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Research Output 2012 2019

  • 732 Citations
  • 11 h-Index
  • 34 Article
  • 1 Review article
2019

Immune effector monocyte–neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer

Hagerling, C., Gonzalez, H., Salari, K., Wang, C. Y., Lin, C., Robles, I., van Gogh, M., Dejmek, A., Jirström, K. & Werb, Z., Oct 22 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 43, p. 21704-21714 11 p.

Research output: Contribution to journalArticle

Open Access
Monocytes
Neutrophils
Breast Neoplasms
Neoplasms
Lung
1 Citation (Scopus)

RasGRP1 is a potential biomarker for stratifying anti-EGFR therapy response in colorectal cancer

Gbenedio, O. M., Bonnans, C., Grun, D., Wang, C. Y., Hatch, A. J., Mahoney, M. R., Barras, D., Matli, M., Miao, Y., Christopher Garcia, K., Tejpar, S., Delorenzi, M., Venook, A. P., Nixon, A. B., Warren, R. S., Roose, J. P. & Depeille, P., Aug 8 2019, In : JCI insight. 4, 15, e127552.

Research output: Contribution to journalArticle

Open Access
Colorectal Neoplasms
Biomarkers
Therapeutics
Organoids
Drug Therapy
2018
11 Citations (Scopus)

Distinct expression of CDCA3, CDCA5, and CDCA8 leads to shorter relapse free survival in breast cancer patient

Phan, N. N., Wang, C. Y., Li, K. L., Chen, C. F., Chiao, C. C., Yu, H. G., Huang, P. L. & Lin, Y. C., Jan 1 2018, In : Oncotarget. 9, 6, p. 6977-6992 16 p.

Research output: Contribution to journalArticle

Open Access
Breast Neoplasms
Recurrence
Survival
cdc Genes
Genes
5 Citations (Scopus)

Endovascular Biopsy: In Vivo Cerebral Aneurysm Endothelial Cell Sampling and Gene Expression Analysis

Cooke, D. L., McCoy, D. B., Halbach, V. V., Hetts, S. W., Amans, M. R., Dowd, C. F., Higashida, R. T., Lawson, D., Nelson, J., Wang, C. Y., Kim, H., Werb, Z., McCulloch, C., Hashimoto, T., Su, H. & Sun, Z., Feb 1 2018, In : Translational Stroke Research. 9, 1, p. 20-33 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation

Weng, T. Y., Wu, H. F., Li, C. Y., Hung, Y. H., Chang, Y. W., Chen, Y. L., Hsu, H. P., Chen, Y. H., Wang, C. Y., Chang, J. Y. & Lai, M. D., Dec 1 2018, In : Scientific Reports. 8, 1, 8216.

Research output: Contribution to journalArticle

Open Access
Mutation
Neoplasms
B-Lymphocytes
Lung
Cytokines
6 Citations (Scopus)

Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells

Sun, Z., Wang, C. Y., Lawson, D. A., Kwek, S., Velozo, H. G., Owyong, M., Lai, M. D., Fong, L., Wilson, M., Su, H., Werb, Z. & Cooke, D. L., Jan 1 2018, In : Oncotarget. 9, 13, p. 10945-10961 17 p.

Research output: Contribution to journalArticle

Open Access
RNA Sequence Analysis
Transcriptome
Endothelial Cells
Breast Neoplasms
Genes
2017
7 Citations (Scopus)

Argininosuccinate lyase interacts with cyclin A2 in cytoplasm and modulates growth of liver tumor cells

Hung, Y. H., Huang, H. L., Chen, W. C., Yen, M. C., Cho, C. Y., Weng, T. Y., Wang, C. Y., Chen, Y. L., Chen, L. T. & Lai, M. D., Feb 1 2017, In : Oncology Reports. 37, 2, p. 969-978 10 p.

Research output: Contribution to journalArticle

Open Access
Cyclin A2
Argininosuccinate Lyase
Cultured Tumor Cells
Liver Neoplasms
Reverse Transcriptase Polymerase Chain Reaction
13 Citations (Scopus)

Cyclin D1 overexpression correlates with poor tumor differentiation and prognosis in gastric cancer

Shan, Y. S., Hsu, H. P., Lai, M. D., Hung, Y. H., Wang, C. Y., Yen, M. C. & Chen, Y. L., Jan 1 2017, In : Oncology Letters. 14, 4, p. 4517-4526 10 p.

Research output: Contribution to journalArticle

Open Access
Cyclin D1
Disease-Free Survival
Stomach Neoplasms
Cyclin D2
Stomach
10 Citations (Scopus)

GATA3 targets semaphorin 3B in mammary epithelial cells to suppress breast cancer progression and metastasis

Shahi, P., Wang, C. Y., Chou, J., Hagerling, C., Gonzalez Velozo, H., Ruderisch, A., Yu, Y., Lai, M. D. & Werb, Z., Oct 5 2017, In : Oncogene. 36, 40, p. 5567-5575 9 p.

Research output: Contribution to journalArticle

Semaphorins
Breast
Epithelial Cells
Breast Neoplasms
Neoplasm Metastasis
1 Citation (Scopus)

Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction

Thuy, T. D., Phan, N. N., Wang, C. Y., Yu, H. G., Wang, S. Y., Huang, P. L., Do, Y. Y. & Lin, Y. C., Jan 1 2017, In : Molecular Medicine Reports. 15, 5, p. 2949-2956 8 p.

Research output: Contribution to journalArticle

Open Access
Therapeutic Uses
Medical problems
Experimental Diabetes Mellitus
Cardiomegaly
Bioinformatics
3 Citations (Scopus)

PSMB5 plays a dual role in cancer development and immunosuppression

Wang, C. Y., Li, C. Y., Hsu, H. P., Cho, C. Y., Yen, M. C., Weng, T. Y., Chen, W. C., Hung, Y. H., Lee, K. T., Hung, J. H., Chen, Y. L. & Lai, M. D., Jan 1 2017, In : American Journal of Cancer Research. 7, 11, p. 2103-2120 18 p.

Research output: Contribution to journalArticle

Immunosuppression
Neoplasms
Proteasome Endopeptidase Complex
Computational Biology
Macrophages
6 Citations (Scopus)

Silencing of argininosuccinate lyase inhibits colorectal cancer formation

Huang, H. L., Chen, W. C., Hsu, H. P., Cho, C. Y., Hung, Y. H., Wang, C. Y. & Lai, M. D., Jan 1 2017, In : Oncology Reports. 37, 1, p. 163-170 8 p.

Research output: Contribution to journalArticle

Open Access
Neoplastic Gene Expression Regulation
Xenograft Model Antitumor Assays
Cyclin A2
Argininosuccinate Lyase
Neoplastic Cell Transformation

Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients

Wang, C-Y., Shahi, P., Huang, J. T. W., Phan, N. N., Sun, Z., Lin, Y-C., Lai, M-D. & Werb, Z., Jan 2017, In : Molecular and Clinical Oncology. 6, 1, p. 7-18 12 p.

Research output: Contribution to journalArticle

Achaete-Scute Complex Genome Region
Neoplasms
Colonic Neoplasms
Breast Neoplasms
Brain Neoplasms
22 Citations (Scopus)

Voltage-gated calcium channels: Novel targets for cancer therapy

Phan, N. N., Wang, C. Y., Chen, C. F., Sun, Z., Lai, M. D. & Lin, Y. C., Jan 1 2017, In : Oncology Letters. 14, 2, p. 2059-2074 16 p.

Research output: Contribution to journalArticle

Open Access
Calcium Channels
Genes
Neoplasms
Brain Neoplasms
Kidney Neoplasms
5 Citations (Scopus)

ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression

Shahi, P., Wang, C. Y., Lawson, D. A., Slorach, E. M., Lu, A., Yu, Y., Lai, M. D., Velozo, H. G. & Werb, Z., Mar 21 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 12, p. 3169-3174 6 p.

Research output: Contribution to journalArticle

Open Access
Down-Regulation
Breast Neoplasms
GATA3 Transcription Factor
Breast
Epithelial Cells
2016
10 Citations (Scopus)

Cancer stem cell marker CD90 inhibits ovarian cancer formation via β3 integrin

Chen, W. C., Hsu, H. P., Li, C. Y., Yang, Y. J., Hung, Y. H., Cho, C. Y., Wang, C. Y., Weng, T. Y. & Lai, M. D., Nov 1 2016, In : International Journal of Oncology. 49, 5, p. 1881-1889 9 p.

Research output: Contribution to journalArticle

Open Access
Xenograft Model Antitumor Assays
Thy-1 Antigens
Anoikis
Cultured Tumor Cells
Integrin beta3
16 Citations (Scopus)

Differential expression pattern of THBS1 and THBS2 in lung cancer: Clinical outcome and a systematic-analysis of microarray databases

Weng, T. Y., Wang, C. Y., Hung, Y. H., Chen, W. C., Chen, Y. L. & Lai, M. D., Aug 1 2016, In : PLoS ONE. 11, 8, e0161007.

Research output: Contribution to journalArticle

Open Access
Thrombospondin 1
lung neoplasms
Microarray Analysis
Microarrays
adenocarcinoma
10 Citations (Scopus)

MST3 promotes proliferation and tumorigenicity through the VAV2/Rac1 signal axis in breast cancer

Cho, C. Y., Lee, K. T., Chen, W. C., Wang, C. Y., Chang, Y. S., Huang, H. L., Hsu, H. P., Yen, M. C., Lai, M. Z. & Lai, M. D., Mar 22 2016, In : Oncotarget. 7, 12, p. 14586-14604 19 p.

Research output: Contribution to journalArticle

Cyclin D1
Phosphotransferases
Breast Neoplasms
Proline
Growth
3 Citations (Scopus)

Novel regulations of MEF2-A, MEF2-D, and CACNA1S in the functional incompetence of adipose-derived mesenchymal stem cells by induced indoxyl sulfate in chronic kidney disease

Thi Do, D., Phan, N. N., Wang, C. Y., Sun, Z. & Lin, Y. C., Dec 1 2016, In : Cytotechnology. 68, 6, p. 2589-2604 16 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Systematic analysis of gene expression alterations and clinical outcomes for long-chain acyl-coenzyme A synthetase family in cancer

Chen, W. C., Wang, C. Y., Hung, Y. H., Weng, T. Y., Yen, M. C. & Lai, M. D., May 1 2016, In : PLoS ONE. 11, 5, e0155660.

Research output: Contribution to journalArticle

Open Access
Coenzyme A Ligases
acyl coenzyme A
ligases
Gene expression
prognosis
2015
10 Citations (Scopus)

Argininosuccinate lyase is a potential therapeutic target in breast cancer

Huang, H. L., Chen, W. C., Hsu, H. P., Cho, C. Y., Hung, Y. H., Wang, C. Y. & Lai, M. D., Dec 1 2015, In : Oncology Reports. 34, 6, p. 3131-3139 9 p.

Research output: Contribution to journalArticle

Open Access
Neoplastic Gene Expression Regulation
Cyclin A2
Argininosuccinate Lyase
Cyclin A
Endoplasmic Reticulum Stress
4 Citations (Scopus)

Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels

Sun, Z., Lawson, D. A., Sinclair, E., Wang, C. Y., Lai, M. D., Hetts, S. W., Higashida, R. T., Dowd, C. F., Halbach, V. V., Werb, Z., Su, H. & Cooke, D. L., Sep 1 2015, In : Biotechnology Reports. 7, p. 157-165 9 p., 106.

Research output: Contribution to journalArticle

Open Access
100 Citations (Scopus)

Matrix metalloproteinases in stem cell regulation and cancer

Kessenbrock, K., Wang, C. Y. & Werb, Z., May 1 2015, In : Matrix Biology. 44-46, p. 184-190 7 p.

Research output: Contribution to journalReview article

Open Access
Neoplastic Stem Cells
Matrix Metalloproteinases
Neoplasms
Developmental Biology
Matrix Metalloproteinase Inhibitors
30 Citations (Scopus)

Meta-analysis of public microarray datasets reveals voltage-gated calcium gene signatures in clinical cancer patients

Wang, C. Y., Lai, M. D., Phan, N. N., Sun, Z. & Lin, Y. C., Jul 6 2015, In : PLoS ONE. 10, 7, e0125766.

Research output: Contribution to journalArticle

Open Access
Calcium Channels
Microarrays
meta-analysis
calcium channels
Meta-Analysis
21 Citations (Scopus)

RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth

Depeille, P., Henricks, L. M., Van De Ven, R. A. H., Lemmens, E., Wang, C. Y., Matli, M., Werb, Z., Haigis, K. M., Donner, D., Warren, R. & Roose, J. P., Jun 1 2015, In : Nature Cell Biology. 17, 6, p. 804-815 12 p.

Research output: Contribution to journalArticle

Epithelial Cells
Growth
Colorectal Neoplasms
Mutation
Epithelium
321 Citations (Scopus)

Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

Lawson, D. A., Bhakta, N. R., Kessenbrock, K., Prummel, K. D., Yu, Y., Takai, K., Zhou, A., Eyob, H., Balakrishnan, S., Wang, C. Y., Yaswen, P., Goga, A. & Werb, Z., Oct 1 2015, In : Nature. 526, 7571, p. 131-135 5 p.

Research output: Contribution to journalArticle

Single-Cell Analysis
Stem Cells
Breast Neoplasms
Neoplasm Metastasis
Neoplasms
16 Citations (Scopus)

Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer

Chen, W. C., Chang, Y. S., Hsu, H. P., Yen, M. C., Huang, H. L., Cho, C. Y., Wang, C. Y., Weng, T. Y., Lai, P. T., Chen, C. S., Lin, Y. J. & Lai, M. D., Jan 1 2015, In : Oncotarget. 6, 40, p. 42923-42937 15 p.

Research output: Contribution to journalArticle

Open Access
Xenograft Model Antitumor Assays
Thy-1 Antigens
CD Antigens
Molecular Targeted Therapy
Gene Knockdown Techniques
15 Citations (Scopus)

The transcriptional repressor ZNF503/Zeppo2 promotes mammary epithelial cell proliferation and enhances cell invasion

Shahi, P., Slorach, E. M., Wang, C. Y., Chou, J., Lu, A., Ruderisch, A. & Werb, Z., Feb 6 2015, In : Journal of Biological Chemistry. 290, 6, p. 3803-3813 11 p.

Research output: Contribution to journalArticle

Open Access
2014
10 Citations (Scopus)

A novel cancer therapeutic using thrombospondin 1 in dendritic cells

Weng, T. Y., Huang, S. S., Yen, M. C., Lin, C. C., Chen, Y. L., Lin, C. M., Chen, W. C., Wang, C. Y., Chang, J. Y. & Lai, M. D., Jan 1 2014, In : Molecular Therapy. 22, 2, p. 292-302 11 p.

Research output: Contribution to journalArticle

Open Access
Pathologic Neovascularization
Thrombospondin 1
Thrombospondins
Animal Disease Models
Cancer Vaccines
7 Citations (Scopus)

DNA vaccine elicits an efficient antitumor response by targeting the mutant Kras in a transgenic mouse lung cancer model

Weng, T. Y., Yen, M. C., Huang, C. T., Hung, J. J., Chen, Y. L., Chen, W. C., Wang, C. Y., Chang, J. Y. & Lai, M. D., Jan 1 2014, In : Gene Therapy. 21, 10, p. 888-896 9 p.

Research output: Contribution to journalArticle

Open Access
DNA Vaccines
Transgenic Mice
Lung Neoplasms
Therapeutic Uses
Neoplasms
11 Citations (Scopus)

Fatty acid metabolic enzyme acyl-CoA thioesterase 8 promotes the development of hepatocellular carcinoma

Hung, Y. U. H., Chan, Y. I. S., Chang, Y. S., Lee, K. T., Hsu, H. P., Yen, M. C., Chen, W. C., Wang, C. Y. & Lai, M. D., Jan 1 2014, In : Oncology Reports. 31, 6, p. 2797-2803 7 p.

Research output: Contribution to journalArticle

Open Access
Neoplastic Gene Expression Regulation
Palmitoyl-CoA Hydrolase
Acyl Coenzyme A
Hep G2 Cells
Liver Neoplasms
7 Citations (Scopus)

Optimization protein productivity of human interleukin-2 through codon usage, gene copy number and intracellular tRNA concentration in CHO cells

Ou, K. C., Wang, C. Y., Liu, K. T., Chen, Y. L., Chen, Y. C., Lai, M. D. & Yen, M. C., Nov 14 2014, In : Biochemical and Biophysical Research Communications. 454, 2, p. 347-352 6 p.

Research output: Contribution to journalArticle

Gene Dosage
CHO Cells
Transfer RNA
Codon
Genes
11 Citations (Scopus)

The novel regulations of MEF2A, CAMKK2, CALM3, and TNNI3 in ventricular hypertrophy induced by arsenic exposure in rats

Phan, N. N., Wang, C. Y. & Lin, Y. C., Oct 3 2014, In : Toxicology. 324, p. 123-135 13 p.

Research output: Contribution to journalArticle

Arsenic
Hypertrophy
Rats
Cardiomegaly
Skin Neoplasms
2013
5 Citations (Scopus)

An HDAC inhibitor enhances cancer therapeutic efficiency of RNA polymerase III promoter-driven IDO shRNA

Yen, M. C., Weng, T. Y., Chen, Y. L., Lin, C. C., Chen, C. Y., Wang, C. Y., Chao, H. L., Chen, C. S. & Lai, M. D., Jun 1 2013, In : Cancer Gene Therapy. 20, 6, p. 351-357 7 p.

Research output: Contribution to journalArticle

Open Access
Drug Synergism
Phenylbutyrates
Indoleamine-Pyrrole 2,3,-Dioxygenase
RNA Polymerase III
NIH 3T3 Cells
2012
10 Citations (Scopus)

Paeoniae radix reduces PDGF-stimulated hepatic stellate cell migration

Kuo, J. J., Wang, C. Y., Lee, T. F., Huang, Y. T. & Lin, Y. L., Mar 8 2012, In : Planta Medica. 78, 4, p. 341-348 8 p.

Research output: Contribution to journalArticle

Acetophenones
Cell Transdifferentiation
Ranunculaceae
Hydrolyzable Tannins
Paeonia