TMU Research Center of Cancer Translational Medicine

Projects

Projects per year 2010 2014 2015 2016 2017 2018 2022

• 4 Active
• 531 Finished

Projects per year

Search results

• b - Ministry of Science and Technology

  A Novel Lifr Axis in Metabolism Unhinged and Neuroendocrine Differentiation of Prostate Cancer(I)

  Liu, Y.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Roles of Genetic Polymorphisms for Susceptibility and Clinical Outcomes of Colorectal Cancer in Taiwanese Lynch Syndrome Families

  Yeh, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hereditary Nonpolyposis Colorectal Neoplasms 100%
  • DNA Mismatch Repair 57%
  • Colorectal Neoplasms 54%
  • Genetic Polymorphisms 29%
  • Genes 19%

• Targeting Class III Phosphoinositide 3-Kinase (Pi3k) for Anticancer Drug Discovery

  Chen, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Phosphoinositide 100%
  • 3-Methyladenine 41%
  • Antineoplastic Agent 32%
  • Protein Synthesis 25%
  • LY294002 22%

• Bone-Marrow-Derived Mesenchymal Stem Cells in Prostate Cancer-Induced Bone Remodeling

  Hsieh, C., Chen, K. & Sung, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Adipogenic 100%
  • Osteogenic 37%

• The Effect and Mechanisms of Chemotherapy in Recruit Inflammatory Cells into Tumor Microenvironment of Lung Cancer Patients

  Feng, P. & Lee, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Myeloid-Derived Suppressor Cells 100%
  • Neoplasms 26%
  • Tumor Microenvironment 25%
  • Lung Neoplasms 19%
  • Drug Therapy 19%

• 腫瘤相關巨噬細胞在誘發產生表皮生長因子受器酪胺酸酉每抑制劑的抗藥性的角色

  Feng, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Imapct of Oxidative Stress on the Pathogenesis of COPD---An Ivestigation into Its Relationship with Abnormal Inflammation, Dna Instability, Epigenetics and Cell Metabolism

  Lee, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chronic Obstructive Pulmonary Disease 100%
  • Oxidative Stress 47%
  • Inflammation 33%
  • Blood Cells 26%
  • Glucocorticoids 21%

• Effects of Ultrafine Particles on Cardiopulmonary System: a Population-Based Approach

  Chuang, K. & Feng, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Particulate Matter 100%
  • Air Pollution 68%
  • Taiwan 34%
  • United States Environmental Protection Agency 33%
  • Organized Financing 13%

• Impacts of Particulate Air Pollution on Repair and Abnormal Inflammation in Copd: the Role of Itih4 and the Regeneration Pathways

  Lee, K.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chronic Obstructive Pulmonary Disease 100%
  • inter-alpha-inhibitor 82%
  • Particulate Matter 74%
  • Inflammation 30%
  • human ITIH4 protein 25%

• A Toxicological Assessment of Air Pollution in the Vicinity of a Petrochemical Complex

  Chuang, H. & Lee, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Particulate Matter 100%
  • Taiwan 54%
  • Toxicology 44%
  • Risk Assessment 38%
  • Methionine 19%

• Studies on the Carcinogenic Mechanisms of Histamine N-Methyltransferase-Mediated Breast Cancer Formation

  Wu, C. & Ho, Y.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histamine N-Methyltransferase 100%
  • Breast Neoplasms 18%
  • Neoplasms 6%
  • Carcinogenesis 6%

• Study of Novel Genes Regulated by Aberrant DNA Methylation and Application in Colon Cancer Treatment

  Lin, R. & Ho, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neoplasm Genes 100%
  • Methylation 83%
  • Taiwan 82%
  • DNA Methylation 81%
  • Colonic Neoplasms 66%

• Molecular Mechanisms of Alpha 9-Nicotinic Acetylcholine Receptor (Alpha 9-nAChRs)-Mediated Trastuzumab (Herceptin R) Drug Resistance in Breast Cancer Cells

  Ho, Y.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Trastuzumab 79%
  • Liposomes 66%
  • MicroRNAs 56%
  • Nicotinic Receptors 49%

• Molecular Mechanisms of Alpha 9-Nicotinic Acetylcholine Receptor (Alpha 9-Nachr)-Mediated Trastuzumab (Herceptinr) Drug Resistance in Breast Cancer Cells

  Ho, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Liposomes 66%
  • MicroRNAs 56%
  • Trastuzumab 53%
  • Nicotinic Receptors 49%

• Design and Preclinical Translation Study of Mixed-Bispecific/Trispecific Antibody for Enhancing Therapeutic Effectiveness of Anticancer Drug-Loaded Pegylated Nanocarriers by Simultaneously Targeting to Tumor Cells and Cancer/Tumor Associated Fibrobla (I)

  Sheu, M., Chuang, K. & Ho, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Nanocarrier 100%
  • Antigen 77%
  • Tumor Marker 61%
  • Modification 51%
  • Liposome 42%

• Investigation on the Suppressive Mechanisms of Novel Anti-Glypican3 Antibody Drugs

  Yang, Y.

  8/1/14 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glypicans 100%
  • Hepatocellular Carcinoma 20%
  • Antibodies 18%
  • Single-Chain Antibodies 10%
  • Heparan Sulfate Proteoglycans 10%

• Using Big Data and Deep Neural Network to Prevent Medication Errors

  Li, Y.

  11/1/16 → 10/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Inflammatory Gene Polymorphisms on Risk of Post-Stroke Vascular Dementia (I)

  Chiou, H., Chi, N., Lin, H., Wu, C., Hsieh, F., Hu, C. & Hsieh, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Stroke 93%
  • Cognitive Dysfunction 89%
  • Blood Vessels 52%
  • Inflammation 36%
  • Whole Exome Sequencing 16%

• Development a Risk Scoring System for Predicting the Risk of Poststroke Epilepsy to Improve the Quality of Care among Patients with Stroke

  Chien, L.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Epilepsy 100%
  • Stroke 45%
  • Anticonvulsants 24%
  • National Health Programs 20%
  • University Hospitals 15%

• Genetic Polymorphisms in Hypoxia Inducible Factor-1 and Inflammation Pathway Related microRNA and Its Target Genes and Risk of Hyperglycemia in Acute Ischemic Stroke and Its Prognosis Study

  Hsieh, Y., Cho, E., Chi, N. & Chiou, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • MicroRNAs 100%
  • Hyperglycemia 79%
  • Stroke 64%
  • Inflammation 37%
  • Biomarkers 10%

• Dementia Care and Quality Improvement

  Chien, L., Chiou, H., Chi, N. & Hu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • dementia 100%
  • health insurance 28%
  • Medical records 19%
  • utilization 17%
  • resources 9%

• Molecular Mechanisms of Anti-Inflammatory Effects of Intravenous Anesthetic Agent Ketamine on Lipopolysaccharide-Activated Macrophages

  Chen, T. & Chen, R.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • ketamine 100%
  • lipopolysaccharides 80%
  • macrophages 39%
  • Toll-like receptors 32%
  • cytokines 32%

• Application of Regioselective Substitution on 1,4-Benzoquinone Derivatives to Provide Potent Anticancer Agents(3/3)

  Liou, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • 1,4-benzoquinone 100%
  • Wittig Olefination 54%
  • Intramolecular Cyclization 40%
  • Nucleophilic Substitution 38%
  • Regioselectivity 35%

• Syntheses of Anti-Lung Cancer Agents(1/2)

  Liou, J.

  6/1/17 → 5/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Crizotinib 100%
  • Alectinib 59%
  • Ceritinib 55%
  • Drug 29%

• Cell Behaviors and Its Gene Analysis of Nerve-Like Cell on Three-Dimensional Fibrous Matrix

  Tseng, H. & Ho, Y.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • membranes 100%
  • nerves 70%
  • cells 60%
  • gene expression 50%
  • tissue engineering 32%

• Studies on the Mechanisms of Histamine N-Methyltransferase (Hnmt)-Mediated Herceptinr Drug-Resistance in Breast Cancer Cells

  Ho, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histamine N-Methyltransferase 100%
  • Trastuzumab 89%
  • Breast Neoplasms 17%
  • Tissue Array Analysis 9%
  • Gene Expression Profiling 8%

• Generate anti-Fibroblast growth factor receptor 2 (FGFR2) antibody drugs and study on their potential application against gastric cancer

  Lee, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 組織胺甲基化轉換酵素參與第第二型人類表皮因子受體蛋白穩定性之探討

  Ho, Y.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular mechanisms of alpha9-nicotinic acetylcholine receptor (alpha 9-nAChR)-mediated Trastuzumab (HerceptinR) drug resistance in breast cancer cells

  Ho, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Liposomes 66%
  • MicroRNAs 56%
  • Trastuzumab 53%
  • Nicotinic Receptors 49%

• The Association of Nonage Chronic Arsenic Exposure, Methylation Levels of Arsenic Metabolism Genes, and the Risk of Cancer Development

  Chiou, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • arsenic 100%
  • adulthood 37%
  • neoplasms 27%
  • methylation 24%
  • metabolism 15%

• Capacity of Scientific Research in Sri Lanka for Potential Collaboration with Taiwan( I )

  Chiou, H.

  1/1/17 → 6/30/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Sri Lanka 100%
  • university teacher 44%
  • Taiwan 25%
  • manager 21%
  • innovation research 21%

• The Association of Nonage Chronic Arsenic Exposure, Methylation Levels of Arsenic Metabolism Genes, and the Risk of Cancer Development

  Chiou, H.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • arsenic 100%
  • adulthood 37%
  • neoplasms 27%
  • methylation 24%
  • metabolism 15%

• Capacity of Scientific Research in Sri Lanka for Potential Collaboration with Taiwan( II )

  Chiou, H.

  7/1/17 → 6/30/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Mirna and Gut Microbiota in Pathogenesis of Post-Stroke Vascular Cognitive Impairment

  Chiou, H.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• HDAC9與STAT3基因多形性與缺血性中風之相關性研究

  Chiou, H.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Inflammatory Gene Polymorphisms on Risk of Post-Stroke Vascular Dementia( III )

  Chiou, H.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Social Medicine Discipline Research Planning and Promotion Project

  Chiou, H.

  1/1/15 → 12/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Social Medicine 100%
  • Congresses 85%
  • Fees and Charges 53%
  • Geriatric Nursing 35%
  • Research Design 34%

• Investigation of Inflammatory Microenvironment-Regulated Stemess in Glioblastoma

  Ko, C.

  10/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • CCAAT-Enhancer-Binding Protein-delta 100%
  • Glioma 34%
  • Gallbladder Neoplasms 10%
  • Neoplastic Stem Cells 8%
  • Glioblastoma 8%

• Investigation of Astrocytic Cebpd-Regulated Mirnas and Their Effects on Angiogenesis during Neuroinflammation

  Ko, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Alzheimer Disease 100%
  • MicroRNAs 77%
  • Astrocytes 67%
  • Angiogenesis Inducing Agents 41%
  • Endothelial Cells 40%
• c - Ministry of Health and Welfare

  癌症早期發現相關策略研究－分癌別評估癌症篩檢執行人力與未來發展之需求：乳癌、子宮頸癌、大腸癌、口腔癌與肝癌(105年)

  Chen, L. & Wang, S.

  1/1/16 → 12/31/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

• Investigation of the effectiveness on Chinese medication safety promotion and education

  Lin, S.

  4/28/17 → 12/31/17

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • medication 100%
  • promotion 43%
  • pregnant women 42%
  • medicine 42%
  • citizen 23%

• Discovery of Novel DNA Methylation Biomarker of Ovarian Cancer Using New Generation Sequencing Technology

  Lai, H.

  5/1/14 → 4/30/15

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Ovarian Neoplasms 100%
  • DNA Methylation 90%
  • Biomarkers 47%
  • Neoplasms 41%
  • Early Detection of Cancer 34%

• 103年度第二期癌症研究計畫

  Yen, Y.

  1/1/14 → 12/31/14

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Mouth Neoplasms 100%
  • Biomarkers 26%
  • Metagenomics 25%
  • Metabolomics 22%
  • Taiwan 20%

• 提升臨床試驗創新及競爭力計畫

  Yen, Y., Chen, T., Lee, F., Wu, C. & Whang-Peng, J.

  2/27/14 → 12/31/14

  Project: A - Government Institution › c - Ministry of Health and Welfare

• Promoting and Establishing Technology Exchange of Evidence-Based Medicine and Knowledge Sharing of Electronic Database in Taiwan

  Chen, C., Tam, K., Chen, K., Hou, W. & Bai, C.

  1/1/15 → 12/31/15

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Evidence-Based Practice 100%
  • Evidence-Based Medicine 46%
  • Health 31%
  • Education 20%
  • Systematic Reviews 18%

• Development and utilization of indigenous Taiwanese herbal medicine - Uncaria hirsuta Haviland

  Lee, M., Hou, W. & Lin, C.

  5/5/11 → 12/31/11

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Neuroprotective 100%
  • Heat 57%
  • Convulsion 57%
  • Blood Pressure 49%
  • Liquid 42%

• Syntheses of Selective Histone Deacetylase 6 inhibitors

  Liou, J.

  1/1/15 → 12/31/15

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Histone 100%
  • Tubastatin A 97%
  • Antiproliferative 46%
  • Enzyme Activity 38%
  • Bioactivity 33%

• Development of Novel Therapeutic Agents for Breast Cancer through Targeting Nicotinic Acetylcholine Receptors.

  Wu, C., Ho, Y. & Lee, C.

  5/1/14 → 7/30/15

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Resistance 100%
  • Nicotine 97%
  • Acute Toxicity 95%
  • Acetylcholine 85%
  • Drug 83%

• Evaluation on prevention for metabolic syndrome and diabetes mellitus through lifestyle modification intervention in pre-diabetic subjects (100-104)

  Chiou, H.

  12/31/15 → 12/30/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 大數據應用分析人才培訓計畫

  Chiou, H.

  12/1/17 → 11/30/18

  Project: A - Government Institution › c - Ministry of Health and Welfare