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Research Output 2007 2019

  • 570 Citations
  • 12 h-Index
  • 31 Article
2019

A critical period for the development of schizophrenia-like pathology by aberrant postnatal neurogenesis

Sheu, J. R., Hsieh, C. Y., Jayakumar, T., Tseng, M. F., Lee, H. N., Huang, S. W., Manubolu, M. & Yang, C. H., Jan 1 2019, In : Frontiers in Neuroscience. 13, JUN, 635.

Research output: Contribution to journalArticle

Open Access
Neurogenesis
Schizophrenia
Pathology
Critical Period (Psychology)
Hallucinations

Endothelin-1 Induces Mesothelial Mesenchymal Transition and Correlates with Pleural Fibrosis in Tuberculous Pleural Effusions

Wu, Z-H., Tsai, J-H., Hsieh, C-Y., Chen, W-L. & Chung, C-L., Mar 29 2019, In : Journal of Clinical Medicine. 8, 4, 426.

Research output: Contribution to journalArticle

Endothelin-1
Pleural Effusion
Fibrosis
Extracellular Matrix
Pleural Diseases

HDAC6 dysfunction contributes to impaired maturation of adult neurogenesis in vivo: vital role on functional recovery after ischemic stroke

Sheu, J-R., Hsieh, C-Y., Jayakumar, T., Lin, G-Y., Lee, H-N., Huang, S-W. & Yang, C-H., Apr 18 2019, In : Journal of Biomedical Science. 26, 1, 27.

Research output: Contribution to journalArticle

Neurogenesis
Neurons
Stroke
Recovery
Patient rehabilitation
2018
7 Citations (Scopus)

CME-1, a novel polysaccharide, suppresses iNOS expression in lipopolysaccharide-stimulated macrophages through ceramide-initiated protein phosphatase 2A activation

Sheu, J. R., Chen, Z. C., Hsu, M. J., Wang, S. H., Jung, K. W., Wu, W. F., Pan, S. H., Teng, R. D., Yang, C. H. & Hsieh, C. Y., Feb 1 2018, In : Journal of Cellular and Molecular Medicine. 22, 2, p. 999-1013 15 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Ceramides
Nitric Oxide Synthase Type II
Polysaccharides
Lipopolysaccharides
5 Citations (Scopus)

Hinokitiol inhibits migration of A549 lung cancer cells via suppression of MMPs and induction of antioxidant enzymes and apoptosis

Jayakumar, T., Liu, C. H., Wu, G. Y., Lee, T. Y., Manubolu, M., Hsieh, C. Y., Yang, C. H. & Sheu, J. R., Mar 22 2018, In : International Journal of Molecular Sciences. 19, 4, 939.

Research output: Contribution to journalArticle

Enzyme Induction
antioxidants
apoptosis
Cell death
Antioxidants
1 Citation (Scopus)

Inhibitory effect of PDGF-BB and serum-stimulated responses in vascular smooth muscle cell proliferation by hinokitiol via up-regulation of p21 and p53

Li, J-Y., Liu, C-P., Shiao, W-C., Jayakumar, T., Li, Y-S., Chang, N-C., Huang, S-Y. & Hsieh, C-Y., Jan 1 2018, In : Archives of Medical Science. 14, 3, p. 579-587 9 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Smooth Muscle Myocytes
Up-Regulation
Cell Proliferation
Serum
2 Citations (Scopus)
brain damage
Neuroprotective Agents
medicine
Medicine
mice
2017
6 Citations (Scopus)

A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice

Sheu, J. R., Chen, Z. C., Jayakumar, T., Chou, D. S., Yen, T. L., Lee, H. N., Pan, S. H., Hsia, C. H., Yang, C. H. & Hsieh, C. Y., Feb 6 2017, In : Scientific Reports. 7, 42277.

Research output: Contribution to journalArticle

Stroke
Medicine
Middle Cerebral Artery Infarction
Therapeutics
JNK Mitogen-Activated Protein Kinases
3 Citations (Scopus)

Antiplatelet activity of a newly synthesized novel ruthenium (II): A potential role for Akt/JNK signaling

Khamrang, T., Hung, K. C., Hsia, C. H., Hsieh, C. Y., Velusamy, M., Jayakumar, T. & Sheu, J. R., May 1 2017, In : International Journal of Molecular Sciences. 18, 5, 916.

Research output: Contribution to journalArticle

Ruthenium
Platelets
platelets
Platelet Aggregation
ruthenium
2016
21 Citations (Scopus)
Heme Oxygenase-1
Cytoprotection
Endothelial cells
p38 Mitogen-Activated Protein Kinases
Rats
7 Citations (Scopus)

Major vault protein regulates cell growth/survival signaling through oxidative modifications

Das, D., Wang, Y. H., Hsieh, C. Y. & Suzuki, Y. J., Jan 1 2016, In : Cellular Signalling. 28, 1, p. 12-18 7 p.

Research output: Contribution to journalArticle

Cell Survival
Glutaredoxins
Myosins
Growth
Smooth Muscle Myocytes
15 Citations (Scopus)

Prevention of arterial thrombosis by nobiletin: In vitro and in vivo studies

Lu, W-J., Lin, K. C., Liu, C. P., Lin, C. Y., Wu, H. C., Chou, D. S., Geraldine, P., Huang, S. Y., Hsieh, C. Y. & Sheu, J. R., Feb 1 2016, In : Journal of Nutritional Biochemistry. 28, p. 1-8 8 p.

Research output: Contribution to journalArticle

Platelets
Thrombosis
Platelet Aggregation
Platelet Activation
Blood Platelets
2015
7 Citations (Scopus)

Antiproliferative activity of hinokitiol, a tropolone derivative, is mediated via the inductions of p-JNK and p-PLCγ1 signaling in PDGF-BB-Stimulated vascular smooth muscle cells

Yang, P. S., Wang, M. J., Jayakumar, T., Chou, D. S., Ko, C. Y., Hsu, M. J. & Hsieh, C. Y., May 1 2015, In : Molecules. 20, 5, p. 8198-8212 15 p.

Research output: Contribution to journalArticle

Tropolone
smooth muscle
muscle cells
Vascular Smooth Muscle
Smooth Muscle Myocytes
2014
22 Citations (Scopus)

Andrographolide induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade

Chen, Y. Y., Hsieh, C. Y., Jayakumar, T., Lin, K. H., Chou, D. S., Lu, W-J., Hsu, M. J. & Sheu, J. R., Jul 10 2014, In : Scientific Reports. 4, 5651.

Research output: Contribution to journalArticle

Non-Receptor Type 6 Protein Tyrosine Phosphatase
Protein Phosphatase 2
p38 Mitogen-Activated Protein Kinases
Vascular Smooth Muscle
Smooth Muscle Myocytes
11 Citations (Scopus)
JNK Mitogen-Activated Protein Kinases
Vascular Smooth Muscle
tumor
Smooth Muscle Myocytes
Muscle
9 Citations (Scopus)
Protein Phosphatase 2
Tocopherols
Vascular Smooth Muscle
Smooth Muscle Myocytes
Interferons
2013
21 Citations (Scopus)
Ceramides
Vascular Smooth Muscle
Smooth Muscle Myocytes
Reactive Oxygen Species
Apoptosis
24 Citations (Scopus)

A novel antithrombotic effect of sulforaphane via activation of platelet adenylate cyclase: Ex vivo and in vivo studies

Jayakumar, T., Chen, W. F., Lu, W-J., Chou, D. S., Hsiao, G., Hsu, C-Y., Sheu, J. R. & Hsieh, C. Y., Jun 2013, In : Journal of Nutritional Biochemistry. 24, 6, p. 1086-1095 10 p.

Research output: Contribution to journalArticle

Platelet Activation
Platelets
Adenylyl Cyclases
Chemical activation
Phosphorylation
67 Citations (Scopus)
Andrographis
Clinical Pharmacology
Anti-Inflammatory Agents
Acanthaceae
Pharyngitis
11 Citations (Scopus)

IL-22 activates oxidant signaling in pulmonary vascular smooth muscle cells

Bansal, G., Das, D., Hsieh, C. Y., Wang, Y. H., Gilmore, B. A., Wong, C. M. & Suzuki, Y. J., Dec 2013, In : Cellular Signalling. 25, 12, p. 2727-2733 7 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Oxidants
Smooth Muscle Myocytes
Lung
NADPH Oxidase
8 Citations (Scopus)

Novel bioactivity of ellagic acid in inhibiting human platelet activation

Chang, Y., Chen, W. F., Lin, K. H., Hsieh, C. Y., Chou, D. S., Lin, L. J., Sheu, J. R. & Chang, C. C., 2013, In : Evidence-based Complementary and Alternative Medicine. 2013, 595128.

Research output: Contribution to journalArticle

Ellagic Acid
Platelet Activation
Platelet Aggregation
Protein Kinase C
Phosphorylation
2012
49 Citations (Scopus)
Humulus lupulus
Humulus
neuroprotective effect
hops
Neuroprotective Agents
2011
60 Citations (Scopus)

Andrographolide enhances nuclear factor-κB subunit p65 Ser 536 dephosphorylation through activation of protein phosphatase 2A in vascular smooth muscle cells

Hsieh, C. Y., Hsu, M. J., Hsiao, G., Wang, Y. H., Huang, C. W., Chen, S. W., Jayakumar, T., Chiu, P. T., Chiu, Y. H. & Sheu, J. R., Feb 25 2011, In : Journal of Biological Chemistry. 286, 8, p. 5942-5955 14 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
Chemical activation
31 Citations (Scopus)

Chondroprotective role of sesamol by inhibiting MMPs expression via retaining NF-κB signaling in activated SW1353 cells

Lu, Y. C., Jayakumar, T., Duann, Y. F., Chou, Y. C., Hsieh, C. Y., Yu, S. Y., Sheu, J. R. & Hsiao, G., May 11 2011, In : Journal of Agricultural and Food Chemistry. 59, 9, p. 4969-4978 10 p.

Research output: Contribution to journalArticle

osteoarthritis
metalloproteinases
Matrix Metalloproteinases
mitogen-activated protein kinase
cartilage
9 Citations (Scopus)

Platonin inhibited PDGF-BB-induced proliferation of rat vascular smooth muscle cells via JNK1/2-dependent signaling

Chang, Y., Uen, Y. H., Chen, C. C., Lin, S-C., Tseng, S. Y., Wang, Y. H., Sheu, J. R. & Hsieh, C. Y., Nov 2011, In : Acta Pharmacologica Sinica. 32, 11, p. 1337-1344 8 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Smooth Muscle Myocytes
Phosphorylation
Cell Proliferation
Cell Division
2010
10 Citations (Scopus)
Phosphorylation
Cell proliferation
Vitamin E
Vascular Smooth Muscle
Hydroxyl Radical
6 Citations (Scopus)

Inhibitory effect of PMC, a potent hydrophilic α-tocopherol derivative, on vascular smooth muscle cell proliferation: The pivotal role of PKC-α translocation

Chang, C. C., Lee, J. J., Chiang, C-W., Jayakumar, T., Hsiao, G., Hsieh, C. Y. & Sheu, J. R., Aug 2010, In : Pharmaceutical Biology. 48, 8, p. 938-946 9 p.

Research output: Contribution to journalArticle

Tocopherols
Vascular Smooth Muscle
Protein Kinase C
Smooth Muscle Myocytes
Cell Proliferation
2009
55 Citations (Scopus)

Inhibitory effects of ketamine on lipopolysaccharide-induced microglial activation

Sheu, J. R., Chang, Y., Lee, J. J., Hsieh, C. Y., Hsiao, G. & Chou, D. S., 2009, In : Mediators of Inflammation. 2009, 705379.

Research output: Contribution to journalArticle

Ketamine
Lipopolysaccharides
Microglia
Interleukin-1
Nitric Oxide
80 Citations (Scopus)

Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats

Chang, Y., Hsieh, C. Y., Peng, Z. A., Yen, T. L., Hsiao, G., Chou, D. S., Chen, C. M. & Sheu, J. R., 2009, In : Journal of Biomedical Science. 16, 1, 9.

Research output: Contribution to journalArticle

Brain Infarction
Middle Cerebral Artery Infarction
Rats
Brain
Brain Ischemia
Disintegrins
Vascular Smooth Muscle
Cell Adhesion
Protein Kinase C
Smooth Muscle Myocytes
2007
23 Citations (Scopus)

Baicalein induction of hydroxyl radical formation via 12-lipoxygenase in human platelets: An ESR study

Chou, D. S., Lee, J. J., Hsiao, G., Hsieh, C. Y., Tsai, Y. J., Chen, T-F. & Sheu, J. R., Feb 7 2007, In : Journal of Agricultural and Food Chemistry. 55, 3, p. 649-655 7 p.

Research output: Contribution to journalArticle

Arachidonate 12-Lipoxygenase
electron paramagnetic resonance spectroscopy
Electron Spin Resonance Spectroscopy
hydroxyl radicals
lipoxygenase