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Research Output

  • 409 Citations
  • 11 h-Index
  • 28 Article
2020

AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis

Chen, T. C., Chuang, J. Y., Ko, C. Y., Kao, T. J., Yang, P. Y., Yu, C. H., Liu, M. S., Hu, S. L., Tsai, Y. T., Chan, H., Chang, W. C. & Hsu, T. I., Feb 1 2020, In : Redox Biology. 30, p. 101413 101413.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2019
Open Access
2 Citations (Scopus)

CYP17A1 maintains the survival of glioblastomas by regulating SAR1-mediated endoplasmic reticulum health and redox homeostasis

Lin, H. Y., Ko, C. Y., Kao, T. J., Yang, W. B., Tsai, Y. T., Chuang, J. Y., Hu, S. L., Yang, P. Y., Lo, W. L. & Hsu, T. I., Sep 2019, In : Cancers. 11, 9, 1378.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
4 Citations (Scopus)
2018

Astrocytic CCAAT/Enhancer-binding protein delta contributes to reactive oxygen species formation in neuroinflammation

Wang, S. M., Lim, S. W., Wang, Y. H., Lin, H. Y., Lai, M. D., Ko, C. Y. & Wang, J. M., Jun 1 2018, In : Redox Biology. 16, p. 104-112 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Highly sensitive/selective 3D nanostructured immunoparticle-based interface on a multichannel sensor array for detecting amyloid-beta in Alzheimer's disease

Liu, T. C., Lee, Y. C., Ko, C. Y., Liu, R. S., Ke, C. C., Lo, Y. C., Hong, P. S., Chu, C. Y., Chang, C. W., Wu, P. W., Chen, Y. Y. & Chen, S. Y., Jan 1 2018, In : Theranostics. 8, 15, p. 4210-4225 16 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
6 Citations (Scopus)
2017

Bortezomib-induced miRNAs direct epigenetic silencing of locus genes and trigger apoptosis in leukemia

Chu, Y. Y., Ko, C. Y., Wang, S. M., Lin, P. I., Wang, H. Y., Lin, W. C., Wu, D. Y., Wang, L. H. & Wang, J. M., Nov 9 2017, In : Cell death & disease. 8, 11, p. e3167

Research output: Contribution to journalArticle

5 Citations (Scopus)

Dengue virus infection increases microglial cell migration

Jhan, M. K., Tsai, T. T., Chen, C. L., Tsai, C. C., Cheng, Y. L., Lee, Y. C., Ko, C. Y., Lin, Y. S., Chang, C. P., Lin, L. T. & Lin, C. F., Jan 1 2017, In : Scientific Reports. 7, 1, 91.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Distinct roles and differential expression levels of Wnt5a mRNA isoforms in colorectal cancer cells

Huang, T. C., Lee, P. T., Wu, M. H., Huang, C. C., Ko, C. Y., Lee, Y. C., Lin, D. Y., Cheng, Y. W. & Lee, K. H., Aug 1 2017, In : PLoS One. 12, 8, e0181034.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma, which is independent of O6-methylguanine-DNA methyltransferase

Chang, K. Y., Hsu, T. I., Hsu, C. C., Tsai, S. Y., Liu, J. J., Chou, S. W., Liu, M. S., Liou, J. P., Ko, C. Y., Chen, K. Y., Hung, J. J., Chang, W. C., Chuang, C. K., Kao, T. J. & Chuang, J. Y., Oct 1 2017, In : Redox Biology. 13, p. 655-664 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2016

Astrocytic CCAAT/Enhancer-Binding Protein Delta Contributes to Glial Scar Formation and Impairs Functional Recovery After Spinal Cord Injury

Wang, S. M., Hsu, J. Y. C., Ko, C. Y., Chiu, N. E., Kan, W. M., Lai, M. D. & Wang, J. M., Nov 1 2016, In : Molecular Neurobiology. 53, 9, p. 5912-5927

Research output: Contribution to journalArticle

7 Citations (Scopus)

Astrocytic CCAAT/Enhancer Binding Protein δ Regulates Neuronal Viability and Spatial Learning Ability via miR-135a

Chu, Y. Y., Ko, C. Y., Wang, W. J., Wang, S. M., Gean, P. W., Kuo, Y. M. & Wang, J. M., 2016, In : Molecular Neurobiology.

Research output: Contribution to journalArticle

11 Citations (Scopus)

IL-18-induced interaction between IMP3 and HuR contributes to COX-2 mRNA stabilization in acute myeloid leukemia

Ko, C. Y., Wang, W. L., Li, C. F., Jeng, Y. M., Chu, Y. Y., Wang, H. Y., Tseng, J. T. & Wang, J. M., Jan 1 2016, In : Journal of Leukocyte Biology. 99, 1, p. 131-141 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Suberoylanilide hydroxamic acid represses glioma stem-like cells

Hsu, C. C., Chang, W-C., Hsu, T-I., Liu, J. J., Yeh, S. H., Wang, J-Y., Liou, J-P., Ko, C-Y., Chang, K. Y. & Chuang, J-Y., Nov 18 2016, In : Journal of Biomedical Science. 23, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2015

Biological roles of CCAAT/enhancer-binding protein delta during inflammation

Ko, C. Y., Chang, W. C. & Wang, J. M., Jan 16 2015, In : Journal of Biomedical Science. 22, 1, 6.

Research output: Contribution to journalArticle

26 Citations (Scopus)

HMDB and 5-AzadC combination reverses tumor suppressor CCAAT/enhancer-binding protein delta to strengthen the death of liver cancer cells

Li, C. F., Tsai, H. H., Ko, C. Y., Pan, Y. C., Yen, C. J., Lai, H. Y., Yuh, C. H., Wu, W. C. & Wang, J. M., Nov 1 2015, In : Molecular Cancer Therapeutics. 14, 11, p. 2623-2633 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The CCAAT/enhancer-binding protein delta/miR135a/thrombospondin 1 axis mediates PGE2-induced angiogenesis in Alzheimer's disease

Ko, C. Y., Chu, Y. Y., Narumiya, S., Chi, J. Y., Furuyashiki, T., Aoki, T., Wang, S. M., Chang, W. C. & Wang, J. M., Mar 1 2015, In : Neurobiology of Aging. 36, 3, p. 1356-1368 13 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2014

Glycogen synthase kinase-3β-mediated CCAAT/enhancer-binding protein delta phosphorylation in astrocytes promotes migration and activation of microglia/macrophages

Ko, C. Y., Wang, W. L., Wang, S. M., Chu, Y. Y., Chang, W. C. & Wang, J. M., Jan 2014, In : Neurobiology of Aging. 35, 1, p. 24-34 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Increase of Zinc Finger Protein 179 in Response to CCAAT/Enhancer Binding Protein Delta Conferring an Antiapoptotic Effect in Astrocytes of Alzheimer’s Disease

Wang, S. M., Lee, Y. C., Ko, C. Y., Lai, M. D., Lin, D. Y., Pao, P. C., Chi, J. Y., Hsiao, Y. W., Liu, T. L. & Wang, J. M., 2014, In : Molecular Neurobiology. 51, 1, p. 370-382 13 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

The combination of the prodrugs perforin-CEBPD and perforin-granzyme B efficiently enhances the activation of caspase signaling and kills prostate cancer

Chuang, C. H., Wang, W. J., Li, C. F., Ko, C-Y., Chou, Y. H., Chuu, C. P., Cheng, T. L. & Wang, J. M., 2014, In : Cell Death and Disease. 5, 5, e1220.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2012

CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells

Ko, C. Y., Chang, L. H., Lee, Y. C., Sterneck, E., Cheng, C. P., Chen, S. H., Huang, A. M., Tseng, J. T. & Wang, J. M., Feb 2012, In : Neurobiology of Aging. 33, 2

Research output: Contribution to journalArticle

36 Citations (Scopus)
2010

CEBPD reverses RB/E2F1-mediated gene repression and participates in HMDB-induced apoptosis of cancer cells

Pan, Y. C., Li, C. F., Ko, C. Y., Pan, M. H., Chen, P. J., Tseng, J. T., Wu, W. C., Chang, W. C., Huang, A. M., Sterneck, E. & Wang, J. M., Dec 1 2010, In : Clinical Cancer Research. 16, 23, p. 5770-5780 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2008

Epigenetic silencing of CCAAT/enhancer-binding protein δ activity by YY1/polycomb group/DNA methyltransferase complex

Ko, C. Y., Hsu, H. C., Shen, M. R., Chang, W. C. & Wang, J. M., Nov 7 2008, In : Journal of Biological Chemistry. 283, 45, p. 30919-30932 14 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

HDAC1/HDAC3 modulates PPARG2 transcription through the sumoylated CEBPD in hepatic lipogenesis

Lai, P. H., Wang, W. L., Ko, C. Y., Lee, Y. C., Yang, W. M., Shen, T. W., Chang, W. C. & Wang, J. M., Oct 2008, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1783, 10, p. 1803-1814 12 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
2006

Functional role of NF-IL6β and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene

Wang, J. M., Ko, C. Y., Chen, L. C., Wang, W. L. & Chang, W. C., Jan 2006, In : Nucleic Acids Research. 34, 1, p. 217-231 15 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)