• 975 Citations
  • 14 h-Index
20122020

Research output per year

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Research Output

  • 975 Citations
  • 14 h-Index
  • 43 Article
  • 1 Review article

ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression

Shahi, P., Wang, C. Y., Lawson, D. A., Slorach, E. M., Lu, A., Yu, Y., Lai, M. D., Velozo, H. G. & Werb, Z., Mar 21 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 12, p. 3169-3174 6 p.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Voltage-gated calcium channels: Novel targets for cancer therapy

Phan, N. N., Wang, C. Y., Chen, C. F., Sun, Z., Lai, M. D. & Lin, Y. C., Jan 1 2017, In : Oncology Letters. 14, 2, p. 2059-2074 16 p.

Research output: Contribution to journalArticle

Open Access
33 Citations (Scopus)

The transcriptional repressor ZNF503/Zeppo2 promotes mammary epithelial cell proliferation and enhances cell invasion

Shahi, P., Slorach, E. M., Wang, C. Y., Chou, J., Lu, A., Ruderisch, A. & Werb, Z., Feb 6 2015, In : Journal of Biological Chemistry. 290, 6, p. 3803-3813 11 p.

Research output: Contribution to journalArticle

Open Access
20 Citations (Scopus)

Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer

Chen, W. C., Chang, Y. S., Hsu, H. P., Yen, M. C., Huang, H. L., Cho, C. Y., Wang, C. Y., Weng, T. Y., Lai, P. T., Chen, C. S., Lin, Y. J. & Lai, M. D., Jan 1 2015, In : Oncotarget. 6, 40, p. 42923-42937 15 p.

Research output: Contribution to journalArticle

Open Access
28 Citations (Scopus)

The novel regulations of MEF2A, CAMKK2, CALM3, and TNNI3 in ventricular hypertrophy induced by arsenic exposure in rats

Phan, N. N., Wang, C. Y. & Lin, Y. C., Oct 3 2014, In : Toxicology. 324, p. 123-135 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients

Wang, C-Y., Shahi, P., Huang, J. T. W., Phan, N. N., Sun, Z., Lin, Y-C., Lai, M-D. & Werb, Z., Jan 2017, In : Molecular and Clinical Oncology. 6, 1, p. 7-18 12 p.

Research output: Contribution to journalArticle

Systematic analysis of gene expression alterations and clinical outcomes for long-chain acyl-coenzyme A synthetase family in cancer

Chen, W. C., Wang, C. Y., Hung, Y. H., Weng, T. Y., Yen, M. C. & Lai, M. D., May 1 2016, In : PLoS ONE. 11, 5, e0155660.

Research output: Contribution to journalArticle

Open Access
41 Citations (Scopus)

Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells

Sun, Z., Wang, C. Y., Lawson, D. A., Kwek, S., Velozo, H. G., Owyong, M., Lai, M. D., Fong, L., Wilson, M., Su, H., Werb, Z. & Cooke, D. L., Jan 1 2018, In : Oncotarget. 9, 13, p. 10945-10961 17 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

Lawson, D. A., Bhakta, N. R., Kessenbrock, K., Prummel, K. D., Yu, Y., Takai, K., Zhou, A., Eyob, H., Balakrishnan, S., Wang, C. Y., Yaswen, P., Goga, A. & Werb, Z., Oct 1 2015, In : Nature. 526, 7571, p. 131-135 5 p.

Research output: Contribution to journalArticle

396 Citations (Scopus)

Silencing of argininosuccinate lyase inhibits colorectal cancer formation

Huang, H. L., Chen, W. C., Hsu, H. P., Cho, C. Y., Hung, Y. H., Wang, C. Y. & Lai, M. D., Jan 1 2017, In : Oncology Reports. 37, 1, p. 163-170 8 p.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth

Depeille, P., Henricks, L. M., Van De Ven, R. A. H., Lemmens, E., Wang, C. Y., Matli, M., Werb, Z., Haigis, K. M., Donner, D., Warren, R. & Roose, J. P., Jun 1 2015, In : Nature Cell Biology. 17, 6, p. 804-815 12 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

RasGRP1 is a potential biomarker for stratifying anti-EGFR therapy response in colorectal cancer

Gbenedio, O. M., Bonnans, C., Grun, D., Wang, C. Y., Hatch, A. J., Mahoney, M. R., Barras, D., Matli, M., Miao, Y., Christopher Garcia, K., Tejpar, S., Delorenzi, M., Venook, A. P., Nixon, A. B., Warren, R. S., Roose, J. P. & Depeille, P., Aug 8 2019, In : JCI insight. 4, 15, e127552.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

PSMB5 plays a dual role in cancer development and immunosuppression

Wang, C. Y., Li, C. Y., Hsu, H. P., Cho, C. Y., Yen, M. C., Weng, T. Y., Chen, W. C., Hung, Y. H., Lee, K. T., Hung, J. H., Chen, Y. L. & Lai, M. D., Jan 1 2017, In : American Journal of Cancer Research. 7, 11, p. 2103-2120 18 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

PODXL2 maintains cellular stemness and promotes breast cancer development through the Rac1/Akt pathway

Lin, Y. Y., Wang, C. Y., Phan, N. N., Chiao, C. C., Li, C. Y., Sun, Z., Hung, J. H., Chen, Y. L., Yen, M. C., Weng, T. Y., Hsu, H. P. & Lai, M. D., 2020, In : International Journal of Medical Sciences. 17, 11, p. 1639-1651 13 p.

Research output: Contribution to journalArticle

Open Access

Paeoniae radix reduces PDGF-stimulated hepatic stellate cell migration

Kuo, J. J., Wang, C. Y., Lee, T. F., Huang, Y. T. & Lin, Y. L., Mar 8 2012, In : Planta Medica. 78, 4, p. 341-348 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Optimization protein productivity of human interleukin-2 through codon usage, gene copy number and intracellular tRNA concentration in CHO cells

Ou, K. C., Wang, C. Y., Liu, K. T., Chen, Y. L., Chen, Y. C., Lai, M. D. & Yen, M. C., Nov 14 2014, In : Biochemical and Biophysical Research Communications. 454, 2, p. 347-352 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction

Thuy, T. D., Phan, N. N., Wang, C. Y., Yu, H. G., Wang, S. Y., Huang, P. L., Do, Y. Y. & Lin, Y. C., Jan 1 2017, In : Molecular Medicine Reports. 15, 5, p. 2949-2956 8 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Novel regulations of MEF2-A, MEF2-D, and CACNA1S in the functional incompetence of adipose-derived mesenchymal stem cells by induced indoxyl sulfate in chronic kidney disease

Thi Do, D., Phan, N. N., Wang, C. Y., Sun, Z. & Lin, Y. C., Dec 1 2016, In : Cytotechnology. 68, 6, p. 2589-2604 16 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Mutation of the PTCH1 gene predicts recurrence of breast cancer

Wang, C. Y., Chang, Y. C., Kuo, Y. L., Lee, K. T., Chen, P. S., Cheung, C. H. A., Chang, C. P., Phan, N. N., Shen, M. R. & Hsu, H. P., Dec 1 2019, In : Scientific Reports. 9, 1, 16359.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

MST3 promotes proliferation and tumorigenicity through the VAV2/Rac1 signal axis in breast cancer

Cho, C. Y., Lee, K. T., Chen, W. C., Wang, C. Y., Chang, Y. S., Huang, H. L., Hsu, H. P., Yen, M. C., Lai, M. Z. & Lai, M. D., Mar 22 2016, In : Oncotarget. 7, 12, p. 14586-14604 19 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy

Owyong, M., Chou, J., van den Bijgaart, R. J. E., Kong, N., Efe, G., Maynard, C., Talmi-Frank, D., Solomonov, I., Koopman, C., Hadler-Olsen, E., Headley, M., Lin, C., Wang, C. Y., Sagi, I., Werb, Z. & Plaks, V., Jan 1 2019, In : Life Science Alliance. 2, 6, e201800226.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Meta-analysis of public microarray datasets reveals voltage-gated calcium gene signatures in clinical cancer patients

Wang, C. Y., Lai, M. D., Phan, N. N., Sun, Z. & Lin, Y. C., Jul 6 2015, In : PLoS ONE. 10, 7, e0125766.

Research output: Contribution to journalArticle

Open Access
32 Citations (Scopus)

Matrix metalloproteinases in stem cell regulation and cancer

Kessenbrock, K., Wang, C. Y. & Werb, Z., May 1 2015, In : Matrix Biology. 44-46, p. 184-190 7 p.

Research output: Contribution to journalReview article

Open Access
113 Citations (Scopus)

LGR5 in breast cancer and ductal carcinoma in situ: a diagnostic and prognostic biomarker and a therapeutic target

Hagerling, C., Owyong, M., Sitarama, V., Wang, C. Y., Lin, C., van den Bijgaart, R. J. E., Koopman, C. D., Brenot, A., Nanjaraj, A., Wärnberg, F., Jirström, K., Klein, O. D., Werb, Z. & Plaks, V., Jun 10 2020, In : BMC Cancer. 20, 1, 1 p., 542.

Research output: Contribution to journalArticle

Open Access

Knockdown of serine/threonine-protein kinase 24 promotes tumorigenesis and myeloid-derived suppressor cell expansion in an orthotopic immunocompetent gastric cancer animal model

Hsu, H. P., Wang, C. Y., Hsieh, P. Y., Fang, J. H. & Chen, Y. L., Jan 1 2020, In : Journal of Cancer. 11, 1, p. 213-228 16 p.

Research output: Contribution to journalArticle

Open Access

Increased expression of secreted frizzled related protein 1 (SFRP1) predicts ampullary adenocarcinoma recurrence

Cheng, L. C., Chao, Y. J., Overman, M. J., Wang, C. Y., Phan, N. N., Chen, Y. L., Wang, T. W., Hsu, H. P., Shan, Y. S. & Lai, M. D., Dec 1 2020, In : Scientific Reports. 10, 1, 13255.

Research output: Contribution to journalArticle

Open Access

Immune effector monocyte–neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer

Hagerling, C., Gonzalez, H., Salari, K., Wang, C. Y., Lin, C., Robles, I., van Gogh, M., Dejmek, A., Jirström, K. & Werb, Z., Oct 22 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 43, p. 21704-21714 11 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation

Weng, T. Y., Wu, H. F., Li, C. Y., Hung, Y. H., Chang, Y. W., Chen, Y. L., Hsu, H. P., Chen, Y. H., Wang, C. Y., Chang, J. Y. & Lai, M. D., Dec 1 2018, In : Scientific Reports. 8, 1, 8216.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Gene signatures of SARS-CoV/SARS-CoV-2-infected ferret lungs in short- and long-term models

Liu, H. L., Yeh, I. J., Phan, N. N., Wu, Y. H., Yen, M. C., Hung, J. H., Chiao, C. C., Chen, C. F., Sun, Z., Jiang, J. Z., Hsu, H. P., Wang, C. Y. & Lai, M. D., Nov 2020, In : Infection, Genetics and Evolution. 85, 104438.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Gene signatures and potential therapeutic targets of amino acid metabolism in estrogen receptor-positive breast cancer

Wang, C-Y., Chiao, C-C., Phan, N. N., Li, C-Y., Sun, Z-D., Jiang, J-Z., Hung, J-H., Chen, Y-L., Yen, M-C., Weng, T-Y., Chen, W-C., Hsu, H-P. & Lai, M-D., 2020, In : American Journal of Cancer Research. 10, 1, p. 95-113 19 p.

Research output: Contribution to journalArticle

GATA3 targets semaphorin 3B in mammary epithelial cells to suppress breast cancer progression and metastasis

Shahi, P., Wang, C. Y., Chou, J., Hagerling, C., Gonzalez Velozo, H., Ruderisch, A., Yu, Y., Lai, M. D. & Werb, Z., Oct 5 2017, In : Oncogene. 36, 40, p. 5567-5575 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Fatty acid metabolic enzyme acyl-CoA thioesterase 8 promotes the development of hepatocellular carcinoma

Hung, Y. U. H., Chan, Y. I. S., Chang, Y. S., Lee, K. T., Hsu, H. P., Yen, M. C., Chen, W. C., Wang, C. Y. & Lai, M. D., Jan 1 2014, In : Oncology Reports. 31, 6, p. 2797-2803 7 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Endovascular Biopsy: In Vivo Cerebral Aneurysm Endothelial Cell Sampling and Gene Expression Analysis

Cooke, D. L., McCoy, D. B., Halbach, V. V., Hetts, S. W., Amans, M. R., Dowd, C. F., Higashida, R. T., Lawson, D., Nelson, J., Wang, C. Y., Kim, H., Werb, Z., McCulloch, C., Hashimoto, T., Su, H. & Sun, Z., Feb 1 2018, In : Translational Stroke Research. 9, 1, p. 20-33 14 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels

Sun, Z., Lawson, D. A., Sinclair, E., Wang, C. Y., Lai, M. D., Hetts, S. W., Higashida, R. T., Dowd, C. F., Halbach, V. V., Werb, Z., Su, H. & Cooke, D. L., Sep 1 2015, In : Biotechnology Reports. 7, p. 157-165 9 p., 106.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

DNA vaccine elicits an efficient antitumor response by targeting the mutant Kras in a transgenic mouse lung cancer model

Weng, T. Y., Yen, M. C., Huang, C. T., Hung, J. J., Chen, Y. L., Chen, W. C., Wang, C. Y., Chang, J. Y. & Lai, M. D., Jan 1 2014, In : Gene Therapy. 21, 10, p. 888-896 9 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Distinct expression of CDCA3, CDCA5, and CDCA8 leads to shorter relapse free survival in breast cancer patient

Phan, N. N., Wang, C. Y., Li, K. L., Chen, C. F., Chiao, C. C., Yu, H. G., Huang, P. L. & Lin, Y. C., Jan 1 2018, In : Oncotarget. 9, 6, p. 6977-6992 16 p.

Research output: Contribution to journalArticle

Open Access
27 Citations (Scopus)

Differential expression pattern of THBS1 and THBS2 in lung cancer: Clinical outcome and a systematic-analysis of microarray databases

Weng, T. Y., Wang, C. Y., Hung, Y. H., Chen, W. C., Chen, Y. L. & Lai, M. D., Aug 1 2016, In : PLoS ONE. 11, 8, e0161007.

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)

Cyclin D1 overexpression correlates with poor tumor differentiation and prognosis in gastric cancer

Shan, Y. S., Hsu, H. P., Lai, M. D., Hung, Y. H., Wang, C. Y., Yen, M. C. & Chen, Y. L., Jan 1 2017, In : Oncology Letters. 14, 4, p. 4517-4526 10 p.

Research output: Contribution to journalArticle

Open Access
21 Citations (Scopus)

Cancer stem cell marker CD90 inhibits ovarian cancer formation via β3 integrin

Chen, W. C., Hsu, H. P., Li, C. Y., Yang, Y. J., Hung, Y. H., Cho, C. Y., Wang, C. Y., Weng, T. Y. & Lai, M. D., Nov 1 2016, In : International Journal of Oncology. 49, 5, p. 1881-1889 9 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Cancer-derived transforming growth factor-β modulates tumor-associated macrophages in ampullary cancer

Cheng, L. C., Chao, Y. J., Wang, C. Y., Phan, N. N., Chen, Y. L., Wang, T. W., Hsu, H. P., Lin, Y. J., Shan, Y. S. & Lai, M. D., 2020, In : OncoTargets and Therapy. 13, p. 7503-7516 14 p.

Research output: Contribution to journalArticle

Open Access

Argininosuccinate lyase is a potential therapeutic target in breast cancer

Huang, H. L., Chen, W. C., Hsu, H. P., Cho, C. Y., Hung, Y. H., Wang, C. Y. & Lai, M. D., Dec 1 2015, In : Oncology Reports. 34, 6, p. 3131-3139 9 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Argininosuccinate lyase interacts with cyclin A2 in cytoplasm and modulates growth of liver tumor cells

Hung, Y. H., Huang, H. L., Chen, W. C., Yen, M. C., Cho, C. Y., Weng, T. Y., Wang, C. Y., Chen, Y. L., Chen, L. T. & Lai, M. D., Feb 1 2017, In : Oncology Reports. 37, 2, p. 969-978 10 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

A novel cancer therapeutic using thrombospondin 1 in dendritic cells

Weng, T. Y., Huang, S. S., Yen, M. C., Lin, C. C., Chen, Y. L., Lin, C. M., Chen, W. C., Wang, C. Y., Chang, J. Y. & Lai, M. D., Jan 1 2014, In : Molecular Therapy. 22, 2, p. 292-302 11 p.

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)

An HDAC inhibitor enhances cancer therapeutic efficiency of RNA polymerase III promoter-driven IDO shRNA

Yen, M. C., Weng, T. Y., Chen, Y. L., Lin, C. C., Chen, C. Y., Wang, C. Y., Chao, H. L., Chen, C. S. & Lai, M. D., Jun 1 2013, In : Cancer Gene Therapy. 20, 6, p. 351-357 7 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)