If you made any changes in Pure these will be visible here soon.

Research Output 1992 2019

  • 1212 Citations
  • 21 h-Index
  • 62 Article
2019

Expression of AHI1 Rescues Amyloidogenic Pathology in Alzheimer’s Disease Model Cells

Ting, L. L., Lu, H. T., Yen, S. F., Ngo, T. H., Tu, F. Y., Tsai, I. S., Tsai, Y. H., Chang, F. Y., Li, X. J., Li, S., Lee, C. K., Kao, S. H., Kuo, Y. M. & Lin, Y. F., Jan 1 2019, In : Molecular Neurobiology.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Alzheimer Disease
Pathology
Amyloid
Protein C
1 Citation (Scopus)

Ganglioside Hp-s1 Analogue Inhibits Amyloidogenic Toxicity in Alzheimer's Disease Model Cells

Tsai, Y. F., Yang, D. J., Ngo, T. H., Shih, C. H., Wu, Y. F., Lee, C. K., Phraekanjanavichid, V., Yen, S. F., Kao, S. H., Lee, H. M., Huang, V. S., Shieh, J. C. C. & Lin, Y. F., Jan 16 2019, In : ACS Chemical Neuroscience. 10, 1, p. 528-536 9 p.

Research output: Contribution to journalArticle

Gangliosides
Amyloid beta-Protein Precursor
Toxicity
Alzheimer Disease
Cells
Lipolysis
Cyclic AMP-Dependent Protein Kinases
Adipocytes
Protein Kinases
Lipase
2018
4 Citations (Scopus)
Apolipoproteins
Lysine
Immunoglobulin M
Alzheimer Disease
Peptides

Melanogenesis inhibitors from the rhizoma of ligusticum sinense in B16-f10 melanoma cells in vitro and zebrafish in vivo

Cheng, M. C., Lee, T. H., Chu, Y. T., Syu, L. L., Hsu, S. J., Cheng, C. H., Wu, J. & Lee, C. K., Dec 1 2018, In : International Journal of Molecular Sciences. 19, 12, 3994.

Research output: Contribution to journalArticle

Ligusticum
Experimental Melanomas
ferulic acid
Cosmetics
Zebrafish

New terpenoids from Chamaecyparis formosensis (Cupressaceae) leaves with modulatory activity on matrix metalloproteases 2 and 9

Chang, M. L., Mei, H. C., Kuo, I. C., Hsiao, G., Kuo, Y. H. & Lee, C. K., Mar 7 2018, In : Molecules. 23, 3, 604.

Research output: Contribution to journalArticle

Chamaecyparis
Cupressaceae
Terpenes
Metalloproteases
leaves
2017

Chemical composition and antioxidant, bactericidal, and matrix metalloproteinase inhibition activity of food-related plant

Chen, C. H., Chang, T. C., Chen, S. Y., Hsu, S. J., Huang, H. W. & Lee, C. K., Sep 1 2017, In : LWT - Food Science and Technology. 82, p. 411-419 9 p.

Research output: Contribution to journalArticle

Edible Plants
gelatinase A
xanthine oxidase
metalloproteinases
Matrix Metalloproteinases
2016
13 Citations (Scopus)

Angiogenesis Inhibitors and Anti-Inflammatory Agents from Phoma sp. NTOU4195

Lee, M. S., Wang, S. W., Wang, G. J., Pang, K. L., Lee, C. K., Kuo, Y. H., Cha, H. J., Lin, R. K. & Lee, T. H., Dec 23 2016, In : Journal of Natural Products. 79, 12, p. 2983-2990 8 p.

Research output: Contribution to journalArticle

Angiogenesis Inhibitors
Macrophages
Endothelial cells
Inhibitory Concentration 50
Lipopolysaccharides
2 Citations (Scopus)

Anti-MMP-2 Activity and Skin-Penetrating Capability of the Chemical Constituents from Rhodiola rosea

Lee, T-H., Hsu, C. C., Hsiao, G., Fang, J. Y., Liu, W. M. & Lee, C. K., May 1 2016, In : Planta Medica. 82, 8, p. 698-704

Research output: Contribution to journalArticle

Rhodiola
Matrix Metalloproteinase 2
Matrix Metalloproteinases
Skin
Collagenases
1 Citation (Scopus)

Antiobesity and antihyperlipidaemic effects of Yan-Sheng-Yin in animals and humans

Wu, C. H., Pan, C. H., Lee, C. K., Sheu, M. J., Liu, F. C., Wang, G. J. & Wu, C. H., Jun 1 2016, In : Journal of Functional Foods. 24, p. 173-182 10 p.

Research output: Contribution to journalArticle

Hypolipidemic Agents
atherogenesis
hyperlipidemia
Hyperlipidemias
Atherosclerosis
2015
6 Citations (Scopus)
PPAR alpha
AMP-Activated Protein Kinases
Lipolysis
Adipocytes
Fatty Acids
2014
8 Citations (Scopus)

Carbamazepine attenuates inducible nitric oxide synthase expression through Akt inhibition in activated microglial cells

Wang, C. H., Hsiao, C. J., Lin, Y. N., Wu, J. W., Kuo, Y. C., Lee, C. K. & Hsiao, G., Nov 1 2014, In : Pharmaceutical Biology. 52, 11, p. 1451-1459 9 p.

Research output: Contribution to journalArticle

Carbamazepine
Nitric Oxide Synthase Type II
Lipopolysaccharides
Cyclooxygenase 2
Reactive Oxygen Species
5 Citations (Scopus)

Two new acidic diterpenoids from the heartwood of pinus massoniana LAMB.

Mohamed, H. A., Hsieh, C. L., Hsu, C., Kuo, C. C., Chang, H. S., Lee, C. K., Lee, T. H., Wu, J. B., Chang, C. I. & Kuo, Y. H., 2014, In : Helvetica Chimica Acta. 97, 8, p. 1146-1151 6 p.

Research output: Contribution to journalArticle

Pinus
Diterpenes
Trientine
acids
Acids
2013
2 Citations (Scopus)

Aconitamide, a novel alkaloid from the roots of Aconitum carmichaeli

Li, Z-H., Chen, Y. C., Lee, C. K., Chang, H. S., Kuo, C. C., Chao, C. Y., Lin, J. J., Lo, L. C. & Kuo, Y. H., 2013, In : Natural Product Communications. 8, 6, p. 827-828 2 p.

Research output: Contribution to journalArticle

Aconitum
telomerase
Far East
Telomerase
Chinese Traditional Medicine
8 Citations (Scopus)

Determination of nimetazepam and 7-aminonimetazepam in human urine by using liquid chromatography-tandem mass spectrometry

Wang, K. C., Cheng, M. C., Hsieh, C. L., Hsu, J. F., Wu, J. D. & Lee, C. K., Jan 10 2013, In : Forensic Science International. 224, 1-3, p. 84-89 6 p.

Research output: Contribution to journalArticle

nimetazepam
Nitrazepam
Tandem Mass Spectrometry
Liquid Chromatography
Urine
7 Citations (Scopus)

Extracts of Koelreuteria henryi Dummer induce apoptosis and autophagy by inhibiting dihydrodiol dehydrogenase, thus enhancing anticancer effects

Chiang, Y. Y., Wang, S. L., Yang, C. L., Yang, H. Y., Yang, H. C., Sudhakar, J. N., Lee, C. K., Huang, H. W., Chen, C. M., Chiou, S. H., Chiang, S. F., Fang, H. Y., Chen, C. Y., Shieh, S. H. & Chow, K. C., Sep 2013, In : International Journal of Molecular Medicine. 32, 3, p. 577-584 8 p.

Research output: Contribution to journalArticle

Autophagy
Apoptosis
Medicinal Plants
Drug Resistance
DNA Repair
4 Citations (Scopus)

Isolation and synthesis of a bioactive benzenoid derivative from the fruiting bodies of Antrodia camphorata

Chen, P. Y., Wu, J. D., Tang, K. Y., Yu, C. C., Kuo, Y. H., Zhong, W-B. & Lee, C. K., Jul 2013, In : Molecules. 18, 7, p. 7600-7608 9 p.

Research output: Contribution to journalArticle

Antrodia
activity (biology)
dioxides
cultured cells
isolation
10 Citations (Scopus)

Phyto-SERM constitutes from Flemingia macrophylla

Lai, W. C., Tsui, Y. T., Singab, A. N. B., El-Shazly, M., Du, Y. C., Hwang, T. L., Wu, C. C., Yen, M. H., Lee, C. K., Hou, M. F., Wu, Y. C. & Chang, F. R., 2013, In : International Journal of Molecular Sciences. 14, 8, p. 15578-15594 17 p.

Research output: Contribution to journalArticle

estrogens
Selective Estrogen Receptor Modulators
Phytoestrogens
Spectroscopic analysis
Genetically Modified Plants
2012
4 Citations (Scopus)

Heptadecanols from the leaves of Persea americana var. americana

Li, Z-H., Tsai, Y. F., Huang, T. T., Chen, P. Y., Liang, W. L. & Lee, C. K., May 15 2012, In : Food Chemistry. 132, 2, p. 921-924 4 p.

Research output: Contribution to journalArticle

Persea americana var. americana
Persea
Fruits
Fruit
chemical derivatives
8 Citations (Scopus)

Regulated expressions of MMP-2, -9 by diterpenoids from Euphorbia formosana hayata

Yu, C. C., Hsieh, C. R., Hsiao, G., Chen, P. Y., Chang, M. L., Yin, H. W., Li, Z-H. & Lee, C. K., Feb 2012, In : Molecules. 17, 2, p. 2082-2090 9 p.

Research output: Contribution to journalArticle

Abietane Diterpenes
Euphorbia
Diterpenes
Fibrosarcoma
gelatins
2011
32 Citations (Scopus)

Antimutagenic constituents of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) with potential cancer chemopreventive activity

Chen, H. H., Chiang, W., Chang, J. Y., Chien, Y. L., Lee, C. K., Liu, K. J., Cheng, Y. T., Chen, T. F., Kuo, Y. H. & Kuo, C. C., Jun 22 2011, In : Journal of Agricultural and Food Chemistry. 59, 12, p. 6444-6452 9 p.

Research output: Contribution to journalArticle

Coix
Coix lacryma-jobi
antimutagenic activity
hulls
neoplasms
21 Citations (Scopus)

Cytotoxic steroidal saponins from Agave sisalana

Chen, P. Y., Chen, C. H., Kuo, C. C., Li, Z-H., Kuo, Y. H. & Lee, C. K., 2011, In : Planta Medica. 77, 9, p. 929-933 5 p.

Research output: Contribution to journalArticle

Agave
Saponins
Sapogenins
Sugars
Nuclear magnetic resonance spectroscopy
3 Citations (Scopus)

Ficuschlorins A-D, lactone chlorins from the leaves of ficus microcarpa

Lin, H. Y., Chiu, H. L., Lan, Y. H., Tzeng, C. Y., Li, Z-H., Lee, C. K., Shao, Y. Y., Chen, C. R., Chang, C. I. & Kuo, Y. H., Sep 2011, In : Chemistry and Biodiversity. 8, 9, p. 1701-1708 8 p.

Research output: Contribution to journalArticle

Pheophytins
Ficus
Lactones
Nuclear magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
5 Citations (Scopus)

Ficusmicrochlorin A - C, two new methoxy lactone chlorins and an anhydride chlorin from the leaves of Ficus microcarpa

Lin, H. Y., Chiu, H. L., Lu, T. L., Tzeng, C. Y., Li, Z-H., Lee, C. K., Shao, Y. Y., Chen, C. R., Chang, C. I. & Kuo, Y. H., Jan 2011, In : Chemical and Pharmaceutical Bulletin. 59, 1, p. 113-116 4 p.

Research output: Contribution to journalArticle

Pheophytins
Ficus
Anhydrides
Lactones
Nuclear magnetic resonance
2010
5 Citations (Scopus)

Rapid identification of the antioxidant constituent of Koelreuteria henryi

Chen, C. H., Chena, P. Y., Wang, K. C. & Lee, C. K., 2010, In : Journal of the Chinese Chemical Society. 57, 3 A, p. 404-410 7 p.

Research output: Contribution to journalArticle

Antioxidants
Xanthine Oxidase
Assays
Scavenging
Quercetin
2009
10 Citations (Scopus)

A new flavonol galloylrhamnoside and a new lignan glucoside from the leaves of Koelreuteria henryi Dummer

Li, Z-H., Chiang, Y. H., Chen, C. H., Chen, P. Y. & Lee, C. K., Apr 2009, In : Journal of Natural Medicines. 63, 2, p. 209-214 6 p.

Research output: Contribution to journalArticle

Lignans
Glucosides
Glycosides
Aromatic compounds
Scavenging
48 Citations (Scopus)

Antioxidant activity of some plant extracts towards xanthine oxidase, lipoxygenase and tyrosinase

Chen, C. H., Chan, H. C., Chu, Y. T., Ho, H. Y., Chen, P. Y., Li, Z-H. & Lee, C. K., Aug 2009, In : Molecules. 14, 8, p. 2947-2958 12 p.

Research output: Contribution to journalArticle

xanthines
Lipoxygenase
Monophenol Monooxygenase
Xanthine Oxidase
oxidase
20 Citations (Scopus)

Constituents of Polyalthia longifolia var. pendula

Li, Z-H., Wang, M. J., Chen, P. Y., Wu, T. Y., Wen, W. C., Tsai, F. Y. & Lee, C. K., Nov 30 2009, In : Journal of Natural Products. 72, 11, p. 1960-1963 4 p.

Research output: Contribution to journalArticle

Polyalthia
Acids
Clerodane Diterpenes
MCF-7 Cells
Cytotoxicity
1 Citation (Scopus)

Determination of antioxidative properties of Morinda citrifolia using near supercritical fluid extraction

Chen, C. H., Lin, T. P., Chung, Y. L., Lee, C. K., Yeh, D. B. & Chen, S. Y., Oct 2009, In : Journal of Food and Drug Analysis. 17, 5

Research output: Contribution to journalArticle

Morinda
Morinda citrifolia
Supercritical Fluid Chromatography
supercritical fluid extraction
Antioxidants
7 Citations (Scopus)

Four new lignans with a bicyclo[3.3.1]nonadienemethanol skeleton from Cunninghamia lanceolata

Lee, C. K., Yeh, M. H., Li, Z-H., Chiu, H. L. & Kuo, Y. H., Oct 2009, In : Helvetica Chimica Acta. 92, 10, p. 1983-1989 7 p.

Research output: Contribution to journalArticle

Cunninghamia
Lignans
musculoskeletal system
Skeleton
Nuclear magnetic resonance
32 Citations (Scopus)

Isolation and immunomodulatory effect of homoisoflavones and flavones from Agave sisalana Perrine Ex Engelm

Chen, P. Y., Kuo, Y. C., Chen, C. H., Kuo, Y. H. & Lee, C. K., May 2009, In : Molecules. 14, 5, p. 1789-1795 7 p.

Research output: Contribution to journalArticle

Agave
Flavones
thymidine
Isoflavones
Spectroscopic analysis
2008
39 Citations (Scopus)

Flavonoids with iNOS inhibitory activity from Pogonatherum crinitum

Wang, G. J., Chen, Y. M., Li, Z-H., Lee, C. K., Chen, K. J. & Lee, T. H., Jun 19 2008, In : Journal of Ethnopharmacology. 118, 1, p. 71-78 8 p.

Research output: Contribution to journalArticle

Flavonoids
Nitric Oxide Synthase
Luteolin
Rutin
Traditional Medicine
47 Citations (Scopus)
glyphosate
Ion chromatography
Liquid chromatography
Herbicides
Diquat
7 Citations (Scopus)

Unexpected novel pheophytin peroxides from the leaves of Biden pilosa

Li, Z-H., Lu, C. K., Kuo, Y. H., Lo, J. M. & Lee, C. K., 2008, In : Helvetica Chimica Acta. 91, 1, p. 79-84 6 p.

Research output: Contribution to journalArticle

Bidens
Pheophytins
FORTRAN
Biosynthetic Pathways
Peroxides
2007
68 Citations (Scopus)

A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata

Li, Z-H., Lee, C. K., Tsou, W. L., Liu, S. Y., Kuo, M. T. & Wen, W. C., Oct 2007, In : Planta Medica. 73, 13, p. 1412-1415 4 p.

Research output: Contribution to journalArticle

Antrodia
Taiwanofungus camphoratus
Ubiquinone
Mycelium
Cytotoxins
21 Citations (Scopus)
Monophenol Monooxygenase
Melanocytes
Melanins
Biflavonoids
Messenger RNA
8 Citations (Scopus)

New lignans from the heartwood of Cunninghamia lanceolata

Li, Z-H., Yeh, M. H., Chang, C. I., Lee, C. K., Shao, Y. Y. & Kuo, Y. H., 2007, In : Bioscience, Biotechnology and Biochemistry. 71, 8, p. 2075-2078 4 p.

Research output: Contribution to journalArticle

Cunninghamia
Cunninghamia lanceolata
Lignans
heartwood
lignans
53 Citations (Scopus)

Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus

Wen, C. C., Kuo, Y. H., Jan, J. T., Liang, P. H., Wang, S. Y., Liu, H. G., Lee, C. K., Chang, S. T., Kuo, C. J., Lee, S. S., Hou, C. C., Hsiao, P. W., Chien, S. C., Shyur, L. F. & Yang, N. S., Aug 23 2007, In : Journal of Medicinal Chemistry. 50, 17, p. 4087-4095 9 p.

Research output: Contribution to journalArticle

Severe Acute Respiratory Syndrome
Coronavirus
Diterpenes
Terpenes
Antiviral Agents
2006
5 Citations (Scopus)

New constituents from the heartwood of Picea morrisonicola HAYATA

Li, Z-H., Yeh, M. H., Chang, C. I., Lee, C. K., Shao, Y. Y. & Kuo, Y. H., 2006, In : Chemical and Pharmaceutical Bulletin. 54, 5, p. 693-695 3 p.

Research output: Contribution to journalArticle

Picea
Lignans
Monoterpenes
Spectroscopic analysis
Derivatives
2005
29 Citations (Scopus)

Prorocentin, a new polyketide from the marine dinoflagellate Prorocentrum lima

Lu, C. K., Chou, H. N., Lee, C. K. & Li, Z-H., Sep 1 2005, In : Organic Letters. 7, 18, p. 3893-3896 4 p.

Research output: Contribution to journalArticle

trienes
Polyketides
Dinoflagellida
epoxidation
epoxy compounds
51 Citations (Scopus)

Separation and determination of chemical constituents in the roots of Rhus javanica L. var. roxburghiana

Li, Z-H., Chiou, J. L., Lee, C. K. & Kuo, Y. H., 2005, In : Journal of the Chinese Chemical Society. 52, 4, p. 833-841 9 p.

Research output: Contribution to journalArticle

Lignans
Cytotoxicity
Flavonoids
Spectrum analysis
Steroids
2004
43 Citations (Scopus)

New prenylated flavones from the roots of Ficus beecheyana

Lee, C. K., Lu, C. K., Kuo, Y. H., Chen, J. Z. & Sun, G. Z., Apr 2004, In : Journal of the Chinese Chemical Society. 51, 2, p. 437-441 5 p.

Research output: Contribution to journalArticle

Flavones
Flavanones
Vanillic Acid
Ficusin
Metabolites
2003
3 Citations (Scopus)

Chemical constituents from the roots of Cassia fistula L.

Lee, C. K., Chung, Y. Y., Hsu, F-L. & Kuo, Y. H., Aug 2003, In : Chinese Pharmaceutical Journal. 55, 4, p. 231-237 7 p.

Research output: Contribution to journalArticle

Emodin
Cassia
Catechin
Glycerol
Stigmasterol
2002
66 Citations (Scopus)

2,2′-Diphenyl-1-picrylhydrazyl radical-scavenging active components from adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) hulls

Kuo, C. C., Chiang, W., Liu, G. P., Chien, Y. L., Chang, J. Y., Lee, C. K., Lo, J. M., Huang, S. L., Shih, M. C. & Kuo, Y. H., Oct 9 2002, In : Journal of Agricultural and Food Chemistry. 50, 21, p. 5850-5855 6 p.

Research output: Contribution to journalArticle

Coix
Coix lacryma-jobi
1-Butanol
Scavenging
butanol
41 Citations (Scopus)

Five new phenolics from the roots of Ficus beecheyana

Li, Z-H., Kuo, Y. C., Wang, G. J., Kuo, Y. H., Chang, C. I., Lu, C. K. & Lee, C. K., Oct 1 2002, In : Journal of Natural Products. 65, 10, p. 1497-1500 4 p.

Research output: Contribution to journalArticle

Ficus
glycols
extracts
Ficus erecta
10 Citations (Scopus)

Inhibitory effects of glycosides from the leaves of Melaleuca quinquenervia on vascular contraction of rats

Lee, T. H., Wang, G. J., Lee, C. K., Kuo, Y. H. & Chou, C. H., 2002, In : Planta Medica. 68, 6, p. 492-496 5 p.

Research output: Contribution to journalArticle

Melaleuca
Melaleuca quinquenervia
cineole
Glycosides
endothelium
2001
19 Citations (Scopus)

Diterpenoids from the leaves of Juniperus chinensis var. kaizuka

Lee, C. K. & Cheng, Y. S., Apr 2001, In : Journal of Natural Products. 64, 4, p. 511-514 4 p.

Research output: Contribution to journalArticle

Juniperus chinensis
Juniperus
Diterpenes
diterpenoids
Abietane Diterpenes
46 Citations (Scopus)

The chemical constituents from the aril of Cassia fistula L.

Lee, C. K., Lee, P. H. & Kuo, Y. H., 2001, In : Journal of the Chinese Chemical Society. 48, 6 A, p. 1053-1058 6 p.

Research output: Contribution to journalArticle

Scopoletin
Chromones
Vanillic Acid
Emodin
Stigmasterol
7 Citations (Scopus)

Two new sesquiterpenes and two new lignans from the leaves of Juniperus chinensis var. kaizuka

Lee, C. K. & Cheng, Y. S., 2001, In : Journal of the Chinese Chemical Society. 48, 6 A, p. 1077-1080 4 p.

Research output: Contribution to journalArticle

ferulic acid
Luteolin
Lignans
Propane
Benzoic Acid
2000
9 Citations (Scopus)

Four new terpenes from the pericarp of Platycladus orientalis

Kuo, Y. H., Chen, W. C. & Lee, C. K., Jun 2000, In : Chemical and Pharmaceutical Bulletin. 48, 6, p. 766-768 3 p.

Research output: Contribution to journalArticle

Terpenes
Acids
Monoterpenes
Diterpenes