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Research Output 2006 2019

  • 1432 Citations
  • 23 h-Index
  • 47 Article
  • 1 Comment/debate
2019
5 Citations (Scopus)
Chitosan
Nanoparticles
Insulin
Medical problems
Glucosidases

Metastatic colorectal cancer rewrites metabolic program through a Glut3-YAP-dependent signaling circuit

Kuo, C. C., Ling, H. H., Chiang, M. C., Chung, C. H., Lee, W. Y., Chu, C. Y., Wu, Y. C., Chen, C. H., Lai, Y. W., Tsai, I. L., Cheng, C. H. & Lin, C. W., Jan 1 2019, In : Theranostics. 9, 9, p. 2526-2540 15 p.

Research output: Contribution to journalArticle

Open Access
Colorectal Neoplasms
Neoplasm Metastasis
Colonic Neoplasms
Neoplasms
Proteins

Reduction in MnSOD promotes the migration and invasion of squamous carcinoma cells

Fan, J. J., Hsu, W. H., Hung, H. H., Zhang, W. J., A Lee, Y. L., Chen, K. C., Chu, C. Y., Ko, T. P., Lee, M. T., Lin, C. W. & Cheng, C. H., Apr 1 2019, In : International Journal of Oncology. 54, 5, p. 1639-1650 12 p.

Research output: Contribution to journalArticle

Open Access
Superoxide Dismutase
Squamous Cell Carcinoma
Reactive Oxygen Species
Luteolin
Cell Line

The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells

Yang, C. E., Lee, W. Y., Cheng, H. W., Chung, C. H., Mi, F. L. & Lin, C. W., Apr 1 2019, In : Chemico-Biological Interactions. 302, p. 28-35 8 p.

Research output: Contribution to journalArticle

Chlorpromazine
Drug Resistance
Antipsychotic Agents
Stem cells
Cells
2018
4 Citations (Scopus)

Activation of fibroblasts by nicotine promotes the epithelial-mesenchymal transition and motility of breast cancer cells

Chen, P. C., Lee, W. Y., Ling, H. H., Cheng, C. H., Chen, K. C. & Lin, C. W., Jan 1 2018, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Fibroblasts
Nicotine
Chemical activation
Cells
7 Citations (Scopus)

Flavonoids Luteolin and Quercetin Inhibit RPS19 and contributes to metastasis of cancer cells through c-Myc reduction

Chen, K. C., Hsu, W. H., Ho, J. Y., Lin, C. W., Chu, C. Y., Kandaswami, C. C., Lee, M. T. & Cheng, C. H., Jan 1 2018, (Accepted/In press) In : Journal of Food and Drug Analysis.

Research output: Contribution to journalArticle

Luteolin
luteolin
Quercetin
Flavonoids
metastasis
2017
18 Citations (Scopus)
Antrodia
Taiwanofungus camphoratus
Ubiquinone
Neoplastic Stem Cells
ubiquinones
Luteolin
uterine cervical neoplasms
luteolin
Quercetin
Flavonoids
30 Citations (Scopus)

Development of a new type of multifunctional fucoidan-based nanoparticles for anticancer drug delivery

Lu, K. Y., Li, R., Hsu, C. H., Lin, C. W., Chou, S. C., Tsai, M. L. & Mi, F. L., Jun 1 2017, In : Carbohydrate Polymers. 165, p. 410-420 11 p.

Research output: Contribution to journalArticle

Drug delivery
Nanoparticles
Cells
Chitosan
Protamines
11 Citations (Scopus)

Dietary flavonoids, luteolin and quercetin, inhibit invasion of cervical cancer by reduction of UBE2S through epithelial-mesenchymal transition signaling

Lin, T. H., Hsu, W. H., Tsai, P. H., Huang, Y. T., Lin, C. W., Chen, K. C., Tsai, I. H., Kandaswami, C. C., Huang, C. J., Chang, G. D., Lee, M. T. & Cheng, C. H., Apr 1 2017, In : Food and Function. 8, 4, p. 1558-1568 11 p.

Research output: Contribution to journalArticle

Luteolin
uterine cervical neoplasms
Epithelial-Mesenchymal Transition
luteolin
Quercetin
28 Citations (Scopus)

Elevation of YAP promotes the epithelial-mesenchymal transition and tumor aggressiveness in colorectal cancer

Ling, H. H., Kuo, C. C., Lin, B. X., Huang, Y. H. & Lin, C. W., Jan 1 2017, In : Experimental Cell Research. 350, 1, p. 218-225 8 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Colorectal Neoplasms
Neoplasms
Proteins
Neoplasm Metastasis
7 Citations (Scopus)
Somatomedins
Glioblastoma
MicroRNAs
Cytokines
Messenger RNA
12 Citations (Scopus)

Panobinostat sensitizes KRAS-mutant non-small-cell lung cancer to gefitinib by targeting TAZ

Lee, W. Y., Chen, P. C., Wu, W. S., Wu, H. C., Lan, C. H., Huang, Y. H., Cheng, C. H., Chen, K. C. & Lin, C. W., 2017, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Histone Deacetylase Inhibitors
gefitinib
panobinostat
3 Citations (Scopus)

Podocalyxin-like protein 1 regulates TAZ signaling and stemness properties in colon cancer

Lee, W. Y., Kuo, C. C., Lin, B. X., Cheng, C. H., Chen, K. C. & Lin, C. W., Oct 1 2017, In : International Journal of Molecular Sciences. 18, 10, 2047.

Research output: Contribution to journalArticle

Colonic Neoplasms
cancer
proteins
Proteins
Neoplasms
7 Citations (Scopus)

The CHAC1-inhibited Notch3 pathway is involved in temozolomide-induced glioma cytotoxicity

Chen, P. H., Shen, W. L., Shih, C-M., Ho, K. H., Cheng, C-H., Lin, C-W., Lee, C-C., Liu, A. J. & Chen, K-C., Apr 1 2017, In : Neuropharmacology. 116, p. 300-314 15 p.

Research output: Contribution to journalArticle

temozolomide
Glioma
Glioblastoma
Poly(ADP-ribose) Polymerases
Transcriptome
4 Citations (Scopus)

The microRNA-302b-inhibited insulin-like growth factor-binding protein 2 signaling pathway induces glioma cell apoptosis by targeting nuclear factor IA

Lee, C. C., Chen, P. H., Ho, K. H., Shih, C. M., Cheng, C. H., Lin, C. W., Cheng, K. T., Liu, A. J. & Chen, K. C., Mar 1 2017, In : PLoS One. 12, 3, e0173890.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 2
insulin-like growth factor binding proteins
Glioblastoma
MicroRNAs
microRNA
2016
13 Citations (Scopus)

The Inhibition of microRNA-128 on IGF-1-Activating mTOR Signaling involves in temozolomide-Induced glioma cell apoptotic death

Chen, P. H., Cheng, C-H., Shih, C-M., Ho, K. H., Lin, C-W., Lee, C-C., Liu, A. J., Chang, C-K. & Chen, K-C., Nov 1 2016, In : PLoS One. 11, 11, e0167096.

Research output: Contribution to journalArticle

temozolomide
Cell death
Sirolimus
MicroRNAs
Insulin-Like Growth Factor I
25 Citations (Scopus)

The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death

Chen, P. H., Chang, C. K., Shih, C. M., Cheng, C. H., Lin, C. W., Lee, C. C., Liu, A. J., Ho, K. H. & Chen, K. C., Nov 1 2016, In : Neuropharmacology. 110, p. 362-375 14 p.

Research output: Contribution to journalArticle

Glioma
Cell Death
MicroRNAs
Humulus
Glioblastoma
2015
15 Citations (Scopus)

An anti-EpCAM antibody EpAb2-6 for the treatment of colon cancer

Liao, M. Y., Lai, J. K., Kuo, M. Y. P., Lu, R. M., Lin, C. W., Cheng, P. C., Liang, K. H. & Wu, H. C., 2015, In : Oncotarget. 6, 28, p. 24947-24968 22 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Antibodies
irinotecan
gemcitabine
Pancreatic Neoplasms
33 Citations (Scopus)
Antrodia
Taiwanofungus camphoratus
gelatinase B
Epithelial-Mesenchymal Transition
Transcription Factor AP-1
19 Citations (Scopus)

CD44-specific nanoparticles for redox-triggered reactive oxygen species production and doxorubicin release

Lin, C-W., Lu, K. Y., Wang, S. Y., Sung, H. W. & Mi, F-L., Oct 19 2015, (Accepted/In press) In : Acta Biomaterialia.

Research output: Contribution to journalArticle

Hyaluronic acid
Chitosan
Nanoparticles
Doxorubicin
Oxidation-Reduction
11 Citations (Scopus)

Effect of Grape Seed Proanthocyanidin-Gelatin Colloidal Complexes on Stability and in Vitro Digestion of Fish Oil Emulsions

Su, Y. R., Tsai, Y. C., Hsu, C. H., Chao, A. C., Lin, C. W., Tsai, M. L. & Mi, F. L., Nov 17 2015, In : Journal of Agricultural and Food Chemistry. 63, 46, p. 10200-10208 9 p.

Research output: Contribution to journalArticle

grape seeds
in vitro digestion
Fish Oils
Gelatin
Emulsions
21 Citations (Scopus)

Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1

Lee, W. Y., Lee, W. T., Cheng, C. H., Chen, K. C., Chou, C. M., Chung, C. H., Sun, M. S., Cheng, H. W., Ho, M. N. & Lin, C. W., 2015, In : Oncotarget. 6, 29, p. 27580-27595 16 p.

Research output: Contribution to journalArticle

Sirtuin 1
Chlorpromazine
Antipsychotic Agents
Colorectal Neoplasms
JNK Mitogen-Activated Protein Kinases
8 Citations (Scopus)

RPS12 increases the invasiveness in cervical cancer activated by c-Myc and inhibited by the dietary flavonoids luteolin and quercetin

Lin, C. W., Lai, G. M., Chen, K. C., Lin, T. H., Fan, J. J., Hsu, R. L., Chou, C. M., Lin, C. M., Kandaswami, C. C., Lee, M. T. & Cheng, C. H., Dec 1 2015, In : Journal of Functional Foods. 19, p. 236-247 12 p.

Research output: Contribution to journalArticle

Luteolin
uterine cervical neoplasms
luteolin
Quercetin
Flavonoids
2014
36 Citations (Scopus)

Delivery of berberine using chitosan/fucoidan-taurine conjugate nanoparticles for treatment of defective intestinal epithelial tight junction barrier

Wu, S. J., Don, T. M., Lin, C-W. & Mi, F-L., Nov 24 2014, In : Marine Drugs. 12, 11, p. 5677-5697 21 p.

Research output: Contribution to journalArticle

Berberine
Tight Junctions
Taurine
Chitosan
Nanoparticles
18 Citations (Scopus)

FRET-based dual-emission and pH-responsive nanocarriers for enhanced delivery of protein across intestinal epithelial cell barrier

Lu, K. Y., Lin, C. W., Hsu, C. H., Ho, Y. C., Chuang, E-T., Sung, H. W. & Mi, F. L., Oct 22 2014, In : ACS Applied Materials and Interfaces. 6, 20, p. 18275-18289 15 p.

Research output: Contribution to journalArticle

Angiogenic Proteins
Epithelial Cells
Proteins
Tight Junctions
Taurine
23 Citations (Scopus)

Induction of ROS-independent JNK-activation-mediated apoptosis by a novel coumarin-derivative, DMAC, in human colon cancer cells

Lin, M. H., Cheng, C. H., Chen, K. C., Lee, W. T., Wang, Y. F., Xiao, C. Q. & Lin, C. W., Jul 25 2014, In : Chemico-Biological Interactions. 218, p. 42-49 8 p.

Research output: Contribution to journalArticle

Coumarins
Colonic Neoplasms
Protein Kinases
irinotecan
Poly(ADP-ribose) Polymerases
17 Citations (Scopus)

MicroRNA-302b-inhibited E2F3 transcription factor is related to all trans retinoic acid-induced glioma cell apoptosis

Chen, P. H., Shih, C. M., Chang, W. C., Cheng, C. H., Lin, C. W., Ho, K. H., Su, P. C. & Chen, K. C., 2014, In : Journal of Neurochemistry. 131, 6, p. 731-742 12 p.

Research output: Contribution to journalArticle

E2F3 Transcription Factor
Tretinoin
MicroRNAs
Glioma
Apoptosis
23 Citations (Scopus)
Squamous Cell Carcinoma
Gene Expression
Neoplasms
Cortactin
Biomarkers
34 Citations (Scopus)

Podocalyxin-like 1 promotes invadopodia formation and metastasis through activation of Rac1/Cdc42/cortactin signaling in breast cancer cells

Lin, C. W., Sun, M. S., Liao, M. Y., Chung, C. H., Chi, Y. H., Chiou, L. T., Yu, J., Lou, K. L. & Wu, H. C., Nov 1 2014, In : Carcinogenesis. 35, 11, p. 2425-2435 11 p.

Research output: Contribution to journalArticle

Cortactin
Breast Neoplasms
Neoplasm Metastasis
Phosphorylation
Paxillin
26 Citations (Scopus)

Tea catechins-cross-linked methylcellulose active films for inhibition of light irradiation and lipid peroxidation induced β-carotene degradation

Yu, S. H., Tsai, M. L., Lin, B. X., Lin, C. W. & Mi, F. L., Nov 4 2014, In : Food Hydrocolloids. 44, p. 491-505 15 p.

Research output: Contribution to journalArticle

methylcellulose
Methylcellulose
Catechin
Tea
Carotenoids
33 Citations (Scopus)
HSP90 Heat-Shock Proteins
Heme Oxygenase-1
Carbon Monoxide
Byproducts
Cells
2013
13 Citations (Scopus)

CHC promotes tumor growth and angiogenesis through regulation of HIF-1α and VEGF signaling

Tung, K. H., Lin, C. W., Kuo, C. C., Li, L. T., Kuo, Y. H., Lin, C. W. & Wu, H. C., Apr 30 2013, In : Cancer Letters. 331, 1, p. 58-67 10 p.

Research output: Contribution to journalArticle

Clathrin Heavy Chains
Vascular Endothelial Growth Factor A
Growth
Neoplasms
Pancreatic Neoplasms
2012
61 Citations (Scopus)

Epithelial cell adhesion molecule regulates tumor initiation and tumorigenesis via activating reprogramming factors and epithelial-mesenchymal transition gene expression in colon cancer

Lin, C. W., Liao, M. Y., Lin, W. W., Wang, Y. P., Lu, T. Y. & Wu, H. C., Nov 16 2012, In : Journal of Biological Chemistry. 287, 47, p. 39449-39459 11 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Cell Adhesion Molecules
Gene expression
Colonic Neoplasms
Tumors
2010
73 Citations (Scopus)
Extracellular Signal-Regulated MAP Kinases
Tetradecanoylphorbol Acetate
Glioblastoma
Matrix Metalloproteinases
Protein Kinase C
66 Citations (Scopus)
Extracellular Signal-Regulated MAP Kinases
Tetradecanoylphorbol Acetate
Cyclooxygenase 2
Glioblastoma
Dinoprostone
2009
11 Citations (Scopus)
JNK Mitogen-Activated Protein Kinases
Enzyme activity
Lipopolysaccharides
Nitric Oxide
Chemical activation
16 Citations (Scopus)
Peptidoglycan
Ubiquitination
Lipopolysaccharides
Nitric Oxide
Heme Oxygenase-1
2008
27 Citations (Scopus)

Differential apoptotic effect of wogonin and nor-wogonin via stimulation of ROS production in human leukemia cells

Chow, J-M., Huang, G. C., Shen, S-C., Wu, C. Y., Lin, C-W. & Chen, Y-C., Apr 1 2008, In : Journal of Cellular Biochemistry. 103, 5, p. 1394-1404 11 p.

Research output: Contribution to journalArticle

Hydroxyl Radical
Leukemia
HL-60 Cells
Flavonoids
Apoptosis
86 Citations (Scopus)
Heme Oxygenase-1
Matrix Metalloproteinase 9
Tetradecanoylphorbol Acetate
Breast Neoplasms
MCF-7 Cells
149 Citations (Scopus)
Proto-Oncogene Proteins c-jun
Quercetin
Extracellular Signal-Regulated MAP Kinases
Matrix Metalloproteinase 9
Transcription Factor AP-1
2007
77 Citations (Scopus)
Heme Oxygenase-1
Hydrogen Peroxide
Apoptosis
Gene Expression
Peroxides
72 Citations (Scopus)

Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells

Ko, C. H., Shen, S. C., Yang, L. Y., Lin, C. W. & Chen, Y. C., Oct 15 2007, In : International Journal of Cancer. 121, 8, p. 1670-1679 10 p.

Research output: Contribution to journalArticle

Gossypol
Colorectal Neoplasms
Reactive Oxygen Species
Mitochondria
Growth
31 Citations (Scopus)
Insulin-Like Growth Factor I
Phosphotransferases
Chemical activation
Cells
Breast Neoplasms
23 Citations (Scopus)
flavone
Nitric Oxide Synthase Type II
Lipopolysaccharides
Nitric Oxide
Macrophages
2006
73 Citations (Scopus)
Oxidative stress
Gene expression
Glioma
Rats
Oxidative Stress
29 Citations (Scopus)
Tetradecanoylphorbol Acetate
Flavonoids
Glioma
Lipopolysaccharides
Metalloproteases
134 Citations (Scopus)

Quercetin inhibition of ROS-dependent and -independent apoptosis in rat glioma C6 cells

Chen, T. J., Jeng, J. Y., Lin, C. W., Wu, C. Y. & Chen, Y. C., Jun 1 2006, In : Toxicology. 223, 1-2, p. 113-126 14 p.

Research output: Contribution to journalArticle

Quercetin
Glioma
Rats
Reactive Oxygen Species
Rutin