells
temozolomide
Neoplastic Stem Cells
Glioma
16 Citations (Scopus)

Elimination of cancer stem-like side population cells in hepatoma cell lines by Chinese herbal mixture Tien-Hsien Liquid

Yao, C. J., Yeh, C-T., Lee, L. M., Chuang, S. E., Yeh, C. F., Chao, W. J., Lai, T-I. & Lai, G. M., 2012, In : Evidence-based Complementary and Alternative Medicine. 2012, 617085.

Research output: Contribution to journalArticle

Side-Population Cells
Hepatocellular Carcinoma
Cell Line
Neoplasms
Neoplastic Stem Cells
11 Citations (Scopus)

Elimination of cancer stem-like cells and potentiation of temozolomide sensitivity by honokiol in glioblastoma multiforme cells

Lai, I. C., Shih, P. H., Yao, C-J., Yeh, C-T., Wang-Peng, J., Lui, T-N., Chuang, S. E., Hu, T. S., Lai, T-Y. & Lai, G-M., Mar 12 2015, In : PLoS One. 10, 3, e0114830.

Research output: Contribution to journalArticle

temozolomide
Side-Population Cells
Neoplastic Stem Cells
Glioblastoma
Stem cells
1 Citation (Scopus)

Electrospun polylactic acid (PLLA) microtube array membrane (MTAM)-An advanced substrate for anticancer drug screening

Tseng, C. H., Huang, W. T., Chew, C. H., Lai, J. K., Tu, S. H., Wei, P. L., Lee, K. Y., Lai, G. M. & Chen, C. C., Feb 14 2019, In : Materials. 12, 4, 569.

Research output: Contribution to journalArticle

Open Access
Assays
Screening
Membranes
Cells
Acids
154 Citations (Scopus)

Effect of glutathione on DNA repair in cisplatin-resistant human ovarian cancer cell lines

Lai, G. M., Ozols, R. F., Young, R. C. & Hamilton, T. C., Apr 5 1989, In : Journal of the National Cancer Institute. 81, 7, p. 535-539 5 p.

Research output: Contribution to journalArticle

Cisplatin
Ovarian Cancer
Glutathione
DNA Repair
Ovarian Neoplasms
59 Citations (Scopus)

Dramatic synergistic anticancer effect of clinically achievable doses of lovastatin and troglitazone

Yao, C. J., Lai, G. M., Chan, C. F., Cheng, A. L., Yang, Y. Y. & Chuang, S. E., Mar 1 2006, In : International Journal of Cancer. 118, 3, p. 773-779 7 p.

Research output: Contribution to journalArticle

troglitazone
Lovastatin
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cyclin A
Neoplasms
11 Citations (Scopus)
PC12 Cells
Extracellular Signal-Regulated MAP Kinases
Pheochromocytoma
Intermediate Filaments
Urine
89 Citations (Scopus)

Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells

Yeh, C. T., Rao, Y. K., Yao, C. J., Yeh, C. F., Li, C. H., Chuang, S. E., Luong, J. H. T., Lai, G. M. & Tzeng, Y. M., Nov 18 2009, In : Cancer Letters. 285, 1, p. 73-79 7 p.

Research output: Contribution to journalArticle

Antrodia
Triterpenes
Colonic Neoplasms
HT29 Cells
Apoptosis
213 Citations (Scopus)

Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis

Chuang, S. E., Kuo, M. L., Hsu, C. H., Chen, C. R., Lin, J. K., Lai, G. M., Hsieh, C. Y. & Cheng, A. L., 2000, In : Carcinogenesis. 21, 2, p. 331-335 5 p.

Research output: Contribution to journalArticle

Diethylnitrosamine
Curcumin
Diet
Hepatocellular Carcinoma
Mouth Neoplasms