• 450 Citations
  • 10 h-Index
20072019
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Research Output 2007 2019

  • 450 Citations
  • 10 h-Index
  • 21 Article
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Article
2019
4 Citations (Scopus)

KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC

Wang, H. J., Pochampalli, M., Wang, L. Y., Zou, J. X., Li, P. S., Hsu, S. C., Wang, B. J., Huang, S. H., Yang, P., Yang, J. C., Chu, C. Y., Hsieh, C. L., Sung, S. Y., Li, C. F., Tepper, C. G., Ann, D. K., Gao, A. C., Evans, C. P., Izumiya, Y., Chuu, C. P. & 3 others, Wang, W. C., Chen, H. W. & Kung, H. J., Jan 3 2019, In : Oncogene. 38, 1, p. 17-32

Research output: Contribution to journalArticle

Pyruvate Kinase
Androgen Receptors
Androgens
Castration
Prostatic Neoplasms

Metastatic colorectal cancer rewrites metabolic program through a Glut3-YAP-dependent signaling circuit

Kuo, C. C., Ling, H. H., Chiang, M. C., Chung, C. H., Lee, W. Y., Chu, C. Y., Wu, Y. C., Chen, C. H., Lai, Y. W., Tsai, I. L., Cheng, C. H. & Lin, C. W., Jan 1 2019, In : Theranostics. 9, 9, p. 2526-2540 15 p.

Research output: Contribution to journalArticle

Open Access
Colorectal Neoplasms
Neoplasm Metastasis
Colonic Neoplasms
Neoplasms
Proteins
1 Citation (Scopus)

Reduction in MnSOD promotes the migration and invasion of squamous carcinoma cells

Fan, J. J., Hsu, W. H., Hung, H. H., Zhang, W. J., A Lee, Y. L., Chen, K. C., Chu, C. Y., Ko, T. P., Lee, M. T., Lin, C. W. & Cheng, C. H., Apr 1 2019, In : International Journal of Oncology. 54, 5, p. 1639-1650 12 p.

Research output: Contribution to journalArticle

Open Access
Superoxide Dismutase
Squamous Cell Carcinoma
Reactive Oxygen Species
Luteolin
Cell Line
2018
9 Citations (Scopus)

Dual inhibition of PIK3C3 and FGFR as a new therapeutic approach to treat bladder cancer

Chen, C. H., Changou, C. A., Hsieh, T. H., Lee, Y. C., Chu, C. Y., Hsu, K. C., Wang, H. C., Lin, Y. C., Lo, Y. N., Liu, Y. R., Liou, J. P. & Yen, Y., Mar 1 2018, In : Clinical Cancer Research. 24, 5, p. 1176-1189 14 p.

Research output: Contribution to journalArticle

Autophagy
Urinary Bladder Neoplasms
Cell Death
Therapeutics
Clustered Regularly Interspaced Short Palindromic Repeats
9 Citations (Scopus)

Flavonoids Luteolin and Quercetin Inhibit RPS19 and contributes to metastasis of cancer cells through c-Myc reduction

Chen, K. C., Hsu, W. H., Ho, J. Y., Lin, C. W., Chu, C. Y., Kandaswami, C. C., Lee, M. T. & Cheng, C. H., Jan 1 2018, (Accepted/In press) In : Journal of Food and Drug Analysis.

Research output: Contribution to journalArticle

Luteolin
luteolin
Quercetin
Flavonoids
metastasis
2017
2 Citations (Scopus)

IRF9-Stat2 Fusion Protein as an Innate Immune Inducer to Activate Mx and Interferon-Stimulated Gene Expression in Zebrafish Larvae

Huang, C. J., Chou, C. M., Lien, H. W., Chu, C. Y., Ho, J. Y., Wu, Y. & Cheng, C. H., May 12 2017, (Accepted/In press) In : Marine Biotechnology. p. 1-10 10 p.

Research output: Contribution to journalArticle

Zebrafish
interferons
Danio rerio
Interferons
gene expression
43 Citations (Scopus)

Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression

Shih, J. W., Chiang, W. F., Wu, A. T. H., Wu, M. H., Wang, L. Y., Yu, Y. L., Hung, Y. W., Wang, W. C., Chu, C. Y., Hung, C. L., Changou, C. A., Yen, Y. & Kung, H. J., Jun 22 2017, In : Nature Communications. 8, 15874.

Research output: Contribution to journalArticle

Long Noncoding RNA
Mouth Neoplasms
progressions
hypoxia
cancer
18 Citations (Scopus)

Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down-regulating miR-376c expression

Chen, P. C., Tang, C. H., Lin, L. W., Tsai, C. H., Chu, C. Y., Lin, T. H. & Huang, Y. L., Jan 25 2017, In : Journal of Hematology and Oncology. 10, 1, 33.

Research output: Contribution to journalArticle

Bone Neoplasms
Matrix Metalloproteinase 2
MicroRNAs
Prostatic Neoplasms
Up-Regulation
2016
21 Citations (Scopus)

REST reduction is essential for hypoxia-induced neuroendocrine differentiation of prostate cancer cells by activating autophagy signaling

Lin, T. P., Chang, Y. T., Lee, S. Y., Campbell, M., Wang, T. C., Shen, S. H., Chung, H. J., Chang, Y. H., Chiu, A. W., Pan, C. C., Lin, C. H., Chu, C. Y., Kung, H. J., Cheng, C. Y. & Chang, P. C., May 1 2016, In : Oncotarget. 7, 18, p. 26137-26151 15 p.

Research output: Contribution to journalArticle

Transcriptional Silencer Elements
Autophagy
Prostatic Neoplasms
Transcription Factors
AMP-Activated Protein Kinases
2014
34 Citations (Scopus)

Autophagy pathway is required for IL-6 induced neuroendocrine differentiation and chemoresistance of prostate cancer LNCaP cells

Chang, P. C., Wang, T. Y., Chang, Y. T., Chu, C. Y., Lee, C. L., Hsu, H. W., Zhou, T. A., Wu, Z., Kim, R. H., Desai, S. J., Liu, S. & Kung, H. J., Feb 14 2014, In : PLoS One. 9, 2, e88556.

Research output: Contribution to journalArticle

autophagy
Autophagy
prostatic neoplasms
interleukin-6
Interleukin-6
61 Citations (Scopus)

Cancer: Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells

Qiu, F., Chen, Y. R., Liu, X., Chu, C. Y., Shen, L. J., Xu, J., Gaur, S., Forman, H. J., Zhang, H., Zheng, S., Yen, Y., Huang, J., Kung, H. J. & Ann, D. K., Apr 1 2014, In : Science Signaling. 7, 319

Research output: Contribution to journalArticle

Argininosuccinate Synthase
Starvation
Arginine
Cells
Breast Neoplasms
9 Citations (Scopus)

Differential regulation of Tetraodon nigroviridis Mx gene promoter activity by constitutively-active forms of STAT1, STAT2, and IRF9

Cheng, C. H., Chou, C. M., Chu, C. Y., Chen, G. D., Lien, H. W., Hwang, P. P., Chang, M. S. & Huang, C. J., 2014, In : Fish and Shellfish Immunology. 38, 1, p. 230-243 14 p.

Research output: Contribution to journalArticle

interferons
Interferons
Genes
promoter regions
Interferon-gamma
6 Citations (Scopus)

The Nogo-C2/Nogo receptor complex regulates the morphogenesis of zebrafish lateral line primordium through modulating the expression of dkk1b, a Wnt signal inhibitor

Han, H. W., Chou, C. M., Chu, C. Y., Cheng, C. H., Yang, C. H., Hung, C. C., Hwang, P. P., Lee, S. J., Liao, Y. F. & Huang, C. J., Jan 21 2014, In : PLoS One. 9, 1, e86345.

Research output: Contribution to journalArticle

Zebrafish
Danio rerio
Morphogenesis
morphogenesis
Fishes
2010
112 Citations (Scopus)

Autophagy blockade sensitizes prostate cancer cells towards src family kinase inhibitors

Wu, Z., Chang, P. C., Yang, J. C., Chu, C. Y., Wang, L. Y., Chen, N. T., Ma, A. H., Desai, S. J., Lo, S. H., Evans, C. P., Lam, K. S. & Kung, H. J., 2010, In : Genes and Cancer. 1, 1, p. 40-49 10 p.

Research output: Contribution to journalArticle

src-Family Kinases
Autophagy
Prostatic Neoplasms
Protein-Tyrosine Kinases
Chloroquine
7 Citations (Scopus)

Expression and characterization of a constitutively active STAT6 from Tetraodon

Sung, S. C., Cheng, C. H., Chou, C. M., Chu, C. Y., Chen, G. D., Hwang, P. P., Huang, F. L. & Huang, C. J., May 2010, In : Fish and Shellfish Immunology. 28, 5-6, p. 819-828 10 p.

Research output: Contribution to journalArticle

interleukin-4
exons
Exons
Phosphorylation
Genes
22 Citations (Scopus)

Expression and characterization of the JAK kinase and STAT protein from brine shrimp, Artemia franciscana

Cheng, C. H., Chen, G. D., Yeh, M. S., Chu, C. Y., Hsu, Y. L., Hwang, P. P., Huang, F. L. & Huang, C. J., May 2010, In : Fish and Shellfish Immunology. 28, 5-6, p. 774-782 9 p.

Research output: Contribution to journalArticle

Janus Kinases
Artemia franciscana
Artemia
brine
Drosophila
6 Citations (Scopus)

Identification and characterization of alternative promoters of zebrafish Rtn-4/Nogo genes in cultured cells and zebrafish embryos

Chen, Y. C., Wu, B. K., Chu, C. Y., Cheng, C. H., Han, H. W., Chen, G. D., Lee, M. T., Hwang, P. P., Kawakami, K., Chang, C. C. & Huang, C. J., Apr 8 2010, In : Nucleic Acids Research. 38, 14, p. 4635-4650 16 p., gkq230.

Research output: Contribution to journalArticle

Zebrafish
Cultured Cells
Embryonic Structures
Green Fluorescent Proteins
Genetic Promoter Regions
2008
18 Citations (Scopus)

Erythropoietins from teleosts

Chu, C. Y., Cheng, C. H., Yang, C. H. & Huang, C. J., Nov 2008, In : Cellular and Molecular Life Sciences. 65, 22, p. 3545-3552 8 p.

Research output: Contribution to journalArticle

Zebrafish
Erythropoietin
Takifugu
Erythropoiesis
Vertebrates
7 Citations (Scopus)

Expression and characterization of two STAT isoforms from Sf9 cells

Yeh, M. S., Cheng, C. H., Chou, C. M., Hsu, Y. L., Chu, C. Y., Chen, G. D., Chen, S. T., Chen, G. C. & Huang, C. J., 2008, In : Developmental and Comparative Immunology. 32, 7, p. 814-824 11 p.

Research output: Contribution to journalArticle

Sf9 Cells
Protein Isoforms
Baculoviridae
Drosophila
Alternative Splicing
18 Citations (Scopus)

Zebrafish cdx1b regulates expression of downstream factors of Nodal signaling during early endoderm formation

Cheng, P. Y., Lin, C. C., Wu, C. S., Lu, Y. F., Lin, C. Y., Chung, C. C., Chu, C. Y., Huang, C. J., Tsai, C. Y., Korzh, S., Wu, J. L. & Hwang, S. P. L., Mar 2008, In : Development. 135, 5, p. 941-952 12 p.

Research output: Contribution to journalArticle

Endoderm
Zebrafish
Germ Layers
Embryonic Structures
Synteny
2007
43 Citations (Scopus)

The zebrafish erythropoietin: Functional identification and biochemical characterization

Chu, C. Y., Cheng, C. H., Chen, G. D., Chen, Y. C., Hung, C. C., Huang, K. Y. & Huang, C. J., Sep 4 2007, In : FEBS Letters. 581, 22, p. 4265-4271 7 p.

Research output: Contribution to journalArticle

Globins
Zebrafish
Erythropoietin
Takifugu
Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase