Projects per year
Personal profile
Education
- 1991-1996 Ph.D., Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
- 1989-1991 M.S., Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
- 1984-1989 B.S., School of Pharmacy, China Medical College, Taichung, Taiwan
Experience
- 2019- Vice Director of School of Medicine, Taipei Medical University
- 2016-2017 Professor of Ph.D Program in Biotechnology Research and Development, Taipei Medical University
- 2014- Chairman, Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University /Division of Molecular Pharmacology of Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University
- 2008- Professor, Department of Pharmacology, School of Medicine and Division of Molecular Pharmacology of Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University
- 2011-2013 Adjunct Professor, School of Medicine, College of Medicine, Mackay Medical College
- 2003-2008, Associate Professor, Department of Pharmacology, School of Medicine and Institute of Pharmacology, College of Medicine, Taipei Medical University
- 2006 Visiting Research Scholar, Cardiovascular Laboratory, Department of Physiology, Medical College of Georgia, USA
- 1999-2002 Assistant Professor, Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University
- 1998-1999 Instructor and Postdoctorial, Department of Pharmacology, National Defense Medical College
- 1997 Postdoctorial, Department of Pharmacology, National Taiwan University
Research Interests
- Signal transductions in human monocytes /microglia (phagocytes), pulmonary cells, intestine epithelial cells and tumor cells (AML, chondrosarcoma, and hepatoma )
- Mechanisms of epigenetic, redox-regulatory of anti-matrix metalloproteinase agents
- Drug evaluation and discovery on anti-inflammatory, anti-retinal dysfunction and anti-stroke drugs
Awards
- The Most Influential Paper Award, TMU, Taiwan (2014)
- The Major Research Program Award, TMU, Taiwan (2012-2013)
- Research Award, NSC, Taiwan (1999-2002)
- Excellent Thesis Award, College of Medicine, NTU, Taiwan (1996)
Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
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Matrix Metalloproteinase 9
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2013 2019
探討真菌衍生之抗神經發炎成分及其對視網膜疾病之療效評估(1/3)
8/1/18 → 7/31/19
Project: A - Government Institution › b - Ministry of Science and Technology
The Investigation of Anti-Microglia/Macrophage Mechanisms of Different Tak1/Tabs Regulators and Their Protective Effects in Intracerebral Hemorrhage and Brain Abscess
8/1/16 → 7/31/17
Project: A - Government Institution › b - Ministry of Science and Technology
Short-Chain Fatty Acids Act as Anti-Allergic Regulators on Immune Effector Cells and Exert Immune-Modulatory Effects on Ovalbumin-Induced Allergic Diseases in Mice
8/1/15 → 7/31/16
Project: A - Government Institution › b - Ministry of Science and Technology
The Investigation of Anti-Neuroinflammatory Mechanisms of Differential Histone Deacetylase Regulators and Their Therapeutic Profiles in Experimental Intracerebral Haemorrahge and Encephalitis
8/1/15 → 7/31/16
Project: A - Government Institution › b - Ministry of Science and Technology
The Effect of Endothelin-1 on Myofibroblast Transformation of Pleural Mesothelial Cells and Its Implications for Pleural and Pulmonary Fibrosis
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
Research Output 1996 2019
HDAC8 inhibitor WK2-16 therapeutically targets lipopolysaccharide-induced mouse model of neuroinflammation and microglial activation
Lin, F. L., Yen, J. L., Kuo, Y. C., Kang, J. J., Cheng, Y. W., Huang, W. J. & Hsiao, G., Jan 2 2019, In : International Journal of Molecular Sciences. 20, 2, p. 410 410.Research output: Contribution to journal › Article
Neuroglia
inhibitors
mice
Lipopolysaccharides
Chemical activation
Low-luminance blue light-enhanced phototoxicity in A2E-Laden RPE cell cultures and rats
Lin, C. H., Wu, M. R., Huang, W. J., Chow, D. S. L., Hsiao, G. & Cheng, Y. W., Apr 1 2019, In : International Journal of Molecular Sciences. 20, 7, 1799.Research output: Contribution to journal › Article
Open Access
Phototoxic Dermatitis
Retinal Pigments
luminance
pigments
Cell culture
The fungus-derived retinoprotectant theissenolactone C improves glaucoma-like injury mediated by MMP-9 inhibition
Lin, F. L., Cheng, Y. W., Yu, M., Ho, J. D., Kuo, Y. C., Chiou, G. C. Y., Chang, H. M., Lee, T. H. & Hsiao, G., Mar 15 2019, In : Phytomedicine. 56, p. 207-214 8 p.Research output: Contribution to journal › Article
Matrix Metalloproteinase 9
Glaucoma
Reperfusion Injury
Interleukin-1
Chemokine CCL2
1
Citation
(Scopus)
Haloperidol Abrogates Matrix Metalloproteinase-9 Expression by Inhibition of NF-κB Activation in Stimulated Human Monocytic Cells
Lee, Y. L., Hsiao, C. J., Lin, F. L., Jan, J. S., Chou, Y. C., Lin, Y. Y., Chen, C. K., Lam, K. K. & Hsiao, G., Jan 1 2018, In : Mediators of Inflammation. 2018, 1 p., 9541459.Research output: Contribution to journal › Article
Matrix Metalloproteinase 9
Haloperidol
Matrix Metalloproteinases
Lipopolysaccharides
Tumor Necrosis Factor-alpha
New terpenoids from Chamaecyparis formosensis (Cupressaceae) leaves with modulatory activity on matrix metalloproteases 2 and 9
Chang, M. L., Mei, H. C., Kuo, I. C., Hsiao, G., Kuo, Y. H. & Lee, C. K., Mar 7 2018, In : Molecules. 23, 3, 604.Research output: Contribution to journal › Article
Chamaecyparis
Cupressaceae
Terpenes
Metalloproteases
leaves