TMU Research Center of Cancer Translational Medicine

Projects

Projects per year 2010 2014 2015 2016 2017 2018 2022

• 5 Active
• 531 Finished

Projects per year

Search results

• Bone-Marrow-Derived Mesenchymal Stem Cells in Prostate Cancer-Induced Bone Remodeling

  Hsieh, C., Chen, K. & Sung, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Adipogenic 100%
  • Osteogenic 37%

• An Association Study of Early Arsenic Exposure and Genes Related to Arsenic Metabolic Capacity on the Risk of Cardiovascular Disease (II)

  Hsieh, F. & Chiou, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Novel Therapeutic Agents for Breast Cancer through Targeting Nicotinic Acetylcholine Receptors.

  Wu, C., Ho, Y. & Lee, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Resistance 100%
  • Nicotine 97%
  • Acute Toxicity 95%
  • Acetylcholine 85%
  • Drug 83%

• Dissected the Role of Glucose-Regulated Protein 94 (GRP94),The Clinically Therapeutic Implication and Drug Development in Colon Cancer

  Wei, P. & Chang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • glucose-regulated proteins 100%
  • Colonic Neoplasms 43%
  • Colorectal Neoplasms 38%
  • Neoplasms 23%
  • Neoplasm Metastasis 19%

• Dementia Care and Quality Improvement

  Chien, L., Chiou, H., Chi, N. & Hu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • dementia 100%
  • health insurance 28%
  • Medical records 19%
  • utilization 17%
  • resources 9%

• 幹細胞基礎研究與前臨床動物試驗

  Huang, Y.

  8/1/15 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• The Effectiveness of the Physician-Nurse-Pharmacist Collaboration Model in Medication Reconciliation Using National Health Insurance Pharmacloud in Ambulatory Care

  Hu, S. H., Li, Y., Sheu, S. & Lin, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • medication 100%
  • ambulatory care 45%
  • pharmacist 40%
  • reconciliation 39%
  • physician 33%

• To See Is to Believe- Visualization of the Spectrum on Chronic Kidney Disease (II)

  Jian, W., Li, Y. & Wu, M.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Health care 100%
  • Data visualization 75%
  • Patient treatment 50%
  • Disease control 49%
  • Health insurance 49%

• Role of HBX and IL-6 in Regulating SENP1/Stemness Properties of HBV-Related HCC under Hypoxia and Its Clinical Implication

  Huang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Interleukin-6 100%
  • Hepatocellular Carcinoma 94%
  • Hypoxia 55%
  • Drug Resistance 32%
  • Neoplasms 30%

• Effects of Uteroplacental Insufficiency and Hyperoxia on Lung Development and Epigenetic Alterations in the Rat Offspring

  Chen, C. & Lin, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Fetal Growth Retardation 100%
  • Hyperoxia 99%
  • Receptor for Advanced Glycation End Products 74%
  • Epigenomics 69%
  • Lung 48%

• HMGA2, a New Target of Thyroid Hormone-Induced Progression in Colorectal Cancers

  Lin, H., Chang, T. & Yen, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • AT-Hook Motifs 100%
  • Thyroid Hormones 75%
  • tetraiodothyroacetic acid 70%
  • Colorectal Neoplasms 43%
  • Integrins 28%

• Reflecting on Issues of End-Of-Life by Approaching Ventilator-Dependent Patients: an Interdisciplinary Educational Action Research

  Chen, C., Lin, W., Lin, S. & Tang, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • team teaching 100%
  • action research 70%
  • curriculum 64%
  • medicine 57%
  • dialogue 56%

• Activation Autophagy by the Combination of a Histone Deacetylase Inhibitor and Radiation Limits BNIP3 Regulation in Triple-Negative Breast Cancer Cells and Orthotopic Mouse Model

  Chiu, H. & Ho, Y.

  8/1/15 → 6/30/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Triple Negative Breast Neoplasms 100%
  • Histone Deacetylase Inhibitors 97%
  • Ionizing Radiation 42%
  • Autophagy 39%
  • human ERBB2 protein 25%

• Biomarkers for the Early Prediction and Prognosis for Colorectal Cancer---Construction of Kinetic

  Chang, W. & Wei, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Colorectal Neoplasms 100%
  • Calcium Channels 40%
  • Calcium 34%
  • Biomarkers 24%
  • Podosomes 18%

• Discovering Blood Circulating and Bone Micrornas as Biomarker Signatures for Diagnosis or Therapy of Osteoporosis in Men and Male Osteoporotic Fracture

  Chen, R.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • osteoporosis 100%
  • microRNA 57%
  • bones 36%
  • biomarkers 27%
  • bone fractures 19%

• Characterization of 5-Hydroxymethylcytosine and Ten-to-Eleven Translocation Gene (TET) in Cervical Cancer

  Lai, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • 5-hydroxymethylcytosine 100%
  • Uterine Cervical Neoplasms 38%
  • Epigenomics 20%
  • 5-Methylcytosine 17%
  • Carcinogenesis 9%

• Elucidation of the Molecular Mechnism of Aglaia Elliptifolia Extract Rocaglamide Induced Cell Death in Breast Cancer Cells---PHB as a Target

  Huang, T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Rocaglamide 100%
  • Oncogenic 11%
  • Cell Death 8%

• Cocaine Induces Sig-1R Nuclear Envelope Localization to Regulate MAOB Expression by Interacting with Emerin-HDACs Co-Repressor Complex

  Chuang, J.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • sigma-1 receptor 100%
  • Cocaine 63%
  • Monoamine Oxidase 42%
  • emerin 30%
  • Co-Repressor Proteins 29%

• Studies on the Role of ORMDL3 in Thrombin-Induced IL-8/CXCL8 Expression and Airway Inflammation

  Chen, B.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Orosomucoid 100%
  • Thrombin 74%
  • Interleukin-8 34%
  • Transcription Factor AP-1 26%
  • Asthma 23%

• Chemo-Sensitizer Conjugated Carbon Nanotubes as a Novel Cancer Therapeutical Delivery System

  Cho, E.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Carbon Nanotube 100%
  • Radiation Sensitizing Agent 38%
  • Ribonucleotide 28%
  • Water Soluble 17%
  • Drug 12%

• The Roles of Genetic Polymorphisms for Susceptibility and Clinical Outcomes of Colorectal Cancer in Taiwanese Lynch Syndrome Families

  Yeh, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hereditary Nonpolyposis Colorectal Neoplasms 100%
  • DNA Mismatch Repair 57%
  • Colorectal Neoplasms 54%
  • Genetic Polymorphisms 29%
  • Genes 19%

• Study the Anti-Tumor Activity of E1A Gene Therapy---Focus on the Function and Biogenesis of microRNA

  Chen, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • MicroRNAs 100%
  • Neoplasms 27%
  • Breast Neoplasms 26%
  • Formal Social Control 14%
  • Genetic Therapy 12%

• Identification of Rewired APC Mutation Signaling Network in Chemotherapy Resistant Response in Colorectal Cancer (II)

  Huang, T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Combination Treatment of Tetrac- and Cetuximab-Induced Anti-Proliferation in Colorectal Cancer with Different APC Status (II)

  Lin, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of ADAM 17 in Hypoxia-Induced CTGF Expression and Pulmonary Fibrosis (III)

  Chen, B.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • ADAM17 Protein 100%
  • Connective Tissue Growth Factor 83%
  • Hypoxia 49%
  • Small Interfering RNA 38%
  • Fibrosis 21%

• 顱內靜脈血管系統異常與缺血性中風及皮質下血管性失智症的相關性研究

  Chiou, H.

  8/1/15 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Neuroprotective Effects of Sig-1R-Znf179-Sp1 Pathway on Brain Injury

  Chang, W. & Chuang, J.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • sigma-1 receptor 100%
  • Traumatic Brain Injury 50%
  • Hydrogen Peroxide 31%
  • Neuroprotective Agents 19%
  • Wounds and Injuries 12%

• Design and Preclinical Translation Study of Mixed-Bispecific/Trispecific Antibody for Enhancing Therapeutic Effectiveness of Anticancer Drug-Loaded Pegylated Nanocarriers by Simultaneously Targeting to Tumor Cells and Cancer/Tumor Associated Fibrobla (I)

  Sheu, M., Chuang, K. & Ho, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Nanocarrier 100%
  • Antigen 77%
  • Tumor Marker 61%
  • Modification 51%
  • Liposome 42%

• Gene Knock out Mice Model for Studying the Molecular Mechanisms of Early Onset Breast Tumor Microenvironment Regulation.

  Wu, C., Ho, Y. & Tu, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • breast 100%
  • cancer 97%
  • tumors 59%
  • fibroblasts 33%
  • genes 31%

• The Role of Inflammatory Gene Polymorphisms on Risk of Post-Stroke Vascular Dementia (I)

  Chiou, H., Chi, N., Lin, H., Wu, C., Hsieh, F., Hu, C. & Hsieh, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Stroke 93%
  • Cognitive Dysfunction 89%
  • Blood Vessels 52%
  • Inflammation 36%
  • Whole Exome Sequencing 16%

• Analyses of ADAM9 on Integrin B4 Turnover to Facilitate Prostate Cancer Migration and Invasion

  Sung, S. & Hsieh, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • metastasis 100%
  • integrins 89%
  • neoplasm progression 42%
  • prostatic neoplasms 38%
  • neoplasms 38%

• Study of Expression and Functional Mechanisms of Histamine N-Methyltransferase (HNMT) in Tumorigenesis and Correlation with Progression in Lung Cancer

  Wang, L., Lee, W., Ho, Y. & Wu, A. T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histamine N-Methyltransferase 100%
  • Lung Neoplasms 43%
  • Carcinogenesis 18%
  • Neoplasms 10%
  • Genes 9%

• Smart Mouth Guard 3D Drug Delivery and Wound Dressing Device Development (Project 1)

  Deng, W. & Ou, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mouth Protectors 100%
  • Bandages 50%
  • Equipment and Supplies 38%
  • Pharmaceutical Preparations 26%
  • Periodontitis 26%

• The Effect and Mechanisms of Chemotherapy in Recruit Inflammatory Cells into Tumor Microenvironment of Lung Cancer Patients

  Feng, P. & Lee, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Myeloid-Derived Suppressor Cells 100%
  • Neoplasms 26%
  • Tumor Microenvironment 25%
  • Lung Neoplasms 19%
  • Drug Therapy 19%

• TMU103-AE1-B31

  Feng, P.

  8/1/15 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Study of Novel Genes Regulated by Aberrant DNA Methylation and Application in Colon Cancer Treatment

  Lin, R. & Ho, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neoplasm Genes 100%
  • Methylation 83%
  • Taiwan 82%
  • DNA Methylation 81%
  • Colonic Neoplasms 66%

• Development of Novel Therapeutic Agents for Herceptin Resistance Breast Cancer Cells through Targeting Nicotinic Acetylcholine Receptors

  Lee, C. & Ho, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Trastuzumab 88%
  • Neoplastic Stem Cells 39%
  • Drug Resistance 27%
  • Luciferases 20%

• A Toxicological Assessment of Air Pollution in the Vicinity of a Petrochemical Complex

  Chuang, H. & Lee, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Particulate Matter 100%
  • Taiwan 54%
  • Toxicology 44%
  • Risk Assessment 38%
  • Methionine 19%

• Pre-Clinical Evaluation of the Tumor Suppression Effectiveness and Mechanism of Small Molecule Drugs in Oral Cancer

  Chen, Y. & Wu, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Pharmaceutical Preparations 100%
  • Mouth Neoplasms 70%
  • Pharmaceutical Databases 22%
  • Neoplasm Genes 17%
  • Biological Products 15%

• 建立多構面癌症防治預測模式:以大腸癌為例－建立多構面癌症防治預測模式:以大腸癌為例

  Shao, Y.

  9/1/15 → 8/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the Carcinogenic Mechanisms of Glucose Transporters in Gastrointestinal Cancer Cells and Its Clinical Therapeutic Applications

  Chen, L. & Wu, C.

  9/1/15 → 8/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glucose 100%
  • Antitumor 19%
  • Occurrence in Nature 17%
  • Pharmacological Metabolism 11%
  • Biological Role 8%

• A Phase I, First-In-Human, Dose-Seeking Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of Orally Administered MPT0E028 in Subjects with Advanced Solid Malignancies without Standard Treatment (II)

  Liou, J.

  9/1/15 → 8/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Differential Machinery of Pluripotency Regulation in Stem Cells in Embryonic Stage and Somatic Cancers and Its Clinical Implications in Human Diseases --Crosstalk among Niche Growth Factor/Cytokine Signaling, Extracellular Matrix, and Epigenetic Netw (II)

  Huang, Y.

  10/1/15 → 9/30/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 新北市醫療照護資源垂直整合模式成效評估計畫

  Chiou, H.

  10/22/15 → 7/11/16

  Project: A - Government Institution › f - Other (Funded by Government)

• Service for Sharing Precious Instruments of Taipei Medical University

  Chen, Y., Liou, J. & Chien, L.

  12/1/15 → 12/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Reservation systems 100%
  • Mass spectrometers 91%
  • Nuclear magnetic resonance 77%
  • Magnetic resonance spectrometers 60%
  • Online systems 38%

• 104年度科學及技術類委託研究計畫「健保已給付新藥副作用之風險評估_以口服抗凝血劑為例」計畫案

  Chien, L., Ko, Y., Chien, S. & Chi, N.

  12/23/15 → 12/22/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

• Evaluation on prevention for metabolic syndrome and diabetes mellitus through lifestyle modification intervention in pre-diabetic subjects (100-104)

  Chiou, H.

  12/31/15 → 12/30/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

• Development of DNA methylation biomarker for endometrial cancer detection

  Lai, H.

  1/1/16 → 12/31/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Endometrial Neoplasms 100%
  • Methylation 31%
  • Myoma 17%
  • Genes 14%
  • Taiwan 13%

• Epigenetic Characterization of Ovarian Cancer Initiating Cells

  Lai, H.

  1/1/16 → 12/31/16

  Project: A - Government Institution › a - National Health Research Institutes

  • Ovarian Neoplasms 100%
  • Neoplastic Stem Cells 64%
  • Epigenomics 43%
  • 5-hydroxymethylcytosine 16%
  • Stem Cell Research 14%

• 高功率奈米製程之摻鉺光纖雷射在皮膚分段光熱分解療法之應用

  HuangFu, W.

  1/1/16 → 12/31/16

  Project: C - Project of Alliance › j - National Taipei University of Technology