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Research Output

  • 2707 Citations
  • 27 h-Index
  • 63 Article
  • 3 Chapter
  • 2 Comment/debate
  • 1 Letter
1986

Malignant germ cell tumors in adults and adolescents--analysis of 36 cases including testis, mediastinum and retroperitoneum origins

Liaw, C. C., Ng, K. T., Lai, G. M., Chen, M. H., Lin, F. J. & Huang, M. H., Sep 20 1986, Changgeng yi xue za zhi / Changgeng ji nian yi yuan = Chang Gung medical journal / Chang Gung Memorial Hospital. 3 ed. Vol. 9. p. 194-203 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1987

Adrenal crisis due to metastatic carcinoma of the adrenal glands.

Wang, J. M. & Lai, G. M., Sep 20 1987, Changgeng yi xue za zhi / Changgeng ji nian yi yuan = Chang Gung medical journal / Chang Gung Memorial Hospital. 3 ed. Vol. 10. p. 245-250 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bone marrow metastases from solid tumors--clinical analysis of 96 cases.

Wang, J. M., Shih, L. Y., Lai, G. M. & Ng, K. T., Dec 20 1987, Changgeng yi xue za zhi / Changgeng ji nian yi yuan = Chang Gung medical journal / Chang Gung Memorial Hospital. 4 ed. Vol. 10. p. 283-293 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)
1988

Enhanced DNA repair and resistance to cisplatin in human ovarian cancer

Lai, G. M., Ozols, R. F., Smyth, J. F., Young, R. C. & Hamilton, T. C., Dec 15 1988, In : Biochemical Pharmacology. 37, 24, p. 4597-4600 4 p.

Research output: Contribution to journalArticle

152 Citations (Scopus)

Increased DNA repair as a mechanism of acquired resistance to cis-diamminedichloroplatinum(II) in human ovarian cancer cell lines

Masuda, H., Ozols, R. F., Lai, G. M., Fojo, A., Rothenberg, M. & Hamilton, T. C., 1988, In : Cancer Research. 48, 20, p. 5713-5716 4 p.

Research output: Contribution to journalArticle

297 Citations (Scopus)
1989

Effect of glutathione on DNA repair in cisplatin-resistant human ovarian cancer cell lines

Lai, G. M., Ozols, R. F., Young, R. C. & Hamilton, T. C., Apr 5 1989, In : Journal of the National Cancer Institute. 81, 7, p. 535-539 5 p.

Research output: Contribution to journalArticle

156 Citations (Scopus)

Mechanisms of resistance to cisplatin and alkylating agents.

Hamilton, T. C., Lai, G. M., Rothenberg, M. L., Fojo, A. T., Young, R. C. & Ozols, R. F., 1989, In : Cancer Treatment and Research. 48, p. 151-169 19 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)
1990

Epidemiological characteristics and multiple risk factors of stomach cancer in Taiwan

Lee, H. H., Wu, H. Y., Chuang, Y. C., Chang, A. S., Chao, H. H., Chen, K. Y., Chen, H. K., Lai, G. M., Huang, H. H. & Chen, C. J., 1990, In : Anticancer Research. 10, 4, p. 875-882 8 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)

Epidemiologic characteristics and multiple risk factors of lung cancer in Taiwan

Chen, C. J., Wu, H. Y., Chuang, Y. C., Chang, A. S., Luh, K. T., Chao, H. H., Chen, K. Y., Chen, S. G., Lai, G. M., Huang, H. H. & Lee, H. H., 1990, In : Anticancer Research. 10, 4, p. 971-976 6 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

Resistance of a human ovarian cancer line to 5-fluorouracil associated with decreased levels of 5-fluorouracil in DNA

Chu, E., Lai, G. M., Zinn, S. & Allegra, C. J., 1990, In : Molecular Pharmacology. 38, 3, p. 410-417 8 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
1991

Contribution of glutathione and glutathione‐dependent enzymes in the reversal of adriamycin resistance in colon carcinoma cell lines

Lai, G. M., Moscow, J. A., Alvarez, M. G., Fojo, A. T. & Bates, S. E., 1991, In : International Journal of Cancer. 49, 5, p. 688-695 8 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

P‐glycoprotein expression and schedule dependence of adriamycin cytotoxicity in human colon carcinoma cell lines

Lai, G. M., Chen, Y. N., Mickley, L. A., Fojo, A. T. & Bates, S. E., 1991, In : International Journal of Cancer. 49, 5, p. 696-703 8 p.

Research output: Contribution to journalArticle

134 Citations (Scopus)
1992

Meningeal carcinomatosis from solid tumors: clinical analysis of 42 cases.

Liaw, C. C., Ng, K. T., Huang, J. S., Wang, C. H., Kiu, M. C. & Lai, G. M., Mar 1992, In : Journal of the Formosan Medical Association = Taiwan yi zhi. 91, 3, p. 299-303 5 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Prognosis of thymic carcinoma: Analysis of 16 cases

Chang, H. K., Wang, C. H., Liaw, C. C., Ng, K. T., Chang, J. P., Chen, M. S., Kuo, T. & Lai, G. M., 1992, In : Journal of the Formosan Medical Association = Taiwan yi zhi. 91, 8, p. 764-769 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
1995

Cisplatin and 5-fluorouracil as neoadjuvant chemotherapy: Predicting response in head and neck squamous cell cancer

Wang, H. M., Wang, C. H., Chen, J. S., Chang, H. K., Kiu, M. C., Liaw, C. C., Ng, K. T. & Lai, G. M., 1995, In : Journal of the Formosan Medical Association = Taiwan yi zhi. 94, 3, p. 87-94 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Combination chemotherapy with carmustine and cisplatin before, during, and after radiotherapy for adult malignant gliomas

Kiu, M. C., Chang, C. N., Cheng, W. C., Lin, T. K., Wong, C. W., Tang, S. G., Leung, W. M., Chen, L. H., Ho, Y. S., Ng, K. T., Chen, J. S., Yang, T. H. & Lai, G. M., Oct 1995, In : Journal of Neuro-Oncology. 25, 3, p. 215-220 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
1996

Clinical trial of low-dose rHuG-CSF in neutropenic cancer patients following anti-cancer chemotherapy

Chang, M. C., Lai, G. M., Tsan, K. W., Wang, R. S. & Wu, J. H., Nov 1996, In : Journal of the Formosan Medical Association = Taiwan yi zhi. 95, 11, p. 845-850 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
9 Citations (Scopus)

Newly established MST-1 tumour cell line and tumour-infiltrating lymphocyte culture from a patient with soft tissue melanoma (clear cell sarcoma) and their potential applications to patient immunotherapy

Liao, S. K., Perng, Y. P., Lee, L. A., Chang, K. S. S., Lai, G. M., Wong, E. & Ho, Y. S., Feb 1996, In : European Journal of Cancer. 32, 2, p. 346-356 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Prognostic factors of locoregionally recurrent nasopharyngeal carcinoma - A retrospective review of 182 cases

Yang, T. S., Ng, K. T., Wang, H. M., Wang, C. H., Liaw, C. C. & Lai, G. M., 1996, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 19, 4, p. 337-343 7 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
1997

Intensive Chemotherapy plus Recombinant Human Granulocyte Colony Stimulating Factor Support for Distant Metastatic Nasopharyngeal Carcinoma

Wang, C. H., Wang, H. M., Chen, J. S., Chang, W. J. & Lai, G. M., Jan 1997, In : Oncology. 54, SUPPL. 1, p. 34-37 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Weekly CAF chemotherapy for advanced breast cancer patients

Hwang, W. S., Hsiung, C. A., Ko, W. S., Wang, C. C., Chang, J. Y., Lai, G. M., Hsieh, R. K., Tsao, C. J., Chen, L. T., Law, C. K., Cheng, A. L., Fan, S. F., Tzeng, C. H., Chiou, T. J. & Whang-Peng, J., Jul 1997, In : Oncology. 54, 4, p. 293-297 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
1998

Malignant thyroid teratoma of an adult: A long-term survival after chemotherapy

Chen, J. S., Lai, G. M. & Hsueh, S., Apr 1998, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 21, 2, p. 212-214 3 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2000

Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis

Chuang, S. E., Kuo, M. L., Hsu, C. H., Chen, C. R., Lin, J. K., Lai, G. M., Hsieh, C. Y. & Cheng, A. L., 2000, In : Carcinogenesis. 21, 2, p. 331-335 5 p.

Research output: Contribution to journalArticle

215 Citations (Scopus)
2002

Basal levels and patterns of anticancer drug-induced activation of nuclear factor-κB (NF-κB), and its attenuation by tamoxifen, dexamethasone, and curcumin in carcinoma cells

Chuang, S. E., Yeh, P. Y., Lu, Y. S., Lai, G. M., Liao, C. M., Gao, M. & Cheng, A. L., May 1 2002, In : Biochemical Pharmacology. 63, 9, p. 1709-1716 8 p.

Research output: Contribution to journalArticle

141 Citations (Scopus)

Expression of epidermal growth factor receptor in head and neck cancers correlates with clinical progression: A multicentre immunohistochemical study in the Asia-Pacific region

Putti, T. C., To, K. F., Hsu, H. C., Chan, A. T. C., Lai, G. M., Tse, G., Lee, Y. S., Whang-Peng, J., Millward, M., Lin, L., Lin, X. & Lee, C. S., 2002, In : Histopathology. 41, 2, p. 144-151 8 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)
2005
11 Citations (Scopus)

Identification and characterization of a novel gene Saf transcribed from the opposite strand of Fas

Yan, M. D., Hong, C. C., Lai, G. M., Cheng, A. L., Lin, Y. W. & Chuang, S. E., Jun 1 2005, In : Human Molecular Genetics. 14, 11, p. 1465-1474 10 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)
2006

Dramatic synergistic anticancer effect of clinically achievable doses of lovastatin and troglitazone

Yao, C. J., Lai, G. M., Chan, C. F., Cheng, A. L., Yang, Y. Y. & Chuang, S. E., Mar 1 2006, In : International Journal of Cancer. 118, 3, p. 773-779 7 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)
2007

Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells

Chen, C. N., Huang, H. H., Wu, C. L., Lin, C. P. C., Hsu, J. T. A., Hsieh, H. P., Chuang, S. E. & Lai, G. M., Feb 8 2007, In : Cancer Letters. 246, 1-2, p. 237-252 16 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinoma cells expressing AXL

Lay, J. D., Hong, C. C., Huang, J. S., Yang, Y. Y., Pao, C. Y., Liu, C. H., Lai, Y. P., Lai, G. M., Cheng, A. L., Su, I. J. & Chuang, S. E., Apr 15 2007, In : Cancer Research. 67, 8, p. 3878-3887 10 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)
2008

Carbonic anhydrase III promotes transformation and invasion capability in hepatoma cells through FAK signaling pathway

Dai, H. Y., Hong, C. C., Liang, S. C., Yan, M. D., Lai, G. M., Cheng, A. L. & Chuang, S. E., Dec 2008, In : Molecular Carcinogenesis. 47, 12, p. 956-963 8 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia

Hong, C. C., Lay, J. D., Huang, J. S., Cheng, A. L., Tang, J. L., Lin, M. T., Lai, G. M. & Chuang, S. E., Sep 18 2008, In : Cancer Letters. 268, 2, p. 314-324 11 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)
2009

Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells

Yeh, C. T., Rao, Y. K., Yao, C. J., Yeh, C. F., Li, C. H., Chuang, S. E., Luong, J. H. T., Lai, G. M. & Tzeng, Y. M., Nov 18 2009, In : Cancer Letters. 285, 1, p. 73-79 7 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)
2010

The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells

Yan, K. H., Yao, C. J., Chang, H. Y., Lai, G. M., Cheng, A. L. & Chuang, S. E., Mar 2010, In : Molecular Carcinogenesis. 49, 3, p. 235-246 12 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2011
22 Citations (Scopus)

Targeting PML-RARα and oncogenic signaling pathways by Chinese herbal mixture Tien-Hsien liquid in acute promyelocytic leukemia NB4 cells

Lai, T-I., Yao, C. J., Yang, C. M., Chuang, S. E., Yan, J. L., Liu, C. Y., Chen, S. W., Yan, K. H. & Lai, G. M., 2011, In : Evidence-based Complementary and Alternative Medicine. 2011, 984154.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2012
16 Citations (Scopus)
73 Citations (Scopus)
2013

Aspirin antagonizes the cytotoxic effect of methotrexate in lung cancer cells

Yan, K. H., Lee, L. M., Hsieh, M-C., Yan, M. D., Yao, C. J., Chang, P. Y., Chen, T. L., Chang, H. Y., Cheng, A. L., Lai, G. M. & Chuang, S. E., Sep 2013, In : Oncology Reports. 30, 3, p. 1497-1505 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
31 Citations (Scopus)

Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells

Chang, K. H., Yan, M. D., Yao, C. J., Lin, P. C. & Lai, G. M., Nov 2013, In : Oncology Letters. 6, 5, p. 1435-1438 4 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt, ERK, JNK and AMPK signaling

Yan, K. H., Yao, C. J., Hsiao, C. H., Lin, K. H., Lin, Y. W., Wen, Y-C., Liu, C. C., Yan, M. D., Chuang, S. E., Lai, G. M. & Lee, L. M., Oct 2013, In : Oncology Letters. 5, 5, p. 1541-1545 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Mefloquine induces cell death in prostate cancer cells and provides a potential novel treatment strategy in vivo

Yan, K. H., Lin, Y. W., Hsiao, C. H., Wen, Y-C., Lin, K. H., Liu, C. C., Hsieh, M-C., Yao, C. J., Yan, M. D., Lai, G. M., Chuang, S. E. & Lee, L. M., Oct 2013, In : Oncology Letters. 5, 5, p. 1567-1571 5 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Oxidative stress enhances Axl-mediated cell migration through an Akt1/Rac1-dependent mechanism

Huang, J. S., Cho, C. Y., Hong, C. C., Yan, M. D., Hsieh, M-C., Lay, J. D., Lai, G. M., Cheng, A. L. & Chuang, S. E., 2013, In : Free Radical Biology and Medicine. 65, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2014

Elimination of cancer stem-like side population in human glioblastoma cells accompanied with stemness gene suppression by Korean herbal recipe MSC500

Yao, C. J., Han, T. Y., Shih, P. H., Yi, T. Y., Lai, I. C., Chang, K. H., Lai, T-I., Chang, C. L. & Lai, G. M., Nov 19 2014, In : Integrative Cancer Therapies. 13, 6, p. 541-554 14 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Erratum: Oxidative stress enhances AXL-mediated cell migration through AKT1/Rac1-dependent mechanism (Free Radical Biology and Medicine (2013) 65 (1246-1256))

Huang, J. S., Cho, C. Y., Hong, C. C., Yan, M. D., Hsieh, M-C., Lay, J. D., Lai, G. M., Ann-Lii, C. & Chuang, S. E., Feb 2014, In : Free Radical Biology and Medicine. 67, p. 416 1 p.

Research output: Contribution to journalArticle

Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cells

Hsiao, P. C., Lee, W-J., Yang, S. F., Tan, P., Chen, H. Y., Lee, L-M., Chang, J. L., Lai, G-M., Chow, J-M. & Chien, M-H., Dec 1 2014, In : Tumor Biology. 35, 12, p. 11903-11911 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2015

Elimination of cancer stem-like cells and potentiation of temozolomide sensitivity by honokiol in glioblastoma multiforme cells

Lai, I. C., Shih, P. H., Yao, C-J., Yeh, C-T., Wang-Peng, J., Lui, T-N., Chuang, S. E., Hu, T. S., Lai, T-Y. & Lai, G-M., Mar 12 2015, In : PLoS One. 10, 3, e0114830.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Fucoidan elevates MicroRNA-29b to regulate DNMT3B-MTSS1 axis and inhibit EMT in human hepatocellular carcinoma cells

Yan, M. D., Yao, C. J., Chow, J. M., Chang, C. L., Hwang, P. A., Chuang, S. E., Whang-Peng, J. & Lai, G. M., Oct 1 2015, In : Marine Drugs. 13, 10, p. 6099-6116 18 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)