If you made any changes in Pure these will be visible here soon.

Research Output 2003 2019

  • 729 Citations
  • 15 h-Index
  • 34 Article
2019
3 Citations (Scopus)

Chloramphenicol induces autophagy and inhibits the hypoxia inducible factor-1 alpha pathway in non-small cell lung cancer cells

Hsu, H. L., Liao, P. L., Cheng, Y. W., Huang, S. H., Wu, C. H., Li, C. H. & Kang, J. J., Jan 1 2019, In : International Journal of Molecular Sciences. 20, 1, 157.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
hypoxia
Autophagy
Chloramphenicol
Non-Small Cell Lung Carcinoma
1 Citation (Scopus)

Glycemia Lowering Effect of an Aqueous Extract of Hedychium coronarium Leaves in Diabetic Rodent Models

Tse, L. S., Liao, P. L., Tsai, C. H., Li, C. H., Liao, J. W., Kang, J. J. & Cheng, Y. W., Mar 14 2019, In : Nutrients. 11, 3

Research output: Contribution to journalArticle

Open Access
Hedychium coronarium
Zingiberaceae
Type 2 Diabetes Mellitus
blood glucose
Rodentia
2018
1 Citation (Scopus)

Role of activating transcription factor 3 in fructose-induced metabolic syndrome in mice

Chou, C. L., Li, C. H., Lin, H., Liao, M. H., Wu, C. C., Chen, J. S., Sue, Y. M. & Fang, T. C., Aug 1 2018, In : Hypertension Research. 41, 8, p. 589-597 9 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Fructose
Knockout Mice
Diet
Blood Pressure
2 Citations (Scopus)

Safety assessment of the Cistanche tubulosa health food product Memoregain®: Genotoxicity and 28-day repeated dose toxicity test

Liao, P. L., Li, C. H., Tse, L. S., Kang, J. J. & Cheng, Y. W., Aug 1 2018, In : Food and Chemical Toxicology. 118, p. 581-588 8 p.

Research output: Contribution to journalArticle

Cistanche
Toxicity Tests
Salmonella
health foods
safety assessment
2017
15 Citations (Scopus)

Anti-inflammatory properties of shikonin contribute to improved early-stage diabetic retinopathy

Liao, P. L., Lin, C. H., Li, C. H., Tsai, C. H., Ho, J. D., Chiou, G. C. Y., Kang, J. J. & Cheng, Y. W., Mar 21 2017, In : Scientific Reports. 7, 44985.

Research output: Contribution to journalArticle

Diabetic Retinopathy
Anti-Inflammatory Agents
Retinal Pigments
Inbred C57BL Mouse
Glucose
12 Citations (Scopus)

Cytoplasmic aryl hydrocarbon receptor regulates glycogen synthase kinase 3 beta, accelerates vimentin degradation, and suppresses epithelial–mesenchymal transition in non-small cell lung cancer cells

Li, C. H., Liu, C. W., Tsai, C. H., Peng, Y. J., Yang, Y. H., Liao, P. L., Lee, C. C., Cheng, Y. W. & Kang, J. J., May 1 2017, In : Archives of Toxicology. 91, 5, p. 2165-2178 14 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Aryl Hydrocarbon Receptors
Vimentin
Non-Small Cell Lung Carcinoma
Cells
14 Citations (Scopus)

Periodic exposure to smartphone-mimic low-luminance blue light induces retina damage through Bcl-2/BAX-dependent apoptosis

Lin, C. H., Wu, M. R., Li, C. H., Cheng, H. W., Huang, S. H., Tsai, C. H., Lin, F. L., Ho, J. D., Kang, J. J., Hsiao, G. & Cheng, Y. W., May 1 2017, In : Toxicological Sciences. 157, 1, p. 196-210 15 p.

Research output: Contribution to journalArticle

Smartphones
Retina
Luminance
Apoptosis
Light
12 Citations (Scopus)

The inhibition of lung cancer cell migration by AhR-regulated autophagy

Tsai, C. H., Li, C. H., Cheng, Y. W., Lee, C. C., Liao, P. L., Lin, C. H., Huang, S. H. & Kang, J. J., Feb 14 2017, In : Scientific Reports. 7, 41927.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Autophagy
Cell Movement
Lung Neoplasms
Epithelial-Mesenchymal Transition
2016
10 Citations (Scopus)

Ligand independent aryl hydrocarbon receptor inhibits lung cancer cell invasion by degradation of Smad4

Lee, C. C., Yang, W. H., Li, C. H., Cheng, Y. W., Tsai, C. H. & Kang, J. J., Jul 1 2016, In : Cancer Letters. 376, 2, p. 211-217 7 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Lung Neoplasms
Ligands
Proteasome Endopeptidase Complex
Carcinogenesis
2015
32 Citations (Scopus)

Gold nanoparticles increase endothelial paracellular permeability by altering components of endothelial tight junctions, and increase blood-brain barrier permeability in mice

Li, C. H., Shyu, M. K., Jhan, C., Cheng, Y. W., Tsai, C. H., Liu, C. W., Lee, C. C., Chen, R. M. & Kang, J. J., Nov 1 2015, In : Toxicological Sciences. 148, 1, p. 192-203 12 p., kfv176.

Research output: Contribution to journalArticle

Tight Junctions
Endothelial cells
Blood-Brain Barrier
Gold
Nanoparticles
5 Citations (Scopus)

Long-term Fluorometholone Topical Use Induces Ganglion Cell Damage in Rats Analyzed With Optical Coherence Tomography

Lin, C. H., Liao, P. L., Hsiao, G., Li, C. H., Huang, S. H., Tsai, C. H., Wu, M. R., Lin, F. L., Ho, J. D., Cheng, H. W. & Cheng, Y. W., Oct 1 2015, In : Toxicological Sciences. 147, 2, p. 317-325 9 p., kfv132.

Research output: Contribution to journalArticle

Fluorometholone
Optical tomography
Optical Coherence Tomography
Ganglia
Rats
9 Citations (Scopus)

NcoA2-dependent inhibition of HIF-1α activation is regulated via AhR

Tsai, C. H., Li, C. H., Liao, P. L., Cheng, Y. W., Lin, C. H., Huang, S. H. & Kang, J. J., Dec 1 2015, In : Toxicological Sciences. 148, 2, p. 517-530 14 p., kfv199.

Research output: Contribution to journalArticle

Nuclear Receptor Coactivator 2
Hypoxia-Inducible Factor 1
Aryl Hydrocarbon Receptors
Chemical activation
Aryl Hydrocarbon Receptor Nuclear Translocator
2014
11 Citations (Scopus)

Minocycline accelerates hypoxia-inducible factor-1 alpha degradation and inhibits hypoxia-induced neovasculogenesis through prolyl hydroxylase, von Hippel-Lindau-dependent pathway

Li, C. H., Liao, P. L., Yang, Y. T., Huang, S. H., Lin, C. H., Cheng, Y. W. & Kang, J. J., Mar 2014, In : Archives of Toxicology. 88, 3, p. 659-671 13 p.

Research output: Contribution to journalArticle

Prolyl Hydroxylases
Hypoxia-Inducible Factor 1
Minocycline
Degradation
Tumors
45 Citations (Scopus)

Snail regulates Nanog status during the epithelial-mesenchymal transition via the Smad1/Akt/GSK3β signaling pathway in non-small-cell lung cancer

Liu, C. W., Li, C. H., Peng, Y. J., Cheng, Y. W., Chen, H. W., Liao, P. L., Kang, J. J. & Yeng, M. H., 2014, In : Oncotarget. 5, 11, p. 3880-3894 15 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Non-Small Cell Lung Carcinoma
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
Snails
Stem Cells
17 Citations (Scopus)

Zinc oxide nanoparticles impair bacterial clearance by macrophages

Lin, C. D., Kou, Y. Y., Liao, C. Y., Li, C. H., Huang, S. P., Cheng, Y. W., Liao, W. C., Chen, H. X., Wu, P. L., Kang, J. J., Lee, C. C. & Lai, C. H., Jul 1 2014, In : Nanomedicine. 9, 9, p. 1327-1339 13 p.

Research output: Contribution to journalArticle

Zinc Oxide
Macrophages
Zinc oxide
Nanoparticles
contagious disease
2013
17 Citations (Scopus)

Evaluation of acute 13-week subchronic toxicity and genotoxicity of the powdered root of Tongkat Ali (Eurycoma Longifolia Jack)

Li, C. H., Liao, J. W., Liao, P. L., Huang, W. K., Tse, L. S., Lin, C. H., Kang, J. J. & Cheng, Y. W., 2013, In : Evidence-based Complementary and Alternative Medicine. 2013, 102987.

Research output: Contribution to journalArticle

Eurycoma
Safety Management
No-Observed-Adverse-Effect Level
Urinalysis
Phosphocreatine
42 Citations (Scopus)
Macular Degeneration
Sirolimus
Phosphatidylinositol 3-Kinases
Vascular Endothelial Growth Factor A
Hypoxia-Inducible Factor 1
2012
9 Citations (Scopus)

Anti-ageing effects of alpha-naphthoflavone on normal and UVB-irradiated human skin fibroblasts

Liao, P. L., Li, C. H., Chang, C. Y., Lu, S. R., Lin, C. H., Tse, L. S. & Cheng, Y. W., Jul 2012, In : Experimental Dermatology. 21, 7, p. 546-548 3 p.

Research output: Contribution to journalArticle

Fibroblasts
Matrix Metalloproteinases
Skin
Collagen
Aging of materials
23 Citations (Scopus)

Motorcycle exhaust particles up-regulate expression of vascular adhesion molecule-1 and intercellular adhesion molecule-1 in human umbilical vein endothelial cells

Lee, C. C., Huang, S. H., Yang, Y. T., Cheng, Y. W., Li, C. H. & Kang, J. J., Jun 2012, In : Toxicology in Vitro. 26, 4, p. 552-560 9 p.

Research output: Contribution to journalArticle

Motorcycles
Endothelial cells
Human Umbilical Vein Endothelial Cells
Intercellular Adhesion Molecule-1
Vascular Cell Adhesion Molecule-1
128 Citations (Scopus)

Organ biodistribution, clearance, and genotoxicity of orally administered zinc oxide nanoparticles in mice

Li, C. H., Shen, C. C., Cheng, Y. W., Huang, S. H., Wu, C. C., Kao, C. C., Liao, J. W. & Kang, J. J., Nov 2012, In : Nanotoxicology. 6, 7, p. 746-756 11 p.

Research output: Contribution to journalArticle

Zinc Oxide
Zinc oxide
Nanoparticles
Liver
Tissue
29 Citations (Scopus)

Zinc oxide nanoparticles-induced intercellular adhesion molecule 1 expression requires Rac1/Cdc42, mixed lineage kinase 3, and c-Jun N-terminal kinase activation in endothelial cells

Li, C. H., Liao, P. L., Shyu, M. K., Liu, C. W., Kao, C. C., Huang, S. H., Cheng, Y. W. & Kang, J. J., 2012, In : Toxicological Sciences. 126, 1, p. 162-172 11 p.

Research output: Contribution to journalArticle

Zinc Oxide
JNK Mitogen-Activated Protein Kinases
Endothelial cells
Intercellular Adhesion Molecule-1
Cell Division
2010
14 Citations (Scopus)
1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Epidermal Growth Factor Receptor
Smooth Muscle Myocytes
Cell Movement
17 Citations (Scopus)

Benzo[a]pyrene inhibits angiogenic factors-induced αvβ3 integrin expression, neovasculogenesis, and angiogenesis in human umbilical vein endothelial cells

Li, C. H., Cheng, Y. W., Hsu, Y. T., Hsu, Y. J., Liao, P. L. & Kang, J. J., Dec 2010, In : Toxicological Sciences. 118, 2, p. 544-553 10 p., kfq279.

Research output: Contribution to journalArticle

Angiogenesis Inducing Agents
Benzo(a)pyrene
Endothelial cells
Human Umbilical Vein Endothelial Cells
Integrins
34 Citations (Scopus)

Chloramphenicol causes mitochondrial stress, decreases ATP biosynthesis, induces matrix metalloproteinase-13 expression, and solid-tumor cell invasion

Li, C. H., Cheng, Y. W., Liao, P. L., Yang, Y. T. & Kang, J. J., Mar 25 2010, In : Toxicological Sciences. 116, 1, p. 140-150 11 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 13
Biosynthesis
Chloramphenicol
Tumors
Adenosine Triphosphate

Safety assessment of musk substitute from nutria of Myocastor coypus in mice

Yu, W. C., Horng, Y. L., Shoei, S. L., Jun, W. L., Hui, W. C., Ching, H. L., Po, L. L. & Jaw, J. K., Dec 2010, In : Journal of Food and Drug Analysis. 18, 6, p. 380-390 11 p.

Research output: Contribution to journalArticle

Myocastor coypus
safety assessment
subacute toxicity
Safety
genotoxicity
14 Citations (Scopus)
Mitomycin
Phospholipids
CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
Mitochondria
Cell Death
2009
12 Citations (Scopus)

Cholesterol-3-beta, 5-alpha, 6-beta-triol induced PI3K-Akt-eNOS-dependent cyclooxygenase-2 expression in endothelial cells

Liao, P. L., Cheng, Y. W., Li, C. H., Lo, Y. L. & Kang, J. J., Oct 28 2009, In : Toxicology Letters. 190, 2, p. 172-178 7 p.

Research output: Contribution to journalArticle

Endothelial cells
Cyclooxygenase 2
Phosphatidylinositol 3-Kinases
Endothelial Cells
Phosphorylation
2006
22 Citations (Scopus)

Physiological and functional interactions between Tcf4 and Daxx in colon cancer cells

Tzeng, S. L., Cheng, Y. W., Li, C. H., Lin, Y. S., Hsu, H. C. & Kang, J. J., Jun 2 2006, In : Journal of Biological Chemistry. 281, 22, p. 15405-15411 7 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Colon
Cells
Yeast
Yeasts
2005
45 Citations (Scopus)

Chloramphenicol-induced mitochondrial stress increases p21 expression and prevents cell apoptosis through a p21-dependent pathway

Li, C. H., Tzeng, S. L., Cheng, Y. W. & Kang, J. J., Jul 15 2005, In : Journal of Biological Chemistry. 280, 28, p. 26193-26199 7 p.

Research output: Contribution to journalArticle

Mitomycin
Chloramphenicol
Chemical activation
Apoptosis
Caspase 3
2004
10 Citations (Scopus)

Activation and up-regulation of nitric oxide synthase in human umbilical vein endothelial cells by polycyclic aromatic hydrocarbons

Li, C. H., Lee, C. C., Cheng, Y. W., Juang, H. A. & Kang, J. J., Jul 15 2004, In : Toxicology Letters. 151, 2, p. 367-374 8 p.

Research output: Contribution to journalArticle

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole
Polycyclic Aromatic Hydrocarbons
Endothelial cells
Human Umbilical Vein Endothelial Cells
Polycyclic aromatic hydrocarbons
25 Citations (Scopus)

Genotoxicity of motorcycle exhaust particles in vivo and in vitro

Cheng, Y. W., Lee, W. W., Li, C. H., Lee, C. C. & Kang, J. J., Sep 2004, In : Toxicological Sciences. 81, 1, p. 103-111 9 p.

Research output: Contribution to journalArticle

Motorcycles
Chromosomes
Chromosome Aberrations
Micronucleus Tests
Tocopherols
41 Citations (Scopus)

Reactive oxygen species are crucial for hydroxychavicol toxicity toward KB epithelial cells

Jeng, J. H., Wang, Y. J., Chang, W. H., Wu, H. L., Li, C. H., Uang, B. J., Kang, J. J., Lee, J. J., Hahn, L. J., Lin, B. R. & Chang, M. C., Jan 2004, In : Cellular and Molecular Life Sciences. 61, 1, p. 83-96 14 p.

Research output: Contribution to journalArticle

Piper betle
KB Cells
Toxicity
Reactive Oxygen Species
Cell Cycle Checkpoints
2003
9 Citations (Scopus)
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole
Vasodilation
Endothelium
Calcium
Human Umbilical Vein Endothelial Cells
49 Citations (Scopus)

Induction of vasorelaxation through activation of nitric oxide synthase in endothelial cells by brazilin

Hu, C. M., Kang, J. J., Lee, C. C., Li, C. H., Liao, J. W. & Cheng, Y. W., May 2 2003, In : European Journal of Pharmacology. 468, 1, p. 37-45 9 p.

Research output: Contribution to journalArticle

Vasodilation
Nitric Oxide Synthase
Endothelial Cells
Guanosine Monophosphate
NG-Nitroarginine Methyl Ester