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Personal profile

Education

  • 1991-1996 Ph.D., Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
  • 1989-1991 M.S., Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
  • 1984-1989 B.S., School of Pharmacy, China Medical College, Taichung, Taiwan

Experience

  • 2014-present., Chairman, Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University /Division of Molecular Pharmacology of Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University
  • 2008-present., Professor, Department of Pharmacology, School of Medicine and Division of Molecular Pharmacology of Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University
  • 2011- 2013 Adjunct Professor, School of Medicine, College of Medicine, Mackay Medical College
  • 2003-2008, Associate Professor, Department of Pharmacology, School of Medicine and Institute of Pharmacology, College of Medicine, Taipei Medical University
  • 2006, Visiting Research Scholar, Cardiovascular Laboratory, Department of Physiology, Medical College of Georgia, USA
  • 1999-2002, Assistant Professor, Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University
  • 1998-1999, Instructor and Postdoctorial., Department of Pharmacology, National Defense Medical College
  • 1997, Postdoctorial., Department of Pharmacology, NTU

Research Interests

  • Signal transductions in human monocytes /microglia (phagocytes), pulmonary cells, intestine epithelial cells and tumor cells (AML, chondrosarcoma, and hepatoma )
  • Mechanisms of epigenetic, redox-regulatory of anti-matrix metalloproteinase agents
  • Drug evaluation and discovery on anti-inflammatory, anti-retinal dysfunction and anti-stroke drugs

Awards

  • The Most Influential Paper Award, TMU, Taiwan (2014)
  • The Major Research Program Award, TMU, Taiwan (2012-2013)
  • Research Award, NSC, Taiwan (1999-2002)
  • Excellent Thesis Award, College of Medicine, NTU, Taiwan (1996)

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Projects 2013 2019

Research Output 1996 2019

  • 3388 Citations
  • 33 h-Index
  • 141 Article
  • 1 Comment/debate

The fungus-derived retinoprotectant theissenolactone C improves glaucoma-like injury mediated by MMP-9 inhibition

Lin, F. L., Cheng, Y. W., Yu, M., Ho, J. D., Kuo, Y. C., Chiou, G. C. Y., Chang, H. M., Lee, T. H. & Hsiao, G., Mar 15 2019, In : Phytomedicine. 56, p. 207-214 8 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Glaucoma
Reperfusion Injury
Interleukin-1beta
Chemokine CCL2

Haloperidol Abrogates Matrix Metalloproteinase-9 Expression by Inhibition of NF-κB Activation in Stimulated Human Monocytic Cells

Lee, Y. L., Hsiao, C. J., Lin, F. L., Jan, J. S., Chou, Y. C., Lin, Y. Y., Chen, C. K., Lam, K. K. & Hsiao, G., Jan 1 2018, In : Mediators of Inflammation. 2018, 1 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Haloperidol
Matrix Metalloproteinases
Lipopolysaccharides
Tumor Necrosis Factor-alpha

New terpenoids from Chamaecyparis formosensis (Cupressaceae) leaves with modulatory activity on matrix metalloproteases 2 and 9

Chang, M. L., Mei, H. C., Kuo, I. C., Hsiao, G., Kuo, Y. H. & Lee, C. K., Jan 1 2018, In : Molecules. 23, 3, 604.

Research output: Contribution to journalArticle

Chamaecyparis
Cupressaceae
Terpenes
Metalloproteases
leaves
Cistanche
Light
Retinal Pigments
Staining and Labeling
Phototoxic Dermatitis
2 Citations

Theissenolactone C exhibited ocular protection of endotoxin-induced uveitis by attenuating ocular inflammatory responses and glial activation

Lin, F. L., Ho, J. D., Cheng, Y. W., Chiou, G. C. Y., Yen, J. L., Chang, H. M., Lee, T. H. & Hsiao, G., Apr 9 2018, In : Frontiers in Pharmacology. 9, APR, 326.

Research output: Contribution to journalArticle

Uveitis
Endotoxins
Neuroglia
Microglia
Tumor Necrosis Factor-alpha