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Research Output 1999 2019

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Article
2019

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Shen, T. J., Jhan, M. K., Kao, J. C., Ho, M. R., Tsai, T. T., Tseng, P-C., Wang, Y. T. & Lin, C-F., 2019, In : Journal of Visualized Experiments.

Research output: Contribution to journalArticle

Viral Encephalitis
Dengue Virus
Viruses
Severe Dengue
Arboviruses
Ionizing radiation
Ionizing Radiation
Interferons
Cytotoxicity
STAT1 Transcription Factor
2 Citations (Scopus)

Functional neutralization of anti-IFN-γ autoantibody in patients with nontuberculous mycobacteria infection

Krisnawati, D. I., Liu, Y. C., Lee, Y. J., Wang, Y. T., Chen, C. L., Tseng, P. C. & Lin, C. F., Apr 5 2019, In : Scientific Reports. 9, 1, p. 5682 5682.

Research output: Contribution to journalArticle

Open Access
Nontuberculous Mycobacterium Infections
Autoantibodies
Interferons
Serum
Chemokines

HECT E3 Ubiquitin Ligase-Regulated Txnip Degradation Facilitates TLR2-Mediated Inflammation During Group A Streptococcal Infection

Tseng, P-C., Kuo, C-F., Cheng, M-H., Wan, S-W., Lin, C-F., Chang, C-P., Lin, Y-S., Wu, J-J., Huang, C-C. & Chen, C-L., 2019, In : Frontiers in Immunology. 10, p. 2147 1 p.

Research output: Contribution to journalArticle

Streptolysin S induces mitochondrial damage and macrophage death through inhibiting degradation of glycogen synthase kinase-3β in Streptococcus pyogenes infection

Tsao, N., Kuo, C. F., Cheng, M. H., Lin, W. C., Lin, C. F. & Lin, Y. S., Dec 1 2019, In : Scientific Reports. 9, 1, 5371.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Streptococcus pyogenes
Streptococcus
Macrophages
Infection
2018
4 Citations (Scopus)

Anti-TNF-α restricts dengue virus-induced neuropathy

Jhan, M. K., Huangfu, W. C., Chen, Y. F., Kao, J. C., Tsai, T. T., Ho, M. R., Shen, T. J., Tseng, P. C., Wang, Y. T. & Lin, C. F., Jan 1 2018, (Accepted/In press) In : Journal of Leukocyte Biology.

Research output: Contribution to journalArticle

Dengue Virus
Encephalitis
Virus Diseases
Dengue
Neurons
1 Citation (Scopus)

Autophagy regulates vinorelbine sensitivity due to continued Keap1-mediated ROS generation in lung adenocarcinoma cells

Wu, Y-W., Lin, C-F., Lin, Y-S., Su, W-C. & Chiu, W-H., 2018, In : Cell Death Discovery. 5, p. 33

Research output: Contribution to journalArticle

Autophagy
Antioxidant Response Elements
Apoptosis
Drug Therapy
Physiological Stress
9 Citations (Scopus)
Protein-Tyrosine Kinases
Disease-Free Survival
Cytotoxic T-Lymphocytes
Bevacizumab
Myeloid-Derived Suppressor Cells
4 Citations (Scopus)

S100A9+ MDSC and TAM-mediated EGFR-TKI resistance in lung adenocarcinoma: The role of RELB

Feng, P. H., Yu, C. T., Chen, K. Y., Luo, C. S., Wu, S. M., Liu, C. Y., Kuo, L. W., Chan, Y. F., Chen, T. T., Chang, C. C., Lee, C. N., Chuang, H. C., Lin, C. F., Han, C. L., Lee, W. H. & Lee, K. Y., Jan 26 2018, In : Oncotarget. 9, 7, p. 7631-7643 13 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Macrophages
Microarray Analysis
Blood Cells
Alveolar Macrophages

Signaling of Macrophage Inflammatory Protein (MIP)-3β Facilitates Dengue Virus-Induced Microglial Cell Migration

Jhan, M-K., Shen, T-J., Tseng, P-C., Wang, Y-T. & Lin, C-F., Dec 1 2018, In : Viruses. 10, 12

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
Dengue Virus
Cell Movement
Conditioned Culture Medium
JNK Mitogen-Activated Protein Kinases
8 Citations (Scopus)

The antiparasitic drug niclosamide inhibits dengue virus infection by interfering with endosomal acidification independent of mTOR

Kao, J. C., HuangFu, W. C., Tsai, T. T., Ho, M. R., Jhan, M. K., Shen, T. J., Tseng, P. C., Wang, Y. T. & Lin, C. F., Aug 1 2018, In : PLoS Neglected Tropical Diseases. 12, 8, e0006715.

Research output: Contribution to journalArticle

Niclosamide
Antiparasitic Agents
Dengue Virus
Virus Diseases
Sirolimus
2017
16 Citations (Scopus)

AR-12 suppresses dengue virus replication by down-regulation of PI3K/AKT and GRP78

Chen, H., Chen, C. C., Lin, Y. S., Chang, P. C., Lu, Z. Y., Lin, C. F., Chen, C. L. & Chang, C. P., Jun 1 2017, In : Antiviral Research. 142, p. 158-168 11 p.

Research output: Contribution to journalArticle

Dengue Virus
Virus Replication
Phosphatidylinositol 3-Kinases
Down-Regulation
Virus Diseases
10 Citations (Scopus)

Blockade of dengue virus infection and viral cytotoxicity in neuronal cells in vitro and in vivo by targeting endocytic pathways

Ho, M. R., Tsai, T. T., Chen, C. L., Jhan, M. K., Tsai, C. C., Lee, Y. C., Chen, C. H. & Lin, C. F., Dec 1 2017, In : Scientific Reports. 7, 1, 7023.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Clathrin
Vacuolar Proton-Translocating ATPases
Endocytosis
9 Citations (Scopus)

Dengue virus infection increases microglial cell migration

Jhan, M. K., Tsai, T. T., Chen, C. L., Tsai, C. C., Cheng, Y. L., Lee, Y. C., Ko, C. Y., Lin, Y. S., Chang, C. P., Lin, L. T. & Lin, C. F., Jan 1 2017, In : Scientific Reports. 7, 1, 91.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Cell Movement
Clathrin
Viral RNA
1 Citation (Scopus)
Mycobacterium kansasii
Sinus Histiocytosis
Mycobacterium Infections
Autoantibodies
Interferons
15 Citations (Scopus)

Exophagy of annexin A2 via RAB11, RAB8A and RAB27A in IFN-γ-stimulated lung epithelial cells

Chen, Y. D., Fang, Y. T., Cheng, Y. L., Lin, C. F., Hsu, L. J., Wang, S. Y., Anderson, R., Chang, C. P. & Lin, Y. S., Dec 1 2017, In : Scientific Reports. 7, 1, 5676.

Research output: Contribution to journalArticle

Annexin A2
Annexins
Epithelial Cells
Lung
Multivesicular Bodies
4 Citations (Scopus)

Galectin-3 inhibits galectin-8/parkin- mediated ubiquitination of group A streptococcus

Cheng, Y. L., Wu, Y. W., Kuo, C. F., Lu, S. L., Liu, F. T., Anderson, R., Lin, C. F., Liu, Y. L., Wang, W. Y., Chen, Y. D., Zheng, P. X., Wu, J. J. & Lin, Y. S., Jul 1 2017, In : mBio. 8, 4, e00899-17.

Research output: Contribution to journalArticle

Galectins
Galectin 3
Ubiquitination
Streptococcus
Endothelial Cells
12 Citations (Scopus)

Reactive oxygen species are required for zoledronic acid-induced apoptosis in osteoclast precursors and mature osteoclast-like cells

Tai, T. W., Chen, C. Y., Su, F. C., Tu, Y. K., Tsai, T. T., Lin, C. F. & Jou, I. M., Mar 10 2017, In : Scientific Reports. 7, 44245.

Research output: Contribution to journalArticle

zoledronic acid
Osteoclasts
Reactive Oxygen Species
Apoptosis
Glycogen Synthase Kinase 3
3 Citations (Scopus)

S100A10 Regulates ULK1 Localization to ER–Mitochondria Contact Sites in IFN-γ-Triggered Autophagy

Chen, Y. D., Fang, Y. T., Chang, C. P., Lin, C. F., Hsu, L. J., Wu, S. R., Chiu, Y. C., Anderson, R. & Lin, Y. S., Jan 6 2017, In : Journal of Molecular Biology. 429, 1, p. 142-157 16 p.

Research output: Contribution to journalArticle

Autophagy
Annexin A2
High Mobility Group Proteins
Annexins
Autophagosomes
3 Citations (Scopus)

Targeting heat shock factor 1 as an antiviral strategy against dengue virus replication in vitro and in vivo

Tsai, T. T., Chen, C. L., Tsai, C. C. & Lin, C. F., Sep 1 2017, In : Antiviral Research. 145, p. 44-53 10 p.

Research output: Contribution to journalArticle

Dengue Virus
Virus Replication
Antiviral Agents
Shock
Hot Temperature
10 Citations (Scopus)

Therapeutic effects of monoclonal antibody against dengue virus NS1 in a STAT1 knockout mouse model of dengue infection

Wan, S. W., Chen, P. W., Chen, C. Y., Lai, Y. C., Chu, Y. T., Hung, C. Y., Lee, H., Wu, H. F., Chuang, Y. C., Lin, J., Chang, C. P., Wang, S., Liu, C. C., Ho, T. S., Lin, C. F., Lee, C. K., Wu-Hsieh, B. A., Anderson, R., Yeh, T. M. & Lin, Y. S., Oct 15 2017, In : Journal of Immunology. 199, 8, p. 2834-2844 11 p.

Research output: Contribution to journalArticle

Dengue Virus
Dengue
Therapeutic Uses
Knockout Mice
Monoclonal Antibodies
2016
17 Citations (Scopus)

Activation of Nrf2 by the dengue virus causes an increase in CLEC5A, which enhances TNF-α production by mononuclear phagocytes

Cheng, Y. L., Lin, Y. S., Chen, C. L., Tsai, T. T., Tsai, C. C., Wu, Y. W., Ou, Y. D., Chu, Y. Y., Wang, J. M., Yu, C. Y. & Lin, C. F., Aug 26 2016, In : Scientific Reports. 6, 32000.

Research output: Contribution to journalArticle

Dengue Virus
Phagocytes
Tumor Necrosis Factor-alpha
Virus Diseases
Toll-Like Receptor 3
9 Citations (Scopus)
Galectin 3
Interferons
Stomach Neoplasms
Signal Transduction
Glycogen Synthase Kinase 3
10 Citations (Scopus)

Anti-dengue virus nonstructural protein 1 antibodies contribute to platelet phagocytosis by macrophages

Wan, S. W., Yang, Y. W., Chu, Y. T., Lin, C. F., Chang, C. P., Yeh, T. M., Anderson, R. & Lin, Y. S., 2016, In : Thrombosis and Haemostasis. 115, 3, p. 646-656 11 p.

Research output: Contribution to journalArticle

Dengue Virus
Phagocytosis
Blood Platelets
Macrophages
Antibodies
9 Citations (Scopus)

Effectiveness and Mechanism of Preoperative Lugol Solution for Reducing Thyroid Blood Flow in Patients with Euthyroid Graves' Disease

Huang, S. M., Liao, W. T., Lin, C. F., Sun, H. S. & Chow, N. H., Mar 1 2016, In : World Journal of Surgery. 40, 3, p. 505-509 5 p.

Research output: Contribution to journalArticle

Graves Disease
Thyroid Gland
Interleukin-16
Vascular Endothelial Growth Factor A
Thyrotoxicosis
9 Citations (Scopus)

Glycogen synthase kinase-3β and caspase-2 mediate ceramide-And etoposide-induced apoptosis by regulating the lysosomal-mitochondrial axis

Lin, C. F., Tsai, C. C., Huang, W. C., Wang, Y. C., Tseng, P. C., Tsai, T. T. & Chen, C. L., Jan 4 2016, In : PLoS One. 11, 1, e0145460.

Research output: Contribution to journalArticle

caspase-2
Caspase 2
Glycogen Synthase Kinase 3
cathepsin D
Cathepsin D
5 Citations (Scopus)
Autophagy
Interferons
DNA Damage
Cell Death
Epithelial Cells
27 Citations (Scopus)

Microglia retard dengue virus-induced acute viral encephalitis

Tsai, T. T., Chen, C. L., Lin, Y. S., Chang, C. P., Tsai, C. C., Cheng, Y. L., Huang, C. C., Ho, C. J., Lee, Y. C., Lin, L. T., Jhan, M. K. & Lin, C. F., Jun 9 2016, In : Scientific Reports. 6, 27670.

Research output: Contribution to journalArticle

Viral Encephalitis
Dengue Virus
Microglia
Virus Diseases
Cytotoxic T-Lymphocytes
3 Citations (Scopus)

Oxidative stress facilitates IFN-γ-induced mimic extracellular trap cell death in A549 lung epithelial cancer cells

Lin, C-F., Chen, C-L., Chien, S. Y., Tseng, P. C., Wang, Y. C. & Tsai, T. T., Aug 1 2016, In : PLoS One. 11, 8, e0162157.

Research output: Contribution to journalArticle

Oxidative stress
Cell death
cell death
reactive oxygen species
Reactive Oxygen Species
1 Citation (Scopus)

Streptococcal pyrogenic exotoxin B inhibits apoptotic cell clearance by macrophages through protein S cleavage

Chen, C. L., Wu, Y. Y., Lin, C. F., Kuo, C. F., Han, C. L., Wang, S., Chuang, W. J., Chen, C. Y., Wu, J. J., Tsai, P. J., Liu, C. C. & Lin, Y. S., May 16 2016, In : Scientific Reports. 6, 26026.

Research output: Contribution to journalArticle

Protein S
Macrophages
streptopain
Streptococcus
Phagocytosis
2015
11 Citations (Scopus)

Anesthetic propofol overdose causes vascular hyperpermeability by reducing endothelial glycocalyx and ATP production

Lin, M. C., Lin, C-F., Li, C. F., Sun, D. P., Wang, L. Y. & Hsing, C-H., May 27 2015, In : International Journal of Molecular Sciences. 16, 6, p. 12092-12107 16 p.

Research output: Contribution to journalArticle

anesthetics
Glycocalyx
Anesthetics
adenosine triphosphate
Adenosinetriphosphate
6 Citations (Scopus)

An increase in glucosylceramide synthase induces BclxL-mediated cell survival in vinorelbine-resistant lung adenocarcinoma cells

Chiu, W. H., Su, W. C., Li, C. L., Chen, C. L. & Lin, C. F., 2015, In : Oncotarget. 6, 24, p. 20513-20524 12 p.

Research output: Contribution to journalArticle

ceramide glucosyltransferase
Cell Survival
Glucosylceramides
Ceramides
vinorelbine
7 Citations (Scopus)

Correlation between serum levels of anti-endothelial cell autoantigen and anti-dengue virus nonstructural protein 1 antibodies in dengue patients

Cheng, H. J., Luo, Y. H., Wan, S. W., Lin, C. F., Wang, S. T., Hung, N. T., Liu, C. C., Ho, T. S., Liu, H. S., Yeh, T. M. & Lin, Y. S., May 1 2015, In : American Journal of Tropical Medicine and Hygiene. 92, 5, p. 989-995 7 p.

Research output: Contribution to journalArticle

Dengue Virus
Dengue
Autoantigens
Protein Disulfide-Isomerases
Immunoglobulin M
6 Citations (Scopus)

Dengue Virus Infection Causes the Activation of Distinct NF- κ B Pathways for Inducible Nitric Oxide Synthase and TNF- Expression in RAW264.7 Cells

Cheng, Y-L., Lin, Y-S., Chen, C-L., Wan, S-W., Ou, Y-D., Yu, C-Y., Tsai, T-T., Tseng, P-C. & Lin, C. F., 2015, In : Mediators of Inflammation. 2015, 274025.

Research output: Contribution to journalArticle

Dengue Virus
Nitric Oxide Synthase Type II
Virus Diseases
Nitric Oxide
Viral Proteins
3 Citations (Scopus)

Detection of reactive oxygen species during the cell cycle under normal culture conditions using a modified fixed-sample staining method

Hsieh, C. Y., Chen, C. L., Yang, K. C., Ma, C. T., Choi, P. C. & Lin, C. F., Mar 4 2015, In : Journal of Immunoassay and Immunochemistry. 36, 2, p. 149-161 13 p.

Research output: Contribution to journalArticle

Cell culture
Reactive Oxygen Species
Cell Cycle
Cells
Staining and Labeling
21 Citations (Scopus)

Enterovirus 71 proteins 2A and 3D antagonize the antiviral activity of gamma interferon via signaling attenuation

Wang, L. C., Chen, S. O., Chang, S. P., Lee, Y. P., Yu, C. K., Chen, C. L., Tseng, P. C., Hsieh, C. Y., Chen, S. H. & Lin, C. F., 2015, In : Journal of Virology. 89, 14, p. 7028-7037 10 p.

Research output: Contribution to journalArticle

Enterovirus
interferons
interferon-gamma
Interferons
Interferon-gamma
41 Citations (Scopus)

Kallistatin protects against sepsis-related acute lung injury via inhibiting inflammation and apoptosis

Lin, W. C., Chen, C. W., Huang, Y. W., Chao, L., Chao, J., Lin, Y. S. & Lin, C. F., Jul 22 2015, In : Scientific Reports. 5, 12463.

Research output: Contribution to journalArticle

Acute Lung Injury
Sepsis
Apoptosis
Inflammation
Bronchoalveolar Lavage Fluid
5 Citations (Scopus)

Loss of PTEN causes SHP2 activation, making lung cancer cells unresponsive to IFN-γ

Chen, C-L., Chiang, T-H., Tseng, P-C., Wang, Y-C. & Lin, C. F., Oct 23 2015, In : Biochemical and Biophysical Research Communications. 466, 3, p. 578-584 7 p.

Research output: Contribution to journalArticle

Interferons
Lung Neoplasms
Chemical activation
Cells
Cell proliferation
4 Citations (Scopus)

Phosphorylation of glycogen synthase kinase-3β in metabolically abnormal obesity affects immune stimulation-induced cytokine production

Yen, C. L., Chao, W. C., Wu, C-H., Huang, Y-F., Chang, C. S., Tsai, Y. S., Lin, C. F. & Shieh, C. C., Feb 11 2015, In : International Journal of Obesity. 39, 2, p. 270-278 9 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Obesity
Phosphorylation
Cytokines
Leukocytes
6 Citations (Scopus)

Propofol treatment inhibits constitutive apoptosis in human primary neutrophils and granulocyte-differentiated human HL60 cells

Hsing, C-H., Chen, C-L., Lin, W-C. & Lin, C-F., Jun 10 2015, In : PLoS One. 10, 6, e0129693.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
HL-60 Cells
Propofol
granulocytes
Granulocytes
2014
19 Citations (Scopus)

Activation of p38 MAPK-regulated Bcl-xL signaling increases survival against zoledronic acid-induced apoptosis in osteoclast precursors

Tai, T. W., Su, F. C., Chen, C. Y., Jou, I. M. & Lin, C. F., 2014, In : Bone. 67, p. 166-174 9 p.

Research output: Contribution to journalArticle

zoledronic acid
p38 Mitogen-Activated Protein Kinases
Osteoclasts
Apoptosis
Survival
7 Citations (Scopus)

An increase in integrin-linked kinase non-canonically confers NF-κB-mediated growth advantages to gastric cancer cells by activating ERK1/2

Tseng, P-C., Chen, C-L., Shan, Y-S., Chang, W-T., Liu, H-S., Hong, T-M., Hsieh, C-Y., Lin, S-H. & Lin, C-F., 2014, In : Cell Communication and Signaling. 12, p. 69 1 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Cells
Growth
Cell growth
Chemical activation
61 Citations (Scopus)

Annexin A2: Its molecular regulation and cellular expression in cancer development

Wang, C. Y. & Lin, C. F., 2014, In : Disease Markers. 2014, 308976.

Research output: Contribution to journalArticle

Annexin A2
Annexins
Neoplasms
Post Translational Protein Processing
Drug Resistance
23 Citations (Scopus)

Antibody-Dependent Enhancement Infection Facilitates Dengue Virus-Regulated Signaling of IL-10 Production in Monocytes

Tsai, T-T., Chuang, Y-J., Lin, Y-S., Chang, C-P., Wan, S-W., Lin, S-H., Chen, C-L. & Lin, C. F., 2014, In : PLoS Neglected Tropical Diseases. 8, 11

Research output: Contribution to journalArticle

Antibody-Dependent Enhancement
Dengue Virus
Interleukin-10
Monocytes
1-Phosphatidylinositol 4-Kinase
17 Citations (Scopus)

Autophagy facilitates antibody-enhanced dengue virus infection in human pre-basophil/mast cells

Fang, Y. T., Wan, S. W., Lu, Y. T., Yao, J. H., Lin, C. F., Hsu, L. J., Brown, M. G., Marshall, J. S., Anderson, R. & Lin, Y. S., Oct 16 2014, In : PLoS One. 9, 10, 110655.

Research output: Contribution to journalArticle

Dengue virus
Dengue Virus
basophils
Basophils
autophagy
11 Citations (Scopus)

Autophagy facilitates cytokine-induced ICAM-1 expression

Wang, C-Y., Chiang, T-H., Chen, C-L., Tseng, P-C., Chien, S-Y., Chuang, Y-J., Yang, T-T., Hsieh, C-Y., Choi, P-C. & Lin, C. F., Feb 2014, In : Innate Immunity. 20, 2, p. 200-213 14 p.

Research output: Contribution to journalArticle

Autophagy
Intercellular Adhesion Molecule-1
Cytokines
SH2 Domain-Containing Protein Tyrosine Phosphatases
U937 Cells
20 Citations (Scopus)

Helicobacter pylori infection activates Src homology-2 domain-containing phosphatase 2 to suppress IFN-γ signaling

Wang, Y-C., Chen, C-L., Sheu, B-S., Yang, Y-J., Tseng, P-C., Hsieh, C-Y. & Lin, C. F., Oct 15 2014, In : Journal of Immunology. 193, 8, p. 4149-4158 10 p.

Research output: Contribution to journalArticle

SH2 Domain-Containing Protein Tyrosine Phosphatases
Helicobacter Infections
Helicobacter pylori
Cytotoxins
Stomach
7 Citations (Scopus)

Inhibiting glucosylceramide synthase facilitates the radiosensitizing effects of vinorelbine in lung adenocarcinoma cells

Chiu, W. H., Chen, H. H. W., Chang, J. Y., Luo, S. J., Li, C. L., Chen, C. L., Su, W. C. & Lin, C. F., Jul 28 2014, In : Cancer Letters. 349, 2, p. 144-151 8 p.

Research output: Contribution to journalArticle

ceramide glucosyltransferase
Radiation-Sensitizing Agents
Chemoradiotherapy
Apoptosis
Non-Small Cell Lung Carcinoma
13 Citations (Scopus)

Macrophage migration inhibitory factor triggers chemotaxis of CD74+CXCR2+NKT cells in chemically induced IFN-γ-Mediated skin inflammation

Hsieh, C-Y., Chen, C-L., Lin, Y-S., Yeh, T-M., Tsai, T-T., Hong, M-Y. & Lin, C. F., Oct 1 2014, In : Journal of Immunology. 193, 7, p. 3693-3703 11 p.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Natural Killer T-Cells
Chemotaxis
Inflammation
Skin
25 Citations (Scopus)

Panton-valentine leukocidin facilitates the escape of staphylococcus aureus from human keratinocyte endosomes and induces apoptosis

Chi, C. Y., Lin, C. C., Liao, I. C., Yao, Y. C., Shen, F. C., Liu, C. C. & Lin, C. F., Jan 15 2014, In : Journal of Infectious Diseases. 209, 2, p. 224-235 12 p.

Research output: Contribution to journalArticle

Endosomes
Keratinocytes
Methicillin-Resistant Staphylococcus aureus
Staphylococcus aureus
Apoptosis