• 2167 Citations
  • 16 h-Index
19952020
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Research Output 1995 2019

2019

A critical period for the development of schizophrenia-like pathology by aberrant postnatal neurogenesis

Sheu, J. R., Hsieh, C. Y., Jayakumar, T., Tseng, M. F., Lee, H. N., Huang, S. W., Manubolu, M. & Yang, C. H., Jan 1 2019, In : Frontiers in Neuroscience. 13, JUN, 635.

Research output: Contribution to journalArticle

Open Access
Neurogenesis
Schizophrenia
Pathology
Critical Period (Psychology)
Hallucinations

Correction to: Rescue of Methyl-CpG Binding Protein 2 Dysfunction-induced Defects in Newborn Neurons by Pentobarbital (Neurotherapeutics, (2015), 12, 2, (477-490), 10.1007/s13311-015-0343-0)

Ma, D., Yoon, S. I., Yang, C. H., Marcy, G., Zhao, N., Leong, W. Y., Ganapathy, V., Han, J., Van Dongen, A. M. J., Hsu, K. S., Ming, G. L., Augustine, G. J. & Goh, E. L. K., Jan 1 2019, In : Neurotherapeutics.

Research output: Contribution to journalErratum

Open Access
Methyl-CpG-Binding Protein 2
Pentobarbital
Publications
Neurons

HDAC6 dysfunction contributes to impaired maturation of adult neurogenesis in vivo: vital role on functional recovery after ischemic stroke

Sheu, J-R., Hsieh, C-Y., Jayakumar, T., Lin, G-Y., Lee, H-N., Huang, S-W. & Yang, C-H., Apr 18 2019, In : Journal of Biomedical Science. 26, 1, 27.

Research output: Contribution to journalArticle

Neurogenesis
Neurons
Stroke
Recovery
Patient rehabilitation

Hirsutanol A attenuates lipopolysaccharide-mediated matrix metalloproteinase 9 expression and cytokines production and improves endotoxemia-induced acute sickness behavior and acute lung injury

Jan, J. S., Yang, C. H., Wang, M. H., Lin, F. L., Yen, J. L., Hsieh, I., Khotimchenko, M., Lee, T. H. & Hsiao, G., Jun 17 2019, In : Marine Drugs. 17, 6, 360.

Research output: Contribution to journalArticle

Open Access
Illness Behavior
Endotoxemia
Acute Lung Injury
Matrix Metalloproteinase 9
Lipopolysaccharides
2018
7 Citations (Scopus)

CME-1, a novel polysaccharide, suppresses iNOS expression in lipopolysaccharide-stimulated macrophages through ceramide-initiated protein phosphatase 2A activation

Sheu, J. R., Chen, Z. C., Hsu, M. J., Wang, S. H., Jung, K. W., Wu, W. F., Pan, S. H., Teng, R. D., Yang, C. H. & Hsieh, C. Y., Feb 1 2018, In : Journal of Cellular and Molecular Medicine. 22, 2, p. 999-1013 15 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Ceramides
Nitric Oxide Synthase Type II
Polysaccharides
Lipopolysaccharides
Open Access
Organometallic Compounds
Molecular Medicine
Iridium
Platelet Activation
Medicine
5 Citations (Scopus)

Hinokitiol inhibits migration of A549 lung cancer cells via suppression of MMPs and induction of antioxidant enzymes and apoptosis

Jayakumar, T., Liu, C. H., Wu, G. Y., Lee, T. Y., Manubolu, M., Hsieh, C. Y., Yang, C. H. & Sheu, J. R., Mar 22 2018, In : International Journal of Molecular Sciences. 19, 4, 939.

Research output: Contribution to journalArticle

Enzyme Induction
antioxidants
apoptosis
Cell death
Antioxidants
2 Citations (Scopus)
brain damage
Neuroprotective Agents
medicine
Medicine
mice
5 Citations (Scopus)

Novel iridium (III)-derived organometallic compound for the inhibition of human platelet activation

Shyu, K. G., Velusamy, M., Hsia, C. W., Yang, C. H., Hsia, C. H., Chou, D. S., Jayakumar, T., Sheu, J. R. & Li, J. Y., May 1 2018, In : International Journal of Molecular Medicine. 41, 5, p. 2589-2600 12 p.

Research output: Contribution to journalArticle

Organometallic Compounds
Iridium
Platelet Activation
Platelet Aggregation
Collagen
1 Citation (Scopus)

Structure⁻Activity Relationship Study of Newly Synthesized Iridium-III Complexes as Potential Series for Treating Thrombotic Diseases

Yang, C. H., Hsia, C. W., Jayakumar, T., Sheu, J. R., Hsia, C. H., Khamrang, T., Chen, Y. J., Manubolu, M. & Chang, Y., Nov 19 2018, In : International Journal of Molecular Sciences. 19, 11

Research output: Contribution to journalArticle

Iridium
iridium
collagens
Collagen
Iridium compounds
2017
6 Citations (Scopus)

A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice

Sheu, J. R., Chen, Z. C., Jayakumar, T., Chou, D. S., Yen, T. L., Lee, H. N., Pan, S. H., Hsia, C. H., Yang, C. H. & Hsieh, C. Y., Feb 6 2017, In : Scientific Reports. 7, 42277.

Research output: Contribution to journalArticle

Stroke
Medicine
Middle Cerebral Artery Infarction
Therapeutics
JNK Mitogen-Activated Protein Kinases
29 Citations (Scopus)

Multi-targeting andrographolide, a novel NF-κB inhibitor, as a potential therapeutic agent for stroke

Yang, C. H., Yen, T. L., Hsu, C. Y., Thomas, P. A., Sheu, J. R. & Jayakumar, T., Aug 1 2017, In : International Journal of Molecular Sciences. 18, 8, 1638.

Research output: Contribution to journalReview article

Neuroprotective Agents
Cell death
strokes
inhibitors
Stroke
2016
23 Citations (Scopus)
Heme Oxygenase-1
Cytoprotection
Endothelial cells
p38 Mitogen-Activated Protein Kinases
Rats
9 Citations (Scopus)

The pharmacodynamics of antiplatelet compounds in thrombosis treatment

Jayakumar, T., Yang, C. H., Geraldine, P., Yen, T. L. & Sheu, J. R., Jun 2 2016, In : Expert Opinion on Drug Metabolism and Toxicology. 12, 6, p. 615-632 18 p.

Research output: Contribution to journalReview article

Pharmacodynamics
Platelet Aggregation Inhibitors
Platelets
Thrombosis
clopidogrel
2015
7 Citations (Scopus)

Antrodia camphorata Potentiates Neuroprotection against Cerebral Ischemia in Rats via Downregulation of iNOS/HO-1/Bax and Activated Caspase-3 and Inhibition of Hydroxyl Radical Formation

Yang, P. S., Lin, P. Y., Chang, C. C., Yu, M. C., Yen, T. L., Lan, C. C., Jayakumar, T. & Yang, C. H., 2015, In : Evidence-based Complementary and Alternative Medicine. 2015, 232789.

Research output: Contribution to journalArticle

Antrodia
Heme Oxygenase (Decyclizing)
Nitric Oxide Synthase Type II
Brain Ischemia
Caspase 3
12 Citations (Scopus)

Rescue of Methyl-CpG Binding Protein 2 Dysfunction-induced Defects in Newborn Neurons by Pentobarbital

Ma, D., Yoon, S. I., Yang, C. H., Marcy, G., Zhao, N., Leong, W. Y., Ganapathy, V., Han, J., Van Dongen, A. M. J., Hsu, K. S., Ming, G. L., Augustine, G. J. & Goh, E. L. K., Apr 1 2015, In : Neurotherapeutics. 12, 2, p. 477-490 14 p.

Research output: Contribution to journalArticle

Methyl-CpG-Binding Protein 2
Pentobarbital
Rett Syndrome
Aminobutyrates
Neurons
2012
21 Citations (Scopus)
Protein Tyrosine Phosphatases
Individuality
Extracellular Signal-Regulated MAP Kinases
Nifedipine
Intraperitoneal Injections
22 Citations (Scopus)

Vascular endothelial growth factor-dependent spinogenesis underlies antidepressant-like effects of enriched environment

Huang, Y. F., Yang, C. H., Huang, C. C. & Hsu, K. S., Nov 30 2012, In : Journal of Biological Chemistry. 287, 49, p. 40938-40955 18 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Antidepressive Agents
Hypoxia-Inducible Factor 1
MicroRNAs
Hippocampus
2011
9 Citations (Scopus)

Generalization of fear inhibition by disrupting hippocampal protein synthesis-dependent reconsolidation process

Yang, C. H., Huang, C. C. & Hsu, K. S., Sep 2011, In : Neuropsychopharmacology. 36, 10, p. 1992-2008 17 p.

Research output: Contribution to journalArticle

Fear
Cues
Proteins
Hippocampus
Inhibition (Psychology)
2010
37 Citations (Scopus)

Acute stress impairs hippocampal mossy fiber-CA3 long-term potentiation by enhancing cAMP-specific phosphodiesterase 4 activity

Chen, C. C., Yang, C. H., Huang, C. C. & Hsu, K. S., Jun 2010, In : Neuropsychopharmacology. 35, 7, p. 1605-1617 13 p.

Research output: Contribution to journalArticle

Hippocampal Mossy Fibers
Type 4 Cyclic Nucleotide Phosphodiesterase
Long-Term Potentiation
Cyclic AMP
Adenosine
48 Citations (Scopus)
Hypoxia-Inducible Factor 1
Synaptic Transmission
Vascular Endothelial Growth Factor A
Pharmacology
Neurons

Vascular endothelial growth factor regulates excitatory synaptic transmission in hippocampal neurons

Huang, Y. F., Yang, C. H., Chiou, C. S., Huang, C. C. & Hsu, K. S., 2010, In : Molecular and Cellular Pharmacology. 2, 4, p. 137-141 5 p.

Research output: Contribution to journalArticle

Synaptic Transmission
Vascular Endothelial Growth Factor A
Neurons
Vascular Endothelial Growth Factor Receptor
Neuronal Plasticity
2009
99 Citations (Scopus)

Estrogen modulates sexually dimorphic contextual fear extinction in rats through estrogen receptor β

Chang, Y. J., Yang, C. H., Liang, Y. C., Yeh, C. M., Huang, C. C. & Hsu, K. S., Nov 2009, In : Hippocampus. 19, 11, p. 1142-1150 9 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Fear
Estrogens
Sex Characteristics
Freezing
2008
11 Citations (Scopus)

Differential roles of basolateral and central amygdala on the effects of uncontrollable stress on hippocampal synaptic plasticity

Yang, C. H., Huang, C. C. & Hsu, K. S., 2008, In : Hippocampus. 18, 6, p. 548-563 16 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Phosphorylation
Amygdala
2-Amino-5-phosphonovalerate
Mitogen-Activated Protein Kinase 3
60 Citations (Scopus)

Phosphatidylinositol 3-kinase activation is required for stress protocol-induced modification of hippocampal synaptic plasticity

Yang, P. C., Yang, C. H., Huang, C. C. & Hsu, K. S., Feb 1 2008, In : Journal of Biological Chemistry. 283, 5, p. 2631-2643 13 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Neuronal Plasticity
Plasticity
Chemical activation
Long-Term Potentiation
2007
602 Citations (Scopus)

A Critical Period for Enhanced Synaptic Plasticity in Newly Generated Neurons of the Adult Brain

Ge, S., Yang, C. H., Hsu, K. S., Ming, G. L. & Song, H., May 24 2007, In : Neuron. 54, 4, p. 559-566 8 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Neurons
Brain
Long-Term Potentiation
Neurogenesis
471 Citations (Scopus)

Disrupted-In-Schizophrenia 1 Regulates Integration of Newly Generated Neurons in the Adult Brain

Duan, X., Chang, J. H., Ge, S., Faulkner, R. L., Kim, J. Y., Kitabatake, Y., Liu, X. B., Yang, C. H., Jordan, J. D., Ma, D. K., Liu, C. Y., Ganesan, S., Cheng, H. J., Ming, G. L., Lu, B. & Song, H., Sep 21 2007, In : Cell. 130, 6, p. 1146-1158 13 p.

Research output: Contribution to journalArticle

Neurons
Brain
Schizophrenia
Neurogenesis
Genes
2006
27 Citations (Scopus)

Novelty exploration elicits a reversal of acute stress-induced modulation of hippocampal synaptic plasticity in the rat

Yang, C. H., Huang, C. C. & Hsu, K. S., Dec 1 2006, In : Journal of Physiology. 577, 2, p. 601-615 15 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Corpus Striatum
Adrenergic Antagonists
Long-Term Potentiation
N-Methyl-D-Aspartate Receptors
2005
138 Citations (Scopus)

Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake

Yang, C. H., Huang, C. C. & Hsu, K. S., Apr 27 2005, In : Journal of Neuroscience. 25, 17, p. 4288-4293 6 p.

Research output: Contribution to journalArticle

Glutamic Acid
N-Methyl-D-Aspartate Receptors
Hippocampal CA1 Region
Neurotransmitter Receptor
Neuronal Plasticity
36 Citations (Scopus)

Do stress and long-term potentiation share the same molecular mechanisms?

Huang, C. C., Yang, C. H. & Hsu, K. S., Dec 2005, In : Molecular Neurobiology. 32, 3, p. 223-235 13 p.

Research output: Contribution to journalReview article

Neuronal Plasticity
Long-Term Potentiation
Depression
Biological Factors
Cognition
20 Citations (Scopus)

Neonatal isolation accelerates the developmental switch in the signalling cascades for long-term potentiation induction

Huang, C. C., Chou, P. H., Yang, C. H. & Hsu, K. S., Dec 15 2005, In : Journal of Physiology. 569, 3, p. 789-799 11 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Long-Term Potentiation
Corticotropin-Releasing Hormone
Hippocampus
Protein Kinase Inhibitors
2004
136 Citations (Scopus)
MAP Kinase Kinase 2
Neuronal Plasticity
Long-Term Potentiation
Extracellular Signal-Regulated MAP Kinases
Corticosterone
1996
5 Citations (Scopus)

Guillain-Barre syndrome in northern China. The spectrum of neuropathological changes in clinically defined cases [2]

Menkes, D. L., Hood, D. C., Griffin, J. W., Li, C. Y., Ho, T. W., Xue, P., Macko, C., Gao, C. Y., Yang, C., Tian, M., Mishu, B., Cornblath, D. R., McKhann, G. M. & Asbury, A. K., 1996, In : Brain. 119, 2, p. 676-680 5 p.

Research output: Contribution to journalLetter

Guillain-Barre Syndrome
China
1995
319 Citations (Scopus)

Guillain-Barré syndrome in northern China: The spectrum of neuropathological changes in clinically defined cases

Griffin, J. W., Li, C. Y., Ho, T. W., Xue, P., Macko, C., Gao, C. Y., Yang, C., Tian, M., Mishu, B., Cornblath, D. R., McKhann, G. M. & Asbury, A. K., Jun 1995, In : Brain. 118, 3, p. 577-595 19 p.

Research output: Contribution to journalArticle

Acute
peripheral nervous system diseases
China
Nerve
Guillain-Barre Syndrome