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Cheng-Hsien Chen

Associate Professor

 https://orcid.org/0000-0002-5833-2230
  • 1458 Citations
  • 26 h-Index
19972020

Research output per year

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Research Output

  • 1458 Citations
  • 26 h-Index
  • 62 Article
  • 3 Comment/debate
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Article
2020

Far-infrared radiation prevents decline in β-cell mass and function in diabetic mice via the mitochondria-mediated Sirtuin1 pathway

Hsu, Y. H., Chen, Y. C., Chen, Y. W., Chiu, T. H., Kuo, Y. T. & Chen, C. H., Mar 2020, In : Metabolism: Clinical and Experimental. 104, 154143.

Research output: Contribution to journal › Article

2019

Detecting the limits of the biological effects of far-infrared radiation on epithelial cells

Hsu, Y. H., Chen, Y. W., Cheng, C. Y., Lee, S. L., Chiu, T. H. & Chen, C. H., Dec 1 2019, In : Scientific Reports. 9, 1, 11586.

Research output: Contribution to journal › Article

Open Access
2 Citations (Scopus)

Study protocol for a prospective observational study to investigate the role of luminal pressure on arteriovenous fistula maturation

Cheng, H. S., Chang, T. I., Chen, C. H., Hsu, S. C., Hsieh, H. L., Chen, C. Y., Huang, W. C., Sue, Y. M., Lin, F. Y., Shih, C. M., Chen, J. W., Lin, S. J., Huang, P. H. & Liu, C. T., Oct 1 2019, In : Medicine (United States). 98, 40, e17238.

Research output: Contribution to journal › Article

Open Access
2018

Alleviative effect of fucoxanthin-containing extract from brown seaweed Laminaria japonica on renal tubular cell apoptosis through upregulating Na+/H+ exchanger NHE1 in chronic kidney disease mice

Chen, Y. C., Cheng, C. Y., Liu, C. T., Sue, Y. M., Chen, T. H., Hsu, Y. H., Hwang, P. A. & Chen, C. H., Oct 5 2018, In : Journal of Ethnopharmacology. 224, p. 391-399 9 p.

Research output: Contribution to journal › Article

1 Citation (Scopus)
2017

Far infrared promotes wound healing through activation of Notch1 signaling

Hsu, Y. H., Lin, Y. F., Chen, C. H., Chiu, Y. J. & Chiu, H. W., Aug 22 2017, (Accepted/In press) In : Journal of Molecular Medicine. p. 1-11 11 p.

Research output: Contribution to journal › Article

5 Citations (Scopus)

Far-infrared protects vascular endothelial cells from advanced glycation end products-induced injury via PLZF-mediated autophagy in diabetic mice

Chen, C. H., Chen, T. H., Wu, M. Y., Chou, T. C., Chen, J. R., Wei, M. J., Lee, S. L., Hong, L. Y., Zheng, C. M., Chiu, I. J., Lin, Y. F., Hsu, C. M. & Hsu, Y. H., Jan 10 2017, In : Scientific Reports. 7, 40442.

Research output: Contribution to journal › Article

14 Citations (Scopus)

Far-infrared suppresses skin photoaging in ultraviolet B-exposed fibroblasts and hairless mice

Chiu, H. W., Chen, C. H., Chen, Y. J. & Hsu, Y. H., Mar 1 2017, In : PLoS One. 12, 3, e0174042.

Research output: Contribution to journal › Article

9 Citations (Scopus)

Oligo-fucoidan prevents renal tubulointerstitial fibrosis by inhibiting the CD44 signal pathway

Chen, C-H., Sue, Y-M., Cheng, C-Y., Chen, Y. C., Liu, C. T., Hsu, Y-H., Hwang, P. A., Huang, N. J. & Chen, T-H., Jan 18 2017, In : Scientific Reports. 7, 40183.

Research output: Contribution to journal › Article

11 Citations (Scopus)
2016

Far-infrared promotes burn wound healing by suppressing NLRP3 inflammasome caused by enhanced autophagy

Chiu, H. W., Chen, C. H., Chang, J. N., Chen, C. H. & Hsu, Y. H., Feb 11 2016, (Accepted/In press) In : Journal of Molecular Medicine. p. 1-11 11 p.

Research output: Contribution to journal › Article

26 Citations (Scopus)

Multifunctions of Excited Gold Nanoparticles Decorated Artificial Kidney with Efficient Hemodialysis and Therapeutic Potential

Chen, H. C., Cheng, C. Y., Lin, H. C., Chen, H. H., Chen, C. H., Yang, C. P., Yang, K. H., Lin, C. M., Lin, T. Y., Shih, C. M. & Liu, Y. C., Aug 3 2016, In : ACS Applied Materials and Interfaces. 8, 30, p. 19691-19700 10 p.

Research output: Contribution to journal › Article

11 Citations (Scopus)
2015

Lycopene inhibits cyclic strain-induced endothelin-1 expression through the suppression of reactive oxygen species generation and induction of heme oxygenase-1 in human umbilical vein endothelial cells

Sung, L. C., Chao, H. H., Chen, C. H., Tsai, J. C., Liu, J. C., Hong, H. J., Cheng, T-H. & Chen, J. J., Jun 1 2015, In : Clinical and Experimental Pharmacology and Physiology. 42, 6, p. 632-639 8 p.

Research output: Contribution to journal › Article

11 Citations (Scopus)

Peroxisome proliferator-activated receptor α protects renal tubular cells from gentamicin-induced apoptosis via upregulating Na+/H+ exchanger NHE1

Chen, C-H., Chen, T-H., Wu, M-Y., Chen, J. R., Hong, L. Y., Zheng, C., Chiu, I. J., Lin, Y-F. & Hsu, Y-H., Nov 23 2015, In : Molecular Medicine. 21, p. 886-899 14 p.

Research output: Contribution to journal › Article

7 Citations (Scopus)

Urinary neutrophil gelatinase-associated lipocalin is associated with heavy metal exposure in welding workers

Chuang, K. J., Pan, C. H., Su, C-L., Lai, C. H., Lin, W. Y., Ma, C. M., Ho, S. C., Bien, M. Y., Chen, C. H. & Chuang, H. C., Dec 17 2015, In : Scientific Reports. 5, 18048.

Research output: Contribution to journal › Article

8 Citations (Scopus)
2014

Lycopene inhibits urotensin-II-induced cardiomyocyte hypertrophy in neonatal rat cardiomyocytes

Chao, H. H., Sung, L-C., Chen, C. H., Liu, J. C., Chen, J. J. & Cheng, T-H., 2014, In : Evidence-based Complementary and Alternative Medicine. 2014, 724670.

Research output: Contribution to journal › Article

5 Citations (Scopus)

MicroRNA-328 inhibits renal tubular cell epithelial-to-mesenchymal transition by targeting the CD44 in pressure-induced renal fibrosis

Chen, C. H., Cheng, C. Y., Chen, Y. C., Sue, Y. M., Liu, C. T., Cheng, T-H., Hsu, Y. H. & Chen, T. H., Jun 11 2014, In : PLoS One. 9, 6, e99802.

Research output: Contribution to journal › Article

26 Citations (Scopus)

Protective effects of Zhibai Dihuang Wan on renal tubular cells affected with gentamicin-induced apoptosis

Hsu, Y. H., Chen, T. H., Wu, M. Y., Lin, Y. F., Chen, W. L., Cheng, T-H. & Chen, C. H., Jan 10 2014, In : Journal of Ethnopharmacology. 151, 1, p. 635-642 8 p.

Research output: Contribution to journal › Article

11 Citations (Scopus)
2013

Rosuvastatin inhibits pressure-induced fibrotic responses via the expression regulation of prostacyclin and prostaglandin E2 in rat renal tubular cells

Chen, C. H., Cheng, C. Y., Chen, Y. C., Sue, Y. M., Hsu, Y. H., Tsai, W. L. & Chen, T. H., Jan 30 2013, In : European Journal of Pharmacology. 700, 1-3, p. 65-73 9 p.

Research output: Contribution to journal › Article

11 Citations (Scopus)

The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice

Chen, T. H., Kuro-O, M., Chen, C. H., Sue, Y. M., Chen, Y. C., Wu, H. H. & Cheng, C. Y., Jan 5 2013, In : European Journal of Pharmacology. 698, 1-3, p. 67-73 7 p.

Research output: Contribution to journal › Article

55 Citations (Scopus)

Urotensin II exerts antiapoptotic effect on NRK-52E cells through prostacyclin-mediated peroxisome proliferator-activated receptor alpha and Akt activation

Hsu, Y. H., Chen, T. H., Chen, Y. C., Cheng, C. Y., Sue, Y. M., Chen, J. R. & Chen, C. H., Dec 5 2013, In : Molecular and Cellular Endocrinology. 381, 1-2, p. 168-174 7 p.

Research output: Contribution to journal › Article

7 Citations (Scopus)
2012

Far-infrared therapy induces the nuclear translocation of PLZF which inhibits VEGF-induced proliferation in human umbilical vein endothelial cells

Hsu, Y. H., Chen, Y. C., Chen, T. H., Sue, Y. M., Cheng, T-H., Chen, J. R. & Chen, C. H., Jan 23 2012, In : PLoS One. 7, 1, e30674.

Research output: Contribution to journal › Article

33 Citations (Scopus)

Long-term leptin treatment exerts a pro-apoptotic effect on renal tubular cells via prostaglandin E2 augmentation

Hsu, Y. H., Cheng, C. Y., Chen, Y. C., Chen, T. H., Sue, Y. M., Tsai, W. L. & Chen, C. H., Aug 15 2012, In : European Journal of Pharmacology. 689, 1-3, p. 65-71 7 p.

Research output: Contribution to journal › Article

7 Citations (Scopus)
2011

Dipyridamole inhibits lipopolysaccharide-induced cyclooxygenase-2 and monocyte chemoattractant protein-1 via heme oxygenase-1-mediated reactive oxygen species reduction in rat mesangial cells

Chen, Y. C., Chen, C. H., Ko, W. S., Cheng, C. Y., Sue, Y. M. & Chen, T. H., Jan 10 2011, In : European Journal of Pharmacology. 650, 1, p. 445-450 6 p.

Research output: Contribution to journal › Article

9 Citations (Scopus)

L-carnitine reduces doxorubicin-induced apoptosis through a prostacyclin-mediated pathway in neonatal rat cardiomyocytes

Chao, H. H., Liu, J. C., Hong, H. J., Lin, J. W., Chen, C. H. & Cheng, T-H., Jan 21 2011, In : International Journal of Cardiology. 146, 2, p. 145-152 8 p.

Research output: Contribution to journal › Article

46 Citations (Scopus)

Leptin reduces gentamicin-induced apoptosis in rat renal tubular cells via the PI3K-Akt signaling pathway

Chen, Y. C., Chen, C. H., Hsu, Y. H., Chen, T. H., Sue, Y. M., Cheng, C. Y. & Chen, T-W., May 11 2011, In : European Journal of Pharmacology. 658, 2-3, p. 213-218 6 p.

Research output: Contribution to journal › Article

37 Citations (Scopus)
2010

L-Carnitine attenuates angiotensin II-induced proliferation of cardiac fibroblasts: Role of NADPH oxidase inhibition and decreased sphingosine-1-phosphate generation

Chao, H. H., Chen, C. H., Liu, J. C., Lin, J. W., Wong, K. L. & Cheng, T-H., Jul 2010, In : Journal of Nutritional Biochemistry. 21, 7, p. 580-588 9 p.

Research output: Contribution to journal › Article

7 Citations (Scopus)

Propofol depresses angiotensin II-induced cell proliferation in rat cardiac fibroblasts

Cheng, T-H., Leung, Y. M., Cheung, C. W., Chen, C. H., Chen, Y. L. & Wong, K. L., Jan 2010, In : Anesthesiology. 112, 1, p. 108-118 11 p.

Research output: Contribution to journal › Article

20 Citations (Scopus)

Uric acid activates extracellular signal-regulated kinases and thereafter endothelin-1 expression in rat cardiac fibroblasts

Cheng, T-H., Lin, J. W., Chao, H. H., Chen, Y. L., Chen, C. H., Chan, P. & Liu, J. C., Feb 18 2010, In : International Journal of Cardiology. 139, 1, p. 42-49 8 p.

Research output: Contribution to journal › Article

42 Citations (Scopus)
2009

Antioxidation and anti-inflammation by haem oxygenase-1 contribute to protection by tetramethylpyrazine against gentamicin-induced apoptosis in murine renal tubular cells

Sue, Y. M., Cheng, C. F., Chang, C. C., Chou, Y., Chen, C. H. & Juan, S. H., Mar 2009, In : Nephrology Dialysis Transplantation. 24, 3, p. 769-777 9 p.

Research output: Contribution to journal › Article

63 Citations (Scopus)

Dipyridamole inhibits cobalt chloride-induced osteopontin expression in NRK52E cells

Chen, T. H., Chang, C. F., Yu, S. C., Wang, J. C., Chen, C. H., Chan, P. & Lee, H. M., Jun 24 2009, In : European Journal of Pharmacology. 613, 1-3, p. 10-18 9 p.

Research output: Contribution to journal › Article

5 Citations (Scopus)

Dipyridamole Inhibits Lipopolysaccharide-Induced Interleukin-6 Secretion via Activation of Mitogen-Activated Protein Kinase Phosphatase-1 in Rat Mesangial Cells

范揚智(Yang-Chih F, 鄭仲益(Chung-Yi C, 陳正憲(Cheng-Hsien C, 陳振文(Tzen-Wen C & 陳作孝(Tso-Hsiao C, 2009, In : Acta Nephrologica. 23, 1, p. 33-39 7 p.

Research output: Contribution to journal › Article

Effects of propofol on cyclic strain-induced endothelin-1 expression in human umbilical vein endothelial cells

Cheng, T-H., Chen, J. J., Chen, C. H. & Wong, K. L., Jan 2009, In : Anesthesiology. 110, 1, p. 74-80 7 p.

Research output: Contribution to journal › Article

14 Citations (Scopus)

Mechanical stretch induces endothelial nitric oxide synthase gene expression in neonatal rat cardiomyocytes

Cheng, T-H., Chen, J. J. W., Shih, N. L., Lin, J. W., Liu, J. C., Chen, Y. L., Chen, C. H. & Chen, J. J., May 2009, In : Clinical and Experimental Pharmacology and Physiology. 36, 5-6, p. 559-566 8 p.

Research output: Contribution to journal › Article

9 Citations (Scopus)

Peroxisome proliferator-activated receptor alpha plays a crucial role in l-carnitine anti-apoptosis effect in renal tubular cells

Chen, H. H., Sue, Y. M., Chen, C. H., Hsu, Y. H., Hou, C-C., Cheng, C. Y., Lin, S. L., Tsai, W. L., Chen, T-W. & Chen, T. H., Oct 2009, In : Nephrology Dialysis Transplantation. 24, 10, p. 3042-3049 8 p.

Research output: Contribution to journal › Article

30 Citations (Scopus)

Urotensin II-induced endothelin-1 expression and cell proliferation via epidermal growth factor receptor transactivation in rat aortic smooth muscle cells

Tsai, C. S., Loh, S. H., Liu, J. C., Lin, J. W., Chen, Y. L., Chen, C. H. & Cheng, T-H., Sep 2009, In : Atherosclerosis. 206, 1, p. 86-94 9 p.

Research output: Contribution to journal › Article

23 Citations (Scopus)

Urotensin II induces rat cardiomyocyte hypertrophy via the transient oxidization of Src homology 2-containing tyrosine phosphatase and transactivation of epidermal growth factor receptor

Liu, J. C., Chen, C. H., Chen, J. J. & Cheng, T-H., Dec 2009, In : Molecular Pharmacology. 76, 6, p. 1186-1195 10 p.

Research output: Contribution to journal › Article

26 Citations (Scopus)

Urotensin II induces transactivation of the epidermal growth factor receptor via transient oxidation of SHP-2 in the rat renal tubular cell line NRK-52E

Sue, Y. M., Chen, C. H., Hsu, Y. H., Hou, C-C., Cheng, C. Y., Chen, Y. C., Lin, S. L., Chen, T-W. & Chen, T. H., 2009, In : Growth Factors. 27, 3, p. 155-162 8 p.

Research output: Contribution to journal › Article

7 Citations (Scopus)
2008

Involvement of reactive oxygen species in urotensin II-induced proliferation of cardiac fibroblasts

Chen, Y. L., Liu, J. C., Loh, S. H., Chen, C. H., Hong, C. Y., Chen, J. J. & Cheng, T. H., Sep 28 2008, In : European Journal of Pharmacology. 593, 1-3, p. 24-29 6 p.

Research output: Contribution to journal › Article

28 Citations (Scopus)

Prostacyclin protects renal tubular cells from gentamicin-induced apoptosis via a PPARα-dependent pathway

Hsu, Y. H., Chen, C. H., Hou, C. C., Sue, Y. M., Cheng, C. Y., Cheng, T. H., Lin, H., Tsai, W. L., Chan, P. & Chen, T. H., Mar 2008, In : Kidney International. 73, 5, p. 578-587 10 p.

Research output: Contribution to journal › Article

24 Citations (Scopus)

Uric acid stimulates endothelin-1 gene expression associated with NADPH oxidase in human aortic smooth muscle cells

Chao, H. H., Liu, J. C., Lin, J. W., Chen, C. H., Wu, C. H. & Cheng, T. H., Nov 2008, In : Acta Pharmacologica Sinica. 29, 11, p. 1301-1312 12 p.

Research output: Contribution to journal › Article

47 Citations (Scopus)
2007

Peroxisomal proliferator-activated receptor-α protects renal tubular cells from doxorubicin-induced apoptosis

Lin, H., Hou, C. C., Cheng, C. F., Chiu, T. H., Hsu, Y. H., Sue, Y. M., Chen, T. H., Hou, H. H., Chao, Y. C., Cheng, T. H. & Chen, C. H., Nov 2007, In : Molecular Pharmacology. 72, 5, p. 1238-1245 8 p.

Research output: Contribution to journal › Article

37 Citations (Scopus)

Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells

Chen, T. H., Hsu, Y. T., Chen, C. H., Kao, S. H. & Lee, H. M., Feb 2007, In : Mitochondrion. 7, 1-2, p. 101-105 5 p.

Research output: Contribution to journal › Article

56 Citations (Scopus)

Tetramethylpyrazine protects rat renal tubular cell apoptosis induced by gentamicin

Juan, S. H., Chen, C. H., Hsu, Y. H., Hou, C. C., Chen, T. H., Lin, H., Chu, Y. L. & Sue, Y. M., Mar 2007, In : Nephrology Dialysis Transplantation. 22, 3, p. 732-739 8 p.

Research output: Contribution to journal › Article

68 Citations (Scopus)
2006

Antiproliferative effect of isosteviol on angiotensin-II-treated rat aortic smooth muscle cells

Wong, K. L., Lin, J. W., Liu, J. C., Yang, H. Y., Kao, P. F., Chen, C. H., Loh, S. H., Chiu, W. T., Cheng, T-H., Lin, J. G. & Hong, H. J., Apr 2006, In : Pharmacology. 76, 4, p. 163-169 7 p.

Research output: Contribution to journal › Article

32 Citations (Scopus)

Dipyridamole activation of mitogen-activated protein kinase phosphatase-1 mediates inhibition of lipopolysaccharide-induced cyclooxygenase-2 expression in RAW 264.7 cells

Chen, T. H., Kao, Y. C., Chen, B. C., Chen, C. H., Chan, P. & Lee, H. M., Jul 17 2006, In : European Journal of Pharmacology. 541, 3, p. 138-146 9 p.

Research output: Contribution to journal › Article

41 Citations (Scopus)

Reactive oxygen species generation is involved in epidermal growth factor receptor transactivation through the transient oxidization of Src homology 2-containing tyrosine phosphatase in endothelin-1 signaling pathway in rat cardiac fibroblasts

Chen, C. H., Cheng, T. H., Lin, H., Shih, N. L., Chen, Y. L., Chen, Y. S., Cheng, C. F., Lian, W. S., Meng, T. C., Chiu, W. T. & Chen, J. J., Apr 2006, In : Molecular Pharmacology. 69, 4, p. 1347-1355 9 p.

Research output: Contribution to journal › Article

87 Citations (Scopus)

Src homology 2-containing phosphotyrosine phosphatase regulates endothelin-1-induced epidermal growth factor receptor transactivation in rat renal tubular cell NRK-52E

Cheng-Hsien, C., Yung-Ho, H., Yuh-Mou, S., Chun-Cheng, H., Horng-Mo, L., Huei-Mei, H. & Tso-Hsiao, C., Apr 2006, In : Pflugers Archiv European Journal of Physiology. 452, 1, p. 16-24 9 p.

Research output: Contribution to journal › Article

16 Citations (Scopus)

Tetramethylpyrazine attenuates adriamycin-induced apoptotic injury in rat renal tubular cells NRK-52E

Cheng, C. Y., Sue, Y. M., Chen, C. H., Hou, C-C., Chan, P., Chu, Y. L., Chen, T. H. & Hsu, Y. H., Aug 2006, In : Planta Medica. 72, 10, p. 888-893 6 p.

Research output: Contribution to journal › Article

21 Citations (Scopus)

The protective effect of prostacyclin on adriamycin-induced apoptosis in rat renal tubular cells

Chen, C. H., Lin, H., Hsu, Y. H., Sue, Y. M., Cheng, T. H., Chan, P. & Chen, T. H., Jan 4 2006, In : European Journal of Pharmacology. 529, 1-3, p. 8-15 8 p.

Research output: Contribution to journal › Article

23 Citations (Scopus)
2005

Inhibition of angiotensin II induced endothelin-1 gene expression by 17-β-oestradiol in rat cardiac fibroblast

Chao, H. H., Chen, J. J., Chen, C. H., Lin, H., Cheng, C. F., Lian, W. S., Chen, Y. L., Juan, S. H., Liu, J. C., Liou, J. Y., Chan, P. & Cheng, T-H., May 2005, In : Heart. 91, 5, p. 664-669 6 p.

Research output: Contribution to journal › Article

27 Citations (Scopus)

Inhibition of cyclic strain-induced endothelin-1 secretion by tetramethylpyrazine

Bi, W. F., Yang, H. Y., Liu, J. C., Cheng, T. H., Chen, C. H., Shih, C. M., Lin, H., Wang, T. C., Lian, W. S., Chen, J. J., Chiu, H. C. & Chang, N. C., Jul 2005, In : Clinical and Experimental Pharmacology and Physiology. 32, 7, p. 536-540 5 p.

Research output: Contribution to journal › Article

8 Citations (Scopus)