Gi-Ming Lai

Research output

Research output per year 1986 2020

• 2846 Citations
• 27 h-Index
• 66 Article
• 3 Chapter
• 2 Comment/debate
• 1 Letter

Research output per year

Research output per year

Search results

• 2020

  Astragalus Polysaccharide (PG2) Suppresses Macrophage Migration Inhibitory Factor and Aggressiveness of Lung Adenocarcinoma Cells

  Liao, C. H., Yong, C. Y., Lai, G. M., Chow, J. M., Cheng, C. F., Fang, C. L., Lin, P. C., Chang, C. L., Zheng, Y. M., Chuang, S. E., Whang-Peng, J. & Yao, C. J., 2020, (Accepted/In press) In: American Journal of Chinese Medicine. 48, 6, p. 1491-1509 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Macrophage Migration-Inhibitory Factors
  • Adenocarcinoma of Lung
  • Polysaccharides
  • Matrix Metalloproteinase 13
  • Severe Combined Immunodeficiency
  1 Citation (Scopus)

• Omega-3 Fatty Acid-Enriched Fish Oil and Selenium Combination Modulates Endoplasmic Reticulum Stress Response Elements and Reverses Acquired Gefitinib Resistance in HCC827 Lung Adenocarcinoma Cells

  Liao, C. H., Tzeng, Y. T., Lai, G. M., Chang, C. L., Hu, M. H., Tsai, W. L., Liu, Y. R., Hsia, S., Chuang, S. E., Chiou, T. J., Wang, L. M., Whang-Peng, J. & Yao, C. J., Jul 29 2020, In: Marine Drugs. 18, 8, 399.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Gefitinib
  • Fish Oils
  • Endoplasmic Reticulum Stress
  • Selenium
  • Omega-3 Fatty Acids
  3 Citations (Scopus)

• Subcutaneous Panniculitis Like T Cell Lymphoma Complicated With Hemophagocytic Lymphohistiocytosis - A Challenging Case Report

  Zheng, Y. M., Chang, C., Hu, M-H., Chao, H-M., Whang-Peng, J., Lai, G-M. & Chiou, T-J., Jan 1 2020, In: Archives of Clinical and Medical Case Reports. 04

  Research output: Contribution to journal › Article › peer-review
• 2019

  Electrospun polylactic acid (PLLA) microtube array membrane (MTAM)-An advanced substrate for anticancer drug screening

  Tseng, C. H., Huang, W. T., Chew, C. H., Lai, J. K., Tu, S. H., Wei, P. L., Lee, K. Y., Lai, G. M. & Chen, C. C., Feb 14 2019, In: Materials. 12, 4, 569.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • poly(lactide)
  • Assays
  • Screening
  • Acids
  • Membranes
  4 Citations (Scopus)

• Epigenetic modification and differentiation induction of malignant glioma cells by oligo-fucoidan

  Liao, C. H., Lai, I. C., Kuo, H. C., Chuang, S. E., Lee, H. L., Whang-Peng, J., Yao, C. J. & Lai, G. M., Sep 8 2019, In: Marine Drugs. 17, 9, 525.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • fucoidan
  • Glioma
  • Epigenomics
  • DNA methyltransferase 3B
  • DNA methyltransferase 3A
  4 Citations (Scopus)

• Hematuria induced by combination regorafenib and hyperthermia–a radiation recall effect

  Zheng, Y. M., Chow, J. M., Chang, C. L., Chao, L. H., Whang-Peng, J. & Lai, G. M., Jan 1 2019, In: International Journal of Hyperthermia. 36, 1, p. 1186-1189 4 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access
  1 Citation (Scopus)

• Identification of novel anti-liver cancer small molecules with better therapeutic index than sorafenib via zebrafish drug screening platform

  Lin, H. S., Huang, Y. L., Wang, Y. R., Hsiao, E., Hsu, T. A., Shiao, H. Y., Jiaang, W. T., Sampurna, B. P., Lin, K. H., Wu, M. S., Lai, G. M. & Yuh, C. H., Jun 1 2019, In: Cancers. 11, 6, 739.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sorafenib
  • Therapeutic Index
  • Preclinical Drug Evaluations
  • Zebrafish
  • Liver Neoplasms
  15 Citations (Scopus)

• Protective effect of Antrodia cinnamomea extract against irradiation-induced acute hepatitis

  Kuo, T. H., Kuo, Y. H., Cho, C. Y., Yao, C. J., Lai, G. M. & Chuang, S. E., Feb 2 2019, In: International Journal of Molecular Sciences. 20, 4, 846.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Antrodia
  • hepatitis
  • Free radicals
  • Radiotherapy
  • Liver
  4 Citations (Scopus)

• PTBP1-mediated regulation of AXL mRNA stability plays a role in lung tumorigenesis

  Cho, C. Y., Chung, S. Y., Lin, S., Huang, J. S., Chen, Y. L., Jiang, S. S., Cheng, L. C., Kuo, T. H., Lay, J. D., Yang, Y. Y., Lai, G. M. & Chuang, S. E., Dec 1 2019, In: Scientific Reports. 9, 1, 16922.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Stability
  • Carcinogenesis
  • Messenger RNA
  • Lung
  • Drug Resistance
  5 Citations (Scopus)
• 2018

  Human Urine Extract Cell Differentiation Agent 2 Protects PC12 Cells from Serum Deprivation-Induced Apoptosis Accompanied with Priming of Extracellular Signal-Regulated Kinase Activation and Differentiation Induction

  Yao, C. J., Chuang, S. E., Yang, Y. Y. & Lai, G. M., Feb 17 2018, (Accepted/In press) In: Chinese Journal of Integrative Medicine. p. 1-7 7 p.

  Research output: Contribution to journal › Article › peer-review

  • PC12 Cells
  • Extracellular Signal-Regulated MAP Kinases
  • Cell Differentiation
  • Urine
  • Apoptosis

• Opposite regulation of CHOP and GRP78 and synergistic apoptosis induction by selenium yeast and fish oil via AMPK activation in lung adenocarcinoma cells

  Kao, R. H., Lai, G. M., Chow, J. M., Liao, C. H., Zheng, Y. M., Tsai, W. L., Hsia, S., Lai, I. C., Lee, H. L., Chuang, S. E., Whang-Peng, J. & Yao, C. J., Oct 8 2018, In: Nutrients. 10, 10, 1458.

  Research output: Contribution to journal › Article › peer-review

  • AMP-activated protein kinase
  • Fish Oils
  • AMP-Activated Protein Kinases
  • adenocarcinoma
  • Selenium
  4 Citations (Scopus)

• Promoting Physical and Psychological Rehabilitation Activities and Evaluating Potential Links Among Cancer-Related Fatigue, Fear of Recurrence, Quality of Life, and Physiological Indicators in Cancer Survivors

  Lee, Y. H., Lai, G. M., Lee, D. C., Tsai Lai, L. J. & Chang, Y. P., Dec 1 2018, In: Integrative Cancer Therapies. 17, 4, p. 1183-1194 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Qigong
  • Cancer Survivors
  • Fear
  • Fatigue
  • Rehabilitation
  8 Citations (Scopus)
• 2017

  Active fraction (HS7) from Taiwanofungus camphoratus inhibits AKT-mTOR, ERK and STAT3 pathways and induces CDK inhibitors in CL1-0 human lung cancer cells

  Lai, I. C., Lai, G. M., Chow, J. M., Lee, H. L., Yeh, C. F., Li, C. H., Yan, J. L., Chuang, S. E., Whang-Peng, J., Bai, K. J. & Yao, C. J., Nov 15 2017, In: Chinese Medicine (United Kingdom). 12, 1, 33.

  Research output: Contribution to journal › Article › peer-review

  • MAP Kinase Signaling System
  • Non-Small Cell Lung Carcinoma
  • Lung Neoplasms
  • n-hexane
  • Protein-Tyrosine Kinases
  7 Citations (Scopus)

• Corrigendum: Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stress

  Lee, W. J., Chien, M. H., Chow, J. M., Chang, J. L., Wen, Y. C., Lin, Y. W., Cheng, C. W., Lai, G. M., Hsiao, M. & Lee, L-M., Feb 22 2017, In: Scientific Reports. 7, 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access
  1 Citation (Scopus)

• Corrigendum to “RPS12 increases the invasiveness in cervical cancer activated by c-Myc and inhibited by the dietary flavonoids luteolin and quercetin” [J. Funct. Foods (2015) 19PA (236–247)] (S1756464615004478)(10.1016/j.jff.2015.09.030)

  Lin, C-W., Lai, G-M., Chen, K-C., Lin, T. H., Fan, J. J., Hsu, R. L., Chou, C-M., Lin, C-M., Kandaswami, C. C., Lee, M. T. & Cheng, C-H., Feb 1 2017, In: Journal of Functional Foods. 29, p. 303 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  • uterine cervical neoplasms
  • Luteolin
  • luteolin
  • Quercetin
  • Flavonoids

• Induction of Forkhead Class box O3a and apoptosis by a standardized ginsenoside formulation, KG-135, is potentiated by autophagy blockade in A549 human lung cancer cells

  Yao, C. J., Chow, J. M., Chuang, S. E., Chang, C. L., Yan, M. D., Lee, H. L., Lai, I. C., Lin, P. C. & Lai, G. M., Jul 2017, In: Journal of Ginseng Research. 41, 3, p. 247-256

  Research output: Contribution to journal › Article › peer-review

  • Ginsenosides
  • ginsenosides
  • lung neoplasms
  • autophagy
  • Autophagy
  15 Citations (Scopus)
• 2016

  Activation of p53/miR-34a tumor suppressor axis by Chinese herbal formula JP-1 in A549 lung adenocarcinoma cells

  Yao, C. J., Chow, J. M., Lin, P. C., Hu, T. S., Kuo, H. C., Huang, J. S., Bai, K. J. & Lai, G. M., 2016, In: Evidence-based Complementary and Alternative Medicine. 2016, 5989681.

  Research output: Contribution to journal › Article › peer-review

  • Adenocarcinoma of Lung
  • Apoptosis
  • Neoplasms
  • Lung Neoplasms
  • Survivin
  6 Citations (Scopus)

• Chinese Herbal Mixture, Tien-Hsien Liquid, Induces G2/M Cycle Arrest and Radiosensitivity in MCF-7 Human Breast Cancer Cells through Mechanisms Involving DNMT1 and Rad51 Downregulation

  Yao, C. J., Chow, J. M., Yang, C. M., Kuo, H. C., Chang, C. L., Lee, H. L., Lai, I. C., Chuang, S. E. & Lai, G. M., Jan 1 2016, In: Evidence-based Complementary and Alternative Medicine. 2016, 3251046.

  Research output: Contribution to journal › Article › peer-review

  • tien-hsien liquid
  • Radiation Tolerance
  • Methyltransferases
  • Down-Regulation
  • Breast Neoplasms
  3 Citations (Scopus)

• Honokiol inhibits sphere formation and xenograft growth of oral cancer side population cells accompanied with JAK/STAT signaling pathway suppression and apoptosis induction

  Huang, J. S., Yao, C. J., Chuang, S. E., Yeh, C-T., Lee, L. M., Chen, R. M., Chao, W. J., Whang-Peng, J. & Lai, G. M., Mar 24 2016, In: BMC Cancer. 16, 1, 245.

  Research output: Contribution to journal › Article › peer-review

  • honokiol
  • Side-Population Cells
  • Mouth Neoplasms
  • Heterografts
  • Neoplastic Stem Cells
  27 Citations (Scopus)

• Negative feedback regulation of AXL by miR-34a modulates apoptosis in lung cancer cells

  Cho, C. Y., Huang, J. S., Shiah, S. G., Chung, S. Y., Lay, J. D., Yang, Y. Y., Lai, G. M., Cheng, A. L., Chen, L. T. & Chuang, S. E., Feb 1 2016, In: RNA. 22, 2, p. 303-315 13 p.

  Research output: Contribution to journal › Article › peer-review

  • MicroRNAs
  • Lung Neoplasms
  • Activating Transcription Factors
  • Apoptosis
  • MAP Kinase Signaling System
  21 Citations (Scopus)
• 2015

  Elimination of cancer stem-like cells and potentiation of temozolomide sensitivity by honokiol in glioblastoma multiforme cells

  Lai, I. C., Shih, P. H., Yao, C-J., Yeh, C-T., Wang-Peng, J., Lui, T-N., Chuang, S. E., Hu, T. S., Lai, T-Y. & Lai, G-M., Mar 12 2015, In: PLoS ONE. 10, 3, e0114830.

  Research output: Contribution to journal › Article › peer-review

  • honokiol
  • Side-Population Cells
  • glioblastoma
  • Temozolomide
  • Neoplastic Stem Cells
  16 Citations (Scopus)

• Fucoidan elevates MicroRNA-29b to regulate DNMT3B-MTSS1 axis and inhibit EMT in human hepatocellular carcinoma cells

  Yan, M. D., Yao, C. J., Chow, J. M., Chang, C. L., Hwang, P. A., Chuang, S. E., Whang-Peng, J. & Lai, G. M., Oct 1 2015, In: Marine Drugs. 13, 10, p. 6099-6116 18 p.

  Research output: Contribution to journal › Article › peer-review

  • fucoidan
  • MicroRNAs
  • Hepatocellular Carcinoma
  • Neoplasm Metastasis
  • Cadherins
  54 Citations (Scopus)

• Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stress

  Lee, W. J., Chien, M. H., Chow, J. M., Chang, J. L., Wen, Y-C., Lin, Y. W., Cheng, C. W., Lai, G. M., Hsiao, M. & Lee, L. M., May 27 2015, In: Scientific Reports. 5, 10420.

  Research output: Contribution to journal › Article › peer-review

  • Curcumin
  • Endoplasmic Reticulum Stress
  • Reactive Oxygen Species
  • Prostatic Neoplasms
  • Cell Death
  35 Citations (Scopus)

• RPS12 increases the invasiveness in cervical cancer activated by c-Myc and inhibited by the dietary flavonoids luteolin and quercetin

  Lin, C. W., Lai, G. M., Chen, K. C., Lin, T. H., Fan, J. J., Hsu, R. L., Chou, C. M., Lin, C. M., Kandaswami, C. C., Lee, M. T. & Cheng, C. H., Dec 1 2015, In: Journal of Functional Foods. 19, p. 236-247 12 p.

  Research output: Contribution to journal › Article › peer-review

  • uterine cervical neoplasms
  • Luteolin
  • luteolin
  • Quercetin
  • Flavonoids
  13 Citations (Scopus)
• 2014

  Elimination of cancer stem-like side population in human glioblastoma cells accompanied with stemness gene suppression by Korean herbal recipe MSC500

  Yao, C. J., Han, T. Y., Shih, P. H., Yi, T. Y., Lai, I. C., Chang, K. H., Lai, T-I., Chang, C. L. & Lai, G. M., Nov 19 2014, In: Integrative Cancer Therapies. 13, 6, p. 541-554 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Glioblastoma
  • Side-Population Cells
  • Neoplastic Stem Cells
  • Glioma
  • Temozolomide
  5 Citations (Scopus)

• Erratum: Oxidative stress enhances AXL-mediated cell migration through AKT1/Rac1-dependent mechanism (Free Radical Biology and Medicine (2013) 65 (1246-1256))

  Huang, J. S., Cho, C. Y., Hong, C. C., Yan, M. D., Hsieh, M-C., Lay, J. D., Lai, G. M., Ann-Lii, C. & Chuang, S. E., Feb 2014, In: Free Radical Biology and Medicine. 67, p. 416 1 p.

  Research output: Contribution to journal › Article › peer-review

• Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cells

  Hsiao, P. C., Lee, W-J., Yang, S. F., Tan, P., Chen, H. Y., Lee, L-M., Chang, J. L., Lai, G-M., Chow, J-M. & Chien, M-H., Dec 1 2014, In: Tumor Biology. 35, 12, p. 11903-11911 9 p.

  Research output: Contribution to journal › Article › peer-review

  • nobiletin
  • Caspase 8
  • Myeloid Cells
  • Acute Myeloid Leukemia
  • Apoptosis
  27 Citations (Scopus)
• 2013

  Aspirin antagonizes the cytotoxic effect of methotrexate in lung cancer cells

  Yan, K. H., Lee, L. M., Hsieh, M-C., Yan, M. D., Yao, C. J., Chang, P. Y., Chen, T. L., Chang, H. Y., Cheng, A. L., Lai, G. M. & Chuang, S. E., Sep 2013, In: Oncology Reports. 30, 3, p. 1497-1505 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Methotrexate
  • Aspirin
  • Lung Neoplasms
  • Tetrahydrofolate Dehydrogenase
  • S Phase
  13 Citations (Scopus)

• Honokiol eliminates human oral cancer stem-like cells accompanied with suppression of Wnt/ β -Catenin signaling and apoptosis induction

  Yao, C. J., Lai, G. M., Yeh, C-T., Lai, M. T., Shih, P. H., Chao, W. J., Whang-Peng, J., Chuang, S. E. & Lai, T-Y., 2013, In: Evidence-based Complementary and Alternative Medicine. 2013, 146136.

  Research output: Contribution to journal › Article › peer-review

  • honokiol
  • Catenins
  • Mouth Neoplasms
  • Side-Population Cells
  • Neoplastic Stem Cells
  36 Citations (Scopus)

• Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells

  Chang, K. H., Yan, M. D., Yao, C. J., Lin, P. C. & Lai, G. M., Nov 2013, In: Oncology Letters. 6, 5, p. 1435-1438 4 p.

  Research output: Contribution to journal › Article › peer-review

  • honokiol
  • Glioblastoma
  • Autophagy
  • Apoptosis
  • Biphenyl Compounds
  47 Citations (Scopus)

• Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt, ERK, JNK and AMPK signaling

  Yan, K. H., Yao, C. J., Hsiao, C. H., Lin, K. H., Lin, Y. W., Wen, Y-C., Liu, C. C., Yan, M. D., Chuang, S. E., Lai, G. M. & Lee, L. M., Oct 2013, In: Oncology Letters. 5, 5, p. 1541-1545 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Mefloquine
  • Adenosine Monophosphate
  • Extracellular Signal-Regulated MAP Kinases
  • Protein Kinases
  • Reactive Oxygen Species
  19 Citations (Scopus)

• Mefloquine induces cell death in prostate cancer cells and provides a potential novel treatment strategy in vivo

  Yan, K. H., Lin, Y. W., Hsiao, C. H., Wen, Y-C., Lin, K. H., Liu, C. C., Hsieh, M-C., Yao, C. J., Yan, M. D., Lai, G. M., Chuang, S. E. & Lee, L. M., Oct 2013, In: Oncology Letters. 5, 5, p. 1567-1571 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Mefloquine
  • Prostatic Neoplasms
  • Cell Death
  • PC-3 Cells
  • diacetyldichlorofluorescein
  17 Citations (Scopus)

• Oxidative stress enhances Axl-mediated cell migration through an Akt1/Rac1-dependent mechanism

  Huang, J. S., Cho, C. Y., Hong, C. C., Yan, M. D., Hsieh, M-C., Lay, J. D., Lai, G. M., Cheng, A. L. & Chuang, S. E., 2013, In: Free Radical Biology and Medicine. 65, p. 1246-1256 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative stress
  • Cell Movement
  • Reactive Oxygen Species
  • Oxidative Stress
  • Oxidation-Reduction
  30 Citations (Scopus)
• 2012

  Elimination of cancer stem-like side population cells in hepatoma cell lines by Chinese herbal mixture Tien-Hsien Liquid

  Yao, C. J., Yeh, C-T., Lee, L. M., Chuang, S. E., Yeh, C. F., Chao, W. J., Lai, T-I. & Lai, G. M., 2012, In: Evidence-based Complementary and Alternative Medicine. 2012, 617085.

  Research output: Contribution to journal › Article › peer-review

  • tien-hsien liquid
  • Side-Population Cells
  • Hepatocellular Carcinoma
  • Cell Line
  • Neoplastic Stem Cells
  16 Citations (Scopus)

• Honokiol traverses the blood-brain barrier and induces apoptosis of neuroblastoma cells via an intrinsic bax-mitochondrion-cytochrome c-caspase protease pathway

  Lin, J. W., Chen, J. T., Ye, H-C., Lin, Y. L., Wang, K. T., Yao, C. J., Lai, G. M. & Chen, R. M., Mar 2012, In: Neuro-Oncology. 14, 3, p. 302-314 13 p.

  Research output: Contribution to journal › Article › peer-review

  • honokiol
  • Cytochromes c
  • Caspases
  • Neuroblastoma
  • Blood-Brain Barrier
  80 Citations (Scopus)
• 2011

  Apoptotic cell death and inhibition of Wnt/ β-catenin signaling pathway in human colon cancer cells by an active fraction (hs7) from taiwanofungus camphoratus

  Yeh, C-T., Yao, C. J., Yan, J. L., Chuang, S. E., Lee, L. M., Chen, C-M., Yeh, C. F., Li, C. H. & Lai, G. M., 2011, In: Evidence-based Complementary and Alternative Medicine. 2011, 750230.

  Research output: Contribution to journal › Article › peer-review

  • Catenins
  • Wnt Signaling Pathway
  • Colonic Neoplasms
  • Cell Death
  • Apoptosis
  25 Citations (Scopus)

• Targeting PML-RARα and oncogenic signaling pathways by Chinese herbal mixture Tien-Hsien liquid in acute promyelocytic leukemia NB4 cells

  Lai, T-I., Yao, C. J., Yang, C. M., Chuang, S. E., Yan, J. L., Liu, C. Y., Chen, S. W., Yan, K. H. & Lai, G. M., 2011, In: Evidence-based Complementary and Alternative Medicine. 2011, 984154.

  Research output: Contribution to journal › Article › peer-review

  • tien-hsien liquid
  • Acute Promyelocytic Leukemia
  • Apoptosis
  • Arsenic Trioxide
  • Cyclin B1
  10 Citations (Scopus)
• 2010

  The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells

  Yan, K. H., Yao, C. J., Chang, H. Y., Lai, G. M., Cheng, A. L. & Chuang, S. E., Mar 2010, In: Molecular Carcinogenesis. 49, 3, p. 235-246 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Troglitazone
  • Cell Cycle Checkpoints
  • Aspirin
  • Lung Neoplasms
  • Apoptosis
  35 Citations (Scopus)
• 2009

  Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells

  Yeh, C. T., Rao, Y. K., Yao, C. J., Yeh, C. F., Li, C. H., Chuang, S. E., Luong, J. H. T., Lai, G. M. & Tzeng, Y. M., Nov 18 2009, In: Cancer Letters. 285, 1, p. 73-79 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Antrodia
  • Triterpenes
  • Colonic Neoplasms
  • HT29 Cells
  • 1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol
  96 Citations (Scopus)
• 2008

  Carbonic anhydrase III promotes transformation and invasion capability in hepatoma cells through FAK signaling pathway

  Dai, H. Y., Hong, C. C., Liang, S. C., Yan, M. D., Lai, G. M., Cheng, A. L. & Chuang, S. E., Dec 2008, In: Molecular Carcinogenesis. 47, 12, p. 956-963 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Carbonic Anhydrase III
  • Focal Adhesion Protein-Tyrosine Kinases
  • Hepatocellular Carcinoma
  • Hydro-Lyases
  • Aptitude
  29 Citations (Scopus)

• Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia

  Hong, C. C., Lay, J. D., Huang, J. S., Cheng, A. L., Tang, J. L., Lin, M. T., Lai, G. M. & Chuang, S. E., Sep 18 2008, In: Cancer Letters. 268, 2, p. 314-324 11 p.

  Research output: Contribution to journal › Article › peer-review

  • U937 Cells
  • Receptor Protein-Tyrosine Kinases
  • Acute Myeloid Leukemia
  • Drug Resistance
  • Leukemia
  147 Citations (Scopus)
• 2007

  Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells

  Chen, C. N., Huang, H. H., Wu, C. L., Lin, C. P. C., Hsu, J. T. A., Hsieh, H. P., Chuang, S. E. & Lai, G. M., Feb 8 2007, In: Cancer Letters. 246, 1-2, p. 237-252 16 p.

  Research output: Contribution to journal › Article › peer-review

  • costunolide
  • Sesquiterpenes
  • Lactones
  • Mitochondrial Membranes
  • Caspases
  55 Citations (Scopus)

• Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinoma cells expressing AXL

  Lay, J. D., Hong, C. C., Huang, J. S., Yang, Y. Y., Pao, C. Y., Liu, C. H., Lai, Y. P., Lai, G. M., Cheng, A. L., Su, I. J. & Chuang, S. E., Apr 15 2007, In: Cancer Research. 67, 8, p. 3878-3887 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Sulfasalazine
  • Adenocarcinoma of Lung
  • Drug Resistance
  • Non-Small Cell Lung Carcinoma
  • Receptor Protein-Tyrosine Kinases
  76 Citations (Scopus)
• 2006

  Dramatic synergistic anticancer effect of clinically achievable doses of lovastatin and troglitazone

  Yao, C. J., Lai, G. M., Chan, C. F., Cheng, A. L., Yang, Y. Y. & Chuang, S. E., Mar 1 2006, In: International Journal of Cancer. 118, 3, p. 773-779 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Troglitazone
  • Lovastatin
  • isofenphos
  • Cyclin A
  • Cell Cycle Proteins
  61 Citations (Scopus)
• 2005

  Differentiation of pheochromocytoma PC 12 cells induced by human urine extract and the involvement of the extracellular signal-regulated kinase signaling pathway

  Yao, C. J., Lai, G. M., Chan, C. F., Yang, Y. Y., Liu, F. C. & Chuang, S. E., Oct 2005, In: Journal of Alternative and Complementary Medicine. 11, 5, p. 903-908 6 p.

  Research output: Contribution to journal › Article › peer-review

  • PC12 Cells
  • Pheochromocytoma
  • Extracellular Signal-Regulated MAP Kinases
  • U 0126
  • Intermediate Filaments
  11 Citations (Scopus)

• Identification and characterization of a novel gene Saf transcribed from the opposite strand of Fas

  Yan, M. D., Hong, C. C., Lai, G. M., Cheng, A. L., Lin, Y. W. & Chuang, S. E., Jun 1 2005, In: Human Molecular Genetics. 14, 11, p. 1465-1474 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Apoptosis
  • Genes
  • Antisense RNA
  • Jurkat Cells
  • Transcription Initiation Site
  75 Citations (Scopus)
• 2002

  Basal levels and patterns of anticancer drug-induced activation of nuclear factor-κB (NF-κB), and its attenuation by tamoxifen, dexamethasone, and curcumin in carcinoma cells

  Chuang, S. E., Yeh, P. Y., Lu, Y. S., Lai, G. M., Liao, C. M., Gao, M. & Cheng, A. L., May 1 2002, In: Biochemical Pharmacology. 63, 9, p. 1709-1716 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Metabolic Activation
  • Curcumin
  • Tamoxifen
  • Cells
  • Dexamethasone
  145 Citations (Scopus)

• Expression of epidermal growth factor receptor in head and neck cancers correlates with clinical progression: A multicentre immunohistochemical study in the Asia-Pacific region

  Putti, T. C., To, K. F., Hsu, H. C., Chan, A. T. C., Lai, G. M., Tse, G., Lee, Y. S., Whang-Peng, J., Millward, M., Lin, L., Lin, X. & Lee, C. S., 2002, In: Histopathology. 41, 2, p. 144-151 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Head and Neck Neoplasms
  • ErbB Receptors
  • Multicenter Studies
  • Squamous Cell Carcinoma of Head and Neck
  • Neoplasms
  63 Citations (Scopus)
• 2000

  Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis

  Chuang, S. E., Kuo, M. L., Hsu, C. H., Chen, C. R., Lin, J. K., Lai, G. M., Hsieh, C. Y. & Cheng, A. L., 2000, In: Carcinogenesis. 21, 2, p. 331-335 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Diethylnitrosamine
  • Curcumin
  • Diet
  • Hepatocellular Carcinoma
  • Mouth Neoplasms
  221 Citations (Scopus)
• 1998

  Malignant thyroid teratoma of an adult: A long-term survival after chemotherapy

  Chen, J. S., Lai, G. M. & Hsueh, S., Apr 1998, In: American Journal of Clinical Oncology: Cancer Clinical Trials. 21, 2, p. 212-214 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Teratoma
  • Thyroid Gland
  • Drug Therapy
  • Survival
  • Testicular Germ Cell Tumor
  12 Citations (Scopus)