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Research Output

  • 1049 Citations
  • 15 h-Index
  • 41 Article
  • 2 Review article
2020

ABL genomic editing sufficiently abolishes oncogenesis of human chronic myeloid leukemia cells in vitro and in vivo

Chen, S. H., Hsieh, Y. Y., Tzeng, H. E., Lin, C. Y., Hsu, K. W., Chiang, Y. S., Lin, S. M., Su, M. J., Hsieh, W. S. & Lee, C. H., Jun 2020, In : Cancers. 12, 6, 1399.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

An integrated genomic strategy to identify CHRNB4 as a diagnostic/prognostic biomarker for targeted therapy in head and neck cancer

Chuang, Y. H., Lee, C. H., Lin, C. Y., Liu, C. L., Huang, S. H., Lee, J. Y., Chiu, Y. Y., Lee, J. C. & Yang, J. M., May 2020, In : Cancers. 12, 5, 1324.

Research output: Contribution to journalArticle

Open Access
2019

HDAC1,2 Knock-Out and HDACi Induced Cell Apoptosis in Imatinib-Resistant K562 Cells

Chen, S. H., Chow, J. M., Hsieh, Y. Y., Lin, C. Y., Hsu, K. W., Hsieh, W. S., Chi, W. M., Shabangu, B. M. & Lee, C. H., May 1 2019, In : International Journal of Molecular Sciences. 20, 9, 2271.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

HDAC1 and HDAC2 double knockout triggers cell apoptosis in advanced thyroid cancer

Lin, C. L., Tsai, M. L., Lin, C. Y., Hsu, K. W., Hsieh, W. S., Chi, W. M., Huang, L. C. & Lee, C. H., Jan 2 2019, In : International Journal of Molecular Sciences. 20, 2, 454.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Membrane protein-regulated networks across human cancers

Lin, C. Y., Lee, C. H., Chuang, Y. H., Lee, J. Y., Chiu, Y. Y., Wu Lee, Y. H., Jong, Y. J., Hwang, J. K., Huang, S. H., Chen, L. C., Wu, C. H., Tu, S. H., Ho, Y. S. & Yang, J. M., Dec 1 2019, In : Nature Communications. 10, 1, 3131.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Wound Closure after Thyroid and Parathyroid Surgery: A Meta-Analysis of Randomized Controlled Trials

Huang, Y-H., Chen, C., Lee, C-H., Loh, E-W. & Tam, K-W., Jun 2019, In : Scandinavian Journal of Surgery. 108, 2, p. 101-108

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

CRISPR/Cas9 Genome Editing of Epidermal Growth Factor Receptor Sufficiently Abolished Oncogenicity in Anaplastic Thyroid Cancer

Huang, L-C., Tam, K-W., Liu, W-N., Lin, C-Y., Hsu, K-W., Hsieh, W-S., Chi, W-M., Lee, A-W., Yang, J-M., Lin, C-L. & Lee, C-H., Jan 1 2018, In : Disease Markers. 2018, p. 3835783 1 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
4 Citations (Scopus)

Efficacy and Safety of Rituximab for the Treatment of Graves' Orbitopathy: A Meta-analysis of Randomized Controlled Trials

Shen, W. C., Lee, C. H., Loh, E. W., Hsieh, A. T., Chen, L. & Tam, K. W., May 1 2018, In : Pharmacotherapy. 38, 5, p. 503-510 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
6 Citations (Scopus)

Prediction of novel target genes and pathways involved in bevacizumab-resistant colorectal cancer

Makondi, P. T., Lee, C. H., Huang, C. Y., Chu, C. M., Chang, Y. J. & Wei, P. L., Jan 1 2018, In : PLoS One. 13, 1, e0189582.

Research output: Contribution to journalArticle

5 Citations (Scopus)
18 Citations (Scopus)

The application of non-invasive apoptosis detection sensor (NIADS) on histone deacetylation inhibitor (HDACI)-induced breast cancer cell death

Hsu, K. W., Huang, C. Y., Tam, K. W., Lin, C. Y., Huang, L. C., Lin, C. L., Hsieh, W. S., Chi, W. M., Chang, Y. J., Wei, P. L., Chen, S. T. & Lee, C. H., Feb 2 2018, In : International Journal of Molecular Sciences. 19, 2, 452.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Tyrosine kinase inhibitors for advanced or metastatic thyroid cancer: a meta-analysis of randomized controlled trials

Liu, J. W., Chen, C., Loh, E. W., Chu, C. C., Wang, M. Y., Ouyang, H. J., Chang, Y. T., Zhuang, W. Z., Chou, C. W., Huang, D. J., Lee, C. H., Yen, Y. & Tam, K. W., 2018, In : Current Medical Research and Opinion. p. 1-9 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

α-Tocopherol succinate enhances pterostilbene anti-tumor activity in human breast cancer cells in vivo and in vitro

Tam, K. W., Ho, C. T., Tu, S. H., Lee, W. J., Huang, C. S., Chen, C. S., Wu, C. H., Lee, C. H. & Ho, Y. S., 2018, In : Oncotarget. 9, 4, p. 4593-4606 14 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2017

A rapid and quantitative method to detect human circulating tumor cells in a preclinical animal model

Tu, S. H., Hsieh, Y. C., Huang, L. C., Lin, C. Y., Hsu, K. W., Hsieh, W. S., Chi, W. M. & Lee, C. H., Jun 23 2017, In : BMC Cancer. 17, 1, 440.

Research output: Contribution to journalArticle

8 Citations (Scopus)
12 Citations (Scopus)
7 Citations (Scopus)

Nicotinic Acetylcholine Receptor Subtype Alpha-9 Mediates Triple-Negative Breast Cancers Based on a Spontaneous Pulmonary Metastasis Mouse Model

Huang, L-C., Lin, C-L., Qiu, J-Z., Lin, C-Y., Hsu, K-W., Tam, K-W., Lee, J-Y., Yang, J-M. & Lee, C-H., Nov 3 2017, In : Frontiers in Cellular Neuroscience. 11

Research output: Contribution to journalArticle

10 Citations (Scopus)
2014

CHRNA9 polymorphisms and smoking exposure synergize to increase the risk of breast cancer in Taiwan

Hsieh, Y. C., Lee, C. H., Tu, S. H., Wu, C. H., Hung, C. S., Hsieh, M. C., Chuang, C. W., Ho, Y. S. & Chiou, H. Y., Nov 1 2014, In : Carcinogenesis. 35, 11, p. 2520-2525 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2013

Alteration of α-tocopherol-associated protein (TAP) expression in human breast epithelial cells during breast cancer development

Tam, K-W., Ho, C. T., Lee, W. J., Tu, S-H., Huang, C. S., Chen, C. S., Lee, C-H., Wu, C-H. & Ho, Y-S., Jun 1 2013, In : Food Chemistry. 138, 2-3, p. 1015-1021 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2012

Human breast cancer cell metastasis is attenuated by lysyl oxidase inhibitors through down-regulation of focal adhesion kinase and the paxillin-signaling pathway

Chen, L. C., Tu, S. H., Huang, C. S., Chen, C. S., Ho, C. T., Lin, H. W., Lee, C. H., Chang, H. W., Chang, C. H., Wu, C. H., Lee, W. S. & Ho, Y. S., Aug 2012, In : Breast Cancer Research and Treatment. 134, 3, p. 989-1004 16 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)
2011

Crosstalk between nicotine and estrogen-induced estrogen receptor activation induces α9-nicotinic acetylcholine receptor expression in human breast cancer cells

Lee, C. H., Chang, Y. C., Chen, C. S., Tu, S. H., Wang, Y. J., Chen, L. C., Chang, Y. J., Wei, P. L., Chang, H. W., Chang, C. H., Huang, C. S., Wu, C. H. & Ho, Y. S., Sep 2011, In : Breast Cancer Research and Treatment. 129, 2, p. 331-345 15 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

From smoking to cancers: Novel targets to neuronal nicotinic acetylcholine receptors

Lee, C-H., Wu, C-H. & Ho, Y-S., 2011, In : Journal of Oncology. 693424.

Research output: Contribution to journalReview article

13 Citations (Scopus)

Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins

Chen, C. S., Lee, C-H., Hsieh, C. D., Ho, C. T., Pan, M. H., Huang, C. S., Tu, S-H., Wang, Y. J., Chen, L-C., Chang, Y-J., Wei, P-L., Yang, Y-Y., Wu, C-H. & Ho, Y-S., Jan 2011, In : Breast Cancer Research and Treatment. 125, 1, p. 73-87 15 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Nicotinic acetylcholine receptor-based blockade: Applications of molecular targets for cancer therapy

Wu, C. H., Lee, C. H. & Ho, Y. S., Jun 1 2011, In : Clinical Cancer Research. 17, 11, p. 3533-3541 9 p.

Research output: Contribution to journalReview article

74 Citations (Scopus)

Smoking-induced Human Breast Cancer Formation through Induction of α9-nicotinic Acetylcholine Receptor

Ho, Y-S., Lee, C-H. & Wu, C-H., 2011, In : Formosan Journal of Surgery. 44, 2, p. 47-52 6 p.

Research output: Contribution to journalArticle

Tea polyphenol (-)-epigallocatechin-3-gallate inhibits nicotine- and estrogen-induced α9-nicotinic acetylcholine receptor upregulation in human breast cancer cells

Tu, S. H., Ku, C. Y., Ho, C. T., Chen, C. S., Huang, C. S., Lee, C. H., Chen, L. C., Pan, M. H., Chang, H. W., Chang, C. H., Chang, Y. J., Wei, P. L., Wu, C. H. & Ho, Y. S., Mar 2011, In : Molecular Nutrition and Food Research. 55, 3, p. 455-466 12 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)
12 Citations (Scopus)
8 Citations (Scopus)
2010

Increased expression of enolase α in human breast cancer confers tamoxifen resistance in human breast cancer cells

Tu, S. H., Chang, C. C., Chen, C. S., Tam, K. W., Wang, Y. J., Lee, C. H., Lin, H. W., Cheng, T. C., Huang, C. S., Chu, J. S., Shih, N. Y., Chen, L. C., Leu, S. J., Ho, Y. S. & Wu, C. H., Jun 2010, In : Breast Cancer Research and Treatment. 121, 3, p. 539-553 15 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Long-term ethanol exposure causes human liver cancer cells to become resistant to mitomycin c treatment through the inactivation of bad-mediated apoptosis

Huang, C. S., Lee, Y. R., Chen, C. S., Tu, S. H., Wang, Y. J., Lee, C. H., Chen, L. C., Chang, H. W., Chang, C. H., Su, C-M., Wu, C. H. & Ho, Y. S., Aug 2010, In : Molecular Carcinogenesis. 49, 8, p. 728-738 11 p.

Research output: Contribution to journalArticle

Overexpression and activation of the α9-nicotinic receptor during tumorigenesis in human breast epithelial cells

Lee, C. H., Huang, C. S., Chen, C. S., Tu, S. H., Wang, Y. J., Chang, Y. J., Tam, K. W., Wei, P. L., Cheng, T. C., Chu, J. S., Chen, L. C., Wu, C. H. & Ho, Y. S., Sep 8 2010, In : Journal of the National Cancer Institute. 102, 17, p. 1322-1335 14 p.

Research output: Contribution to journalArticle

106 Citations (Scopus)
2009

Apple polyphenol phloretin potentiates the anticancer actions of paclitaxel through induction of apoptosis in human Hep G2 cells

Yang, K. C., Tsai, C. Y., Wang, Y. J., Wei, P-L., Lee, C-H., Chen, J. H., Wu, C-H. & Ho, Y-S., May 2009, In : Molecular Carcinogenesis. 48, 5, p. 420-431 12 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Extended use of intravenous bisphosphonate therapy for the prevention of skeletal complications in patients with cancer

Wang, X., Ni, J., Hsu, C. L., Johnykutty, S., Tang, P., Ho, Y. S., Lee, C. H. & Yeh, S., Nov 13 2009, In : Cancer Investigation. 27, 10, p. 971-977 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

In vitro and in vivo study of phloretin-induced apoptosis in human liver cancer cells involving inhibition of type II glucose transporter

Wu, C. H., Ho, Y. S., Tsai, C. Y., Wang, Y. J., Tseng, H., Wei, P. L., Lee, C. H., Liu, R. S. & Lin, S. Y., May 1 2009, In : International Journal of Cancer. 124, 9, p. 2210-2219 10 p.

Research output: Contribution to journalArticle

89 Citations (Scopus)

Reduced expression of tocopherol-associated protein (TAP/Sec14L2) in human breast cancer.

Wang, X., Ni, J., Hsu, C. L., Johnykutty, S., Tang, P., Ho, Y. S., Lee, C. H. & Yeh, S., Dec 2009, In : Cancer Investigation. 27, 10, p. 971-977 7 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)
2008

SP1-regulated p27/Kip1 gene expression is involved in terbinafine-induced human A431 cancer cell differentiation: An in vitro and in vivo study

Huang, C. S., Ho, W. L., Lee, W. S., Sheu, M. T., Wang, Y. J., Tu, S. H., Chen, R. J., Chu, J. S., Chen, L. C., Lee, C. H., Tseng, H., Ho, Y. S. & Wu, C. H., May 1 2008, In : Biochemical Pharmacology. 75, 9, p. 1783-1796 14 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2007

Tubulozole-induced G2/M cell cycle arrest in human colon cancer cells through formation of microtubule polymerization mediated by ERK1/2 and Chk1 kinase activation

Chou, Y. H., Ho, Y. S., Wu, C-C., Chai, C. Y., Chen, S-C., Lee, C. H., Tsai, P. S. & Wu, C. H., Aug 2007, In : Food and Chemical Toxicology. 45, 8, p. 1356-1367 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2006

Involvement of proapoptotic Bcl-2 family members in terbinafine-induced mitochondrial dysfunction and apoptosis in HL60 cells

Yang, K-C., Wu, C-C., Wu, C-H., Chen, J. H., Chu, C. H., Chen, C-H., Chou, Y. H., Wang, Y. J., Lee, W-S., Tseng, H., Lin, S-Y., Lee, C-H. & Ho, Y-S., Feb 2006, In : Food and Chemical Toxicology. 44, 2, p. 214-226 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2005
31 Citations (Scopus)

Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFκB activation and cyclin D1 up-regulation

Ho, Y. S., Chen, C. H., Wang, Y. J., Pestell, R. G., Albanese, C., Chen, R. J., Chang, M. C., Jeng, J. H., Lin, S. Y., Liang, Y. C., Tseng, H., Lee, W. S., Lin, J. K., Chu, J. S., Chen, L. C., Lee, C. H., Tso, W. L., Lai, Y. C. & Wu, C. H., Jun 1 2005, In : Toxicology and Applied Pharmacology. 205, 2, p. 133-148 16 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)