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Research Output

  • 1934 Citations
  • 25 h-Index
  • 61 Article
  • 4 Review article
  • 1 Chapter
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A conditional replication-competent adenoviral vector, AD-OC-E1a, to cotarget prostate cancer and bone stroma in an experimental model of androgen-independent prostate cancer bone metastasis

Matsubara, S., Wada, Y., Gardner, T. A., Egawa, M., Par, M. S., Hsieh, C. L., Zhau, H. E., Kao, C., Kamidono, S., Gillenwater, J. Y. & Chung, L. W. K., Aug 15 2001, In : Cancer Research. 61, 16, p. 6012-6019 8 p.

Research output: Contribution to journalArticle

134 Citations (Scopus)

ADAR1 deaminase contributes to scheduled skeletal myogenesis progression via stage-specific functions

Hsieh, C. L., Liu, H., Huang, Y., Kang, L., Chen, H. W., Chen, Y. T., Wee, Y. R., Chen, S. J. & Tan, B. C. M., 2014, In : Cell Death and Differentiation. 21, 5, p. 707-719 13 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

A functional genomic approach reveals the transcriptional role of EDD in the expression and function of angiogenesis regulator ACVRL1

Chen, H. W., Yang, C. C., Hsieh, C. L., Liu, H., Lee, S. C. & Tan, B. C. M., Dec 2013, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1829, 12, p. 1309-1319 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

A luciferase transgenic mouse model: Visualization of prostate development and its androgen responsiveness in live animals

Hsieh, C. L., Xie, Z., Liu, Z. Y., Green, J. E., Martin, W. D., Datta, M. W., Yeung, F., Pan, D. & Chung, L. W. K., Oct 2005, In : Journal of Molecular Endocrinology. 35, 2, p. 293-304 12 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Amentoflavone enhances sorafenib-induced apoptosis through extrinsic and intrinsic pathways in sorafenib-resistant hepatocellular carcinoma SK-hep1 cells in vitro

Chen, W. L., Hsieh, C. L., Chen, J. H., Huang, C. S., Chen, W. T., Kuo, Y. C., Chen, C. Y. & Hsu, F. T., 2017, In : Oncology Letters. 14, 3, p. 3229-3234 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Amentoflavone Induces Apoptosis and Inhibits NF-ĸB-modulated Anti-apoptotic Signaling in Glioblastoma Cells

Yen, T-H., Hsieh, C-L., Liu, T-T., Huang, C-S., Chen, Y-C., Chuang, Y-C., Lin, S-S. & Hsu, F-T., Feb 25 2018, In : In Vivo. 32, 2, p. 279-285 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Amplification and overexpression of prosaposin in prostate cancer

Koochekpour, S., Zhang, Y., Beroukhim, R., Hsieh, C. L., Hofer, M. D., Zhau, H. E., Hiraiwa, M., Pattan, D. Y., Ware, J. L., Luftig, R. B., Sandhoff, K., Sawyers, C. L., Pienta, K. J., Rubin, M. A., Vessella, R. L., Sellers, W. R. & Sartor, O., Dec 2005, In : Genes Chromosomes and Cancer. 44, 4, p. 351-364 14 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Analysis of host versus tumor interaction in cancer patients: Opposing role of transforming growth factor-β1 and interleukin-6 in the development of in situ tumor immunity

Tsai, J. P., Chen, H. W., Cheng, M. L., Liu, H. K., Lee, Y. P., Hsieh, C. L., Luh, K. T., Wu, C. W., Hsu, L. H., Chao, T. Y., Wang, W. H., Chang, C. M. & Ting, C. C., Nov 15 2005, In : Immunobiology. 210, 9, p. 661-671 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
1 Citation (Scopus)

A novel targeting modality for renal cell carcinoma: Human osteocalcin promoter-mediated gene therapy synergistically induced by vitamin C and vitamin D3

Johnson, N. A., Chen, B. H., Sung, S. Y., Liao, C. H., Hsiao, W. C., W.K. Chung, L. & Hsieh, C. L., Nov 2010, In : Journal of Gene Medicine. 12, 11, p. 892-903 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

A novel targeting modality to enhance adenoviral replication by vitamin D3 in androgen-independent human prostate cancer cells and tumors

Hsieh, C. L., Zhau, H. E., Chung, L. W. K., Yang, L., Miao, L., Yeung, F., Kao, C. & Yang, H., Jun 1 2002, In : Cancer Research. 62, 11, p. 3084-3092 9 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Caspase activation during phorbol ester-induced apoptosis requires ROCK-dependent myosin-mediated contraction

Lai, J. M., Hsieh, C. L. & Chang, Z. F., Sep 1 2003, In : Journal of Cell Science. 116, 17, p. 3491-3501 11 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Cellular Magnetic Resonance Imaging with Superparamagnetic Iron Oxide: Methods and Applications in Cancer

Hsu, F. T., Sun, R. & Hsieh, C. L., Jan 1 2019, In : SPIN.

Research output: Contribution to journalArticle

Coevolution of prostate cancer and bone stroma in three-dimensional coculture: Implications for cancer growth and metastasis

Sung, S. Y., Hsieh, C. L., Law, A., Zhau, H. E., Pathak, S., Multani, A. S., Lim, S., Coleman, I. M., Wu, L. C., Figg, W. D., Dahut, W. L., Nelson, P., Lee, J. K., Amin, M. B., Lyles, R., Johnstone, P. A. J., Marshall, F. F. & Chung, L. W. K., Dec 1 2008, In : Cancer Research. 68, 23, p. 9996-10003 8 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)
6 Citations (Scopus)

Cotargeting tumor and stroma in a novel chimeric tumor model involving the growth of both human prostate cancer and bone stromal cells

Hsieh, C. L., Gardner, T. A., Miao, L., Balian, G. & Chung, L. W. K., Feb 2004, In : Cancer Gene Therapy. 11, 2, p. 148-155 8 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Cotargeting tumor and tumor endothelium effectively inhibits the growth of human prostate cancer in adenovirus-mediated antiangiogenesis and oncolysis combination therapy

Jin, F., Xie, Z., Kuo, C. J., Chung, L. W. K. & Hsieh, C. L., Mar 2005, In : Cancer Gene Therapy. 12, 3, p. 257-267 11 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Differential gene expression of scopolamine-treated rat hippocampus-application of cDNA microarray technology

Hsieh, M. T., Hsieh, C. L., Lin, L. W., Wu, C. R. & Huang, G. S., Jul 11 2003, In : Life Sciences. 73, 8, p. 1007-1016 10 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Discovery and mechanisms of host defense to oncogenesis: targeting the β-defensin-1 peptide as a natural tumor inhibitor

Sun, C. Q., Arnold, R. S., Hsieh, C. L., Dorin, J. R., Lian, F., Li, Z. & Petros, J. A., Jun 3 2019, In : Cancer Biology and Therapy. 20, 6, p. 774-786 13 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Effects of tobacco prevention education program on adolescents' knowledge of and attitude toward smoking

Tsai, W. C., Kung, P. T., Hu, H. Y., Ho, C. S., Lin, D. J., Hsieh, C. L., Teng, Y. L., Chen, C. H., Wu, J. F., Chiang, C. Y. & Yang, T. J., Dec 2005, In : Mid-Taiwan Journal of Medicine. 10, 4, p. 171-180 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Epigeneitc silencing of ribosomal RNA genes by Mybbp1a

Tan, B. C. M., Yang, C. C., Hsieh, C. L., Chou, Y. H., Zhong, C. Z., Yung, B. Y. M. & Liu, H., 2012, In : Journal of Biomedical Science. 19, 1, 57.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Epigenetic silencing of myogenic gene program by Myb-binding protein 1a suppresses myogenesis

Yang, C. C., Liu, H., Chen, S. L., Wang, T. H., Hsieh, C. L., Huang, Y., Chen, S. J., Chen, H. C., Yung, B. Y. M. & Tan, B. C. M., Apr 4 2012, In : EMBO Journal. 31, 7, p. 1739-1751 13 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Erlotinib-Conjugated Iron Oxide Nanoparticles as a Smart Cancer-Targeted Theranostic Probe for MRI

Ali, A. A. A., Hsu, F. T., Hsieh, C. L., Shiau, C. Y., Chiang, C. H., Wei, Z. H., Chen, C. Y. & Huang, H. S., Nov 11 2016, In : Scientific Reports. 6, 36650.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Identification of α-enolase as an autoantigen in lung cancer: Its overexpression is associated with clinical outcomes

Chang, G. C., Liu, K. J., Hsieh, C. L., Hu, T. S., Charoenfuprasert, S., Liu, H. K., Luh, K. T., Hsu, L. H., Wu, C. W., Ting, C. C., Chen, C. Y., Chen, K. C., Yang, T. Y., Chou, T. Y., Wang, W. H., Whang-Peng, J. & Shih, N. Y., Oct 1 2006, In : Clinical Cancer Research. 12, 19, p. 5746-5754 9 p.

Research output: Contribution to journalArticle

108 Citations (Scopus)

IGF-I secretion by prostate carcinoma cells does not alter tumor-bone cell interactions in vitro or in vivo

Rubin, J., Fan, X., Rahnert, J., Sen, B., Hsieh, C. L., Murphy, T. C., Nanes, M. S., Horton, L. G., Beamer, W. G. & Rosen, C. J., Jun 1 2006, In : Prostate. 66, 8, p. 789-800 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

IL-6-transfected tumor cells modulate the status of CD8+ and CD4+ T cells to control tumor growth

Hsieh, C. L., Liu, S. J., Shen, C. R., Chen, M. Y., Hsu, S. C., Tsai, J. P., Li, Y. S., Yang, C. J., Chong, P. & Chen, H. W., Jun 2010, In : Immunobiology. 215, 6, p. 486-491 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Improved Gene Expression by a Modified Bicistronic Retroviral Vector

Hsieh, C. L., Chen, B. F., Wang, C. C., Liu, H. H., Chen, D. S. & Hwang, L. H., Sep 25 1995, In : Biochemical and Biophysical Research Communications. 214, 3, p. 910-917 8 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Improved gene expression by a U3-based retroviral vector

Chen, B. F., Hsieh, C. L., Chen, D. S. & Hwang, L. H., Apr 15 1992, In : Biochemical and Biophysical Research Communications. 184, 1, p. 330-337 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Increased expression of IL-21 reduces tumor growth by modulating the status of tumor-infiltrated lymphocytes

Hsieh, C. L., Hsu, S. C., Shen, C. R., Chen, M. Y., Liu, S. J., Chong, P. & Chen, H. W., 2011, In : Immunobiology. 216, 4, p. 491-496 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Induction of a distinct CD8 Tnc17 subset by transforming growth factor-β and interleukin-6

Liu, S. J., Tsai, J. P., Shen, C. R., Sher, Y. P., Hsieh, C. L., Yeh, Y. C., Chou, A. H., Chang, S. R., Hsiao, K. N., Yu, F. W. & Chen, H. W., Aug 1 2007, In : Journal of Leukocyte Biology. 82, 2, p. 354-360 7 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)

Induction of antitumor immunity with combination of HER2/neu DNA vaccine and interleukin 2 gene-modified tumor vaccine

Chen, S. A., Tsai, M. H., Wu, F. T., Hsiang, A., Chen, Y. L., Lei, H. Y., Tzai, T. S., Leung, H. W. C., Jin, Y. T., Hsieh, C. L., Hwang, L. H. & Lai, M. D., 2000, In : Clinical Cancer Research. 6, 11, p. 4381-4388 8 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Inhibition of ADAM9 expression induces epithelial phenotypic alterations and sensitizes human prostate cancer cells to radiation and chemotherapy

Josson, S., Anderson, C. S., Sung, S. Y., Johnstone, P. A. S., Kubo, H., Hsieh, C. L., Arnold, R., Gururajan, M., Yates, C. & Chung, L. W. K., Feb 15 2011, In : Prostate. 71, 3, p. 232-240 9 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

In Vivo Targeting of ADAM9 Gene Expression Using Lentivirus-Delivered shRNA Suppresses Prostate Cancer Growth by Regulating REG4 Dependent Cell Cycle Progression

Liu, C. M., Hsieh, C. L., He, Y. C., Lo, S. J., Liang, J. A., Hsieh, T. F., Josson, S., Chung, L. W. K., Hung, M. C. & Sung, S. Y., Jan 16 2013, In : PLoS One. 8, 1, e53795.

Research output: Contribution to journalArticle

15 Citations (Scopus)

In-vivo xenograft murine human uveal melanoma model develops hepatic micrometastases

Yang, H., Fang, G., Huang, X., Yu, J., Hsieh, C. L. & Grossniklaus, H. E., Apr 2008, In : Melanoma Research. 18, 2, p. 95-103 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Involvement of the 5' proximal coding sequences of hepatitis C virus with internal initiation of viral translation

Hwang, L. H., Hsieh, C. L., Yen, A., Chung, Y. L. & Chen, D. S., Nov 18 1998, In : Biochemical and Biophysical Research Communications. 252, 2, p. 455-460 6 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
4 Citations (Scopus)

KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC

Wang, H. J., Pochampalli, M., Wang, L. Y., Zou, J. X., Li, P. S., Hsu, S. C., Wang, B. J., Huang, S. H., Yang, P., Yang, J. C., Chu, C. Y., Hsieh, C. L., Sung, S. Y., Li, C. F., Tepper, C. G., Ann, D. K., Gao, A. C., Evans, C. P., Izumiya, Y., Chuu, C. P. & 3 others, Wang, W. C., Chen, H. W. & Kung, H. J., Jan 3 2019, In : Oncogene. 38, 1, p. 17-32

Research output: Contribution to journalArticle

12 Citations (Scopus)

Loss of let-7 microRNA upregulates IL-6 in bone marrow-derived mesenchymal stem cells triggering a reactive stromal response to prostate cancer.

Sung, S. Y., Liao, C. H., Wu, H. P., Hsiao, W. C., Wu, I. H., Jinpu, Yu, Lin, S. H. & Hsieh, C. L., 2013, In : PLoS One. 8, 8, e71637.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Mitochondrial DNA mutation stimulates prostate cancer growth in bone stromal environment

Arnold, R. S., Sun, C. Q., Richards, J. C., Grigoriev, G., Coleman, I. M., Nelson, P. S., Hsieh, C. L., Lee, J. K., Xu, Z., Rogatko, A., Osunkoya, A. O., Zayzafoon, M., Chung, L. & Petros, J. A., Jan 1 2009, In : Prostate. 69, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Morin sulphates/glucuronides enhance macrophage function in microgravity culture system

Hsieh, C. L., Chao, P. D. L. & Fang, S. H., Sep 2005, In : European Journal of Clinical Investigation. 35, 9, p. 591-596 6 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

MRI tracking of polyethylene glycol-coated superparamagnetic iron oxide-labelled placenta-derived mesenchymal stem cells toward glioblastoma stem-like cells in a mouse model

Hsu, F. T., Wei, Z. H., Hsuan, Y. C. Y., Lin, W., Su, Y. C., Liao, C. H. & Hsieh, C. L., Jan 1 2018, (Accepted/In press) In : Artificial Cells, Nanomedicine and Biotechnology.

Research output: Contribution to journalArticle

5 Citations (Scopus)

New prospectives of prostate cancer gene therapy: Molecular targets and animal models

Hsieh, C. L. & Chung, L. W. K., 2001, In : Critical Reviews in Eukaryotic Gene Expression. 11, 1-3, p. 77-120 44 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

New targets for therapy in prostate cancer: Modulation of stromal-epithelial interactions

Chung, L. W. K., Hsieh, C. L., Law, A., Sung, S. Y., Gardner, T. A., Egawa, M., Matsubara, S. & Zhau, H. E., Nov 2003, In : Urology. 62, 5 SUPPL. 1, p. 44-54 11 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Non-invasive bioluminescent detection of prostate cancer growth and metastasis in a bigenic transgenic mouse model

Hsieh, C. L., Xie, Z., Yu, J., Martin, W. D., Datta, M. W., Wu, G. J. & Chung, L. W. K., May 15 2007, In : Prostate. 67, 7, p. 685-691 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Osthole improves aspects of spatial performance in ovariectomized rats

Hsieh, M. T., Hsieh, C. L., Wang, W. H., Chen, C. S., Lin, C. J. & Wu, C. R., 2004, In : American Journal of Chinese Medicine. 32, 1, p. 11-20 10 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Petroleum ether extract of Cnidium monnieri ameliorated scopolamine-induced amnesia through adrenal gland-mediated mechanism in male rats

Wu, C. R., Lin, L. W., Hsieh, C. L., Wang, W. H., Lin, Y. T. & Hsieh, M. T., May 22 2008, In : Journal of Ethnopharmacology. 117, 3, p. 403-407 5 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Reactive oxygen species-mediated switching expression of MMP-3 in stromal fibroblasts and cancer cells during prostate cancer progression

Hsieh, C. L., Liu, C. M., Chen, H. A., Yang, S. T., Shigemura, K., Kitagawa, K., Yamamichi, F., Fujisawa, M., Liu, Y. R., Lee, W. H., Chen, K. C., Shen, C. N., Lin, C. C., Chung, L. W. K. & Sung, S. Y., Dec 1 2017, In : Scientific Reports. 7, 1, 9065.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Regression of established mouse leukemia by GM-CSF-Transduced tumor vaccine: Implications for cytotoxic T lymphocyte responses and tumor burdens

Hsieh, C. L., Pang, V. F., Chen, D. S. & Hwang, L. H., 1997, In : Human Gene Therapy. 8, 16, p. 1843-1854 12 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Regression of orthotopic brain tumors by cytokine-assisted tumor vaccines primed in the brain

Tseng, S. H., Hsieh, C. L., Lin, S. M. & Hwang, L. H., 1999, In : Cancer Gene Therapy. 6, 4, p. 302-312 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Stromal-epithelial interaction in prostate cancer progression

Chung, L. W. K., Huang, W. C., Sung, S. Y., Wu, D., Odero-Marah, V., Nomura, T., Shigemura, K., Miyagi, T., Seo, S., Shi, C., Molitierno, J., Elmore, J., Anderson, C., Isotani, S., Edlund, M., Hsieh, C. L., Wang, R., Shehata, B. & Zhau, H. E., 2006, In : Clinical Genitourinary Cancer. 5, 2, p. 162-170 9 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)