• 1918 Citations
  • 27 h-Index
20042020

Research output per year

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Research Output

  • 1918 Citations
  • 27 h-Index
  • 73 Article
  • 1 Review article
2020
Open Access
2019

Blockade effects of anti-interferon- (ifn-) γ autoantibodies on ifn- γ -regulated antimicrobial immunity

Krisnawati, D. I., Liu, Y. C., Lee, Y. J., Wang, Y. T., Chen, C. L., Tseng, P. C., Shen, T. J. & Lin, C. F., Jan 1 2019, In : Journal of Immunology Research. 2019, 1629258.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Functional neutralization of anti-IFN-γ autoantibody in patients with nontuberculous mycobacteria infection

Krisnawati, D. I., Liu, Y. C., Lee, Y. J., Wang, Y. T., Chen, C. L., Tseng, P. C. & Lin, C. F., Apr 5 2019, In : Scientific Reports. 9, 1, p. 5682 5682.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy

Cheng, Y. L., Kuo, C. F., Lu, S. L., Hiroko, O., Wu, Y. N., Hsie, C. L., Nod, T., Wu, S. R., Anderson, R., Lin, C. F., Chen, C. L., Wu, J. J. & Lin, Y. S., Jan 1 2019, In : mBio. 10, 5, e02148-19.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

HECT E3 Ubiquitin Ligase-Regulated Txnip Degradation Facilitates TLR2-Mediated Inflammation During Group A Streptococcal Infection

Tseng, P-C., Kuo, C-F., Cheng, M-H., Wan, S-W., Lin, C-F., Chang, C-P., Lin, Y-S., Wu, J-J., Huang, C-C. & Chen, C-L., 2019, In : Frontiers in Immunology. 10, p. 2147 1 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Microglial activation and inflammation caused by traffic-related particulate matter

Bai, K. J., Chuang, K. J., Chen, C. L., Jhan, M. K., Hsiao, T. C., Cheng, T. J., Chang, L. T., Chang, T. Y. & Chuang, H. C., Sep 25 2019, In : Chemico-Biological Interactions. 311, 108762.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2018

Dextromethorphan attenuates NADPH oxidase-regulated glycogen synthase kinase 3 and NF-B activation and reduces nitric oxide production in group a streptococcal infection

Chen, C-L., Cheng, M-H., Kuo, C-F., Cheng, Y-L., Li, M-H., Chang, C-P., Wu, J-J., Anderson, R., Wang, S., Tsai, P-J., Liu, C-C. & Lin, Y-S., Jun 1 2018, In : Antimicrobial Agents and Chemotherapy. 62, 6, e02045-17.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2017

AR-12 suppresses dengue virus replication by down-regulation of PI3K/AKT and GRP78

Chen, H., Chen, C. C., Lin, Y. S., Chang, P. C., Lu, Z. Y., Lin, C. F., Chen, C. L. & Chang, C. P., Jun 1 2017, In : Antiviral Research. 142, p. 158-168 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Blockade of dengue virus infection and viral cytotoxicity in neuronal cells in vitro and in vivo by targeting endocytic pathways

Ho, M. R., Tsai, T. T., Chen, C. L., Jhan, M. K., Tsai, C. C., Lee, Y. C., Chen, C. H. & Lin, C. F., Dec 1 2017, In : Scientific Reports. 7, 1, 7023.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Dengue virus infection increases microglial cell migration

Jhan, M. K., Tsai, T. T., Chen, C. L., Tsai, C. C., Cheng, Y. L., Lee, Y. C., Ko, C. Y., Lin, Y. S., Chang, C. P., Lin, L. T. & Lin, C. F., Jan 1 2017, In : Scientific Reports. 7, 1, 91.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Escape from IFN-γ-dependent immunosurveillance in tumorigenesis

Lin, C. F., Lin, C. M., Lee, K. Y., Wu, S. Y., Feng, P. H., Chen, K. Y., Chuang, H. C., Chen, C-L., Wang, Y. C., Tseng, P. C. & Tsai, T. T., Feb 1 2017, In : Journal of Biomedical Science. 24, 1, p. 1-9 9 p.

Research output: Contribution to journalReview article

38 Citations (Scopus)

Resveratrol treatment reveals a novel role for HMGB1 in regulation of the type 1 interferon response in dengue virus infection

Zainal, N., Chang, C. P., Cheng, Y. L., Wu, Y. W., Anderson, R., Wan, S. W., Chen, C. L., Ho, T. S., Abubakar, S. & Lin, Y. S., Feb 20 2017, In : Scientific Reports. 7, 42998.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Targeting heat shock factor 1 as an antiviral strategy against dengue virus replication in vitro and in vivo

Tsai, T. T., Chen, C. L., Tsai, C. C. & Lin, C. F., Sep 1 2017, In : Antiviral Research. 145, p. 44-53 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2016

Activation of Nrf2 by the dengue virus causes an increase in CLEC5A, which enhances TNF-α production by mononuclear phagocytes

Cheng, Y. L., Lin, Y. S., Chen, C. L., Tsai, T. T., Tsai, C. C., Wu, Y. W., Ou, Y. D., Chu, Y. Y., Wang, J. M., Yu, C. Y. & Lin, C. F., Aug 26 2016, In : Scientific Reports. 6, 32000.

Research output: Contribution to journalArticle

23 Citations (Scopus)
10 Citations (Scopus)

Galectin-1-induced autophagy facilitates cisplatin resistance of hepatocellular carcinoma

Su, Y. C., Davuluri, G. V. N., Chen, C. H., Shiau, D. C., Chen, C. C., Chen, C. L., Lin, Y. S. & Chang, C. P., Feb 1 2016, In : PLoS One. 11, 2, e0148408.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Glycogen synthase kinase-3β and caspase-2 mediate ceramide-And etoposide-induced apoptosis by regulating the lysosomal-mitochondrial axis

Lin, C. F., Tsai, C. C., Huang, W. C., Wang, Y. C., Tseng, P. C., Tsai, T. T. & Chen, C. L., Jan 4 2016, In : PLoS One. 11, 1, e0145460.

Research output: Contribution to journalArticle

13 Citations (Scopus)
6 Citations (Scopus)

Microglia retard dengue virus-induced acute viral encephalitis

Tsai, T. T., Chen, C. L., Lin, Y. S., Chang, C. P., Tsai, C. C., Cheng, Y. L., Huang, C. C., Ho, C. J., Lee, Y. C., Lin, L. T., Jhan, M. K. & Lin, C. F., Jun 9 2016, In : Scientific Reports. 6, 27670.

Research output: Contribution to journalArticle

29 Citations (Scopus)
13 Citations (Scopus)

Oxidative stress facilitates IFN-γ-induced mimic extracellular trap cell death in A549 lung epithelial cancer cells

Lin, C-F., Chen, C-L., Chien, S. Y., Tseng, P. C., Wang, Y. C. & Tsai, T. T., Aug 1 2016, In : PLoS One. 11, 8, e0162157.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Streptococcal pyrogenic exotoxin B inhibits apoptotic cell clearance by macrophages through protein S cleavage

Chen, C. L., Wu, Y. Y., Lin, C. F., Kuo, C. F., Han, C. L., Wang, S., Chuang, W. J., Chen, C. Y., Wu, J. J., Tsai, P. J., Liu, C. C. & Lin, Y. S., May 16 2016, In : Scientific Reports. 6, 26026.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS

Chang, C-F., Lee, Y-C., Lee, K-H., Lin, C. H., Chen, C-L., Shen, C. K. J. & Huang, C-C., Oct 21 2016, In : Journal of Biomedical Science. 23, 1, 72.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2015

An increase in glucosylceramide synthase induces BclxL-mediated cell survival in vinorelbine-resistant lung adenocarcinoma cells

Chiu, W. H., Su, W. C., Li, C. L., Chen, C. L. & Lin, C. F., 2015, In : Oncotarget. 6, 24, p. 20513-20524 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Dengue Virus Infection Causes the Activation of Distinct NF- κ B Pathways for Inducible Nitric Oxide Synthase and TNF- Expression in RAW264.7 Cells

Cheng, Y-L., Lin, Y-S., Chen, C-L., Wan, S-W., Ou, Y-D., Yu, C-Y., Tsai, T-T., Tseng, P-C. & Lin, C. F., 2015, In : Mediators of Inflammation. 2015, 274025.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Detection of reactive oxygen species during the cell cycle under normal culture conditions using a modified fixed-sample staining method

Hsieh, C. Y., Chen, C. L., Yang, K. C., Ma, C. T., Choi, P. C. & Lin, C. F., Mar 4 2015, In : Journal of Immunoassay and Immunochemistry. 36, 2, p. 149-161 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Enterovirus 71 proteins 2A and 3D antagonize the antiviral activity of gamma interferon via signaling attenuation

Wang, L. C., Chen, S. O., Chang, S. P., Lee, Y. P., Yu, C. K., Chen, C. L., Tseng, P. C., Hsieh, C. Y., Chen, S. H. & Lin, C. F., 2015, In : Journal of Virology. 89, 14, p. 7028-7037 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Loss of PTEN causes SHP2 activation, making lung cancer cells unresponsive to IFN-γ

Chen, C-L., Chiang, T-H., Tseng, P-C., Wang, Y-C. & Lin, C. F., Oct 23 2015, In : Biochemical and Biophysical Research Communications. 466, 3, p. 578-584 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Propofol treatment inhibits constitutive apoptosis in human primary neutrophils and granulocyte-differentiated human HL60 cells

Hsing, C-H., Chen, C-L., Lin, W-C. & Lin, C-F., Jun 10 2015, In : PLoS One. 10, 6, e0129693.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2014

An increase in integrin-linked kinase non-canonically confers NF-κB-mediated growth advantages to gastric cancer cells by activating ERK1/2

Tseng, P-C., Chen, C-L., Shan, Y-S., Chang, W-T., Liu, H-S., Hong, T-M., Hsieh, C-Y., Lin, S-H. & Lin, C-F., 2014, In : Cell Communication and Signaling. 12, p. 69 1 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Antibody-Dependent Enhancement Infection Facilitates Dengue Virus-Regulated Signaling of IL-10 Production in Monocytes

Tsai, T-T., Chuang, Y-J., Lin, Y-S., Chang, C-P., Wan, S-W., Lin, S-H., Chen, C-L. & Lin, C. F., 2014, In : PLoS Neglected Tropical Diseases. 8, 11

Research output: Contribution to journalArticle

29 Citations (Scopus)

Autophagy facilitates cytokine-induced ICAM-1 expression

Wang, C-Y., Chiang, T-H., Chen, C-L., Tseng, P-C., Chien, S-Y., Chuang, Y-J., Yang, T-T., Hsieh, C-Y., Choi, P-C. & Lin, C. F., Feb 2014, In : Innate Immunity. 20, 2, p. 200-213 14 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Helicobacter pylori infection activates Src homology-2 domain-containing phosphatase 2 to suppress IFN-γ signaling

Wang, Y-C., Chen, C-L., Sheu, B-S., Yang, Y-J., Tseng, P-C., Hsieh, C-Y. & Lin, C. F., Oct 15 2014, In : Journal of Immunology. 193, 8, p. 4149-4158 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Inhibiting glucosylceramide synthase facilitates the radiosensitizing effects of vinorelbine in lung adenocarcinoma cells

Chiu, W. H., Chen, H. H. W., Chang, J. Y., Luo, S. J., Li, C. L., Chen, C. L., Su, W. C. & Lin, C. F., Jul 28 2014, In : Cancer Letters. 349, 2, p. 144-151 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Macrophage migration inhibitory factor triggers chemotaxis of CD74+CXCR2+NKT cells in chemically induced IFN-γ-Mediated skin inflammation

Hsieh, C-Y., Chen, C-L., Lin, Y-S., Yeh, T-M., Tsai, T-T., Hong, M-Y. & Lin, C. F., Oct 1 2014, In : Journal of Immunology. 193, 7, p. 3693-3703 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
18 Citations (Scopus)
2013

A modified fixed staining method for the simultaneous measurement of reactive oxygen species and oxidative responses

Shen, W-J., Hsieh, C-Y., Chen, C-L., Yang, K-C., Ma, C-T., Choi, P-C. & Lin, C. F., Jan 4 2013, In : Biochemical and Biophysical Research Communications. 430, 1, p. 442-447 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

An emerging role for the anti-inflammatory cytokine interleukin-10 in dengue virus infection

Tsai, T-T., Chuang, Y-J., Lin, Y-S., Wan, S-W., Chen, C-L. & Lin, C. F., 2013, In : Journal of Biomedical Science. 20, 1, 40.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Anti-dengue virus nonstructural protein 1 antibodies cause NO-mediated endothelial cell apoptosis via ceramide-regulated glycogen synthase kinase-3β and NF-κB activation

Chen, C-L., Lin, C. F., Wan, S-W., Wei, L-S., Chen, M-C., Yeh, T-M., Liu, H-S., Anderson, R. & Lin, Y-S., Aug 15 2013, In : Journal of Immunology. 191, 4, p. 1744-1752 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Glycogen synthase kinase-3β inactivation is an intracellular marker and regulator for endotoxemic neutrophilia

Yang, T-T., Chen, C-L., Lin, W-C., Lin, Y-S., Tseng, P-C., Hsieh, C-Y., Chen, Y-H., Huang, W-C., Tsai, C-C., Wang, C-Y., Shieh, C-C. & Lin, C. F., Feb 2013, In : Journal of Molecular Medicine. 91, 2, p. 207-217 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Regulatory role of GSK-3 β on NF-B, nitric oxide, and TNF-α in group A streptococcal infection

Chang, Y-T., Chen, C-L., Lin, C. F., Lu, S-L., Cheng, M-H., Kuo, C-F. & Lin, Y-S., 2013, In : Mediators of Inflammation. 2013, 720689.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Uropathogenic Escherichia coli causes cortical tubular necrotic cell death and the release of macrophage migration inhibitory factor

Hong, M-Y., Tseng, C-C., Chuang, C-C., Chen, C-L., Lin, Y-H., Hsieh, C-Y., Chang, Y-T., Hsing, C. H., Chang, K-Y. & Lin, C. F., Mar 2013, In : Cytokine. 61, 3, p. 945-952 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2012

Albumin prevents reactive oxygen species-induced mitochondrial damage, autophagy, and apoptosis during serum starvation

Liu, S-Y., Chen, C-L., Yang, T-T., Huang, W-C., Hsieh, C-Y., Shen, W-J., Tsai, T-T., Shieh, C-C. & Lin, C. F., Nov 2012, In : Apoptosis. 17, 11, p. 1156-1169 14 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Anesthetic propofol causes glycogen synthase kinase-3β-regulated lysosomal/mitochondrial apoptosis in macrophages

Hsing, C. H., Chen, Y. H., Chen, C. L., Huang, W. C., Lin, M. C., Tseng, P. C., Wang, C. Y., Tsai, C. C., Choi, P. C. & Lin, C. F., Apr 2012, In : Anesthesiology. 116, 4, p. 868-881 14 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Anesthetic propofol overdose causes endothelial cytotoxicity in vitro and endothelial barrier dysfunction in vivo

Lin, M-C., Chen, C-L., Yang, T-T., Choi, P-C., Hsing, C-H. & Lin, C-F., Dec 1 2012, In : Toxicology and Applied Pharmacology. 265, 2, p. 253-262 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Annexin A2 silencing induces G2 arrest of non-small cell lung cancer cells through p53-dependent and -independent mechanisms

Wang, C. Y., Chen, C. L., Tseng, Y. L., Fang, Y. T., Lin, Y. S., Su, W. C., Chen, C. C., Chang, K. C., Wang, Y. C. & Lin, C. F., Sep 21 2012, In : Journal of Biological Chemistry. 287, 39, p. 32512-32524 13 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Inhibiting glycogen synthase kinase-3 decreases 12-O-tetradecanoylphorbol- 13-acetate-induced interferon-γ-mediated skin inflammation

Hsieh, C-Y., Chen, C-L., Tsai, C-C., Huang, W-C., Tseng, P-C., Lin, Y-S., Chen, S-H., Wong, T-W., Choi, P-C. & Lin, C. F., Oct 2012, In : Journal of Pharmacology and Experimental Therapeutics. 343, 1, p. 125-133 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Regulation of SHP2 by PTEN/AKT/GSK-3β signaling facilitates IFN-γ resistance in hyperproliferating gastric cancer

Tseng, P-C., Huang, W-C., Chen, C-L., Sheu, B-S., Shan, Y-S., Tsai, C-C., Wang, C-Y., Chen, S-O., Hsieh, C-Y. & Lin, C. F., Sep 2012, In : Immunobiology. 217, 9, p. 926-934 9 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Urinary macrophage migration inhibitory factor serves as a potential biomarker for acute kidney injury in patients with acute pyelonephritis

Hong, M-Y., Tseng, C-C., Chuang, C-C., Chen, C-L., Lin, S-H. & Lin, C. F., 2012, In : Mediators of Inflammation. 2012, 381358.

Research output: Contribution to journalArticle

13 Citations (Scopus)