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Research Output 2000 2020

  • 1636 Citations
  • 24 h-Index
  • 61 Article
  • 2 Patent
  • 1 Comment/debate
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Article
2020

Electrochemical substrate for active profiling of cellular surface leucine aminopeptidase activity and drug resistance in cancer cells

Balamurugan, T. S. T., Chen, G. Z., Kumaravel, S., Lin, C. M., Huang, S. T., Lee, Y. C., Chen, C. H. & Luo, G. R., Feb 15 2020, In : Biosensors and Bioelectronics. 150, 111948.

Research output: Contribution to journalArticle

2019
2 Citations (Scopus)

Fluorine-Modified Rutaecarpine Exerts Cyclooxygenase-2 Inhibition and Anti-inflammatory Effects in Lungs

Lee, C., Liao, J., Chen, S., Yen, C., Lee, Y., Huang, S., Huang, S., Lin, C. M. & Chang, V. H., 2019, In : Frontiers in Pharmacology. 10, p. 91

Research output: Contribution to journalArticle

Fluorine
Cyclooxygenase 2
Anti-Inflammatory Agents
Lung
Myofibroblasts
Ventilator-Induced Lung Injury
Continuous Positive Airway Pressure
Lung Injury
Pneumonia
Respiration
2017

Lysosomal acid phosphatase 2 is an unfavorable prognostic factor but is associated with better survival in stage II colorectal cancer patients receiving chemotherapy

Lee, Y. C., Su, C. Y., Lin, Y. F., Lin, C. M., Fang, C. Y., Lin, Y-K., Hsiao, M. & Chen, C. L., 2017, In : Oncotarget. 8, 7, p. 12120-12132 13 p.

Research output: Contribution to journalArticle

Acid Phosphatase
Colorectal Neoplasms
Drug Therapy
Survival
Adjuvant Chemotherapy
5 Citations (Scopus)

Synthetic fluororutaecarpine inhibits inflammatory stimuli and activates endothelial transient receptor potential vanilloid-type 1

Lee, C-M., Gu, J. A., Rau, T. G., Wang, C., Yen, C. H., Huang, S. H., Lin, F. Y., Lin, C. M. & Huang, S. T., Apr 1 2017, In : Molecules. 22, 4, 656.

Research output: Contribution to journalArticle

vasodilation
macrophages
Macrophages
nitric oxide
Cytotoxicity
2016
10 Citations (Scopus)

Multifunctions of Excited Gold Nanoparticles Decorated Artificial Kidney with Efficient Hemodialysis and Therapeutic Potential

Chen, H. C., Cheng, C. Y., Lin, H. C., Chen, H. H., Chen, C. H., Yang, C. P., Yang, K. H., Lin, C. M., Lin, T. Y., Shih, C. M. & Liu, Y. C., Aug 3 2016, In : ACS Applied Materials and Interfaces. 8, 30, p. 19691-19700 10 p.

Research output: Contribution to journalArticle

Gold
Dialysis
Nanoparticles
Oxidative stress
Platelets
2 Citations (Scopus)
Retinoids
Fetal Growth Retardation
Lung
Retinoic Acid Receptors
Tretinoin
2015
12 Citations (Scopus)

Electrochemical OFF-ON ratiometric chemodosimeters for the selective and rapid detection of fluoride

Mani, V., Li, W. Y., Gu, J. A., Lin, C. M. & Huang, S. T., 2015, In : Talanta. 131, p. 121-126 6 p.

Research output: Contribution to journalArticle

Fluorides
Oxidation-Reduction
Surface states
Signal-To-Noise Ratio
Benzene
67 Citations (Scopus)

Glucose biosensor based on glucose oxidase immobilized at gold nanoparticles decorated graphene-carbon nanotubes

Devasenathipathy, R., Mani, V., Chen, S. M., Huang, S. T., Huang, T. T., Lin, C. M., Hwa, K. Y., Chen, T. Y. & Chen, B. J., Oct 1 2015, In : Enzyme and Microbial Technology. 78, p. 40-45 6 p.

Research output: Contribution to journalArticle

Glucose Oxidase
Carbon Nanotubes
Glucose oxidase
Graphite
Biosensing Techniques
9 Citations (Scopus)

RPS12 increases the invasiveness in cervical cancer activated by c-Myc and inhibited by the dietary flavonoids luteolin and quercetin

Lin, C. W., Lai, G. M., Chen, K. C., Lin, T. H., Fan, J. J., Hsu, R. L., Chou, C. M., Lin, C. M., Kandaswami, C. C., Lee, M. T. & Cheng, C. H., Dec 1 2015, In : Journal of Functional Foods. 19, p. 236-247 12 p.

Research output: Contribution to journalArticle

Luteolin
uterine cervical neoplasms
luteolin
Quercetin
Flavonoids
16 Citations (Scopus)

Targeting of Topoisomerase I for Prognoses and Therapeutics of Camptothecin-Resistant Ovarian Cancer

Lee, Y. C., Lee, C. H., Tsai, H. P., An, H. W., Lee, C-M., Wu, J. C., Chen, C. S., Huang, S. H., Hwang, J., Cheng, K. T., Leiw, P. L., Chen, C. L. & Lin, C. M., Jul 24 2015, In : PLoS One. 10, 7, e0132579.

Research output: Contribution to journalArticle

DNA topoisomerase
Camptothecin
Type I DNA Topoisomerase
ovarian neoplasms
Ovarian Neoplasms
2014
24 Citations (Scopus)

Active and stable liquid water innovatively prepared using resonantly illuminated gold nanoparticles

Chen, H. C., Hwang, B. J., Mai, F. D., Liu, Y. C., Lin, C. M., Kuo, H-S., Chou, D. S., Lee, M. J., Yang, K. H., Yu, C. C., Chen, J. R., Lo, T. Y., Tsai, H. Y., Yang, C. P., Wang, C., Hsieh, H. T. & Rick, J., Mar 25 2014, In : ACS Nano. 8, 3, p. 2704-2713 10 p.

Research output: Contribution to journalArticle

Gold
gold
Nanoparticles
nanoparticles
Water
8 Citations (Scopus)

CFS-1686 causes cell cycle arrest at intra-S phase by interference of interaction of topoisomerase 1 with DNA

Lin, R. W., Yang, C. N., Ku, S., Ho, C. J., Huang, S. B., Yang, M. C., Chang, H. W., Lin, C. M., Hwang, J., Chen, Y. L., Tzeng, C. C. & Wang, C., Dec 2 2014, In : PLoS One. 9, 12, e113832.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
crossover interference
S Phase
interphase
Camptothecin
21 Citations (Scopus)

Innovative strategy with potential to increase hemodialysis efficiency and safety

Chen, H. C., Lin, H. C., Chen, H. H., Mai, F. D., Liu, Y. C., Lin, C. M., Chang, C. C., Tsai, H. Y. & Yang, C. P., Mar 21 2014, In : Scientific Reports. 4, 4425.

Research output: Contribution to journalArticle

Renal Dialysis
Safety
Water
Dialysis Solutions
Creatinine
13 Citations (Scopus)

Maternal nicotine exposure exacerbates neonatal hyperoxia-induced lung fibrosis in rats

Huang, L. T., Chou, H. C., Lin, C. M., Yeh, T. F. & Chen, C. M., 2014, In : Neonatology. 106, 2, p. 94-101 8 p.

Research output: Contribution to journalArticle

Maternal Exposure
Hyperoxia
Nicotine
Fibrosis
Connective Tissue Growth Factor
34 Citations (Scopus)
HSP90 Heat-Shock Proteins
Heme Oxygenase-1
Carbon Monoxide
Byproducts
Cells
2013
21 Citations (Scopus)

Clinical and Prognostic Implications of Transcription Factor SOX4 in Patients with Colon Cancer

Lin, C. M., Fang, C. L., Hseu, Y. C., Chen, C. L., Wang, J. W., Hsu, S. L., Tu, M. D., Hung, S. T., Tai, C., Uen, Y. H. & Lin, K. Y., Jun 27 2013, In : PLoS One. 8, 6, e67128.

Research output: Contribution to journalArticle

SOXC Transcription Factors
colorectal neoplasms
Colonic Neoplasms
transcription factors
Tissue
4 Citations (Scopus)

Low-cytotoxic synthetic bromorutaecarpine exhibits anti-inflammation and activation of transient receptor potential vanilloid type 1 activities

Lee, C-M., Gu, J. A., Rau, T. G., Yang, C. H., Yang, W. C., Huang, S. H., Lin, F. Y., Lin, C. M. & Huang, S. T., 2013, In : BioMed Research International. 2013, 795095.

Research output: Contribution to journalArticle

Chemical activation
Inflammation
Cytotoxicity
Lipopolysaccharides
Evodia
4 Citations (Scopus)

Photoproducts of Indomethacin exhibit decreased hydroxyl radical scavenging and xanthine oxidase inhibition activities

Lien, G-S., Chen, C. S., Chen, W-Y., Huang, S. H., Cheng, K-T., Lin, C-M. & Chao, S. H., Sep 2013, In : Journal of Food and Drug Analysis. 21, 3, p. 332-336 5 p.

Research output: Contribution to journalArticle

xanthine oxidase
indomethacin
Xanthine Oxidase
hydroxyl radicals
Indomethacin
8 Citations (Scopus)

Topoisomerase i inhibitor evodiamine acts as an antibacterial agent against drug-resistant Klebsiella pneumoniae

Wu, J. Y., Chang, M. C., Chen, C. S., Lin, H. C., Tsai, H. P., Yang, C. C., Yang, C. H. & Lin, C. M., 2013, In : Planta Medica. 79, 1, p. 27-29 3 p.

Research output: Contribution to journalArticle

Topoisomerase Inhibitors
Klebsiella pneumoniae
Anti-Bacterial Agents
Type I DNA Topoisomerase
Pharmaceutical Preparations
2012
14 Citations (Scopus)

Alpha-methylacyl coenzyme A racemase overexpression in gallbladder carcinoma confers an independent prognostic indicator

Wu, L. C., Chen, L. T., Tsai, Y. J., Lin, C. M., Lin, C. Y., Tian, Y. F., Sheu, M. J., Uen, Y. H., Shiue, Y. L., Wang, Y. H., Yang, S. J., Wu, W. R., Li, S. H., Iwamuro, M., Kobayasshi, N., Huang, H. Y. & Li, C. F., Apr 2012, In : Journal of Clinical Pathology. 65, 4, p. 309-314 6 p.

Research output: Contribution to journalArticle

Racemases and Epimerases
Coenzyme A
Gallbladder
Carcinoma
Neoplasms
4 Citations (Scopus)

Assessment of renal function by the stable oxygen and hydrogen isotopes in human blood plasma

Kuo, T. C., Wang, C. H., Lin, H. C., Lin, Y. H., Lin, M., Lin, C. M. & Kuo, H-S., Feb 13 2012, In : PLoS One. 7, 2, e32137.

Research output: Contribution to journalArticle

Oxygen Isotopes
renal function
blood plasma
Isotopes
hydrogen
24 Citations (Scopus)

Associations of Rsf-1 overexpression with poor therapeutic response and worse survival in patients with nasopharyngeal carcinoma

Tai, H. C., Huang, H. Y., Lee, S. W., Lin, C. Y., Sheu, M. J., Chang, S. L., Wu, L. C., Shiue, Y. L., Wu, W. R., Lin, C. M. & Li, C. F., Mar 2012, In : Journal of Clinical Pathology. 65, 3, p. 248-253 6 p.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
Survival
Neoplasm Metastasis
Neoplasms
Histone Chaperones
27 Citations (Scopus)

C 60 fullerene derivatized nanoparticles and their application to therapeutics

Lin, C-M. & Lu, T. Y., Jun 2012, In : Recent Patents on Nanotechnology. 6, 2, p. 105-113 9 p.

Research output: Contribution to journalArticle

Fullerenes
fullerenes
Nanoparticles
nanoparticles
blood-brain barrier
24 Citations (Scopus)

HuR cytoplasmic expression is associated with increased cyclin A expression and poor outcome with upper urinary tract urothelial carcinoma

Liang, P. I., Li, W. M., Wang, Y. H., Wu, T. F., Wu, W. R., Liao, A. C., Shen, K. H., Wei, Y. C., Hsing, C-H., Shiue, Y. L., Huang, H. Y., Hsu, H. P., Chen, L. T., Lin, C. Y., Tai, C., Lin, C-M. & Li, C. F., Dec 21 2012, In : BMC Cancer. 12, 611.

Research output: Contribution to journalArticle

Cyclin A
Urinary Tract
Carcinoma
Survival
Neoplasm Metastasis
22 Citations (Scopus)
Reishi
Glucans
Molecular Weight
Molecular weight
Cell death
2011
24 Citations (Scopus)

A potent sphingomyelinase inhibitor from Cordyceps mycelia contributes its cytoprotective effect against oxidative stress in macrophages

Wang, S. H., Yang, W. B., Liu, Y. C., Chiu, Y. H., Chen, C. T., Kao, P. F. & Lin, C. M., Mar 2011, In : Journal of Lipid Research. 52, 3, p. 471-479 9 p.

Research output: Contribution to journalArticle

Cordyceps
Sphingomyelin Phosphodiesterase
Oxidative stress
Macrophages
Ceramides
7 Citations (Scopus)

C 60 fullerene nanoparticle prevents β-amyloid peptide induced cytotoxicity in neuro 2A cells

Lu, T. Y., Kao, P. F., Lee, C-M., Huang, S. T. & Lin, C. M., Jun 2011, In : Journal of Food and Drug Analysis. 19, 2

Research output: Contribution to journalArticle

fullerene
nanoparticles
amyloid
Amyloid
Nanoparticles
58 Citations (Scopus)

C60 fullerene-pentoxifylline dyad nanoparticles enhance autophagy to avoid cytotoxic effects caused by the β-amyloid peptide

Lee, C-M., Huang, S. T., Huang, S. H., Lin, H. W., Tsai, H. P., Wu, J. Y., Lin, C. M. & Chen, C. T., Feb 2011, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 7, 1, p. 107-114 8 p.

Research output: Contribution to journalArticle

Pentoxifylline
Autophagy
Fullerenes
Amyloid
Nanoparticles
3 Citations (Scopus)

Cloning of crystallin from orange-spotted grouper and characterization of its activity as potential protective agent

Chen, Y. M., Kuo, C. E., Lin, C. M., Shiea, P. S. & Chen, T. Y., 2011, In : Results in Immunology. 1, 1, p. 60-69 10 p.

Research output: Contribution to journalArticle

Protective Agents
Crystallins
Organism Cloning
Eye Proteins
Oxidative Stress
39 Citations (Scopus)

Development of a sensitive long-wavelength fluorogenic probe for nitroreductase: A new fluorimetric indictor for analyte determination by dehydrogenase-coupled biosensors

Huang, H. C., Wang, K. L., Huang, S. T., Lin, H. Y. & Lin, C. M., Apr 15 2011, In : Biosensors and Bioelectronics. 26, 8, p. 3511-3516 6 p.

Research output: Contribution to journalArticle

Nitroreductases
Biosensing Techniques
Biosensors
Oxidoreductases
Fluorescence
34 Citations (Scopus)

Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis

Huang, W. C., Tsai, C. C., Chen, C. L., Chen, T. Y., Chen, Y. P., Lin, Y. S., Lu, P. J., Lin, C. M., Wang, S. H., Tsao, C. W., Wang, C. Y., Cheng, Y. L., Hsieh, C. Y., Tseng, P. C. & Lin, C. F., Oct 2011, In : FASEB Journal. 25, 10, p. 3661-3673 13 p.

Research output: Contribution to journalArticle

ceramide glucosyltransferase
Glycogen Synthase Kinase 3
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Apoptosis
Ceramides
10 Citations (Scopus)

Inhibition of AMPK-associated autophagy enhances caffeic acid phenethyl ester-induced cell death in C6 glioma cells

Yu, S. H., Kao, Y. T., Wu, J. Y., Huang, S. H., Huang, S. T., Lee, C-M., Cheng, K. T. & Lin, C. M., 2011, In : Planta Medica. 77, 9, p. 907-914 8 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Autophagy
Cell death
Glioma
Cell Death
55 Citations (Scopus)

One-pot synthesis of luotonin A and its analogues

Tseng, M. C., Chu, Y. W., Tsai, H. P., Lin, C. M., Hwang, J. & Chu, Y. H., Mar 4 2011, In : Organic Letters. 13, 5, p. 920-923 4 p.

Research output: Contribution to journalArticle

reagents
Chemical Phenomena
analogs
Quinazolines
Type I DNA Topoisomerase
2010
8 Citations (Scopus)
salicylate 1-monooxygenase
Fluorescent Dyes
Biosensors
Oxidoreductases
NAD
13 Citations (Scopus)

Immobilizing topoisomerase I on a surface plasmon resonance biosensor chip to screen for inhibitors

Tsai, H. P., Lin, L. W., Lai, Z. Y., Wu, J. Y., Chen, C. E., Hwang, J., Chen, C. S. & Lin, C. M., 2010, In : Journal of Biomedical Science. 17, 1, 49.

Research output: Contribution to journalArticle

Type I DNA Topoisomerase
Surface Plasmon Resonance
Surface plasmon resonance
Biosensing Techniques
Biosensors
22 Citations (Scopus)

The synthesis and optical characterization of novel iminocoumarin derivatives

Huang, S. T., Jian, J. L., Peng, H. Z., Wang, K. L., Lin, C. M., Huang, C. H. & Yang, T. C. K., Jun 2010, In : Dyes and Pigments. 86, 1, p. 6-14 9 p.

Research output: Contribution to journalArticle

Coloring Agents
Dyes
Derivatives
Wavelength
2009
31 Citations (Scopus)

Evodiamine stabilizes topoisomerase I-DNA cleavable complex to inhibit topoisomerase I activity

Chan, A. L. F., Chang, W. S., Chen, L. M., Lee, C. M., Chen, C. E., Lin, C. M. & Hwang, J. L., Apr 2009, In : Molecules. 14, 4, p. 1342-1352 11 p.

Research output: Contribution to journalArticle

Type I DNA Topoisomerase
deoxyribonucleic acid
DNA
Evodia
Topoisomerase Inhibitors
14 Citations (Scopus)

Hydrophilic ester-bearing chlorogenic acid binds to a novel domain to inhibit xanthine oxidase

Wang, S. H., Chen, C. S., Huang, S. H., Yu, S. H., Lai, Z. Y., Huang, S. T. & Lin, C. M., 2009, In : Planta Medica. 75, 11, p. 1237-1240 4 p.

Research output: Contribution to journalArticle

Bearings (structural)
Chlorogenic Acid
Xanthine Oxidase
Esters
Hydrophobic and Hydrophilic Interactions
43 Citations (Scopus)

Primary urothelial carcinoma of the upper tract: Important clinicopathological factors predicting bladder recurrence after surgical resection

Huang, W. W., Huang, H. Y., Liao, A. C., Shiue, Y. L., Tai, H. L., Lin, C. M., Wang, Y. H., Lin, C. N., Shen, K. H. & Li, C. F., Sep 2009, In : Pathology International. 59, 9, p. 642-649 8 p.

Research output: Contribution to journalArticle

Urinary Bladder
Carcinoma
Recurrence
Laparoscopy
Survival
2008
15 Citations (Scopus)

Antioxidant and flavor properties of Angelica sinensis extracts as affected by processing

Huang, S. H., Chen, C. C., Lin, C. M. & Chiang, B. H., Aug 2008, In : Journal of Food Composition and Analysis. 21, 5, p. 402-409 8 p.

Research output: Contribution to journalArticle

Angelica sinensis
flavor
Antioxidants
antioxidants
extracts
27 Citations (Scopus)

Development and biological evaluation of C60 fulleropyrrolidine-thalidomide dyad as a new anti-inflammation agent

Huang, S. T., Ho, C. S., Lin, C. M., Fang, H. W. & Peng, Y. X., Sep 15 2008, In : Bioorganic and Medicinal Chemistry. 16, 18, p. 8619-8626 8 p.

Research output: Contribution to journalArticle

Thalidomide
Anti-Inflammatory Agents
Macrophages
Inflammation
Bearings (structural)
69 Citations (Scopus)

Protective effects of Angelica sinensis extract on amyloid β-peptide-induced neurotoxicity

Huang, S. H., Lin, C. M. & Chiang, B. H., Sep 3 2008, In : Phytomedicine. 15, 9, p. 710-721 12 p.

Research output: Contribution to journalArticle

Angelica sinensis
neurotoxicity
amyloid
Amyloid
protective effect
138 Citations (Scopus)

Structure-activity relationship of coumarin derivatives on xanthine oxidase-inhibiting and free radical-scavenging activities

Lin, H. C., Tsai, S. H., Chen, C. S., Chang, Y. C., Lee, C. M., Lai, Z. Y. & Lin, C. M., Mar 15 2008, In : Biochemical Pharmacology. 75, 6, p. 1416-1425 10 p.

Research output: Contribution to journalArticle

Coumarins
Xanthine Oxidase
Scavenging
Structure-Activity Relationship
Free Radicals
18 Citations (Scopus)

Synthesis and anti-inflammation evaluation of new C60 fulleropyrrolidines bearing biologically active xanthine

Huang, S. T., Liao, J. S., Fang, H. W. & Lin, C. M., Jan 1 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 1, p. 99-103 5 p.

Research output: Contribution to journalArticle

Bearings (structural)
Xanthine
Anti-Inflammatory Agents
Inflammation
Action Potentials
2007
34 Citations (Scopus)

Structure-activity relationship of C6-C3 phenylpropanoids on xanthine oxidase-inhibiting and free radical-scavenging activities

Chang, Y. C., Lee, F. W., Chen, C. S., Huang, S. T., Tsai, S. H., Huang, S. H. & Lin, C. M., Dec 1 2007, In : Free Radical Biology and Medicine. 43, 11, p. 1541-1551 11 p.

Research output: Contribution to journalArticle

Xanthine Oxidase
Scavenging
Structure-Activity Relationship
Free Radicals
Derivatives
12 Citations (Scopus)

Suppression effect of seminal vesicle autoantigen on platelet-activating factor-induced mouse sperm capacitation

Huang, Y. H., Chen, Y. H., Lin, C. M., Ciou, Y. Y., Kuo, S. P., Chen, C. T., Shih, C. M. & Chang, E-E., Mar 1 2007, In : Journal of Cellular Biochemistry. 100, 4, p. 941-951 11 p.

Research output: Contribution to journalArticle

Sperm Capacitation
Platelet Activating Factor
Spermatozoa
Phosphorylation
Tyrosine
2006
60 Citations (Scopus)

6-Acyl-4-aryl/alkyl-5,7-dihydroxycoumarins as anti-inflammatory agents

Lin, C. M., Huang, S. T., Lee, F. W., Kuo, H. S. & Lin, M. H., Jul 1 2006, In : Bioorganic and Medicinal Chemistry. 14, 13, p. 4402-4409 8 p.

Research output: Contribution to journalArticle

Coumarins
Hydroxyl Radical
Anti-Inflammatory Agents
Phloroglucinol
Derivatives
48 Citations (Scopus)

Degradation of di-butyl-phthalate by soil bacteria

Chao, W. L., Lin, C. M., Shiung, I. I. & Kuo, Y. L., May 2006, In : Chemosphere. 63, 8, p. 1377-1383 7 p.

Research output: Contribution to journalArticle

Dibutyl Phthalate
phthalate
Bacteria
Soil
Soils
2 Citations (Scopus)

Down-regulation of fatty acid synthase is associated with decreased Akt activation in lovastatin induced apoptosis cells

Chang, Y. C., Huang, Y. H., Shih, C. M., Wu, J. Y., Liu, C. L., Wang, S. H. & Lin, C. M., Dec 2006, In : Journal of Food and Drug Analysis. 14, 4, p. 340-345 6 p.

Research output: Contribution to journalArticle

lovastatin
Lovastatin
Fatty Acid Synthases
fatty-acid synthase
Down-Regulation