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Research Output 1993 2018

  • 1069 Citations
  • 20 h-Index
  • 78 Article
2018
Emergency Medical Services
APACHE
Intensive Care Units
Hospital Emergency Service
Critical Illness
4 Citations (Scopus)
temozolomide
Autophagy
Glioma
Apoptosis
Pharmaceutical Preparations
1 Citation (Scopus)

miR-4725-3p targeting stromal interacting molecule 1 signaling is involved in xanthohumol inhibition of glioma cell invasion

Ho, K. H., Chang, C. K., Chen, P. H., Wang, Y. J., Chang, W. C. & Chen, K. C., Aug 1 2018, In : Journal of Neurochemistry. 146, 3, p. 269-288 20 p.

Research output: Contribution to journalArticle

Glioma
Molecules
Glioblastoma
Humulus
Tumors
4 Citations (Scopus)
Erythrocyte Indices
Sepsis
Erythrocytes
Mortality
APACHE
2016
21 Citations (Scopus)

Preclinical effects of honokiol on treating glioblastoma multiforme via G1 phase arrest and cell apoptosis

Lin, C. J., Chang, Y. A., Lin, Y. L., Liu, S. H., Chang, C. K. & Chen, R. M., May 15 2016, In : Phytomedicine. 23, 5, p. 517-527 11 p.

Research output: Contribution to journalArticle

G1 Phase
Glioblastoma
Apoptosis
Glioma
Cyclin D1
12 Citations (Scopus)

The Inhibition of microRNA-128 on IGF-1-Activating mTOR Signaling involves in temozolomide-Induced glioma cell apoptotic death

Chen, P. H., Cheng, C-H., Shih, C-M., Ho, K. H., Lin, C-W., Lee, C-C., Liu, A. J., Chang, C-K. & Chen, K-C., Nov 1 2016, In : PLoS One. 11, 11, e0167096.

Research output: Contribution to journalArticle

temozolomide
Cell death
Sirolimus
MicroRNAs
Insulin-Like Growth Factor I
21 Citations (Scopus)

The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death

Chen, P. H., Chang, C. K., Shih, C. M., Cheng, C. H., Lin, C. W., Lee, C. C., Liu, A. J., Ho, K. H. & Chen, K. C., Nov 1 2016, In : Neuropharmacology. 110, p. 362-375 14 p.

Research output: Contribution to journalArticle

Glioma
Cell Death
MicroRNAs
Humulus
Glioblastoma
2015
10 Citations (Scopus)

A prospective randomized study of brain tissue oxygen pressure-guided management in moderate and severe traumatic brain injury patients

Lin, C. M., Lin, M. C., Huang, S. J., Chang, C. K., Chao, D. P., Lui, T. N., Ma, H. I., Liu, M. Y., Chung, W. Y., Shih, Y. H., Tsai, S. H., Chiou, H. Y., Lin, M. R., Jen, S. L., Wei, L., Wu, C-C., Lin, E. Y., Liao, K. H., Chiang, Y. H., Chiu, W. T. & 1 othersLin, J. W., 2015, In : BioMed Research International. 2015, 529580.

Research output: Contribution to journalArticle

Brain
Prospective Studies
Tissue
Oxygen
Pressure
3 Citations (Scopus)
Spinal Cord Injuries
Peroxisome Proliferator-Activated Receptors
Therapeutics
Adenosine Monophosphate
Protein Kinases
3 Citations (Scopus)

Protecting against ischaemic stroke in rats by heat shock protein 20-mediated exercise

Lin, C. M., Chang, C. K., Chang, C. P., Hsu, Y. C., Lin, M. T. & Lin, J. W., Dec 1 2015, In : European Journal of Clinical Investigation. 45, 12, p. 1297-1305 9 p.

Research output: Contribution to journalArticle

HSP20 Heat-Shock Proteins
Neuroglia
Rats
Stroke
Neurons
2014
6 Citations (Scopus)

Astragaloside improves outcomes of traumatic brain injury in rats by reducing microglia activation

Yang, S. T., Lin, J. W., Chiu, B. Y., Hsu, Y. C., Chang, C. P. & Chang, C. K., May 16 2014, In : American Journal of Chinese Medicine. 42, 6, p. 1357-1370 14 p.

Research output: Contribution to journalArticle

Microglia
Apoptosis
Cerebrovascular Disorders
Therapeutic Uses
Tumor Necrosis Factor-alpha
3 Citations (Scopus)

Characterization of Musclin as a new target for treatment of hypertension

Lin, J. W., Tsai, C. C., Chen, L. J., Niu, H. S., Chang, C. K. & Niu, C. S., 2014, In : BioMed Research International. 2014, 354348.

Research output: Contribution to journalArticle

Rats
Phenylephrine
Hypertension
Muscle
Desoxycorticosterone Acetate
2 Citations (Scopus)

Chronic subdural hematoma in elderly Taiwan patients: A retrospective analysis of 342 surgical cases

Cheng, S. Y., Chang, C. K., Chen, S. J., Lin, J. F. & Tsai, C. C., 2014, In : International Journal of Gerontology. 8, 1, p. 37-41 5 p.

Research output: Contribution to journalArticle

Hematoma, Subdural, Chronic
Taiwan
Glasgow Outcome Scale
Glasgow Coma Scale
Recurrence
6 Citations (Scopus)
leisure time
Leisure Activities
Sleep Initiation and Maintenance Disorders
sleep
Accidents
8 Citations (Scopus)

Exercise preconditioning protects against spinal cord injury in rats by upregulating neuronal and astroglial heat shock protein 72

Chang, C. K., Chou, W., Lin, H. J., Huang, Y. C., Tang, L. Y., Lin, M. T. & Chang, C. P., Oct 20 2014, In : International Journal of Molecular Sciences. 15, 10, p. 19018-19036 19 p.

Research output: Contribution to journalArticle

spinal cord injuries
HSP72 Heat-Shock Proteins
preconditioning
physical exercise
Spinal Cord Injuries
6 Citations (Scopus)

Ginseng is useful to enhance cardiac contractility in animals

Lin, J-W., Cherng, Y-G., Chen, L. J., Niu, H. S., Chang, C-K. & Niu, C. S., 2014, In : BioMed Research International. 2014, 723084.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Panax
Animals
Rats
Hemodynamics
11 Citations (Scopus)

Merit of ginseng in the treatment of heart failure in type 1-like diabetic rats

Tsai, C. C., Chan, P., Chen, L. J., Chang, C. K., Liu, Z. & Lin, J. W., 2014, In : BioMed Research International. 2014, 484161.

Research output: Contribution to journalArticle

Panax
Treatment Failure
Rats
Peroxisome Proliferator-Activated Receptors
Heart Failure
2012
4 Citations (Scopus)

Brain-derived neurotrophic factor-transfected and nontransfected 3T3 fibroblasts enhance migratory neuroblasts and functional restoration in mice with intracerebral hemorrhage

Chen, S. J., Tsai, J. C., Lin, C. Y., Chang, C. K., Tseng, T. H. & Chien, C. L., Dec 2012, In : Journal of Neuropathology and Experimental Neurology. 71, 12, p. 1123-1136 14 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Cerebral Hemorrhage
Fibroblasts
Neurogenesis
Intercellular Signaling Peptides and Proteins

Cause analysis of injury-related out-of-hospital cardiac arrest in the elderly

Chien, D. K., Chang, W. H., Tsai, S. H., Chang, C. K., Lin, M. R., Sun, F. J. & Liu, T. C., Sep 2012, In : International Journal of Gerontology. 6, 3, p. 211-214 4 p.

Research output: Contribution to journalArticle

Out-of-Hospital Cardiac Arrest
Wounds and Injuries
Airway Obstruction
Traffic Accidents
Heart Arrest
3 Citations (Scopus)

Giant intracranial mesenchymal chondrosarcoma with uncal herniation

Lin, H. S., Tsai, C. C., Chang, C. K. & Chen, S. J., Jun 2012, In : Formosan Journal of Surgery. 45, 3, p. 93-96 4 p.

Research output: Contribution to journalArticle

Mesenchymal Chondrosarcoma
Islets of Langerhans
Cartilage
Middle Cranial Fossa
Persistent Vegetative State
18 Citations (Scopus)

Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats

Wu, W. S., Chou, M. T., Chao, C. M., Chang, C. K., Lin, M. T. & Chang, C. P., Jun 2012, In : Acta Pharmacologica Sinica. 33, 6, p. 775-782 8 p.

Research output: Contribution to journalArticle

Heat Stroke
Melatonin
Acute Lung Injury
Edema
Pneumonia
2011
6 Citations (Scopus)

A retrospective survey of patients with malignant gliomas treated in the neuro-oncological care system under the Universal National Health Insurance program in Taiwan

Huang, Y. C., Wei, K. C., Chang, C. H., Yang, J. T., Ho, J. T., Shen, C. C., Su, C. F., Cho, D. Y., Ma, H. I., Lin, J. W., Lee, E. J., Wu, J. J., Tsai, M. D., Chang, C. K., Howng, S. L. & Chang, C. N., Jun 2011, In : Journal of Clinical Neuroscience. 18, 6, p. 784-788 5 p.

Research output: Contribution to journalArticle

National Health Programs
Taiwan
Glioma
Survival Rate
temozolomide
23 Citations (Scopus)

Brushing teeth with purified water to reduce ventilator-associated pneumonia

Yao, L. Y., Chang, C. K., Maa, S. H., Wang, C. & Chen, C. C. H., 2011, In : The journal of nursing research : JNR. 19, 4, p. 289-297 9 p.

Research output: Contribution to journalArticle

Ventilator-Associated Pneumonia
Oral Hygiene
Oral Health
Toothbrushing
Tooth
11 Citations (Scopus)

Implementation of a motorcycle helmet law in Taiwan and traffic deaths over 18 years

Chiu, W. T., Chu, S. F., Chang, C. K., Lui, T. N. & Chiang, Y. H., Jul 20 2011, In : Journal of the American Medical Association. 306, 3, p. 267-268 2 p.

Research output: Contribution to journalArticle

Motorcycles
Head Protective Devices
Death Certificates
Traffic Accidents
Public Policy
6 Citations (Scopus)

Role of bone morphogenetic proteins-7 (BMP-7) in the renal improvement effect of DangGui (Angelica sinensis) in type-1 diabetic rats

Cheng, J. T., Yeh, C. H., Chang, C. K., Cheng, K. C., Li, Y. X. & Zhang, Y. W., 2011, In : Evidence-based Complementary and Alternative Medicine. 2011, 796723.

Research output: Contribution to journalArticle

Angelica sinensis
Bone Morphogenetic Protein 7
Mesangial Cells
Kidney
Glucose
2010
29 Citations (Scopus)
Glial Cell Line-Derived Neurotrophic Factors
Spinal Cord Injuries
Interleukin-10
Oxygen
Growth

Attenuation of Heat-induced Hypothalamic Ischemia, Inflammation, and Damage by Hyperbaric Oxygen in Rats

Tai, P. A., Chang, C-K., Niu, K-C., Lin, M. T., Chiu, W-T. & Lin, J-W., Jun 25 2010, In : Journal of Neurotrauma.

Research output: Contribution to journalArticle

Heat Stroke
Ischemia
Hot Temperature
Oxygen
Inflammation
6 Citations (Scopus)

Increase of plasma insulin by racecadotril, an inhibitor of enkephalinase, in wistar rats

Wu, H. T., Chang, C. K., Cheng, K. C., Chang, C. H., Yeh, C. H. & Cheng, J. T., 2010, In : Hormone and Metabolic Research. 42, 4, p. 261-267 7 p.

Research output: Contribution to journalArticle

Neprilysin
Wistar Rats
Rats
Insulin
Plasmas
6 Citations (Scopus)

Reduction of ischemic and oxidative damage to the hypothalamus by hyperbaric oxygen in heatstroke mice

Tai, P. A., Chang, C. K., Niu, K. C., Lin, M. T., Chiu, W. T. & Lin, J. W., 2010, In : Journal of Biomedicine and Biotechnology. 2010, 609526.

Research output: Contribution to journalArticle

Heat Stroke
Hypothalamus
Oxygen
Hot Temperature
Nitric Oxide Synthase Type II
5 Citations (Scopus)

Subarachnoid hemorrhage-a rare complication after intravenous thrombolysis in an ischemic stroke patient

Chou, C. L., Lin, Y. J., Po, H. L. & Chang, C. K., Oct 2010, In : American Journal of Emergency Medicine. 28, 8

Research output: Contribution to journalArticle

Thrombolytic Therapy
Subarachnoid Hemorrhage
Stroke
Middle Cerebral Artery
Tissue Plasminogen Activator
2009
19 Citations (Scopus)

Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats

Yang, T. T., Chang, C. K., Tsao, C. W., Hsu, Y. M., Hsu, C. T. & Cheng, J. T., Feb 13 2009, In : Neuroscience Letters. 451, 1, p. 57-59 3 p.

Research output: Contribution to journalArticle

Lipolysis
Cholinergic Agents
Adipose Tissue
Acetylcholine
Glucose
8 Citations (Scopus)

A hyperbaric oxygen therapy approach to heat stroke with multiple organ dysfunction

Niu, K. C., Chang, C. K., Lin, M. T. & Huang, K. F., 2009, In : Chinese Journal of Physiology. 52, 3, p. 169-172 4 p.

Research output: Contribution to journalArticle

Heat Stroke
Hyperbaric Oxygenation
Rhabdomyolysis
Disseminated Intravascular Coagulation
Coma
10 Citations (Scopus)

Clinical practice guidelines in severe traumatic brain injury in Taiwan

Liao, K. H., Chang, C. K., Chang, H. C., Chang, K. C., Chen, C. F., Chen, T. Y., Chou, C. W., Chung, W. Y., Chiang, Y. H., Hong, K. S., Hsiao, S. H., Hsu, Y. H., Huang, H. L., Huang, S. C., Hung, C. C., Kung, S. S., Kuo, K. N., Li, K. H., Lin, J. W., Lin, T. G. & 8 othersLin, C. M., Su, C. F., Tsai, M. T., Tsai, S. H., Wang, Y. C., Yang, T. Y., Yu, K. F. & Chiu, W. T., Dec 2009, In : Surgical Neurology. 72, SUPPL. 2

Research output: Contribution to journalArticle

Taiwan
Practice Guidelines
Guidelines
Intracranial Hypertension
Quality of Health Care
21 Citations (Scopus)

Decrease of bone morphogenetic protein-7 (BMP-7) and its type II receptor (BMP-RII) in kidney of type 1-like diabetic rats

Cheng, J. T., Yeh, C. H., Chang, C. K., Cheng, M. F. & Lin, H. J., 2009, In : Hormone and Metabolic Research. 41, 8, p. 605-611 7 p.

Research output: Contribution to journalArticle

Type II Bone Morphogenetic Protein Receptors
Bone Morphogenetic Protein 7
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt
Rats
Streptozocin
11 Citations (Scopus)

Expression of distinct α 1-adrenoceptor phenotypes in the iris of pigmented and albino rabbits

Muramatsu, I., Suzuki, F., Nishimune, A., Anisuzzaman, A., Yoshiki, H., Su, T. H., Chang, C. K. & Morishima, S., Sep 2009, In : British Journal of Pharmacology. 158, 1, p. 354-360 7 p.

Research output: Contribution to journalArticle

Iris
Adrenergic Receptors
Prazosin
Rabbits
Phenotype
17 Citations (Scopus)

Insulin resistance without obesity induced by cotton pellet granuloma in mice

Wu, H. T., Chang, C. K., Tsao, C. W., Wen, Y. J., Ling, S. M., Cheng, K. C., Chang, C. J. & Cheng, J. T., Mar 2009, In : Laboratory Investigation. 89, 3, p. 362-369 8 p.

Research output: Contribution to journalArticle

Granuloma
Insulin Resistance
White Adipose Tissue
Obesity
Adipose Tissue
27 Citations (Scopus)

The antioxidative effect of bone morphogenetic protein-7 against high glucose-induced oxidative stress in mesangial cells

Yeh, C. H., Chang, C. K., Cheng, M. F., Lin, H. J. & Cheng, J. T., May 1 2009, In : Biochemical and Biophysical Research Communications. 382, 2, p. 292-297 6 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 7
Oxidative stress
Mesangial Cells
Oxidative Stress
Glucose
2008
27 Citations (Scopus)

Activation of opioid μ-receptor by sinomenine in cell and mice

Wang, M. H., Chang, C. K., Cheng, J. H., Wu, H. T., Li, Y. X. & Cheng, J. T., Oct 10 2008, In : Neuroscience Letters. 443, 3, p. 209-212 4 p.

Research output: Contribution to journalArticle

Opioid Receptors
Sinomenium
Naloxone
Cricetulus
sinomenine
6 Citations (Scopus)

Cerebral sinus thrombosis with intracerebral hemorrhage in pregnancy: A case report

Lin, H. S., Lin, J. F., Chang, C. K., Tsai, C. C. & Chen, S. J., Sep 2008, In : Acta Neurologica Taiwanica. 17, 3, p. 189-193 5 p.

Research output: Contribution to journalArticle

Intracranial Sinus Thrombosis
Intracranial Thrombosis
Cerebral Hemorrhage
Intracranial Pressure
Heparin
33 Citations (Scopus)

Curcumin inhibits the increase of glutamate, hydroxyl radicals and PGE2 in the hypothalamus and reduces fever during LPS-induced systemic inflammation in rabbits

Huang, W. T., Niu, K. C., Chang, C. K., Lin, M. T. & Chang, C. P., Sep 28 2008, In : European Journal of Pharmacology. 593, 1-3, p. 105-111 7 p.

Research output: Contribution to journalArticle

Curcumin
Dinoprostone
Hydroxyl Radical
Hypothalamus
Lipopolysaccharides
59 Citations (Scopus)

Decrease of peroxisome proliferator-activated receptor delta expression in cardiomyopathy of streptozotocin-induced diabetic rats

Yu, B. C., Chang, C. K., Ou, H. Y., Cheng, K. C. & Cheng, J. T., Oct 2008, In : Cardiovascular Research. 80, 1, p. 78-87 10 p.

Research output: Contribution to journalArticle

PPAR delta
Streptozocin
Cardiomyopathies
Hyperglycemia
Reactive Oxygen Species
22 Citations (Scopus)

Exogenous administration of glial cell line-derived neurotrophic factor improves recovery after spinal cord injury

Kao, C. H., Chen, S. H., Chio, C. C., Chang, C. K. & Lin, M. T., Jun 2008, In : Resuscitation. 77, 3, p. 395-400 6 p.

Research output: Contribution to journalArticle

Glial Cell Line-Derived Neurotrophic Factor
Spinal Cord Injuries
Nerve Growth Factors
Neuroglia
Spinal Cord
18 Citations (Scopus)

Hypofractionated Cyberknife Stereotactic Radiosurgery for Acoustic Neuromas with and without Association to Neurofibromatosis Type 2

Lin, C-M., Tsai, J-T., Lin, M-S., Lin, J-W., Sue, Y-K., Ko, C-P., Wei, L., Chiu, W-T., Chang, C-K. & Yeh, Y. S., 2008, In : 中華民國癌症醫學會雜誌. 24, 1, p. 30-40 11 p.

Research output: Contribution to journalArticle

Neurofibromatosis 2
Acoustic Neuroma
Radiosurgery
Hearing
Trigeminal Nerve
5 Citations (Scopus)

Increase of cardiac M2-muscarinic receptor gene expression in type-1 but not in type-2 diabetic rats

Lee, L. M., Chang, C. K., Cheng, K. C., Kou, D. H., Liu, I. M. & Cheng, J. T., Aug 22 2008, In : Neuroscience Letters. 441, 2, p. 201-204 4 p.

Research output: Contribution to journalArticle

Muscarinic M2 Receptors
Gene Expression
Streptozocin
Blood Pressure
Fructose
16 Citations (Scopus)

Interleukin-1 receptor antagonist restores homeostatic function and limits multiorgan damage in heatstroke

Shen, K. H., Chang, C. K., Lin, M. T. & Chang, C. P., Jul 2008, In : European Journal of Applied Physiology. 103, 5, p. 561-568 8 p.

Research output: Contribution to journalArticle

Heat Stroke
Interleukin-1 Receptors
Respiratory Alkalosis
Respiratory Acidosis
Hyperkalemia
38 Citations (Scopus)

Mediation of β-endorphin in andrographolide-induced plasma glucose-lowering action in type I diabetes-like animals

Yu, B. C., Chang, C. K., Su, C. F. & Cheng, J. T., Jun 2008, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 377, 4-6, p. 529-540 12 p.

Research output: Contribution to journalArticle

Endorphins
Type 1 Diabetes Mellitus
Glucose
Streptozocin
Opioid Receptors
13 Citations (Scopus)

Role of hyperglycaemia in the pathogenesis of hypotension observed in type-1 diabetic rats

Liu, I. M., Chang, C. K., Juang, S. W., Kou, D. H., Tong, Y. C., Cheng, K. C. & Cheng, J. T., Aug 2008, In : International Journal of Experimental Pathology. 89, 4, p. 292-300 9 p.

Research output: Contribution to journalArticle

Hyperglycemia
Hypotension
Blood Pressure
Heart Rate
Gene Expression

從處置呼吸器相關肺炎談論護理照護之核心角色

Yao, L-Y., Wang, C-J., Chang, C-K., Tsai, H-H. & Chen, C. C-H., 2008, In : 重症醫學雜誌. 9, 4, p. 250-256 7 p.

Research output: Contribution to journalArticle

Ventilator-Associated Pneumonia
Nursing Care
Pneumonia
Nurses
Nursing Staff

預防呼吸器相關肺炎的照護策略

Yao, L-Y., Chang, C-K., Wang, C. J., Tsai, H. H. & Chen, C. H., 2008, In : 臺灣醫學. 12, 6, p. 707-712 6 p.

Research output: Contribution to journalArticle

2007
49 Citations (Scopus)

Gene transfer of insulin-like growth factor-I providing neuroprotection after spinal cord injury in rats

Hung, K. S., Tsai, S. H., Lee, T. C., Lin, J. W., Chang, C. K. & Chiu, W. T., Jan 2007, In : Journal of Neurosurgery: Spine. 6, 1, p. 35-46 12 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Spinal Cord Injuries
Genes
Glycogen Synthase Kinase 3
Caspase 9