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Research Output 1986 2019

  • 2571 Citations
  • 27 h-Index
  • 61 Article
  • 3 Chapter
  • 1 Comment/debate
2019
1 Citation (Scopus)

Electrospun polylactic acid (PLLA) microtube array membrane (MTAM)-An advanced substrate for anticancer drug screening

Tseng, C. H., Huang, W. T., Chew, C. H., Lai, J. K., Tu, S. H., Wei, P. L., Lee, K. Y., Lai, G. M. & Chen, C. C., Feb 14 2019, In : Materials. 12, 4, 569.

Research output: Contribution to journalArticle

Open Access
Assays
Screening
Membranes
Cells
Acids
2 Citations (Scopus)

Identification of novel anti-liver cancer small molecules with better therapeutic index than sorafenib via zebrafish drug screening platform

Lin, H. S., Huang, Y. L., Wang, Y. R., Hsiao, E., Hsu, T. A., Shiao, H. Y., Jiaang, W. T., Sampurna, B. P., Lin, K. H., Wu, M. S., Lai, G. M. & Yuh, C. H., Jun 1 2019, In : Cancers. 11, 6, 739.

Research output: Contribution to journalArticle

Open Access
Preclinical Drug Evaluations
Zebrafish
Liver Neoplasms
Hepatocellular Carcinoma
Inhibitory Concentration 50
1 Citation (Scopus)

Protective effect of Antrodia cinnamomea extract against irradiation-induced acute hepatitis

Kuo, T. H., Kuo, Y. H., Cho, C. Y., Yao, C. J., Lai, G. M. & Chuang, S. E., Feb 2 2019, In : International Journal of Molecular Sciences. 20, 4, 846.

Research output: Contribution to journalArticle

Open Access
Antrodia
Bearings (structural)
hepatitis
Radiotherapy
Free radicals
2018
PC12 Cells
Extracellular Signal-Regulated MAP Kinases
Cell Differentiation
Urine
Apoptosis
1 Citation (Scopus)

Opposite regulation of CHOP and GRP78 and synergistic apoptosis induction by selenium yeast and fish oil via AMPK activation in lung adenocarcinoma cells

Kao, R. H., Lai, G. M., Chow, J. M., Liao, C. H., Zheng, Y. M., Tsai, W. L., Hsia, S., Lai, I. C., Lee, H. L., Chuang, S. E., Whang-Peng, J. & Yao, C. J., Oct 8 2018, In : Nutrients. 10, 10, 1458.

Research output: Contribution to journalArticle

AMP-activated protein kinase
AMP-Activated Protein Kinases
Fish Oils
Selenium
adenocarcinoma
2 Citations (Scopus)
Open Access
Fear
Fatigue
Survivors
Rehabilitation
Qigong
2017
6 Citations (Scopus)
MAP Kinase Signaling System
Non-Small Cell Lung Carcinoma
Lung Neoplasms
lissamine rhodamine B
Protein-Tyrosine Kinases
Luteolin
uterine cervical neoplasms
luteolin
Quercetin
Flavonoids
11 Citations (Scopus)
Ginsenosides
autophagy
Autophagy
lung neoplasms
Lung Neoplasms
2016
4 Citations (Scopus)
Neoplasms
Apoptosis
Lung Neoplasms
Proteins
Epithelial-Mesenchymal Transition
3 Citations (Scopus)
Radiation Tolerance
Methyltransferases
Down-Regulation
Breast Neoplasms
DNA
16 Citations (Scopus)
Side-Population Cells
Mouth Neoplasms
Heterografts
Neoplastic Stem Cells
Apoptosis
16 Citations (Scopus)

Negative feedback regulation of AXL by miR-34a modulates apoptosis in lung cancer cells

Cho, C. Y., Huang, J. S., Shiah, S. G., Chung, S. Y., Lay, J. D., Yang, Y. Y., Lai, G. M., Cheng, A. L., Chen, L. T. & Chuang, S. E., Feb 1 2016, In : RNA. 22, 2, p. 303-315 13 p.

Research output: Contribution to journalArticle

MicroRNAs
Lung Neoplasms
Activating Transcription Factors
Apoptosis
MAP Kinase Signaling System
2015
10 Citations (Scopus)

Elimination of cancer stem-like cells and potentiation of temozolomide sensitivity by honokiol in glioblastoma multiforme cells

Lai, I. C., Shih, P. H., Yao, C-J., Yeh, C-T., Wang-Peng, J., Lui, T-N., Chuang, S. E., Hu, T. S., Lai, T-Y. & Lai, G-M., Mar 12 2015, In : PLoS One. 10, 3, e0114830.

Research output: Contribution to journalArticle

temozolomide
Side-Population Cells
Neoplastic Stem Cells
Glioblastoma
Stem cells
35 Citations (Scopus)

Fucoidan elevates MicroRNA-29b to regulate DNMT3B-MTSS1 axis and inhibit EMT in human hepatocellular carcinoma cells

Yan, M. D., Yao, C. J., Chow, J. M., Chang, C. L., Hwang, P. A., Chuang, S. E., Whang-Peng, J. & Lai, G. M., Oct 1 2015, In : Marine Drugs. 13, 10, p. 6099-6116 18 p.

Research output: Contribution to journalArticle

MicroRNAs
Hepatocellular Carcinoma
Neoplasm Metastasis
Cadherins
Tumor Suppressor Proteins
32 Citations (Scopus)
Endoplasmic Reticulum Stress
Curcumin
Reactive Oxygen Species
Prostatic Neoplasms
Cell Death
9 Citations (Scopus)

RPS12 increases the invasiveness in cervical cancer activated by c-Myc and inhibited by the dietary flavonoids luteolin and quercetin

Lin, C. W., Lai, G. M., Chen, K. C., Lin, T. H., Fan, J. J., Hsu, R. L., Chou, C. M., Lin, C. M., Kandaswami, C. C., Lee, M. T. & Cheng, C. H., Dec 1 2015, In : Journal of Functional Foods. 19, p. 236-247 12 p.

Research output: Contribution to journalArticle

Luteolin
uterine cervical neoplasms
luteolin
Quercetin
Flavonoids
2014
5 Citations (Scopus)

Elimination of cancer stem-like side population in human glioblastoma cells accompanied with stemness gene suppression by Korean herbal recipe MSC500

Yao, C. J., Han, T. Y., Shih, P. H., Yi, T. Y., Lai, I. C., Chang, K. H., Lai, T-I., Chang, C. L. & Lai, G. M., Nov 19 2014, In : Integrative Cancer Therapies. 13, 6, p. 541-554 14 p.

Research output: Contribution to journalArticle

Glioblastoma
Side-Population Cells
temozolomide
Neoplastic Stem Cells
Glioma

Erratum: Oxidative stress enhances AXL-mediated cell migration through AKT1/Rac1-dependent mechanism (Free Radical Biology and Medicine (2013) 65 (1246-1256))

Huang, J. S., Cho, C. Y., Hong, C. C., Yan, M. D., Hsieh, M-C., Lay, J. D., Lai, G. M., Ann-Lii, C. & Chuang, S. E., Feb 2014, In : Free Radical Biology and Medicine. 67, p. 416 1 p.

Research output: Contribution to journalArticle

Oxidative stress
Medicine
Free Radicals
21 Citations (Scopus)

Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cells

Hsiao, P. C., Lee, W-J., Yang, S. F., Tan, P., Chen, H. Y., Lee, L-M., Chang, J. L., Lai, G-M., Chow, J-M. & Chien, M-H., Dec 1 2014, In : Tumor Biology. 35, 12, p. 11903-11911 9 p.

Research output: Contribution to journalArticle

Caspase 9
Caspase 8
Myeloid Cells
Acute Myeloid Leukemia
Apoptosis
2013
10 Citations (Scopus)

Aspirin antagonizes the cytotoxic effect of methotrexate in lung cancer cells

Yan, K. H., Lee, L. M., Hsieh, M-C., Yan, M. D., Yao, C. J., Chang, P. Y., Chen, T. L., Chang, H. Y., Cheng, A. L., Lai, G. M. & Chuang, S. E., Sep 2013, In : Oncology Reports. 30, 3, p. 1497-1505 9 p.

Research output: Contribution to journalArticle

Methotrexate
Aspirin
Lung Neoplasms
Tetrahydrofolate Dehydrogenase
S Phase
27 Citations (Scopus)
Catenins
Neoplastic Stem Cells
Mouth Neoplasms
Side-Population Cells
Apoptosis
41 Citations (Scopus)

Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells

Chang, K. H., Yan, M. D., Yao, C. J., Lin, P. C. & Lai, G. M., Nov 2013, In : Oncology Letters. 6, 5, p. 1435-1438 4 p.

Research output: Contribution to journalArticle

Autophagy
Glioblastoma
Apoptosis
lissamine rhodamine B
Cell Line
15 Citations (Scopus)

Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt, ERK, JNK and AMPK signaling

Yan, K. H., Yao, C. J., Hsiao, C. H., Lin, K. H., Lin, Y. W., Wen, Y-C., Liu, C. C., Yan, M. D., Chuang, S. E., Lai, G. M. & Lee, L. M., Oct 2013, In : Oncology Letters. 5, 5, p. 1541-1545 5 p.

Research output: Contribution to journalArticle

Mefloquine
Extracellular Signal-Regulated MAP Kinases
Adenosine Monophosphate
Protein Kinases
Reactive Oxygen Species
11 Citations (Scopus)

Mefloquine induces cell death in prostate cancer cells and provides a potential novel treatment strategy in vivo

Yan, K. H., Lin, Y. W., Hsiao, C. H., Wen, Y-C., Lin, K. H., Liu, C. C., Hsieh, M-C., Yao, C. J., Yan, M. D., Lai, G. M., Chuang, S. E. & Lee, L. M., Oct 2013, In : Oncology Letters. 5, 5, p. 1567-1571 5 p.

Research output: Contribution to journalArticle

Mefloquine
Prostatic Neoplasms
Cell Death
lissamine rhodamine B
Reactive Oxygen Species
27 Citations (Scopus)

Oxidative stress enhances Axl-mediated cell migration through an Akt1/Rac1-dependent mechanism

Huang, J. S., Cho, C. Y., Hong, C. C., Yan, M. D., Hsieh, M-C., Lay, J. D., Lai, G. M., Cheng, A. L. & Chuang, S. E., 2013, In : Free Radical Biology and Medicine. 65, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

Oxidative stress
Cell Movement
Reactive Oxygen Species
Oxidative Stress
Phosphatidylinositol 3-Kinases
2012
16 Citations (Scopus)

Elimination of cancer stem-like side population cells in hepatoma cell lines by Chinese herbal mixture Tien-Hsien Liquid

Yao, C. J., Yeh, C-T., Lee, L. M., Chuang, S. E., Yeh, C. F., Chao, W. J., Lai, T-I. & Lai, G. M., 2012, In : Evidence-based Complementary and Alternative Medicine. 2012, 617085.

Research output: Contribution to journalArticle

Side-Population Cells
Hepatocellular Carcinoma
Cell Line
Neoplasms
Neoplastic Stem Cells
64 Citations (Scopus)
Caspases
Cytochromes c
Blood-Brain Barrier
Neuroblastoma
Mitochondria
2011
20 Citations (Scopus)
Catenins
Wnt Signaling Pathway
Colonic Neoplasms
Cell Death
Apoptosis
10 Citations (Scopus)

Targeting PML-RARα and oncogenic signaling pathways by Chinese herbal mixture Tien-Hsien liquid in acute promyelocytic leukemia NB4 cells

Lai, T-I., Yao, C. J., Yang, C. M., Chuang, S. E., Yan, J. L., Liu, C. Y., Chen, S. W., Yan, K. H. & Lai, G. M., 2011, In : Evidence-based Complementary and Alternative Medicine. 2011, 984154.

Research output: Contribution to journalArticle

Acute Promyelocytic Leukemia
Apoptosis
tien-hsien liquid
Cyclin B1
Cyclin A
2010
31 Citations (Scopus)

The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells

Yan, K. H., Yao, C. J., Chang, H. Y., Lai, G. M., Cheng, A. L. & Chuang, S. E., Mar 2010, In : Molecular Carcinogenesis. 49, 3, p. 235-246 12 p.

Research output: Contribution to journalArticle

troglitazone
Cell Cycle Checkpoints
Aspirin
Lung Neoplasms
Apoptosis
2009
88 Citations (Scopus)

Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells

Yeh, C. T., Rao, Y. K., Yao, C. J., Yeh, C. F., Li, C. H., Chuang, S. E., Luong, J. H. T., Lai, G. M. & Tzeng, Y. M., Nov 18 2009, In : Cancer Letters. 285, 1, p. 73-79 7 p.

Research output: Contribution to journalArticle

Antrodia
Triterpenes
Colonic Neoplasms
HT29 Cells
Apoptosis
2008
22 Citations (Scopus)

Carbonic anhydrase III promotes transformation and invasion capability in hepatoma cells through FAK signaling pathway

Dai, H. Y., Hong, C. C., Liang, S. C., Yan, M. D., Lai, G. M., Cheng, A. L. & Chuang, S. E., Dec 2008, In : Molecular Carcinogenesis. 47, 12, p. 956-963 8 p.

Research output: Contribution to journalArticle

Carbonic Anhydrase III
Focal Adhesion Protein-Tyrosine Kinases
Hepatocellular Carcinoma
Aptitude
Hydro-Lyases
122 Citations (Scopus)

Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia

Hong, C. C., Lay, J. D., Huang, J. S., Cheng, A. L., Tang, J. L., Lin, M. T., Lai, G. M. & Chuang, S. E., Sep 18 2008, In : Cancer Letters. 268, 2, p. 314-324 11 p.

Research output: Contribution to journalArticle

U937 Cells
Receptor Protein-Tyrosine Kinases
Drug Resistance
Acute Myeloid Leukemia
Leukemia
2007
50 Citations (Scopus)

Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells

Chen, C. N., Huang, H. H., Wu, C. L., Lin, C. P. C., Hsu, J. T. A., Hsieh, H. P., Chuang, S. E. & Lai, G. M., Feb 8 2007, In : Cancer Letters. 246, 1-2, p. 237-252 16 p.

Research output: Contribution to journalArticle

Sesquiterpenes
Mitochondrial Membranes
Lactones
Caspases
Melanoma
68 Citations (Scopus)

Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinoma cells expressing AXL

Lay, J. D., Hong, C. C., Huang, J. S., Yang, Y. Y., Pao, C. Y., Liu, C. H., Lai, Y. P., Lai, G. M., Cheng, A. L., Su, I. J. & Chuang, S. E., Apr 15 2007, In : Cancer Research. 67, 8, p. 3878-3887 10 p.

Research output: Contribution to journalArticle

Sulfasalazine
Drug Resistance
Non-Small Cell Lung Carcinoma
Receptor Protein-Tyrosine Kinases
Doxorubicin
2006
59 Citations (Scopus)

Dramatic synergistic anticancer effect of clinically achievable doses of lovastatin and troglitazone

Yao, C. J., Lai, G. M., Chan, C. F., Cheng, A. L., Yang, Y. Y. & Chuang, S. E., Mar 1 2006, In : International Journal of Cancer. 118, 3, p. 773-779 7 p.

Research output: Contribution to journalArticle

troglitazone
Lovastatin
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cyclin A
Neoplasms
2005
11 Citations (Scopus)
PC12 Cells
Extracellular Signal-Regulated MAP Kinases
Pheochromocytoma
Intermediate Filaments
Urine
71 Citations (Scopus)

Identification and characterization of a novel gene Saf transcribed from the opposite strand of Fas

Yan, M. D., Hong, C. C., Lai, G. M., Cheng, A. L., Lin, Y. W. & Chuang, S. E., Jun 1 2005, In : Human Molecular Genetics. 14, 11, p. 1465-1474 10 p.

Research output: Contribution to journalArticle

Apoptosis
Genes
Physiological Phenomena
Antisense RNA
Jurkat Cells
2002
137 Citations (Scopus)

Basal levels and patterns of anticancer drug-induced activation of nuclear factor-κB (NF-κB), and its attenuation by tamoxifen, dexamethasone, and curcumin in carcinoma cells

Chuang, S. E., Yeh, P. Y., Lu, Y. S., Lai, G. M., Liao, C. M., Gao, M. & Cheng, A. L., May 1 2002, In : Biochemical Pharmacology. 63, 9, p. 1709-1716 8 p.

Research output: Contribution to journalArticle

Curcumin
Tamoxifen
Dexamethasone
Chemical activation
Cells
61 Citations (Scopus)

Expression of epidermal growth factor receptor in head and neck cancers correlates with clinical progression: A multicentre immunohistochemical study in the Asia-Pacific region

Putti, T. C., To, K. F., Hsu, H. C., Chan, A. T. C., Lai, G. M., Tse, G., Lee, Y. S., Whang-Peng, J., Millward, M., Lin, L., Lin, X. & Lee, C. S., 2002, In : Histopathology. 41, 2, p. 144-151 8 p.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Epidermal Growth Factor Receptor
Multicenter Studies
Neoplasms
Hypopharynx
2000
212 Citations (Scopus)

Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis

Chuang, S. E., Kuo, M. L., Hsu, C. H., Chen, C. R., Lin, J. K., Lai, G. M., Hsieh, C. Y. & Cheng, A. L., 2000, In : Carcinogenesis. 21, 2, p. 331-335 5 p.

Research output: Contribution to journalArticle

Diethylnitrosamine
Curcumin
Diet
Hepatocellular Carcinoma
Mouth Neoplasms
1998
12 Citations (Scopus)

Malignant thyroid teratoma of an adult: A long-term survival after chemotherapy

Chen, J. S., Lai, G. M. & Hsueh, S., Apr 1998, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 21, 2, p. 212-214 3 p.

Research output: Contribution to journalArticle

Teratoma
Thyroid Gland
Drug Therapy
Survival
Neoplasms
1997
4 Citations (Scopus)

Intensive Chemotherapy plus Recombinant Human Granulocyte Colony Stimulating Factor Support for Distant Metastatic Nasopharyngeal Carcinoma

Wang, C. H., Wang, H. M., Chen, J. S., Chang, W. J. & Lai, G. M., Jan 1997, In : Oncology. 54, SUPPL. 1, p. 34-37 4 p.

Research output: Contribution to journalArticle

Granulocyte Colony-Stimulating Factor
Drug Therapy
Nasopharyngeal carcinoma
Bone Marrow
Epirubicin
1 Citation (Scopus)

Weekly CAF chemotherapy for advanced breast cancer patients

Hwang, W. S., Hsiung, C. A., Ko, W. S., Wang, C. C., Chang, J. Y., Lai, G. M., Hsieh, R. K., Tsao, C. J., Chen, L. T., Law, C. K., Cheng, A. L., Fan, S. F., Tzeng, C. H., Chiou, T. J. & Whang-Peng, J., Jul 1997, In : Oncology. 54, 4, p. 293-297 5 p.

Research output: Contribution to journalArticle

Fluorouracil
Doxorubicin
Cyclophosphamide
Breast Neoplasms
Drug Therapy
1996
1 Citation (Scopus)

Clinical trial of low-dose rHuG-CSF in neutropenic cancer patients following anti-cancer chemotherapy

Chang, M. C., Lai, G. M., Tsan, K. W., Wang, R. S. & Wu, J. H., Nov 1996, In : Journal of the Formosan Medical Association = Taiwan yi zhi. 95, 11, p. 845-850 6 p.

Research output: Contribution to journalArticle

Clinical Trials
Drug Therapy
Neoplasms
Neutrophils
Myalgia
9 Citations (Scopus)
Mastication
Cisplatin
Lymph Nodes
Neoplasm Metastasis
Drug Therapy
21 Citations (Scopus)

Newly established MST-1 tumour cell line and tumour-infiltrating lymphocyte culture from a patient with soft tissue melanoma (clear cell sarcoma) and their potential applications to patient immunotherapy

Liao, S. K., Perng, Y. P., Lee, L. A., Chang, K. S. S., Lai, G. M., Wong, E. & Ho, Y. S., Feb 1996, In : European Journal of Cancer. 32, 2, p. 346-356 11 p.

Research output: Contribution to journalArticle

Clear Cell Sarcoma
Tumor-Infiltrating Lymphocytes
Tumor Cell Line
Immunotherapy
Melanoma
46 Citations (Scopus)

Prognostic factors of locoregionally recurrent nasopharyngeal carcinoma - A retrospective review of 182 cases

Yang, T. S., Ng, K. T., Wang, H. M., Wang, C. H., Liaw, C. C. & Lai, G. M., 1996, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 19, 4, p. 337-343 7 p.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Recurrence
Retreatment
Drug Therapy
Nasopharyngeal carcinoma
1995
17 Citations (Scopus)

Cisplatin and 5-fluorouracil as neoadjuvant chemotherapy: Predicting response in head and neck squamous cell cancer

Wang, H. M., Wang, C. H., Chen, J. S., Chang, H. K., Kiu, M. C., Liaw, C. C., Ng, K. T. & Lai, G. M., 1995, In : Journal of the Formosan Medical Association = Taiwan yi zhi. 94, 3, p. 87-94 8 p.

Research output: Contribution to journalArticle

Squamous Cell Neoplasms
Head and Neck Neoplasms
Fluorouracil
Cisplatin
Head