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Research Output 1995 2019

2019
1 Citation (Scopus)
Open Access
Penfluridol
Unfolded Protein Response
Lung Neoplasms
Cell Death
Adenosine Triphosphate
2 Citations (Scopus)
Chronic Obstructive Pulmonary Disease
Odds Ratio
Propensity Score
Geriatrics
Length of Stay

Endothelin-1 Induces Mesothelial Mesenchymal Transition and Correlates with Pleural Fibrosis in Tuberculous Pleural Effusions

Wu, Z-H., Tsai, J-H., Hsieh, C-Y., Chen, W-L. & Chung, C-L., Mar 29 2019, In : Journal of Clinical Medicine. 8, 4, 426.

Research output: Contribution to journalArticle

Endothelin-1
Pleural Effusion
Fibrosis
Extracellular Matrix
Pleural Diseases
2018

Analysis of Titin in Red and White Muscles: Crucial Role on Muscle Contractions Using a Fish Model

Wu, M. P., Chang, N. C., Chung, C. L., Chiu, W. C., Hsu, C. C., Chen, H. M., Sheu, J. R., Jayakumar, T., Chou, D. S. & Fong, T. H., Nov 18 2018, In : BioMed Research International. 2018, p. 5816875 11 p., 5816875.

Research output: Contribution to journalArticle

Connectin
Muscle Contraction
Fish
Muscle
Muscles

An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets

Lu, W. J., Chung, C. L., Chen, R. J., Huang, L. T., Lien, L. M., Chang, C. C., Lin, K. H. & Sheu, J. R., Nov 14 2018, In : Journal of Clinical Medicine. 7, 11

Research output: Contribution to journalArticle

Phospholipase D
Blood Platelets
Platelet Activation
Platelet Aggregation
Thrombosis

Decreased risk of pneumonia in stroke patients receiving acupuncture: A nationwide matched-pair retrospective cohort study

Chang, C. C., Chen, T. L., Lin, C. S., Chung, C. L., Yeh, C. C., Hu, C. J., Lane, H. L., Liao, C. C. & Shih, C. C., May 1 2018, In : PLoS One. 13, 5, e0196094.

Research output: Contribution to journalArticle

Open Access
Acupuncture
acupuncture
risk reduction
cohort studies
stroke
2 Citations (Scopus)
Geriatrics
Human Influenza
Pneumonia
Vaccination
Hospital Mortality
2 Citations (Scopus)
Chemotactic Factors
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Leukocytes
Lewis Lung Carcinoma
6 Citations (Scopus)

Lipoteichoic acid upregulates plasminogen activator inhibitor-1 expression in parapneumonic effusions

Lee, K. L., Chen, W. L., Chen, R. J., Lai, K. S. & Chung, C. L., Jan 1 2018, In : Respirology. 23, 1, p. 89-95 7 p.

Research output: Contribution to journalArticle

Plasminogen Activator Inhibitor 1
Up-Regulation
Gram-Positive Bacteria
Toll-Like Receptor 2
lipoteichoic acid

Lupus pneumonitis presenting with high titre of anti-ro antibody

Chen, M. C., Wu, Y. L., Lee, K. L., Lai, K. S. & Chung, C. L., Jan 1 2018, In : Respirology Case Reports. 6, 1, e00280.

Research output: Contribution to journalArticle

Anti-Idiotypic Antibodies
Pneumonia
Systemic Lupus Erythematosus
Lung
Serum
2 Citations (Scopus)
brain damage
Neuroprotective Agents
medicine
Medicine
mice
2 Citations (Scopus)

Novel therapeutic agent against platelet activation in vitro and arterial thrombosis in vivo by morin hydrate

Hsia, C. W., Wu, M. P., Velusamy, M., Hsia, C. H., Chou, D. S., Tsai, C. L., Hsu, C. Y., Jayakumar, T., Chung, C. L. & Sheu, J. R., Aug 13 2018, In : International Journal of Molecular Sciences. 19, 8, 2386.

Research output: Contribution to journalArticle

thrombosis
Platelet Activation
Platelets
platelets
Hydrates
2 Citations (Scopus)

Structure-antiplatelet activity relationships of novel ruthenium (ii) complexes: Investigation of its molecular targets

Hsia, C. H., Jayakumar, T., Sheu, J. R., Tsao, S. Y., Velusamy, M., Hsia, C. W., Chou, D. S., Chang, C. C., Chung, C. L., Khamrang, T. & Lin, K. C., Feb 22 2018, In : Molecules. 23, 2, 477.

Research output: Contribution to journalArticle

Ruthenium
Structure-Activity Relationship
Platelets
platelets
ruthenium
2017

Brain metastases in patients with non-small cell lung cancer: the role of mutated-EGFRs with an exon 19 deletion or L858R point mutation in cancer cell dissemination

Hsiao, S-H., Chou, Y-T., Lin, S-E., Hsu, R-C., Chung, C-L., Kao, Y-R., Liu, H. E. & Wu, C-W., Aug 8 2017, In : Oncotarget. 8, 32, p. 53405-53418 14 p.

Research output: Contribution to journalArticle

Point Mutation
Non-Small Cell Lung Carcinoma
Exons
Neoplasm Metastasis
Brain
7 Citations (Scopus)

Diabetes risks and outcomes in chronic obstructive pulmonary disease patients: Two nationwide population-based retrospective cohort studies

Lin, C. S., Liu, C. C., Yeh, C. C., Chang, Y. C., Chung, C. L., Lane, H. L., Shih, C. C., Chen, T. L. & Liao, C. C., 2017, In : PLoS One. 12, 8, p. e0181815

Research output: Contribution to journalArticle

Pulmonary diseases
Medical problems
cohort studies
respiratory tract diseases
Chronic Obstructive Pulmonary Disease
6 Citations (Scopus)

Risk of stroke and post-stroke adverse events in patients with exacerbations of chronic obstructive pulmonary disease

Lin, C-S., Shih, C. C., Yeh, C. C., Hu, C-J., Chung, C-L., Chen, T-L. & Liao, C-C., Jan 1 2017, In : PLoS One. 12, 1, e0169429.

Research output: Contribution to journalArticle

Pulmonary diseases
stroke
respiratory tract diseases
Chronic Obstructive Pulmonary Disease
Stroke
22 Citations (Scopus)
JNK Mitogen-Activated Protein Kinases
Extracellular Signal-Regulated MAP Kinases
apoptosis
Non-Small Cell Lung Carcinoma
cancer
2016
3 Citations (Scopus)

Novel synthetic benzimidazole-derived oligosaccharide, M3BIM, prevents ex vivo platelet aggregation and in vivo thromboembolism

Yen, T. L., Wu, M. P., Chung, C. L., Yang, W. B., Jayakumar, T., Geraldine, P., Chou, C. M., Chang, C. Y., Lu, W-J. & Sheu, J. R., Feb 17 2016, In : Journal of Biomedical Science. 23, 1, 26.

Research output: Contribution to journalArticle

Thromboembolism
Platelets
Oligosaccharides
Platelet Aggregation
Collagen
3 Citations (Scopus)
Cohort Studies
Asthma
Odds Ratio
Population
Confidence Intervals
2015
1 Citation (Scopus)

Adverse outcomes after non-chest surgeries in patients with pulmonary tuberculosis: A nationwide study

Ke, C. C., Lin, C-S., Yeh, C. C., Chung, C-L., Hung, C. J., Liao, C-C., Chen, T-L. & Hozbor, D. F., Jul 14 2015, In : PLoS One. 10, 7, e0133064.

Research output: Contribution to journalArticle

national surveys
Pulmonary Tuberculosis
tuberculosis
Surgery
surgery
3 Citations (Scopus)
Concanavalin A
Cell Cycle Checkpoints
Lymphocytes
T-Lymphocytes
Cell Cycle Resting Phase
9 Citations (Scopus)
Drug therapy
Pulmonary diseases
stroke
respiratory tract diseases
Chronic Obstructive Pulmonary Disease
16 Citations (Scopus)
interstitial collagenase
Matrix Metalloproteinase 1
gelatinase B
tumor necrosis factors
Matrix Metalloproteinase 9

Proper Diagnostic Differentiation of Atypical Adenomatous Hyperplasia and Pulmonary Adenocarcinoma

Lai, K. S., Lin, S-E., Zeng, M-S., Lee, K-L., Hsiao, S-H. & Chung, C-L., Aug 1 2015, In : 胸腔醫學. 30, 4, p. 224-231 8 p.

Research output: Contribution to journalArticle

Hyperplasia
Biopsy
Lung
Adenocarcinoma
Tomography
Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Squamous Cell Carcinoma
Exons
Lung
2 Citations (Scopus)

VEGF correlates with inflammation and fibrosis in tuberculous pleural effusion

Bien, M. Y., Wu, M-P., Chen, W. L. & Chung, C. L., 2015, In : Scientific World Journal. 2015, 417124.

Research output: Contribution to journalArticle

Pleural Effusion
Vascular Endothelial Growth Factor A
Fibrosis
Inflammation
Plasminogen Activator Inhibitor 1
2014
31 Citations (Scopus)

Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption

Hsiao, C. J., Hsiao, G., Chen, W. L., Wang, S. W., Chiang, C. P., Liu, L. Y., Guh, J. H., Li, Z-H. & Chung, C. L., Apr 25 2014, In : Journal of Natural Products. 77, 4, p. 758-765 8 p.

Research output: Contribution to journalArticle

G1 Phase Cell Cycle Checkpoints
Non-Small Cell Lung Carcinoma
Cells
Apoptosis
G1 Phase
11 Citations (Scopus)
Histone Deacetylase Inhibitors
Plasminogen Activator Inhibitor 1
Transcription Factor AP-1
Histone Deacetylases
Mitogen-Activated Protein Kinase Phosphatases
14 Citations (Scopus)

Multidrug resistance protein 4 (MRP4/ABCC4) regulates thrombus formation in vitro and in vivo

Lien, L. M., Chen, Z. C., Chung, C. L., Yen, T. L., Chiu, H. C., Chou, D. S., Huang, S. Y., Sheu, J. R., Lu, W-J. & Lin, K. H., Aug 15 2014, In : European Journal of Pharmacology. 737, p. 159-167 9 p.

Research output: Contribution to journalArticle

P-Glycoproteins
Thrombosis
Cyclic Nucleotides
Platelet Activation
Collagen
1 Citation (Scopus)

Pulmonary air crescent sign

Lee, K. L., Liang, H. H., Chung, C. L., Hsiao, S. H. & Shih, C. H., 2014, In : JAMA Surgery. 149, 1, p. 97-98 2 p.

Research output: Contribution to journalShort survey

Squamous Cell Carcinoma
Lung Neoplasms
Air
Lung
2013
8 Citations (Scopus)

Brazilin isolated from Caesalpinia sappan L. acts as a novel collagen receptor agonist in human platelets

Chang, Y., Huang, S. K. H., Lu, W. J., Chung, C. L., Chen, W. L., Lu, S. H., Lin, K. H. & Sheu, J. R., Jan 25 2013, In : Journal of Biomedical Science. p. 4 1 p.

Research output: Contribution to journalArticle

Caesalpinia
Collagen Receptors
Platelets
Blood Platelets
Platelet Aggregation
8 Citations (Scopus)

Clinical Importance of Angiogenic Cytokines, Fibrinolytic Activity and Effusion Size in Parapneumonic Effusions

Chung, C. L., Hsiao, S. H., Hsiao, G., Sheu, J. R., Chen, W. L. & Chang, S. C., Jan 7 2013, In : PLoS One. 8, 1, e53169.

Research output: Contribution to journalArticle

vascular endothelial growth factors
interleukin-8
Interleukin-8
Vascular Endothelial Growth Factor A
cytokines
8 Citations (Scopus)
lung neoplasms
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
tyrosine

ENdothelin-1 in inflammatory and malignant pleural effusions

Chung, C-L., Chen, W-L., Hsiao, S-H. & Hsiao, G., Oct 1 2013, In : Chest. 144, 4_MeetingAbstracts, p. 516A-516A

Research output: Contribution to journalMeeting Abstract

Malignant Pleural Effusion
Endothelin-1
Pleural Effusion
Epithelial-Mesenchymal Transition
Fibrosis
27 Citations (Scopus)

Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo

Lin, K. H., Kuo, J. R., Lu, W-J., Chung, C. L., Chou, D. S., Huang, S. Y., Lee, H. C. & Sheu, J. R., May 15 2013, In : Biochemical Pharmacology. 85, 10, p. 1478-1485 8 p.

Research output: Contribution to journalArticle

Platelet Activation
Platelets
Thrombosis
Chemical activation
Platelet Aggregation
5 Downloads (Pure)
File
Epidermal Growth Factor Receptor
Lung Neoplasms
Smoking
Mutation
Adenocarcinoma
17 Citations (Scopus)

Identification of subgroup patients with stage IIIB/IV non-small cell lung cancer at higher risk for brain metastases

Hsiao, S. H., Chung, C. L., Chou, Y. T., Lee, H. L., Lin, S. E. & Liu, H. E., Nov 2013, In : Lung Cancer. 82, 2, p. 319-323 5 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Neoplasm Metastasis
Brain
Logistic Models
Medical Records
29 Citations (Scopus)
Epidermal Growth Factor Receptor
Neoplasm Metastasis
Mutation
Survival
Brain
23 Citations (Scopus)

Mechanisms of andrographolide-induced platelet apoptosis in human platelets: Regulatory roles of the extrinsic apoptotic pathway

Lien, L-M., Su, C. C., Hsu, W. H., Lu, W-J., Chung, C-L., Yen, T. L., Chiu, H. C., Sheu, J-R. & Lin, K. H., 2013, In : Phytotherapy Research. 27, 11, p. 1671-1677 7 p.

Research output: Contribution to journalArticle

Blood Platelets
Apoptosis
Caspase 8
Platelet Activation
Andrographis
13 Citations (Scopus)

Suitability of computed tomography-guided biopsy specimens for subtyping and genotyping of non-small-cell lung cancer

Hsiao, S. H., Chung, C. L., Lee, C-M., Chen, W. Y., Chou, Y. T., Wu, Z. H., Chen, Y. C. & Lin, S. E., Nov 2013, In : Clinical Lung Cancer. 14, 6, p. 719-725 7 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Tomography
Biopsy
Lung
2012
8 Citations (Scopus)
Histone Deacetylase Inhibitors
Plasminogen Activator Inhibitor 1
Acids
Transforming Growth Factors
Histone Deacetylases
20 Citations (Scopus)

Pycnidione, a fungus-derived agent, induces cell cycle arrest and apoptosis in A549 human lung cancer cells

Hsiao, C. J., Hsiao, S. H., Chen, W. L., Guh, J. H., Hsiao, G., Chan, Y. J., Li, Z-H. & Chung, C. L., Apr 15 2012, In : Chemico-Biological Interactions. 197, 1, p. 23-30 8 p.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Fungi
Lung Neoplasms
Cells
Apoptosis
22 Citations (Scopus)

Suppression of matrix metalloproteinase-9 expression by andrographolide in human monocytic THP-1 cells via inhibition of NF-κB activation

Lee, W. R., Chung, C. L., Hsiao, C. J., Chou, Y. C., Hsueh, P. J., Yang, P. C., Jan, J. S., Cheng, Y. W. & Hsiao, G., Feb 15 2012, In : Phytomedicine. 19, 3-4, p. 270-277 8 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Tumor Necrosis Factor-alpha
Matrix Metalloproteinases
Lipopolysaccharides
Andrographis
2011

Angiogenic Cytokines And Fibrinolytic Activity In Parapneumonic Effusions: A103. NOVEL INSIGHTS FOR PATIENT SAFETY IN BRONCHOSCOPY AND PLEURAL DISEASE

Chung, C-L., Hsiao, S. H., Chen, W-L. & Chang, S. C., 2011, Am J Respir Crit Care Med. American Thoracic Society, p. A2360-A2360 (American Thoracic Society International Conference Abstracts).

Research output: Chapter in Book/Report/Conference proceedingChapter

Tumor Necrosis Factor-alpha
Chemical activation
7 Citations (Scopus)

Hypertonicity-enhanced TNF-α release from activated human monocytic THP-1 cells requires ERK activation

Chou, Y. C., Sheu, J. R., Chung, C. L., Hsiao, C. J., Hsueh, P. J. & Hsiao, G., Apr 2011, In : Biochimica et Biophysica Acta - General Subjects. 1810, 4, p. 475-484 10 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor-alpha
Chemical activation
Lipopolysaccharides
Sucrose
Acetates
2010
23 Citations (Scopus)
Levofloxacin
Fluoroquinolones
Ciprofloxacin
Cross Infection
Pseudomonas aeruginosa

Histone deacetylase inhibitor CBHA attenuates the expression of plasminogen activator inhibitor-1 in human pleural mesothelial cells

Chung, C-L., Chen, W-L., Cheng, Y-W., Chou, Y-C., Hsu, M-J., Hsiao, C-J., Sheu, J-R. & Hsiao, G., 2010, p. A105-A106. 2 p.

Research output: Contribution to conferencePoster

Histone Deacetylase Inhibitors
Plasminogen Activator Inhibitor 1
Transforming Growth Factors
Histone Deacetylases
Acids
50 Citations (Scopus)

Nuclear-targeted inhibition of NF-κB on MMP-9 production by N-2-(4-bromophenyl) ethyl caffeamide in human monocytic cells

Chou, Y. C., Sheu, J. R., Chung, C. L., Chen, C. Y., Lin, F. L., Hsu, M. J., Kuo, Y. H. & Hsiao, G., Mar 2010, In : Chemico-Biological Interactions. 184, 3, p. 403-412 10 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Tumor Necrosis Factor-alpha
Genes
Inflammation
Phosphorylation