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Research Output 1994 2018

  • 1729 Citations
  • 26 h-Index
  • 94 Article
  • 1 Conference contribution
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Article
2018
1 Citation (Scopus)
Antrodia
Cell growth
Drug Resistance
lungs
Cell Movement
2 Citations (Scopus)

Suppressive activities and mechanisms of ugonin J on vascular smooth muscle cells and balloon angioplasty-induced neointimal hyperplasia

Pan, C. H., Li, P. C., Chien, Y. C., Yeh, W. T., Liaw, C. C., Sheu, M. J. & Wu, C. H., 2018, In : Phytotherapy Research.

Research output: Contribution to journalArticle

Balloon Angioplasty
Vascular Smooth Muscle
Smooth Muscle Myocytes
Hyperplasia
Cell Movement
2017
1 Citation (Scopus)

Activation of IGF-I survival signaling and its compensative inhibition of the cardiac apoptosis on carotid arteries balloon-injured rat hearts

Hsieh, C. H., Pai, P., Wu, J. P., Ho, T. J., Wu, C. H., Shibu, M. A., Day, C. H., Viswanadha, V. P., Chuang, H. L. & Huang, C. Y., 2017, In : Chinese Journal of Physiology. 60, 3, p. 166-173 8 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Carotid Arteries
Apoptosis
Wounds and Injuries
Hypertrophy
6 Citations (Scopus)

Monoamine oxidase A is highly expressed in classical Hodgkin lymphoma

Li, P. C., Siddiqi, I. N., Mottok, A., Loo, E. Y., Wu, C. H., Cozen, W., Steidl, C. & Shih, J. C., Oct 1 2017, In : Journal of Pathology. 243, 2, p. 220-229 10 p.

Research output: Contribution to journalArticle

Monoamine Oxidase
Hodgkin Disease
Lymphoma
Clorgyline
Non-Hodgkin's Lymphoma
6 Citations (Scopus)

Pharmacokinetics and tissue distribution of five major triterpenoids after oral administration of Rhizoma Alismatis extract to rats using ultra high-performance liquid chromatography–tandem mass spectrometry

Xu, W., Li, X., Lin, N., Zhang, X., Huang, X., Wu, T., Tai, Y., Chen, S., Wu, C. H., Huang, M. & Wu, S., Nov 30 2017, In : Journal of Pharmaceutical and Biomedical Analysis. 146, p. 314-323 10 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Tissue Distribution
Mass spectrometry
Oral Administration
Rats
2 Citations (Scopus)

Toxicological effects of NCKU-21, a phenanthrene derivative, on cell growth and migration of A549 and CL1-5 human lung adenocarcinoma cells

Liao, H. F., Pan, C. H., Chou, P. Y., Chen, Y. F., Wu, T. S., Sheu, M. J. & Wu, C. H., Sep 1 2017, In : PLoS One. 12, 9, e0185021.

Research output: Contribution to journalArticle

phenanthrene
Cell growth
adenocarcinoma
cell movement
Toxicology
2016
1 Citation (Scopus)

Antiobesity and antihyperlipidaemic effects of Yan-Sheng-Yin in animals and humans

Wu, C. H., Pan, C. H., Lee, C. K., Sheu, M. J., Liu, F. C., Wang, G. J. & Wu, C. H., Jun 1 2016, In : Journal of Functional Foods. 24, p. 173-182 10 p.

Research output: Contribution to journalArticle

Hypolipidemic Agents
atherogenesis
hyperlipidemia
Hyperlipidemias
Atherosclerosis
5 Citations (Scopus)

Methyl Protodioscin, a Steroidal Saponin, Inhibits Neointima Formation in Vitro and in Vivo

Chung, Y. L., Pan, C. H., Wang, C. C. N., Hsu, K. C., Sheu, M. J., Chen, H. F. & Wu, C. H., Jun 24 2016, In : Journal of Natural Products. 79, 6, p. 1635-1644 10 p.

Research output: Contribution to journalArticle

Neointima
Saponins
Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
2015
14 Citations (Scopus)

Anti-restenotic roles of dihydroaustrasulfone alcohol involved in inhibiting PDGF-BB-stimulated proliferation and migration of vascular smooth muscle cells

Li, P. C., Sheu, M. J., Ma, W. F., Pan, C. H., Sheu, J. H. & Wu, C. H., May 1 2015, In : Marine Drugs. 13, 5, p. 3046-3060 15 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Smooth Muscle Myocytes
Cell Movement
Cell Proliferation
Phosphatidylinositol 3-Kinase
13 Citations (Scopus)

A population-based nested case-control study: The use of 5-alpha-reductase inhibitors and the increased risk of osteoporosis diagnosis in patients with benign prostate hyperplasia

Lin, W. L., Hsieh, Y. W., Lin, C. L., Sung, F. C., Wu, C. H. & Kao, C. H., Apr 1 2015, In : Clinical Endocrinology. 82, 4, p. 503-508 6 p.

Research output: Contribution to journalArticle

5-alpha Reductase Inhibitors
Finasteride
Osteoporosis
Hyperplasia
Case-Control Studies
6 Citations (Scopus)

K20E, an oxidative-coupling compound of methyl caffeate, exhibits anti-angiogenic activities through down-regulations of VEGF and VEGF receptor-2

Pan, C. H., Lin, W. H., Chien, Y. C., Liu, F. C., Sheu, M. J., Kuo, Y. H. & Wu, C. H., Jan 5 2015, In : Toxicology and Applied Pharmacology. 282, 2, p. 215-226 12 p.

Research output: Contribution to journalArticle

Oxidative Coupling
Vascular Endothelial Growth Factor Receptor-2
Endothelial cells
Umbilicus
Vascular Endothelial Growth Factor A
2014
17 Citations (Scopus)

Deep sea water prevents balloon angioplasty-induced hyperplasia through MMP-2: An in vitro and in vivo study

Li, P. C., Pan, C. H., Sheu, M. J., Wu, C. C., Ma, W. F. & Wu, C. H., May 13 2014, In : PLoS One. 9, 5, e96927.

Research output: Contribution to journalArticle

gelatinase A
Balloon Angioplasty
Matrix Metalloproteinase 2
Balloons
Seawater
4 Citations (Scopus)

Effects of garlic oil on interleukin-6 mediated cardiac hypertrophy in hypercholesterol-fed hamsters

Hsieh, Y. L., Pai, P., Ho, T. J., Chung, L. C., Cheng, Y. C., Wu, C. H., Fan, M. J., Day, C. H., Shen, C. Y. & Huang, C. Y., 2014, In : Chinese Journal of Physiology. 57, 6, p. 320-328 9 p.

Research output: Contribution to journalArticle

Cardiomegaly
Cricetinae
Interleukin-6
Cholesterol
Weights and Measures
36 Citations (Scopus)

Hydroalcoholic extract of Rhodiola rosea L. (Crassulaceae) and its hydrolysate inhibit melanogenesis in B16F0 cells by regulating the CREB/MITF/tyrosinase pathway

Chiang, H. M., Chien, Y. C., Wu, C. H., Kuo, Y. H., Wu, W. C., Pan, Y. Y., Su, Y. H. & Wen, K. C., Mar 2014, In : Food and Chemical Toxicology. 65, p. 129-139 11 p.

Research output: Contribution to journalArticle

Crassulaceae
Rhodiola
Rhodiola rosea
Microphthalmia-Associated Transcription Factor
melanogenesis
11 Citations (Scopus)
Lewis Lung Carcinoma
Inbred C57BL Mouse
Non-Small Cell Lung Carcinoma
Neoplasms
Lung Neoplasms
10 Citations (Scopus)

NSC746364, a G-quadruplex-stabilizing agent, suppresses cell growth of A549 human lung cancer cells through activation of the ATR/Chk1-dependent pathway

Chung, Y. L., Pan, C. H., Liou, W. H., Sheu, M. J., Lin, W. H., Chen, T. C., Huang, H. S. & Wu, C. H., 2014, In : Journal of Pharmacological Sciences. 124, 1, p. 7-17 11 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Excipients
Lung Neoplasms
Growth
Cyclin B1
2013
12 Citations (Scopus)

Antihyperlipidemic and antioxidant effects of C-phycocyanin in golden syrian hamsters fed with a hypercholesterolemic diet

Sheu, M. J., Hsieh, Y. Y., Lai, C. H., Chang, C. C. & Wu, C. H., 2013, In : Journal of Traditional and Complementary Medicine. 3, 1, p. 41-47 7 p.

Research output: Contribution to journalArticle

Phycocyanin
Hypolipidemic Agents
Mesocricetus
Antioxidants
Diet
25 Citations (Scopus)

Deep sea water modulates blood pressure and exhibits hypolipidemic effects via the AMPK-ACC pathway: An in Vivo study

Sheu, M. J., Chou, P. Y., Lin, W. H., Pan, C. H., Chien, Y. C., Chung, Y. L., Liu, F. C. & Wu, C. H., Jun 2013, In : Marine Drugs. 11, 6, p. 2183-2202 20 p.

Research output: Contribution to journalArticle

Acetyl-CoA Carboxylase
Seawater
Adenosine Monophosphate
Protein Kinases
Blood Pressure
20 Citations (Scopus)

Demethoxycurcumin, a major active curcuminoid from Curcuma longa, suppresses balloon injury induced vascular smooth muscle cell migration and neointima formation: An in vitro and in vivo study

Sheu, M. J., Lin, H. Y., Yang, Y. H., Chou, C. J., Chien, Y. C., Wu, T. S. & Wu, C. H., Sep 2013, In : Molecular Nutrition and Food Research. 57, 9, p. 1586-1597 12 p.

Research output: Contribution to journalArticle

Neointima
Curcuma
Curcuma longa
in vivo studies
Vascular Smooth Muscle
2 Citations (Scopus)

Electrophoretic coating of amphiphilic chitosan colloids on regulating cellular behavior

Wang, Y. J., Lo, T. Y., Wu, C. H. & Liu, D. M., Sep 6 2013, In : Journal of the Royal Society Interface. 10, 86, 0411.

Research output: Contribution to journalArticle

Electrophoretic coatings
Human Umbilical Vein Endothelial Cells
Chitosan
Colloids
Stainless Steel
13 Citations (Scopus)
Antrodia
Mushroom Bodies
Allografts
Leukemia
Neoplasms
Antrodia
Evidence-Based Medicine
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Complementary Therapies

Erratum: Molecular mechanism of green microalgae, Dunaliella salina, involved in attenuating balloon injury-induced neointimal formation (British Journal of Nutrition (2010) 104 (326-335))

Sheu, M. J., Cheng, H. C., Chien, Y. C., Chou, P. Y., Huang, G. J., Chen, J. S., Lin, S. Y. & Wu, C. H., Jun 2013, In : British Journal of Nutrition. 109, 11, p. 2113 1 p.

Research output: Contribution to journalArticle

Microalgae
Wounds and Injuries
Salinum
6 Citations (Scopus)

Gan-Lu-Yin inhibits proliferation and migration of murine WEHI-3 leukemia cells and tumor growth in BALB/C allograft tumor model

Liu, F. C., Pan, C. H., Lai, M. T., Chang, S. J., Chung, J. G. & Wu, C. H., 2013, In : Evidence-based Complementary and Alternative Medicine. 2013, 684071.

Research output: Contribution to journalArticle

Allografts
Leukemia
Growth
Matrix Metalloproteinases
Neoplasms
8 Citations (Scopus)

Influence of different particle processing on hypocholesterolemic and antiatherogenic activities of yam (Dioscorea pseudojaponica) in cholesterol-fed rabbit model

Pan, C. H., Tsai, C. H., Liu, F. C., Fan, M. J., Sheu, M. J., Hsieh, W. T. & Wu, C. H., Apr 2013, In : Journal of the Science of Food and Agriculture. 93, 6, p. 1278-1283 6 p.

Research output: Contribution to journalArticle

Dioscorea japonica
Dioscorea
yams
rabbits
Cholesterol
32 Citations (Scopus)

OSU-A9 inhibits angiogenesis in human umbilical vein endothelial cells via disrupting Akt-NF-κB and MAPK signaling pathways

Omar, H. A., Arafa, E. S. A., Salama, S. A., Arab, H. H., Wu, C. H. & Weng, J. R., Nov 1 2013, In : Toxicology and Applied Pharmacology. 272, 3, p. 616-624 9 p.

Research output: Contribution to journalArticle

NF-kappa B
Endothelial cells
Human Umbilical Vein Endothelial Cells
Mitogen-Activated Protein Kinases
Vascular Endothelial Growth Factor A
2012
12 Citations (Scopus)

A Chinese herbal formula "Gan-Lu-Yin" suppresses vascular smooth muscle cell migration by inhibiting matrix metalloproteinase-2/9 through the PI3K/AKT and ERK signaling pathways

Chien, Y. C., Sheu, M. J., Wu, C. H., Lin, W. H., Chen, Y. Y., Cheng, P. L. & Cheng, H. C., Aug 24 2012, In : BMC Complementary and Alternative Medicine. 12, 137.

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Phosphatidylinositol 3-Kinases
Vascular Smooth Muscle
8 Citations (Scopus)

Alteration of the tongue manifestation reflects clinical outcomes of peptic ulcer disease

Wang, H. H., Pan, C. H., Wu, P. P., Luo, S. F., Lin, H. J. & Wu, C. H., Nov 1 2012, In : Journal of Alternative and Complementary Medicine. 18, 11, p. 1038-1044 7 p.

Research output: Contribution to journalArticle

Peptic Ulcer
Tongue
Helicobacter pylori
Gastrointestinal Endoscopy
Helicobacter Infections
26 Citations (Scopus)

Anti-inflammatory effects of Calophyllum inophyllum L. in RAW264.7 cells

Tsai, S. C., Liang, Y. H., Chiang, J. H., Liu, F. C., Lin, W. H., Chang, S. J., Lin, W. Y., Wu, C. H. & Weng, J. R., Sep 2012, In : Oncology Reports. 28, 3, p. 1096-1102 7 p.

Research output: Contribution to journalArticle

Calophyllum
Nitric Oxide Synthase Type II
MicroRNAs
Lipopolysaccharides
Anti-Inflammatory Agents
48 Citations (Scopus)
Antrodia
Macrophages
Carrageenan
carrageenan
Nitric Oxide Synthase Type II
14 Citations (Scopus)

Antioxidant and anti-inflammatory properties of Dichondra repens Forst. and its reference compounds

Sheu, M. J., Deng, J. S., Huang, M. H., Liao, J. C., Wu, C. H., Huang, S. S. & Huang, G. J., May 15 2012, In : Food Chemistry. 132, 2, p. 1010-1018 9 p.

Research output: Contribution to journalArticle

Dichondra
Nitrites
anti-inflammatory activity
nitrites
Oxides
15 Citations (Scopus)

Computational analysis of novel drugs designed for use as acetylcholinesterase inhibitors and histamine H 3 receptor antagonists for Alzheimer's disease by docking, scoring and de novo evolution

Chen, P. Y., Tsai, C. T., Ou, C. Y., Hsu, W. T., Jhuo, M. D., Wu, C. H., Shih, T. C., Cheng, T. H. & Chung, J. G., Apr 2012, In : Molecular Medicine Reports. 5, 4, p. 1043-1048 6 p.

Research output: Contribution to journalArticle

Cholinesterase Inhibitors
Histamine
Alzheimer Disease
Pharmaceutical Preparations
Acetylcholine

Erratum: Ethanol extracts of fruiting bodies of Antrodia cinnamomea exihibit anti-migration action in human adenocarcinoma CL1-0 cells through the MAPK and PI3K/AKT signaling pathways (Phytomedicine (2012) 19:8 (768-778))

Chen, Y. Y., Liu, F. C., Chou, P. Y., Chien, Y. C., Wu, C. H., Wu, T. S. & Sheu, M. J., Dec 15 2012, In : Phytomedicine. 20, 1, p. 1-2 2 p.

Research output: Contribution to journalArticle

Antrodia
Phosphatidylinositol 3-Kinases
Adenocarcinoma
Ethanol
28 Citations (Scopus)

Ethanol extracts of fruiting bodies of Antrodia cinnamomea exhibit anti-migration action in human adenocarcinoma CL1-0 cells through the MAPK and PI3K/AKT signaling pathways

Chen, Y. Y., Chou, P. Y., Chien, Y. C., Wu, C. H., Wu, T. S. & Sheu, M. J., Jun 15 2012, In : Phytomedicine. 19, 8-9, p. 768-778 11 p.

Research output: Contribution to journalArticle

Antrodia
Phosphatidylinositol 3-Kinases
Adenocarcinoma
Ethanol
Matrix Metalloproteinase 2
34 Citations (Scopus)
Antrodia
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Matrix Metalloproteinases
Phosphatidylinositol 3-Kinases
16 Citations (Scopus)
Acetyl-CoA Carboxylase
Vitis
Adenosine Monophosphate
Protein Kinases
Rabbits
17 Citations (Scopus)
Chitosan
Vascular Smooth Muscle
Smooth Muscle Myocytes
Hexanols
Nanoparticles
10 Citations (Scopus)

Hispolon attenuates balloon-injured neointimal formation and modulates vascular smooth muscle cell migration via AKT and ERK phosphorylation

Chien, Y. C., Huang, G. J., Cheng, H. C., Wu, C. H. & Sheu, M. J., Sep 28 2012, In : Journal of Natural Products. 75, 9, p. 1524-1533 10 p.

Research output: Contribution to journalArticle

Phosphorylation
Balloons
Vascular Smooth Muscle
Smooth Muscle Myocytes
Cell Movement
38 Citations (Scopus)
Matrix Metalloproteinase 9
Cyclooxygenase 2
Nitric Oxide Synthase
Lipid Peroxidation
Oxidative Stress
6 Citations (Scopus)

Pro-inflammation and pro-fibrosis factors were highly induction in heart tissues of carotid arteries balloon-injured animal model

Hwang, J. M., Wu, C. H., Kuo, W. W., Jong, G. P., Lai, C. H., Tsai, C. H., Tsai, F. J., Chang, M. H., Wu, J. P. & Huang, C. Y., Jul 2012, In : Cell Biochemistry and Function. 30, 5, p. 390-394 5 p.

Research output: Contribution to journalArticle

Carotid Artery Injuries
Balloons
Carotid Arteries
Animals
Fibrosis
21 Citations (Scopus)

Salvianolic acid B inhibits SDF-1α-stimulated cell proliferation and migration of vascular smooth muscle cells by suppressing CXCR4 receptor

Pan, C. H., Chen, C. W., Sheu, M. J. & Wu, C. H., Jan 2012, In : Vascular Pharmacology. 56, 1-2, p. 98-105 8 p.

Research output: Contribution to journalArticle

CXCR4 Receptors
Chemokine CXCL12
Vascular Smooth Muscle
Smooth Muscle Myocytes
Cell Movement
36 Citations (Scopus)
Macrophages
Carrageenan
Nitric Oxide Synthase Type II
Cyclooxygenase 2
Lipopolysaccharides
2011
1 Citation (Scopus)

Ameliorate effects of li-fu formula on IL-6-mediated cardiac hypertrophy in hamsters fed with a hyper-cholesterol diet

Tzang, B. S., Cheng, Y. C., Wu, C. H., Kuo, W. W., Lin, J. A., Wang, H. F., Tsai, F. J., Tsai, C. H., Huang, C. Y. & Hsu, T. C., 2011, In : Evidence-based Complementary and Alternative Medicine. 2011, 485471.

Research output: Contribution to journalArticle

Cardiomegaly
Cricetinae
Interleukin-6
Cholesterol
Diet
83 Citations (Scopus)

Antioxidant and anti-inflammatory properties of Cardiospermum halicacabum and its reference compounds ex vivo and in vivo

Huang, M. H., Huang, S. S., Wang, B. S., Wu, C. H., Sheu, M. J., Hou, W. C., Lin, S. S. & Huang, G. J., Jan 27 2011, In : Journal of Ethnopharmacology. 133, 2, p. 743-750 8 p.

Research output: Contribution to journalArticle

Sapindaceae
Anti-Inflammatory Agents
Antioxidants
Nitrites
Oxides
4 Citations (Scopus)

Attenuated cardiac mitochondrial-dependent apoptotic effects by Li-Fu formula in hamsters fed with a hypercholesterol diet

Tzang, B. S., Kuo, W. W., Hsu, T. C., Chain, M. H., Lai, C. H., Wang, W. H., Tsai, F. J., Tsai, C. H., Wu, C. H. & Huang, C. Y., 2011, In : Evidence-based Complementary and Alternative Medicine. 2011, 530345.

Research output: Contribution to journalArticle

Cricetinae
Cholesterol
Diet
Apoptosis
Heart Ventricles
1 Citation (Scopus)

Computational analysis of De Novo evolution of Hepatitis C virus NS5B polymerase inhibitors

Chen, P. O. Y., Hsu, W. T., Jhuo, M. D. E., Ou, C. Y., Cheng, T. H., Shih, T. C., Wu, C. H., Wu, R. S. C., Hsia, T. E. C. & Chung, J. G., Mar 2011, In : In Vivo. 25, 2, p. 219-228 10 p.

Research output: Contribution to journalArticle

Viruses
Hepacivirus
Ligands
RNA Replicase
Computer-Aided Design
8 Citations (Scopus)

Effects of salvianolic acid B on protein expression in human umbilical vein endothelial cells

Huang, H. C., Chang, T. M., Shi, G. Y., Wu, H. L., Wu, C. H., Su, Y. D., Wang, H. L. & Wen, H. Y., 2011, In : Evidence-based Complementary and Alternative Medicine. 2011, 213050.

Research output: Contribution to journalArticle

Human Umbilical Vein Endothelial Cells
Proteins
Phosphopyruvate Hydratase
HSP27 Heat-Shock Proteins
Calmodulin-Binding Proteins
23 Citations (Scopus)
Hydrogel
Vascular Smooth Muscle
Nanoparticles
Smooth Muscle Myocytes
Cell Movement
39 Citations (Scopus)

Phylogenetic and epidemic modeling of rapidly evolving infectious diseases

Kühnert, D., Wu, C. H. & Drummond, A. J., Dec 2011, In : Infection, Genetics and Evolution. 11, 8, p. 1825-1841 17 p.

Research output: Contribution to journalArticle

infectious disease
infectious diseases
Communicable Diseases
phylogenetics
phylogeny
8 Citations (Scopus)

Sweet potato storage root defensin and its tryptic hydrolysates exhibited angiotensin converting enzyme inhibitory activity in vitro

Huang, G. J., Lu, T. L., Chiu, C. S., Chen, H. J., Wu, C. H., Lin, Y. C., Hsieh, W. T., Liao, J. C., Sheu, M. J. & Lin, Y. H., Jul 2011, In : Botanical Studies. 52, 3, p. 257-264 8 p.

Research output: Contribution to journalArticle

peptidyl-dipeptidase A
sweet potatoes
hydrolysates
trypsin
hydrolysis