TMU Research Center of Drug Discivery

Search results

• Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation

  Lin, F. (Contributor), Chen, C. (Contributor), Liao, P. (Contributor), Tsai, C. (Contributor), Chan, Y. (Contributor), Li, C. (Contributor), Cheng, Y. (Contributor) & Ho, J. (Contributor), figshare Academic Research System, Jan 1 2021

  DOI: 10.6084/m9.figshare.c.5263303.v1, https://doi.org/10.6084%2Fm9.figshare.c.5263303.v1

  Dataset

• Additional file 1: of CCAAT/enhancer-binding protein delta regulates the stemness of glioma stem-like cells through activating PDGFA expression upon inflammatory stimulation

  Wang, S. (Contributor), Lin, H. (Contributor), Chen, Y. (Contributor), Hsu, T. (Contributor), Chuang, J. (Contributor), Kao, T. (Contributor) & Ko, C. (Contributor), Unknown Publisher, Jul 12 2019

  DOI: 10.6084/m9.figshare.8866895.v1, https://springernature.figshare.com/articles/Additional_file_1_of_CCAAT_enhancer-binding_protein_delta_regulates_the_stemness_of_glioma_stem-like_cells_through_activating_PDGFA_expression_upon_inflammatory_stimulation/8866895/1

  Dataset

• CCAAT/enhancer-binding protein delta regulates the stemness of glioma stem-like cells through activating PDGFA expression upon inflammatory stimulation

  Wang, S. (Contributor), Lin, H. (Contributor), Chen, Y. (Contributor), Hsu, T. (Contributor), Chuang, J. (Contributor), Kao, T. (Contributor) & Ko, C. (Contributor), Unknown Publisher, Jul 12 2019

  DOI: 10.6084/m9.figshare.c.4575326.v1, https://doi.org/10.6084%2Fm9.figshare.c.4575326.v1

  Dataset

• Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets

  Chien, C. (Contributor), Chuang, J. (Contributor), Yang, S. (Contributor), Yang, W. (Contributor), Chen, P. (Contributor), Hsu, T. (Contributor), Huang, C. (Contributor), Lo, W. (Contributor), Yang, K. (Contributor), Liu, M. (Contributor), Chu, J. (Contributor), Chung, P. (Contributor), Liu, J. (Contributor), Chou, S. (Contributor), Chen, S. (Contributor) & Chang, K. (Contributor), Unknown Publisher, Jan 1 2019

  DOI: 10.6084/m9.figshare.c.4705370.v1, https://doi.org/10.6084%2Fm9.figshare.c.4705370.v1

  Dataset

• MOESM8 of Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets

  Chien, C. (Contributor), Chuang, J. (Contributor), Yang, S. (Contributor), Yang, W. (Contributor), Chen, P. (Contributor), Hsu, T. (Contributor), Huang, C. (Contributor), Lo, W. (Contributor), Yang, K. (Contributor), Liu, M. (Contributor), Chu, J. (Contributor), Chung, P. (Contributor), Liu, J. (Contributor), Chou, S. (Contributor), Chen, S. (Contributor) & Chang, K. (Contributor), Unknown Publisher, Jan 1 2019

  DOI: 10.6084/m9.figshare.10006883.v1, https://springernature.figshare.com/articles/MOESM8_of_Enrichment_of_superoxide_dismutase_2_in_glioblastoma_confers_to_acquisition_of_temozolomide_resistance_that_is_associated_with_tumor-initiating_cell_subsets/10006883/1

  Dataset

• Additional file 1 of Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation

  Chan, Y. (Contributor), Li, C. (Contributor), Chen, C. (Contributor), Ho, J. (Contributor), Cheng, Y. (Contributor), Liao, P. (Contributor), Tsai, C. (Contributor) & Lin, F. (Contributor), figshare Academic Research System, Jan 1 2021

  DOI: 10.6084/m9.figshare.13550758.v1, https://doi.org/10.6084%2Fm9.figshare.13550758.v1

  Dataset

• Structure-guided design of anti-cancer ribonucleotide reductase inhibitors

  Misko, T. A. (Contributor), Liu, Y. (Contributor), Harris, M. E. (Contributor), Oleinick, N. L. (Contributor), Pink, J. (Contributor), Lee, H. (Contributor) & Dealwis, C. G. (Contributor), Unknown Publisher, Jan 1 2019

  DOI: 10.6084/m9.figshare.7553114.v1, https://tandf.figshare.com/articles/Structure-guided_design_of_anti-cancer_ribonucleotide_reductase_inhibitors/7553114/1

  Dataset

• Investigating the potential effects of selective histone deacetylase 6 inhibitor ACY1215 on infarct size in rats with cardiac ischemia-reperfusion injury

  Lin, C. (Contributor), Hsu, K. (Contributor), HuangFu, W. (Contributor), Lin, T. E. (Contributor), Huang, H. (Contributor) & Pan, S. (Contributor), Unknown Publisher, Mar 12 2020

  DOI: 10.6084/m9.figshare.c.4896705.v1, https://doi.org/10.6084%2Fm9.figshare.c.4896705.v1

  Dataset

• EGFL6 promotes colorectal cancer cell growth and mobility and the anti‐cancer property of anti-EGFL6 antibody

  Lee, Y. (Contributor), Huang, H. (Contributor), Chang, F. (Contributor), Wei, P. (Contributor), HuangFu, W. (Contributor), Sung, T. (Contributor), Pan, S. (Contributor), Cheng, C. (Contributor), Cheng, Y. (Contributor) & Huang, C. (Contributor), figshare Academic Research System, Jan 1 2021

  DOI: 10.6084/m9.figshare.c.5341486.v1, https://doi.org/10.6084%2Fm9.figshare.c.5341486.v1

  Dataset

• CCDC 2000792: Experimental Crystal Structure Determination

  Hsu, M. (Contributor), Hsieh, C. (Contributor), Kapoor, M. (Contributor), Chang, J. (Contributor), Chu, H. (Contributor), Cheng, T. (Contributor), Hsu, K. (Contributor), Lin, T. E. (Contributor), Tsai, F. (Contributor) & Horng, J. (Contributor), Unknown Publisher, May 1 2020

  DOI: 10.5517/ccdc.csd.cc254zp0, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc254zp0&sid=DataCite

  Dataset

• Additional file 1: of The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells

  Tu, H. (Contributor), Lin, Y. (Contributor), Chao, M. (Contributor), Sung, T. (Contributor), Wu, Y. (Contributor), Chen, Y. (Contributor), Lin, M. (Contributor), Liou, J. (Contributor), Pan, S. (Contributor) & Yang, C. (Contributor), Unknown Publisher, Dec 29 2018

  DOI: 10.6084/m9.figshare.7531874.v1, https://springernature.figshare.com/articles/Additional_file_1_of_The_anticancer_effects_of_MPT0G211_a_novel_HDAC6_inhibitor_combined_with_chemotherapeutic_agents_in_human_acute_leukemia_cells/7531874/1

  Dataset

• Additional file 1: of Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status

  Chao, M. (Contributor), Chang, L. (Contributor), Tu, H. (Contributor), Chang, C. (Contributor), Lai, M. (Contributor), Chen, Y. (Contributor), Liou, J. (Contributor), Teng, C. (Contributor) & Pan, S. (Contributor), Unknown Publisher, May 29 2019

  DOI: 10.6084/m9.figshare.8202881.v1, https://springernature.figshare.com/articles/Additional_file_1_of_Combination_treatment_strategy_for_pancreatic_cancer_involving_the_novel_HDAC_inhibitor_MPT0E028_with_a_MEK_inhibitor_beyond_K-Ras_status/8202881/1

  Dataset

• Novel microtubule inhibitor MPT0B098 inhibits hypoxia-induced epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma

  Tsai, I. (Contributor), Kuo, C. (Contributor), Liou, J. (Contributor) & Chang, J. (Contributor), Unknown Publisher, Mar 28 2018

  DOI: 10.6084/m9.figshare.c.4052207.v1, https://figshare.com/collections/Novel_microtubule_inhibitor_MPT0B098_inhibits_hypoxia-induced_epithelial-to-mesenchymal_transition_in_head_and_neck_squamous_cell_carcinoma/4052207/1

  Dataset

• Inhaled gold nanoparticles cause cerebral edema and upregulate endothelial aquaporin 1 expression, involving caveolin 1 dependent repression of extracellular regulated protein kinase activity

  Chen, C. (Contributor), Liao, P. (Contributor), Tsai, C. (Contributor), Chan, Y. (Contributor), Cheng, Y. (Contributor), Hwang, L. (Contributor), Lin, K. (Contributor), Yen, T. (Contributor) & Li, C. (Contributor), Unknown Publisher, Oct 16 2019

  DOI: 10.6084/m9.figshare.c.4701761.v1, https://doi.org/10.6084%2Fm9.figshare.c.4701761.v1

  Dataset

• Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach

  Chao, M. (Contributor), Lin, T. E. (Contributor), HuangFu, W. (Contributor), Chang, C. (Contributor), Tu, H. (Contributor), Chen, L. (Contributor), Yen, S. (Contributor), Sung, T. (Contributor), Huang, W. (Contributor), Yang, C. (Contributor), Pan, S. (Contributor) & Hsu, K. (Contributor), Unknown Publisher, Jan 1 2020

  DOI: 10.6084/m9.figshare.13213424.v1, https://tandf.figshare.com/articles/dataset/Identification_of_a_dual_TAOK1_and_MAP4K5_inhibitor_using_a_structure-based_virtual_screening_approach/13213424/1

  Dataset

• Additional file 1: of Suberoylanilide hydroxamic acid represses glioma stem-like cells

  Hsu, C. (Contributor), Chang, W. (Contributor), Hsu, T. (Contributor), Liu, J. (Contributor), Yeh, S. (Contributor), Wang, J. (Contributor), Liou, J. (Contributor), Ko, C. (Contributor), Chang, K. (Contributor) & Chuang, J. (Contributor), Unknown Publisher, Nov 18 2016

  DOI: 10.6084/m9.figshare.c.3596465_d1.v1, https://springernature.figshare.com/articles/journal_contribution/Additional_file_1_of_Suberoylanilide_hydroxamic_acid_represses_glioma_stem-like_cells/4318721/1

  Dataset

• Association of endothelin genetic variants and hospitalized infection complications in end-stage renal disease (ESRD) patients

  Kao, C. (Contributor), Cheng, S. (Contributor), Wang, Y. (Contributor), Chien, S. (Contributor), Hsu, Y. (Contributor), Wu, M. (Contributor), Lu, H. (Contributor), Nam, S. (Contributor), Sun, T. (Contributor), Wu, M. (Contributor) & Chang, W. (Contributor), Unknown Publisher, Jun 5 2019

  DOI: 10.6084/m9.figshare.c.4531100.v1, https://doi.org/10.6084%2Fm9.figshare.c.4531100.v1

  Dataset

• Humanized bispecific antibody (mPEG × HER2) rapidly confers PEGylated nanoparticles tumor specificity for multimodality imaging in breast cancer

  Cheng, Y. (Contributor), Wu, T. (Contributor), Wang, Y. (Contributor), Cheng, T. (Contributor), Chen, I. (Contributor), Lu, Y. (Contributor), Chuang, K. (Contributor), Wang, C. (Contributor), Chen, C. (Contributor), Lin, R. (Contributor), Chen, H. (Contributor), Liao, T. (Contributor), Liu, E. (Contributor) & Chen, F. (Contributor), Unknown Publisher, Jan 1 2020

  DOI: 10.6084/m9.figshare.c.5105096.v1, https://springernature.figshare.com/collections/Humanized_bispecific_antibody_mPEG_HER2_rapidly_confers_PEGylated_nanoparticles_tumor_specificity_for_multimodality_imaging_in_breast_cancer/5105096/1

  Dataset

• MOESM8 of Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning

  Wong, H. (Contributor), Lin, Y. (Contributor), Lu, H. (Contributor), Liao, W. (Contributor), Chen, C. (Contributor), Wu, J. (Contributor), Chang, W. (Contributor) & Tsai, F. (Contributor), Unknown Publisher, Jan 1 2019

  DOI: 10.6084/m9.figshare.10270466.v1, https://springernature.figshare.com/articles/MOESM8_of_Genomic_interrogation_of_familial_short_stature_contributes_to_the_discovery_of_the_pathophysiological_mechanisms_and_pharmaceutical_drug_repositioning/10270466/1

  Dataset

• Novel application of pluronic lecithin organogels (PLOs) for local delivery of synergistic combination of docetaxel and cisplatin to improve therapeutic efficacy against ovarian cancer

  Chang, C. (Contributor), Hsieh, C. (Contributor), Chen, L. (Contributor), Su, C. (Contributor), Liu, D. (Contributor), Jhan, H. (Contributor), Ho, H. (Contributor) & Sheu, M. (Contributor), Unknown Publisher, Jan 1 2018

  DOI: 10.6084/m9.figshare.5908795.v1, https://tandf.figshare.com/articles/Novel_application_of_pluronic_lecithin_organogels_PLOs_for_local_delivery_of_synergistic_combination_of_docetaxel_and_cisplatin_to_improve_therapeutic_efficacy_against_ovarian_cancer/5908795/1

  Dataset

• MOESM6 of Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning

  Wong, H. (Contributor), Lin, Y. (Contributor), Lu, H. (Contributor), Liao, W. (Contributor), Chen, C. (Contributor), Wu, J. (Contributor), Chang, W. (Contributor) & Tsai, F. (Contributor), Unknown Publisher, Jan 1 2019

  DOI: 10.6084/m9.figshare.10270454.v1, https://springernature.figshare.com/articles/MOESM6_of_Genomic_interrogation_of_familial_short_stature_contributes_to_the_discovery_of_the_pathophysiological_mechanisms_and_pharmaceutical_drug_repositioning/10270454/1

  Dataset

• Associations of genetic variants of endothelin with cardiovascular complications in patients with renal failure

  Kao, C. (Contributor), Cheng, S. (Contributor), Wu, M. (Contributor), Chien, S. (Contributor), Lu, H. (Contributor), Hsu, Y. (Contributor), Zhang, Y. (Contributor), Wu, M. (Contributor) & Chang, W. (Contributor), Unknown Publisher, Sep 7 2017

  DOI: 10.6084/m9.figshare.c.3874468.v1, https://figshare.com/collections/Associations_of_genetic_variants_of_endothelin_with_cardiovascular_complications_in_patients_with_renal_failure/3874468/1

  Dataset

• V-J combinations of T-cell receptor predict responses to erythropoietin in end-stage renal disease patients

  Wong, H. (Contributor), Chang, C. (Contributor), Kao, C. (Contributor), Hsu, Y. (Contributor), Liu, X. (Contributor), Chang, W. (Contributor), Wu, M. (Contributor) & Chang, W. (Contributor), Unknown Publisher, Jul 11 2017

  DOI: 10.6084/m9.figshare.c.3824278.v1, https://figshare.com/collections/V-J_combinations_of_T-cell_receptor_predict_responses_to_erythropoietin_in_end-stage_renal_disease_patients/3824278/1

  Dataset

• MOESM2 of Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning

  Wong, H. (Contributor), Lin, Y. (Contributor), Lu, H. (Contributor), Liao, W. (Contributor), Chen, C. (Contributor), Wu, J. (Contributor), Chang, W. (Contributor) & Tsai, F. (Contributor), Unknown Publisher, Jan 1 2019

  DOI: 10.6084/m9.figshare.10270436.v1, https://springernature.figshare.com/articles/MOESM2_of_Genomic_interrogation_of_familial_short_stature_contributes_to_the_discovery_of_the_pathophysiological_mechanisms_and_pharmaceutical_drug_repositioning/10270436/1

  Dataset

• Additional file 7: of V-J combinations of T-cell receptor predict responses to erythropoietin in end-stage renal disease patients

  Wong, H. (Contributor), Chang, C. (Contributor), Kao, C. (Contributor), Hsu, Y. (Contributor), Liu, X. (Contributor), Chang, W. (Contributor), Wu, M. (Contributor) & Chang, W. (Contributor), Unknown Publisher, Jul 11 2017

  DOI: 10.6084/m9.figshare.c.3824278_d7.v1, https://springernature.figshare.com/articles/journal_contribution/Additional_file_7_of_V-J_combinations_of_T-cell_receptor_predict_responses_to_erythropoietin_in_end-stage_renal_disease_patients/5197576/1

  Dataset