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Research Output

  • 2729 Citations
  • 27 h-Index
  • 64 Article
  • 3 Chapter
  • 2 Comment/debate
  • 1 Letter
2020
Open Access
2019

Electrospun polylactic acid (PLLA) microtube array membrane (MTAM)-An advanced substrate for anticancer drug screening

Tseng, C. H., Huang, W. T., Chew, C. H., Lai, J. K., Tu, S. H., Wei, P. L., Lee, K. Y., Lai, G. M. & Chen, C. C., Feb 14 2019, In : Materials. 12, 4, 569.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Epigenetic modification and differentiation induction of malignant glioma cells by oligo-fucoidan

Liao, C. H., Lai, I. C., Kuo, H. C., Chuang, S. E., Lee, H. L., Whang-Peng, J., Yao, C. J. & Lai, G. M., Sep 8 2019, In : Marine Drugs. 17, 9, 525.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Hematuria induced by combination regorafenib and hyperthermia–a radiation recall effect

Zheng, Y. M., Chow, J. M., Chang, C. L., Chao, L. H., Whang-Peng, J. & Lai, G. M., Jan 1 2019, In : International Journal of Hyperthermia. 36, 1, p. 1186-1189 4 p.

Research output: Contribution to journalLetter

Open Access

Identification of novel anti-liver cancer small molecules with better therapeutic index than sorafenib via zebrafish drug screening platform

Lin, H. S., Huang, Y. L., Wang, Y. R., Hsiao, E., Hsu, T. A., Shiao, H. Y., Jiaang, W. T., Sampurna, B. P., Lin, K. H., Wu, M. S., Lai, G. M. & Yuh, C. H., Jun 1 2019, In : Cancers. 11, 6, 739.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Protective effect of Antrodia cinnamomea extract against irradiation-induced acute hepatitis

Kuo, T. H., Kuo, Y. H., Cho, C. Y., Yao, C. J., Lai, G. M. & Chuang, S. E., Feb 2 2019, In : International Journal of Molecular Sciences. 20, 4, 846.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

PTBP1-mediated regulation of AXL mRNA stability plays a role in lung tumorigenesis

Cho, C. Y., Chung, S. Y., Lin, S., Huang, J. S., Chen, Y. L., Jiang, S. S., Cheng, L. C., Kuo, T. H., Lay, J. D., Yang, Y. Y., Lai, G. M. & Chuang, S. E., Dec 1 2019, In : Scientific Reports. 9, 1, 16922.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2018

Opposite regulation of CHOP and GRP78 and synergistic apoptosis induction by selenium yeast and fish oil via AMPK activation in lung adenocarcinoma cells

Kao, R. H., Lai, G. M., Chow, J. M., Liao, C. H., Zheng, Y. M., Tsai, W. L., Hsia, S., Lai, I. C., Lee, H. L., Chuang, S. E., Whang-Peng, J. & Yao, C. J., Oct 8 2018, In : Nutrients. 10, 10, 1458.

Research output: Contribution to journalArticle

3 Citations (Scopus)
Open Access
6 Citations (Scopus)
2017
7 Citations (Scopus)
14 Citations (Scopus)
2016
4 Citations (Scopus)
3 Citations (Scopus)
21 Citations (Scopus)

Negative feedback regulation of AXL by miR-34a modulates apoptosis in lung cancer cells

Cho, C. Y., Huang, J. S., Shiah, S. G., Chung, S. Y., Lay, J. D., Yang, Y. Y., Lai, G. M., Cheng, A. L., Chen, L. T. & Chuang, S. E., Feb 1 2016, In : RNA. 22, 2, p. 303-315 13 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2015

Elimination of cancer stem-like cells and potentiation of temozolomide sensitivity by honokiol in glioblastoma multiforme cells

Lai, I. C., Shih, P. H., Yao, C-J., Yeh, C-T., Wang-Peng, J., Lui, T-N., Chuang, S. E., Hu, T. S., Lai, T-Y. & Lai, G-M., Mar 12 2015, In : PLoS One. 10, 3, e0114830.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Fucoidan elevates MicroRNA-29b to regulate DNMT3B-MTSS1 axis and inhibit EMT in human hepatocellular carcinoma cells

Yan, M. D., Yao, C. J., Chow, J. M., Chang, C. L., Hwang, P. A., Chuang, S. E., Whang-Peng, J. & Lai, G. M., Oct 1 2015, In : Marine Drugs. 13, 10, p. 6099-6116 18 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)
32 Citations (Scopus)

RPS12 increases the invasiveness in cervical cancer activated by c-Myc and inhibited by the dietary flavonoids luteolin and quercetin

Lin, C. W., Lai, G. M., Chen, K. C., Lin, T. H., Fan, J. J., Hsu, R. L., Chou, C. M., Lin, C. M., Kandaswami, C. C., Lee, M. T. & Cheng, C. H., Dec 1 2015, In : Journal of Functional Foods. 19, p. 236-247 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2014

Elimination of cancer stem-like side population in human glioblastoma cells accompanied with stemness gene suppression by Korean herbal recipe MSC500

Yao, C. J., Han, T. Y., Shih, P. H., Yi, T. Y., Lai, I. C., Chang, K. H., Lai, T-I., Chang, C. L. & Lai, G. M., Nov 19 2014, In : Integrative Cancer Therapies. 13, 6, p. 541-554 14 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Erratum: Oxidative stress enhances AXL-mediated cell migration through AKT1/Rac1-dependent mechanism (Free Radical Biology and Medicine (2013) 65 (1246-1256))

Huang, J. S., Cho, C. Y., Hong, C. C., Yan, M. D., Hsieh, M-C., Lay, J. D., Lai, G. M., Ann-Lii, C. & Chuang, S. E., Feb 2014, In : Free Radical Biology and Medicine. 67, p. 416 1 p.

Research output: Contribution to journalArticle

Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cells

Hsiao, P. C., Lee, W-J., Yang, S. F., Tan, P., Chen, H. Y., Lee, L-M., Chang, J. L., Lai, G-M., Chow, J-M. & Chien, M-H., Dec 1 2014, In : Tumor Biology. 35, 12, p. 11903-11911 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2013

Aspirin antagonizes the cytotoxic effect of methotrexate in lung cancer cells

Yan, K. H., Lee, L. M., Hsieh, M-C., Yan, M. D., Yao, C. J., Chang, P. Y., Chen, T. L., Chang, H. Y., Cheng, A. L., Lai, G. M. & Chuang, S. E., Sep 2013, In : Oncology Reports. 30, 3, p. 1497-1505 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
32 Citations (Scopus)

Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells

Chang, K. H., Yan, M. D., Yao, C. J., Lin, P. C. & Lai, G. M., Nov 2013, In : Oncology Letters. 6, 5, p. 1435-1438 4 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt, ERK, JNK and AMPK signaling

Yan, K. H., Yao, C. J., Hsiao, C. H., Lin, K. H., Lin, Y. W., Wen, Y-C., Liu, C. C., Yan, M. D., Chuang, S. E., Lai, G. M. & Lee, L. M., Oct 2013, In : Oncology Letters. 5, 5, p. 1541-1545 5 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Mefloquine induces cell death in prostate cancer cells and provides a potential novel treatment strategy in vivo

Yan, K. H., Lin, Y. W., Hsiao, C. H., Wen, Y-C., Lin, K. H., Liu, C. C., Hsieh, M-C., Yao, C. J., Yan, M. D., Lai, G. M., Chuang, S. E. & Lee, L. M., Oct 2013, In : Oncology Letters. 5, 5, p. 1567-1571 5 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Oxidative stress enhances Axl-mediated cell migration through an Akt1/Rac1-dependent mechanism

Huang, J. S., Cho, C. Y., Hong, C. C., Yan, M. D., Hsieh, M-C., Lay, J. D., Lai, G. M., Cheng, A. L. & Chuang, S. E., 2013, In : Free Radical Biology and Medicine. 65, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2012
16 Citations (Scopus)
74 Citations (Scopus)
2011
23 Citations (Scopus)

Targeting PML-RARα and oncogenic signaling pathways by Chinese herbal mixture Tien-Hsien liquid in acute promyelocytic leukemia NB4 cells

Lai, T-I., Yao, C. J., Yang, C. M., Chuang, S. E., Yan, J. L., Liu, C. Y., Chen, S. W., Yan, K. H. & Lai, G. M., 2011, In : Evidence-based Complementary and Alternative Medicine. 2011, 984154.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2010

The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells

Yan, K. H., Yao, C. J., Chang, H. Y., Lai, G. M., Cheng, A. L. & Chuang, S. E., Mar 2010, In : Molecular Carcinogenesis. 49, 3, p. 235-246 12 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
2009

Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells

Yeh, C. T., Rao, Y. K., Yao, C. J., Yeh, C. F., Li, C. H., Chuang, S. E., Luong, J. H. T., Lai, G. M. & Tzeng, Y. M., Nov 18 2009, In : Cancer Letters. 285, 1, p. 73-79 7 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)
2008

Carbonic anhydrase III promotes transformation and invasion capability in hepatoma cells through FAK signaling pathway

Dai, H. Y., Hong, C. C., Liang, S. C., Yan, M. D., Lai, G. M., Cheng, A. L. & Chuang, S. E., Dec 2008, In : Molecular Carcinogenesis. 47, 12, p. 956-963 8 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia

Hong, C. C., Lay, J. D., Huang, J. S., Cheng, A. L., Tang, J. L., Lin, M. T., Lai, G. M. & Chuang, S. E., Sep 18 2008, In : Cancer Letters. 268, 2, p. 314-324 11 p.

Research output: Contribution to journalArticle

132 Citations (Scopus)
2007

Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells

Chen, C. N., Huang, H. H., Wu, C. L., Lin, C. P. C., Hsu, J. T. A., Hsieh, H. P., Chuang, S. E. & Lai, G. M., Feb 8 2007, In : Cancer Letters. 246, 1-2, p. 237-252 16 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinoma cells expressing AXL

Lay, J. D., Hong, C. C., Huang, J. S., Yang, Y. Y., Pao, C. Y., Liu, C. H., Lai, Y. P., Lai, G. M., Cheng, A. L., Su, I. J. & Chuang, S. E., Apr 15 2007, In : Cancer Research. 67, 8, p. 3878-3887 10 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)
2006

Dramatic synergistic anticancer effect of clinically achievable doses of lovastatin and troglitazone

Yao, C. J., Lai, G. M., Chan, C. F., Cheng, A. L., Yang, Y. Y. & Chuang, S. E., Mar 1 2006, In : International Journal of Cancer. 118, 3, p. 773-779 7 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)
2005
11 Citations (Scopus)

Identification and characterization of a novel gene Saf transcribed from the opposite strand of Fas

Yan, M. D., Hong, C. C., Lai, G. M., Cheng, A. L., Lin, Y. W. & Chuang, S. E., Jun 1 2005, In : Human Molecular Genetics. 14, 11, p. 1465-1474 10 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)
2002

Basal levels and patterns of anticancer drug-induced activation of nuclear factor-κB (NF-κB), and its attenuation by tamoxifen, dexamethasone, and curcumin in carcinoma cells

Chuang, S. E., Yeh, P. Y., Lu, Y. S., Lai, G. M., Liao, C. M., Gao, M. & Cheng, A. L., May 1 2002, In : Biochemical Pharmacology. 63, 9, p. 1709-1716 8 p.

Research output: Contribution to journalArticle

141 Citations (Scopus)

Expression of epidermal growth factor receptor in head and neck cancers correlates with clinical progression: A multicentre immunohistochemical study in the Asia-Pacific region

Putti, T. C., To, K. F., Hsu, H. C., Chan, A. T. C., Lai, G. M., Tse, G., Lee, Y. S., Whang-Peng, J., Millward, M., Lin, L., Lin, X. & Lee, C. S., 2002, In : Histopathology. 41, 2, p. 144-151 8 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)
2000

Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis

Chuang, S. E., Kuo, M. L., Hsu, C. H., Chen, C. R., Lin, J. K., Lai, G. M., Hsieh, C. Y. & Cheng, A. L., 2000, In : Carcinogenesis. 21, 2, p. 331-335 5 p.

Research output: Contribution to journalArticle

215 Citations (Scopus)
1998

Malignant thyroid teratoma of an adult: A long-term survival after chemotherapy

Chen, J. S., Lai, G. M. & Hsueh, S., Apr 1998, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 21, 2, p. 212-214 3 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
1997

Intensive Chemotherapy plus Recombinant Human Granulocyte Colony Stimulating Factor Support for Distant Metastatic Nasopharyngeal Carcinoma

Wang, C. H., Wang, H. M., Chen, J. S., Chang, W. J. & Lai, G. M., Jan 1997, In : Oncology. 54, SUPPL. 1, p. 34-37 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Weekly CAF chemotherapy for advanced breast cancer patients

Hwang, W. S., Hsiung, C. A., Ko, W. S., Wang, C. C., Chang, J. Y., Lai, G. M., Hsieh, R. K., Tsao, C. J., Chen, L. T., Law, C. K., Cheng, A. L., Fan, S. F., Tzeng, C. H., Chiou, T. J. & Whang-Peng, J., Jul 1997, In : Oncology. 54, 4, p. 293-297 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)