• 1938 Citations
  • 27 h-Index
20042020

Research output per year

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Research Output

  • 1938 Citations
  • 27 h-Index
  • 73 Article
  • 1 Review article
Article

Activation of Nrf2 by the dengue virus causes an increase in CLEC5A, which enhances TNF-α production by mononuclear phagocytes

Cheng, Y. L., Lin, Y. S., Chen, C. L., Tsai, T. T., Tsai, C. C., Wu, Y. W., Ou, Y. D., Chu, Y. Y., Wang, J. M., Yu, C. Y. & Lin, C. F., Aug 26 2016, In : Scientific Reports. 6, 32000.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Albumin prevents reactive oxygen species-induced mitochondrial damage, autophagy, and apoptosis during serum starvation

Liu, S-Y., Chen, C-L., Yang, T-T., Huang, W-C., Hsieh, C-Y., Shen, W-J., Tsai, T-T., Shieh, C-C. & Lin, C. F., Nov 2012, In : Apoptosis. 17, 11, p. 1156-1169 14 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

A modified fixed staining method for the simultaneous measurement of reactive oxygen species and oxidative responses

Shen, W-J., Hsieh, C-Y., Chen, C-L., Yang, K-C., Ma, C-T., Choi, P-C. & Lin, C. F., Jan 4 2013, In : Biochemical and Biophysical Research Communications. 430, 1, p. 442-447 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

An emerging role for the anti-inflammatory cytokine interleukin-10 in dengue virus infection

Tsai, T-T., Chuang, Y-J., Lin, Y-S., Wan, S-W., Chen, C-L. & Lin, C. F., 2013, In : Journal of Biomedical Science. 20, 1, 40.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Anesthetic propofol causes glycogen synthase kinase-3β-regulated lysosomal/mitochondrial apoptosis in macrophages

Hsing, C. H., Chen, Y. H., Chen, C. L., Huang, W. C., Lin, M. C., Tseng, P. C., Wang, C. Y., Tsai, C. C., Choi, P. C. & Lin, C. F., Apr 2012, In : Anesthesiology. 116, 4, p. 868-881 14 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Anesthetic propofol overdose causes endothelial cytotoxicity in vitro and endothelial barrier dysfunction in vivo

Lin, M-C., Chen, C-L., Yang, T-T., Choi, P-C., Hsing, C-H. & Lin, C-F., Dec 1 2012, In : Toxicology and Applied Pharmacology. 265, 2, p. 253-262 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Anesthetic propofol reduces endotoxic inflammation by inhibiting reactive oxygen species-regulated Akt/IKKβ/NF-κB signaling

Hsing, C-H., Lin, M-C., Choi, P-C., Huang, W-C., Kai, J-I., Tsai, C-C., Cheng, Y-L., Hsieh, C-Y., Wang, C-Y., Chang, Y-P., Chen, Y-H., Chen, C-L. & Lin, C-F., 2011, In : PLoS One. 6, 3, e17598.

Research output: Contribution to journalArticle

75 Citations (Scopus)
10 Citations (Scopus)

An increase in glucosylceramide synthase induces BclxL-mediated cell survival in vinorelbine-resistant lung adenocarcinoma cells

Chiu, W. H., Su, W. C., Li, C. L., Chen, C. L. & Lin, C. F., 2015, In : Oncotarget. 6, 24, p. 20513-20524 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

An increase in integrin-linked kinase non-canonically confers NF-κB-mediated growth advantages to gastric cancer cells by activating ERK1/2

Tseng, P-C., Chen, C-L., Shan, Y-S., Chang, W-T., Liu, H-S., Hong, T-M., Hsieh, C-Y., Lin, S-H. & Lin, C-F., 2014, In : Cell Communication and Signaling. 12, p. 69 1 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Annexin A2 silencing induces G2 arrest of non-small cell lung cancer cells through p53-dependent and -independent mechanisms

Wang, C. Y., Chen, C. L., Tseng, Y. L., Fang, Y. T., Lin, Y. S., Su, W. C., Chen, C. C., Chang, K. C., Wang, Y. C. & Lin, C. F., Sep 21 2012, In : Journal of Biological Chemistry. 287, 39, p. 32512-32524 13 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Antibody-Dependent Enhancement Infection Facilitates Dengue Virus-Regulated Signaling of IL-10 Production in Monocytes

Tsai, T-T., Chuang, Y-J., Lin, Y-S., Chang, C-P., Wan, S-W., Lin, S-H., Chen, C-L. & Lin, C. F., 2014, In : PLoS Neglected Tropical Diseases. 8, 11

Research output: Contribution to journalArticle

29 Citations (Scopus)

Anti-dengue virus nonstructural protein 1 antibodies cause NO-mediated endothelial cell apoptosis via ceramide-regulated glycogen synthase kinase-3β and NF-κB activation

Chen, C-L., Lin, C. F., Wan, S-W., Wei, L-S., Chen, M-C., Yeh, T-M., Liu, H-S., Anderson, R. & Lin, Y-S., Aug 15 2013, In : Journal of Immunology. 191, 4, p. 1744-1752 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

AR-12 suppresses dengue virus replication by down-regulation of PI3K/AKT and GRP78

Chen, H., Chen, C. C., Lin, Y. S., Chang, P. C., Lu, Z. Y., Lin, C. F., Chen, C. L. & Chang, C. P., Jun 1 2017, In : Antiviral Research. 142, p. 158-168 11 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Autophagy facilitates an IFN-γ response and signal transduction

Chang, Y-P., Chen, C-L., Chen, S-O., Lin, Y-S., Tsai, C-C., Huang, W-C., Wang, C-Y., Hsieh, C-Y., Choi, P-C. & Lin, C. F., Oct 2011, In : Microbes and Infection. 13, 11, p. 888-894 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Autophagy facilitates cytokine-induced ICAM-1 expression

Wang, C-Y., Chiang, T-H., Chen, C-L., Tseng, P-C., Chien, S-Y., Chuang, Y-J., Yang, T-T., Hsieh, C-Y., Choi, P-C. & Lin, C. F., Feb 2014, In : Innate Immunity. 20, 2, p. 200-213 14 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Autophagy facilitates IFN-δ-induced Jak2-STAT1 activation and cellular inflammation

Chang, Y-P., Tsai, C-C., Huang, W-C., Wang, C-Y., Chen, C-L., Lin, Y-S., Kai, J-I., Hsieh, C-Y., Cheng, Y-L., Choi, P-C., Chen, S-H., Chang, S-P., Liu, H-S. & Lin, C. F., Sep 10 2010, In : Journal of Biological Chemistry. 285, 37, p. 28715-28722 8 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Bcl-2 rescues ceramide- and etoposide-induced mitochondrial apoptosis through blockage of caspase-2 activation

Lin, C. F., Chen, C-L., Chang, W-T., Jan, M-S., Hsu, L-J., Wu, R-H., Fang, Y-T., Tang, M-J., Chang, W. C. & Lin, Y-S., Jun 24 2005, In : Journal of Biological Chemistry. 280, 25, p. 23758-23765 8 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Blockade effects of anti-interferon- (ifn-) γ autoantibodies on ifn- γ -regulated antimicrobial immunity

Krisnawati, D. I., Liu, Y. C., Lee, Y. J., Wang, Y. T., Chen, C. L., Tseng, P. C., Shen, T. J. & Lin, C. F., Jan 1 2019, In : Journal of Immunology Research. 2019, 1629258.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Blockade of dengue virus infection and viral cytotoxicity in neuronal cells in vitro and in vivo by targeting endocytic pathways

Ho, M. R., Tsai, T. T., Chen, C. L., Jhan, M. K., Tsai, C. C., Lee, Y. C., Chen, C. H. & Lin, C. F., Dec 1 2017, In : Scientific Reports. 7, 1, 7023.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Ceramide in apoptotic signaling and anticancer therapy

Lin, C. F., Chen, C-L. & Lin, Y-S., Jun 2006, In : Current Medicinal Chemistry. 13, 14, p. 1609-1616 8 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway

Chen, C-L., Lin, C. F., Chang, W-T., Huang, W-C., Teng, C-F. & Lin, Y-S., Apr 15 2008, In : Blood. 111, 8, p. 4365-4374 10 p.

Research output: Contribution to journalArticle

130 Citations (Scopus)

Dengue Virus Infection Causes the Activation of Distinct NF- κ B Pathways for Inducible Nitric Oxide Synthase and TNF- Expression in RAW264.7 Cells

Cheng, Y-L., Lin, Y-S., Chen, C-L., Wan, S-W., Ou, Y-D., Yu, C-Y., Tsai, T-T., Tseng, P-C. & Lin, C. F., 2015, In : Mediators of Inflammation. 2015, 274025.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Dengue virus infection increases microglial cell migration

Jhan, M. K., Tsai, T. T., Chen, C. L., Tsai, C. C., Cheng, Y. L., Lee, Y. C., Ko, C. Y., Lin, Y. S., Chang, C. P., Lin, L. T. & Lin, C. F., Jan 1 2017, In : Scientific Reports. 7, 1, 91.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Detection of reactive oxygen species during the cell cycle under normal culture conditions using a modified fixed-sample staining method

Hsieh, C. Y., Chen, C. L., Yang, K. C., Ma, C. T., Choi, P. C. & Lin, C. F., Mar 4 2015, In : Journal of Immunoassay and Immunochemistry. 36, 2, p. 149-161 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Dextromethorphan attenuates NADPH oxidase-regulated glycogen synthase kinase 3 and NF-B activation and reduces nitric oxide production in group a streptococcal infection

Chen, C-L., Cheng, M-H., Kuo, C-F., Cheng, Y-L., Li, M-H., Chang, C-P., Wu, J-J., Anderson, R., Wang, S., Tsai, P-J., Liu, C-C. & Lin, Y-S., Jun 1 2018, In : Antimicrobial Agents and Chemotherapy. 62, 6, e02045-17.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Different types of cell death induced by Enterotoxins

Lin, C. F., Chen, C-L., Huang, W-C., Cheng, Y-L., Hsieh, C-Y., Wang, C-Y. & Hong, M-Y., Aug 2010, In : Toxins. 2, 8, p. 2158-2176 19 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Enterovirus 71 proteins 2A and 3D antagonize the antiviral activity of gamma interferon via signaling attenuation

Wang, L. C., Chen, S. O., Chang, S. P., Lee, Y. P., Yu, C. K., Chen, C. L., Tseng, P. C., Hsieh, C. Y., Chen, S. H. & Lin, C. F., 2015, In : Journal of Virology. 89, 14, p. 7028-7037 10 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
1 Citation (Scopus)

Functional neutralization of anti-IFN-γ autoantibody in patients with nontuberculous mycobacteria infection

Krisnawati, D. I., Liu, Y. C., Lee, Y. J., Wang, Y. T., Chen, C. L., Tseng, P. C. & Lin, C. F., Apr 5 2019, In : Scientific Reports. 9, 1, p. 5682 5682.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Galectin-1-induced autophagy facilitates cisplatin resistance of hepatocellular carcinoma

Su, Y. C., Davuluri, G. V. N., Chen, C. H., Shiau, D. C., Chen, C. C., Chen, C. L., Lin, Y. S. & Chang, C. P., Feb 1 2016, In : PLoS One. 11, 2, e0148408.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis

Huang, W. C., Tsai, C. C., Chen, C. L., Chen, T. Y., Chen, Y. P., Lin, Y. S., Lu, P. J., Lin, C. M., Wang, S. H., Tsao, C. W., Wang, C. Y., Cheng, Y. L., Hsieh, C. Y., Tseng, P. C. & Lin, C. F., Oct 2011, In : FASEB Journal. 25, 10, p. 3661-3673 13 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Glycogen synthase kinase-3 and Omi/HtrA2 induce annexin A2 cleavage followed by cell cycle inhibition and apoptosis

Wang, C-Y., Lin, Y-S., Su, W-C., Chen, C-L. & Lin, C. F., Oct 1 2009, In : Molecular Biology of the Cell. 20, 19, p. 4153-4161 9 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Glycogen synthase kinase-3 facilitates con a-induced IFN-γ-mediated immune hepatic injury

Tsai, C-C., Huang, W-C., Chen, C-L., Hsieh, C-Y., Lin, Y-S., Chen, S-H., Yang, K-C. & Lin, C. F., Oct 1 2011, In : Journal of Immunology. 187, 7, p. 3867-3877 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Glycogen synthase kinase-3 negatively regulates anti-inflammatory interleukin-10 for lipopolysaccharide-induced iNOS/NO biosynthesis and RANTES production in microglial cells

Huang, W-C., Lin, Y-S., Wang, C-Y., Tsai, C-C., Tseng, H-C., Chen, C-L., Lu, P-J., Chen, P-S., Qian, L., Hong, J-S. & Lin, C. F., Sep 2009, In : Immunology. 128, 1 PART 2

Research output: Contribution to journalArticle

85 Citations (Scopus)

Glycogen synthase kinase-3β and caspase-2 mediate ceramide-And etoposide-induced apoptosis by regulating the lysosomal-mitochondrial axis

Lin, C. F., Tsai, C. C., Huang, W. C., Wang, Y. C., Tseng, P. C., Tsai, T. T. & Chen, C. L., Jan 4 2016, In : PLoS One. 11, 1, e0145460.

Research output: Contribution to journalArticle

13 Citations (Scopus)
Open Access

Glycogen synthase kinase-3β facilitates IFN-γ-induced STAT1 activation by regulating Src homology-2 domain-containing phosphatase 2

Tsai, C-C., Kai, J-I., Huang, W-C., Wang, C-Y., Wang, Y., Chen, C-L., Fang, Y-T., Lin, Y-S., Anderson, R., Chen, S-H., Tsao, C-W. & Lin, C. F., Jul 15 2009, In : Journal of Immunology. 183, 2, p. 856-864 9 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Glycogen synthase kinase-3β inactivation is an intracellular marker and regulator for endotoxemic neutrophilia

Yang, T-T., Chen, C-L., Lin, W-C., Lin, Y-S., Tseng, P-C., Hsieh, C-Y., Chen, Y-H., Huang, W-C., Tsai, C-C., Wang, C-Y., Shieh, C-C. & Lin, C. F., Feb 2013, In : Journal of Molecular Medicine. 91, 2, p. 207-217 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Glycogen synthase kinase-3β indirectly facilitates interferon-γ-induced nuclear factor-κB activation and nitric oxide biosynthesis

Kai, J-I., Huang, W-C., Tsai, C-C., Chang, W-T., Chen, C-L. & Lin, C. F., Dec 15 2010, In : Journal of Cellular Biochemistry. 111, 6, p. 1522-1530 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Glycogen synthase kinase-3β mediates endoplasmic reticulum stress-induced lysosomal apoptosis in leukemia

Huang, W-C., Lin, Y-S., Chen, C-L., Wang, C-Y., Chiu, W-H. & Lin, C. F., May 2009, In : Journal of Pharmacology and Experimental Therapeutics. 329, 2, p. 524-531 8 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy

Cheng, Y. L., Kuo, C. F., Lu, S. L., Hiroko, O., Wu, Y. N., Hsie, C. L., Nod, T., Wu, S. R., Anderson, R., Lin, C. F., Chen, C. L., Wu, J. J. & Lin, Y. S., Jan 1 2019, In : mBio. 10, 5, e02148-19.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

GSK-3β acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis

Lin, C. F., Chen, C-L., Chiang, C-W., Jan, M-S., Huang, W-C. & Lin, Y-S., Aug 15 2007, In : Journal of Cell Science. 120, 16, p. 2935-2943 9 p.

Research output: Contribution to journalArticle

111 Citations (Scopus)

HECT E3 Ubiquitin Ligase-Regulated Txnip Degradation Facilitates TLR2-Mediated Inflammation During Group A Streptococcal Infection

Tseng, P-C., Kuo, C-F., Cheng, M-H., Wan, S-W., Lin, C-F., Chang, C-P., Lin, Y-S., Wu, J-J., Huang, C-C. & Chen, C-L., 2019, In : Frontiers in Immunology. 10, p. 2147 1 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Helicobacter pylori infection activates Src homology-2 domain-containing phosphatase 2 to suppress IFN-γ signaling

Wang, Y-C., Chen, C-L., Sheu, B-S., Yang, Y-J., Tseng, P-C., Hsieh, C-Y. & Lin, C. F., Oct 15 2014, In : Journal of Immunology. 193, 8, p. 4149-4158 10 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
6 Citations (Scopus)

Increased galectin-3 facilitates leukemia cell survival from apoptotic stimuli

Cheng, Y-L., Huang, W-C., Chen, C-L., Tsai, C-C., Wang, C-Y., Chiu, W-H., Chen, Y-L., Lin, Y-S., Chang, C-F. & Lin, C. F., Aug 26 2011, In : Biochemical and Biophysical Research Communications. 412, 2, p. 334-340 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Inhibiting glucosylceramide synthase facilitates the radiosensitizing effects of vinorelbine in lung adenocarcinoma cells

Chiu, W. H., Chen, H. H. W., Chang, J. Y., Luo, S. J., Li, C. L., Chen, C. L., Su, W. C. & Lin, C. F., Jul 28 2014, In : Cancer Letters. 349, 2, p. 144-151 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Inhibiting glycogen synthase kinase-3 decreases 12-O-tetradecanoylphorbol- 13-acetate-induced interferon-γ-mediated skin inflammation

Hsieh, C-Y., Chen, C-L., Tsai, C-C., Huang, W-C., Tseng, P-C., Lin, Y-S., Chen, S-H., Wong, T-W., Choi, P-C. & Lin, C. F., Oct 2012, In : Journal of Pharmacology and Experimental Therapeutics. 343, 1, p. 125-133 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Inhibiting glycogen synthase kinase-3 reduces endotoxaemic acute renal failure by down-regulating inflammation and renal cell apoptosis

Wang, Y., Huang, W-C., Wang, C-Y., Tsai, C-C., Chen, C-L., Chang, Y-T., Kai, J-I. & Lin, C. F., 2009, In : British Journal of Pharmacology. 157, 6, p. 1004-1013 10 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)