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Research Output

  • 1745 Citations
  • 25 h-Index
  • 62 Article
  • 2 Patent
  • 1 Comment/debate
2020

Electrochemical substrate for active profiling of cellular surface leucine aminopeptidase activity and drug resistance in cancer cells

Balamurugan, T. S. T., Chen, G. Z., Kumaravel, S., Lin, C. M., Huang, S. T., Lee, Y. C., Chen, C. H. & Luo, G. R., Feb 15 2020, In : Biosensors and Bioelectronics. 150, p. 111948 111948.

Research output: Contribution to journalArticle

The study of isotopic enrichment of water in human plasma and erythrocyte

Lin, Y. H., Wang, Y. C., Wu, M. S., Lu, K. C., Lin, H. Y., Kuo, H. S., Chang, G. D., Lin, C. M. & Hsiao, C., 2020, (Accepted/In press) In : FASEB Journal. 34, 9, p. 13049-13062 14 p.

Research output: Contribution to journalArticle

Open Access
2019

Fluorine-Modified Rutaecarpine Exerts Cyclooxygenase-2 Inhibition and Anti-inflammatory Effects in Lungs

Lee, C., Liao, J., Chen, S., Yen, C., Lee, Y., Huang, S., Huang, S., Lin, C. M. & Chang, V. H., 2019, In : Frontiers in Pharmacology. 10, p. 91

Research output: Contribution to journalArticle

5 Citations (Scopus)
2017

Lysosomal acid phosphatase 2 is an unfavorable prognostic factor but is associated with better survival in stage II colorectal cancer patients receiving chemotherapy

Lee, Y. C., Su, C. Y., Lin, Y. F., Lin, C. M., Fang, C. Y., Lin, Y-K., Hsiao, M. & Chen, C. L., 2017, In : Oncotarget. 8, 7, p. 12120-12132 13 p.

Research output: Contribution to journalArticle

Synthetic fluororutaecarpine inhibits inflammatory stimuli and activates endothelial transient receptor potential vanilloid-type 1

Lee, C-M., Gu, J. A., Rau, T. G., Wang, C., Yen, C. H., Huang, S. H., Lin, F. Y., Lin, C. M. & Huang, S. T., Apr 2017, In : Molecules. 22, 4, 656.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2016

Multifunctions of Excited Gold Nanoparticles Decorated Artificial Kidney with Efficient Hemodialysis and Therapeutic Potential

Chen, H. C., Cheng, C. Y., Lin, H. C., Chen, H. H., Chen, C. H., Yang, C. P., Yang, K. H., Lin, C. M., Lin, T. Y., Shih, C. M. & Liu, Y. C., Aug 3 2016, In : ACS Applied Materials and Interfaces. 8, 30, p. 19691-19700 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
3 Citations (Scopus)
2015

Electrochemical OFF-ON ratiometric chemodosimeters for the selective and rapid detection of fluoride

Mani, V., Li, W. Y., Gu, J. A., Lin, C. M. & Huang, S. T., 2015, In : Talanta. 131, p. 121-126 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Glucose biosensor based on glucose oxidase immobilized at gold nanoparticles decorated graphene-carbon nanotubes

Devasenathipathy, R., Mani, V., Chen, S. M., Huang, S. T., Huang, T. T., Lin, C. M., Hwa, K. Y., Chen, T. Y. & Chen, B. J., Oct 1 2015, In : Enzyme and Microbial Technology. 78, p. 40-45 6 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

RPS12 increases the invasiveness in cervical cancer activated by c-Myc and inhibited by the dietary flavonoids luteolin and quercetin

Lin, C. W., Lai, G. M., Chen, K. C., Lin, T. H., Fan, J. J., Hsu, R. L., Chou, C. M., Lin, C. M., Kandaswami, C. C., Lee, M. T. & Cheng, C. H., Dec 1 2015, In : Journal of Functional Foods. 19, p. 236-247 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Targeting of Topoisomerase I for Prognoses and Therapeutics of Camptothecin-Resistant Ovarian Cancer

Lee, Y. C., Lee, C. H., Tsai, H. P., An, H. W., Lee, C-M., Wu, J. C., Chen, C. S., Huang, S. H., Hwang, J., Cheng, K. T., Leiw, P. L., Chen, C. L. & Lin, C. M., Jul 24 2015, In : PLoS One. 10, 7, e0132579.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2014

Active and stable liquid water innovatively prepared using resonantly illuminated gold nanoparticles

Chen, H. C., Hwang, B. J., Mai, F. D., Liu, Y. C., Lin, C. M., Kuo, H-S., Chou, D. S., Lee, M. J., Yang, K. H., Yu, C. C., Chen, J. R., Lo, T. Y., Tsai, H. Y., Yang, C. P., Wang, C., Hsieh, H. T. & Rick, J., Mar 25 2014, In : ACS Nano. 8, 3, p. 2704-2713 10 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

CFS-1686 causes cell cycle arrest at intra-S phase by interference of interaction of topoisomerase 1 with DNA

Lin, R. W., Yang, C. N., Ku, S. Y., Ho, C. J., Huang, S. B., Yang, M. C., Chang, H. W., Lin, C. M., Hwang, J., Chen, Y. L., Tzeng, C. C. & Wang, C., Dec 2 2014, In : PLoS ONE. 9, 12, e113832.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Innovative strategy with potential to increase hemodialysis efficiency and safety

Chen, H. C., Lin, H. C., Chen, H. H., Mai, F. D., Liu, Y. C., Lin, C. M., Chang, C. C., Tsai, H. Y. & Yang, C. P., Mar 21 2014, In : Scientific Reports. 4, 4425.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Maternal nicotine exposure exacerbates neonatal hyperoxia-induced lung fibrosis in rats

Huang, L. T., Chou, H. C., Lin, C. M., Yeh, T. F. & Chen, C. M., 2014, In : Neonatology. 106, 2, p. 94-101 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
40 Citations (Scopus)
2013

Clinical and Prognostic Implications of Transcription Factor SOX4 in Patients with Colon Cancer

Lin, C. M., Fang, C. L., Hseu, Y. C., Chen, C. L., Wang, J. W., Hsu, S. L., Tu, M. D., Hung, S. T., Tai, C., Uen, Y. H. & Lin, K. Y., Jun 27 2013, In : PLoS One. 8, 6, e67128.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Low-cytotoxic synthetic bromorutaecarpine exhibits anti-inflammation and activation of transient receptor potential vanilloid type 1 activities

Lee, C-M., Gu, J. A., Rau, T. G., Yang, C. H., Yang, W. C., Huang, S. H., Lin, F. Y., Lin, C. M. & Huang, S. T., 2013, In : BioMed Research International. 2013, 795095.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Photoproducts of Indomethacin exhibit decreased hydroxyl radical scavenging and xanthine oxidase inhibition activities

Lien, G-S., Chen, C. S., Chen, W-Y., Huang, S. H., Cheng, K-T., Lin, C-M. & Chao, S. H., Sep 2013, In : Journal of Food and Drug Analysis. 21, 3, p. 332-336 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Topoisomerase i inhibitor evodiamine acts as an antibacterial agent against drug-resistant Klebsiella pneumoniae

Wu, J. Y., Chang, M. C., Chen, C. S., Lin, H. C., Tsai, H. P., Yang, C. C., Yang, C. H. & Lin, C. M., 2013, In : Planta Medica. 79, 1, p. 27-29 3 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

一種篩檢拓樸異構酶抑制劑之裝置及其方法: DEVICE OF SCREENING TOPOISOMERASE INHIBITORS AND METHOD THEREOF

Lin, C-M., Tsai, H. P., Shih, C-M., Hwang, J-L. & Lee, C. M., Jan 11 2013, IPC No. C12N 11/14(2006.01), Patent No. I382087

Research output: Patent

第一型去氧核糖核酸拓樸異構酶抑制劑: TYPE I TOPOISOMERASE INHIBITOR

Lin, C-M., Shih, C-M. & Wu, J-Y., Feb 11 2013, IPC No. A61K 36/754(2006.01), A61K 31/519(2006.01), A61P 35/00(2006.01), Patent No. I384995

Research output: Patent

2012

Alpha-methylacyl coenzyme A racemase overexpression in gallbladder carcinoma confers an independent prognostic indicator

Wu, L. C., Chen, L. T., Tsai, Y. J., Lin, C. M., Lin, C. Y., Tian, Y. F., Sheu, M. J., Uen, Y. H., Shiue, Y. L., Wang, Y. H., Yang, S. J., Wu, W. R., Li, S. H., Iwamuro, M., Kobayasshi, N., Huang, H. Y. & Li, C. F., Apr 2012, In : Journal of Clinical Pathology. 65, 4, p. 309-314 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Assessment of renal function by the stable oxygen and hydrogen isotopes in human blood plasma

Kuo, T. C., Wang, C. H., Lin, H. C., Lin, Y. H., Lin, M., Lin, C. M. & Kuo, H-S., Feb 13 2012, In : PLoS ONE. 7, 2, e32137.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Associations of Rsf-1 overexpression with poor therapeutic response and worse survival in patients with nasopharyngeal carcinoma

Tai, H. C., Huang, H. Y., Lee, S. W., Lin, C. Y., Sheu, M. J., Chang, S. L., Wu, L. C., Shiue, Y. L., Wu, W. R., Lin, C. M. & Li, C. F., Mar 2012, In : Journal of Clinical Pathology. 65, 3, p. 248-253 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

C 60 fullerene derivatized nanoparticles and their application to therapeutics

Lin, C-M. & Lu, T. Y., Jun 2012, In : Recent Patents on Nanotechnology. 6, 2, p. 105-113 9 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

HuR cytoplasmic expression is associated with increased cyclin A expression and poor outcome with upper urinary tract urothelial carcinoma

Liang, P. I., Li, W. M., Wang, Y. H., Wu, T. F., Wu, W. R., Liao, A. C., Shen, K. H., Wei, Y. C., Hsing, C-H., Shiue, Y. L., Huang, H. Y., Hsu, H. P., Chen, L. T., Lin, C. Y., Tai, C., Lin, C-M. & Li, C. F., Dec 21 2012, In : BMC Cancer. 12, 611.

Research output: Contribution to journalArticle

28 Citations (Scopus)
24 Citations (Scopus)
2011

A potent sphingomyelinase inhibitor from Cordyceps mycelia contributes its cytoprotective effect against oxidative stress in macrophages

Wang, S. H., Yang, W. B., Liu, Y. C., Chiu, Y. H., Chen, C. T., Kao, P. F. & Lin, C. M., Mar 2011, In : Journal of Lipid Research. 52, 3, p. 471-479 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

C 60 fullerene nanoparticle prevents β-amyloid peptide induced cytotoxicity in neuro 2A cells

Lu, T. Y., Kao, P. F., Lee, C-M., Huang, S. T. & Lin, C. M., Jun 2011, In : Journal of Food and Drug Analysis. 19, 2

Research output: Contribution to journalArticle

7 Citations (Scopus)

C60 fullerene-pentoxifylline dyad nanoparticles enhance autophagy to avoid cytotoxic effects caused by the β-amyloid peptide

Lee, C-M., Huang, S. T., Huang, S. H., Lin, H. W., Tsai, H. P., Wu, J. Y., Lin, C. M. & Chen, C. T., Feb 2011, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 7, 1, p. 107-114 8 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Cloning of crystallin from orange-spotted grouper and characterization of its activity as potential protective agent

Chen, Y. M., Kuo, C. E., Lin, C. M., Shiea, P. S. & Chen, T. Y., 2011, In : Results in Immunology. 1, 1, p. 60-69 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Development of a sensitive long-wavelength fluorogenic probe for nitroreductase: A new fluorimetric indictor for analyte determination by dehydrogenase-coupled biosensors

Huang, H. C., Wang, K. L., Huang, S. T., Lin, H. Y. & Lin, C. M., Apr 15 2011, In : Biosensors and Bioelectronics. 26, 8, p. 3511-3516 6 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis

Huang, W. C., Tsai, C. C., Chen, C. L., Chen, T. Y., Chen, Y. P., Lin, Y. S., Lu, P. J., Lin, C. M., Wang, S. H., Tsao, C. W., Wang, C. Y., Cheng, Y. L., Hsieh, C. Y., Tseng, P. C. & Lin, C. F., Oct 2011, In : FASEB Journal. 25, 10, p. 3661-3673 13 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Inhibition of AMPK-associated autophagy enhances caffeic acid phenethyl ester-induced cell death in C6 glioma cells

Yu, S. H., Kao, Y. T., Wu, J. Y., Huang, S. H., Huang, S. T., Lee, C-M., Cheng, K. T. & Lin, C. M., 2011, In : Planta Medica. 77, 9, p. 907-914 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

One-pot synthesis of luotonin A and its analogues

Tseng, M. C., Chu, Y. W., Tsai, H. P., Lin, C. M., Hwang, J. & Chu, Y. H., Mar 4 2011, In : Organic Letters. 13, 5, p. 920-923 4 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)
2010
8 Citations (Scopus)

Immobilizing topoisomerase I on a surface plasmon resonance biosensor chip to screen for inhibitors

Tsai, H. P., Lin, L. W., Lai, Z. Y., Wu, J. Y., Chen, C. E., Hwang, J., Chen, C. S. & Lin, C. M., 2010, In : Journal of Biomedical Science. 17, 1, 49.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The synthesis and optical characterization of novel iminocoumarin derivatives

Huang, S. T., Jian, J. L., Peng, H. Z., Wang, K. L., Lin, C. M., Huang, C. H. & Yang, T. C. K., Jun 2010, In : Dyes and Pigments. 86, 1, p. 6-14 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2009

Evodiamine stabilizes topoisomerase I-DNA cleavable complex to inhibit topoisomerase I activity

Chan, A. L. F., Chang, W. S., Chen, L. M., Lee, C. M., Chen, C. E., Lin, C. M. & Hwang, J. L., Apr 2009, In : Molecules. 14, 4, p. 1342-1352 11 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Hydrophilic ester-bearing chlorogenic acid binds to a novel domain to inhibit xanthine oxidase

Wang, S. H., Chen, C. S., Huang, S. H., Yu, S. H., Lai, Z. Y., Huang, S. T. & Lin, C. M., 2009, In : Planta Medica. 75, 11, p. 1237-1240 4 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Primary urothelial carcinoma of the upper tract: Important clinicopathological factors predicting bladder recurrence after surgical resection

Huang, W. W., Huang, H. Y., Liao, A. C., Shiue, Y. L., Tai, H. L., Lin, C. M., Wang, Y. H., Lin, C. N., Shen, K. H. & Li, C. F., Sep 2009, In : Pathology International. 59, 9, p. 642-649 8 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)
2008

Antioxidant and flavor properties of Angelica sinensis extracts as affected by processing

Huang, S. H., Chen, C. C., Lin, C. M. & Chiang, B. H., Aug 2008, In : Journal of Food Composition and Analysis. 21, 5, p. 402-409 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Development and biological evaluation of C60 fulleropyrrolidine-thalidomide dyad as a new anti-inflammation agent

Huang, S. T., Ho, C. S., Lin, C. M., Fang, H. W. & Peng, Y. X., Sep 15 2008, In : Bioorganic and Medicinal Chemistry. 16, 18, p. 8619-8626 8 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Protective effects of Angelica sinensis extract on amyloid β-peptide-induced neurotoxicity

Huang, S. H., Lin, C. M. & Chiang, B. H., Sep 3 2008, In : Phytomedicine. 15, 9, p. 710-721 12 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Structure-activity relationship of coumarin derivatives on xanthine oxidase-inhibiting and free radical-scavenging activities

Lin, H. C., Tsai, S. H., Chen, C. S., Chang, Y. C., Lee, C. M., Lai, Z. Y. & Lin, C. M., Mar 15 2008, In : Biochemical Pharmacology. 75, 6, p. 1416-1425 10 p.

Research output: Contribution to journalArticle

144 Citations (Scopus)

Synthesis and anti-inflammation evaluation of new C60 fulleropyrrolidines bearing biologically active xanthine

Huang, S. T., Liao, J. S., Fang, H. W. & Lin, C. M., Jan 1 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 1, p. 99-103 5 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2007

Structure-activity relationship of C6-C3 phenylpropanoids on xanthine oxidase-inhibiting and free radical-scavenging activities

Chang, Y. C., Lee, F. W., Chen, C. S., Huang, S. T., Tsai, S. H., Huang, S. H. & Lin, C. M., Dec 1 2007, In : Free Radical Biology and Medicine. 43, 11, p. 1541-1551 11 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)