TMU Research Center of Cancer Translational Medicine

Projects

Projects per year 2010 2014 2015 2016 2017 2018 2022

• 5 Active
• 531 Finished

Projects per year

Search results

• The Role of SUV39H1 in Control of Inflammatory Genes and in Chronic Inflammation of Copd

  Lee, K., Feng, P. & Chuang, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chronic Obstructive Pulmonary Disease 100%
  • Inflammation 60%
  • Blood Cells 33%
  • Histone Deacetylase 2 32%
  • Glucocorticoids 27%

• Drug Discovery and Pharmacological Study of Novel pan-HDAC Inhibitors as Anti-Angiogenic Drugs

  Pan, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone Deacetylase Inhibitors 100%
  • Histone Deacetylases 36%
  • Drug Discovery 23%
  • 3-(1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)-N-hydroxyacrylamide 18%
  • Animal Models 16%

• Disease Trajectories and Its Association with Metabolic Dysfunction of Prostate Cancer Men Following Androgen Deprivation Therapy and the Potential of Pharmacological Medication in Preventing Metastatic Diseases.

  Shao, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Ultrafine Particles on Cardiopulmonary System: a Population-Based Approach

  Chuang, K. & Feng, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Particulate Matter 100%
  • Air Pollution 68%
  • Taiwan 34%
  • United States Environmental Protection Agency 33%
  • Organized Financing 13%

• 幹細胞基礎研究與前臨床動物試驗

  Huang, Y.

  8/1/15 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Development of Novel Therapeutic Agents for Herceptin Resistance Breast Cancer Cells through Targeting Nicotinic Acetylcholine Receptors

  Lee, C. & Ho, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Trastuzumab 88%
  • Neoplastic Stem Cells 39%
  • Drug Resistance 27%
  • Luciferases 20%

• Bone-Marrow-Derived Mesenchymal Stem Cells in Prostate Cancer-Induced Bone Remodeling

  Hsieh, C., Chen, K. & Sung, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Adipogenic 100%
  • Osteogenic 37%

• Development of Novel Therapeutic Agents for Breast Cancer through Targeting Nicotinic Acetylcholine Receptors.

  Wu, C., Ho, Y. & Lee, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Resistance 100%
  • Nicotine 97%
  • Acute Toxicity 95%
  • Acetylcholine 85%
  • Drug 83%

• HMGA2, a New Target of Thyroid Hormone-Induced Progression in Colorectal Cancers

  Lin, H., Chang, T. & Yen, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • AT-Hook Motifs 100%
  • Thyroid Hormones 75%
  • tetraiodothyroacetic acid 70%
  • Colorectal Neoplasms 43%
  • Integrins 28%

• Study the Anti-Tumor Activity of E1A Gene Therapy---Focus on the Function and Biogenesis of microRNA

  Chen, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • MicroRNAs 100%
  • Neoplasms 27%
  • Breast Neoplasms 26%
  • Formal Social Control 14%
  • Genetic Therapy 12%

• A Toxicological Assessment of Air Pollution in the Vicinity of a Petrochemical Complex

  Chuang, H. & Lee, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Particulate Matter 100%
  • Taiwan 54%
  • Toxicology 44%
  • Risk Assessment 38%
  • Methionine 19%

• Effect of HMGA2 in Chemotherapy Response of Colorectal Cancer Patients with Different APC Status (II)

  Yen, Y., Cheng, Y. & Wei, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Wnt5a and Hsp90 in the Wnt/Beta-Catenin Signaling Pathway of Colorectal Cancer (II)

  Lee, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dissected the Role of Glucose-Regulated Protein 94 (GRP94),The Clinically Therapeutic Implication and Drug Development in Colon Cancer

  Wei, P. & Chang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • glucose-regulated proteins 100%
  • Colonic Neoplasms 43%
  • Colorectal Neoplasms 38%
  • Neoplasms 23%
  • Neoplasm Metastasis 19%

• Characterization of 5-Hydroxymethylcytosine and Ten-to-Eleven Translocation Gene (TET) in Cervical Cancer

  Lai, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • 5-hydroxymethylcytosine 100%
  • Uterine Cervical Neoplasms 38%
  • Epigenomics 20%
  • 5-Methylcytosine 17%
  • Carcinogenesis 9%

• Smart Mouth Guard 3D Drug Delivery and Wound Dressing Device Development (Project 1)

  Deng, W. & Ou, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mouth Protectors 100%
  • Bandages 50%
  • Equipment and Supplies 38%
  • Pharmaceutical Preparations 26%
  • Periodontitis 26%

• The Development and Preclinical Evaluation of a Theronostic Nanovehicle Drug for Treating Acute Myeloid Leukemia and Leukemia Stem Cells (I)

  Yen, Y., Cheng, T. & Wu, A. T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Leukemia 100%
  • haptoglobin-hemoglobin complex 54%
  • Calicheamicins 53%
  • Neoplasms 49%
  • Multifunctional Nanoparticles 49%

• Effects of Uteroplacental Insufficiency and Hyperoxia on Lung Development and Epigenetic Alterations in the Rat Offspring

  Chen, C. & Lin, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Fetal Growth Retardation 100%
  • Hyperoxia 99%
  • Receptor for Advanced Glycation End Products 74%
  • Epigenomics 69%
  • Lung 48%

• The Association of Nonage Chronic Arsenic Exposure, Methylation Levels of Arsenic Metabolism Genes, and the Risk of Cancer Development

  Chiou, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • arsenic 100%
  • adulthood 37%
  • neoplasms 27%
  • methylation 24%
  • metabolism 15%

• Biomarkers for the Early Prediction and Prognosis for Colorectal Cancer---Construction of Kinetic

  Chang, W. & Wei, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Colorectal Neoplasms 100%
  • Calcium Channels 40%
  • Calcium 34%
  • Biomarkers 24%
  • Podosomes 18%

• Construction of gene profiles and connectivity map for ER in a Taiwanese population(先期補助)

  Chang, W.

  8/1/15 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• An Association Study of Early Arsenic Exposure and Genes Related to Arsenic Metabolic Capacity on the Risk of Cardiovascular Disease (II)

  Hsieh, F. & Chiou, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effectiveness of the Physician-Nurse-Pharmacist Collaboration Model in Medication Reconciliation Using National Health Insurance Pharmacloud in Ambulatory Care

  Hu, S. H., Li, Y., Sheu, S. & Lin, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • medication 100%
  • ambulatory care 45%
  • pharmacist 40%
  • reconciliation 39%
  • physician 33%

• 顱內靜脈血管系統異常與缺血性中風及皮質下血管性失智症的相關性研究

  Chiou, H.

  8/1/15 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Study of Novel Genes Regulated by Aberrant DNA Methylation and Application in Colon Cancer Treatment

  Lin, R. & Ho, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neoplasm Genes 100%
  • Methylation 83%
  • Taiwan 82%
  • DNA Methylation 81%
  • Colonic Neoplasms 66%

• Establish the Research Platform for Studying Triple-Negative Breast Tumor Microenvironment Regulation---The Hyaluronan Synthase-3 Mediated Antitumor Effects as an Example

  Ho, Y. & Wu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Gene Expression 46%
  • Tumor Microenvironment 40%
  • Hyaluronan Synthases 30%
  • Fibroblasts 29%

• Application of Regioselective Substitution on 1,4-Benzoquinone Derivatives to Provide Potent Anticancer Agents

  Liou, J.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • 1,4-benzoquinone 100%
  • Wittig Olefination 54%
  • Intramolecular Cyclization 40%
  • Nucleophilic Substitution 38%
  • Regioselectivity 35%

• Analyses of ADAM9 on Integrin B4 Turnover to Facilitate Prostate Cancer Migration and Invasion

  Sung, S. & Hsieh, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • metastasis 100%
  • integrins 89%
  • neoplasm progression 42%
  • prostatic neoplasms 38%
  • neoplasms 38%

• Identification of Rewired APC Mutation Signaling Network in Chemotherapy Resistant Response in Colorectal Cancer (II)

  Huang, T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Wearable Device Evaluation for Medication Management in Patients Taking Sleep Medicine via Cloud Platform Development( I )

  Li, Y., Jian, W. & Lee, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Sleep 100%
  • Wearable technology 35%
  • Health 28%
  • Education 19%
  • Oximeters 11%

• Cocaine Induces Sig-1R Nuclear Envelope Localization to Regulate MAOB Expression by Interacting with Emerin-HDACs Co-Repressor Complex

  Chuang, J.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • sigma-1 receptor 100%
  • Cocaine 63%
  • Monoamine Oxidase 42%
  • emerin 30%
  • Co-Repressor Proteins 29%

• Neuroprotective Effects of Sig-1R-Znf179-Sp1 Pathway on Brain Injury

  Chang, W. & Chuang, J.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • sigma-1 receptor 100%
  • Traumatic Brain Injury 50%
  • Hydrogen Peroxide 31%
  • Neuroprotective Agents 19%
  • Wounds and Injuries 12%

• Age-Related Hearing Loss (Presbycusis)---Cisd2 Deficiency Accelerate the Hearing Defect during Aging Process-Renew

  Chen, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Presbycusis 100%
  • Hearing 57%
  • Longevity 37%
  • Inner Ear 22%
  • Cochlea 22%

• Reflecting on Issues of End-Of-Life by Approaching Ventilator-Dependent Patients: an Interdisciplinary Educational Action Research

  Chen, C., Lin, W., Lin, S. & Tang, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • team teaching 100%
  • action research 70%
  • curriculum 64%
  • medicine 57%
  • dialogue 56%

• The Effect and Mechanisms of Chemotherapy in Recruit Inflammatory Cells into Tumor Microenvironment of Lung Cancer Patients

  Feng, P. & Lee, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Myeloid-Derived Suppressor Cells 100%
  • Neoplasms 26%
  • Tumor Microenvironment 25%
  • Lung Neoplasms 19%
  • Drug Therapy 19%

• TMU103-AE1-B31

  Feng, P.

  8/1/15 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• The Role of ADAM 17 in Hypoxia-Induced CTGF Expression and Pulmonary Fibrosis (III)

  Chen, B.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • ADAM17 Protein 100%
  • Connective Tissue Growth Factor 83%
  • Hypoxia 49%
  • Small Interfering RNA 38%
  • Fibrosis 21%

• To See Is to Believe- Visualization of the Spectrum on Chronic Kidney Disease (II)

  Jian, W., Li, Y. & Wu, M.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Health care 100%
  • Data visualization 75%
  • Patient treatment 50%
  • Disease control 49%
  • Health insurance 49%

• The Pre-clinical Investigation of the Anticancer Effects of Polysaccharides Extracted from Ulva Prolifera on Colon Cancer

  Deng, W.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Polysaccharide 100%
  • Anticoagulant 14%
  • Nutrient 12%
  • Antineoplastic Agent 10%
  • Antioxidant Agent 8%

• Studies on the Role of ORMDL3 in Thrombin-Induced IL-8/CXCL8 Expression and Airway Inflammation

  Chen, B.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Orosomucoid 100%
  • Thrombin 74%
  • Interleukin-8 34%
  • Transcription Factor AP-1 26%
  • Asthma 23%

• Study the Therapeutic Effects and Novel Molecular Mechanisms of Resveratrol in Human Osteosarcoma---The Treatment of Metastatic Cancer

  Chien, M.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Resveratrol 100%
  • MicroRNA 72%
  • Microarrays 10%
  • Non Toxic 10%
  • Dose 7%

• Chemo-Sensitizer Conjugated Carbon Nanotubes as a Novel Cancer Therapeutical Delivery System

  Cho, E.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Carbon Nanotube 100%
  • Radiation Sensitizing Agent 38%
  • Ribonucleotide 28%
  • Water Soluble 17%
  • Drug 12%

• Pre-Clinical Evaluation of the Tumor Suppression Effectiveness and Mechanism of Small Molecule Drugs in Oral Cancer

  Chen, Y. & Wu, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Pharmaceutical Preparations 100%
  • Mouth Neoplasms 70%
  • Pharmaceutical Databases 22%
  • Neoplasm Genes 17%
  • Biological Products 15%

• The Measure of Palliative Care Spiritual Care Competency and the Effectiveness of an Educational Program for Palliative Spiritual Care Providers

  Chiou, J.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Palliative Care 100%
  • Program Evaluation 46%
  • Education 32%
  • Research Design 24%
  • Learning 15%

• Study the Function and Regulation of miRNAs in Pancreatic Cancer Progression (II)

  Huang, M.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) for Patients with Depressive Disorders

  Chang, H. & Chiou, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Cognitive Behavioral Therapy 100%
  • Mindfulness 72%
  • Depressive Disorder 37%
  • Depression 23%
  • Diagnostic and Statistical Manual of Mental Disorders 22%

• Dementia Care and Quality Improvement

  Chien, L., Chiou, H., Chi, N. & Hu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • dementia 100%
  • health insurance 28%
  • Medical records 19%
  • utilization 17%
  • resources 9%

• Genetic Polymorphisms in Hypoxia Inducible Factor-1 and Inflammation Pathway Related microRNA and Its Target Genes and Risk of Hyperglycemia in Acute Ischemic Stroke and Its Prognosis Study

  Hsieh, Y., Cho, E., Chi, N. & Chiou, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • MicroRNAs 100%
  • Hyperglycemia 79%
  • Stroke 64%
  • Inflammation 37%
  • Biomarkers 10%

• The Role of Amyloid-Beta in the Late-Onset Post-Stroke Vascular Cognitive Impairment (I)

  Hu, C., Wu, C., Chiou, H. & Chi, N.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Cognitive Dysfunction 100%
  • Blood Vessels 79%
  • Amyloid 57%
  • Stroke 46%
  • Dementia 45%

• The Role of Inflammatory Gene Polymorphisms on Risk of Post-Stroke Vascular Dementia (I)

  Chiou, H., Chi, N., Lin, H., Wu, C., Hsieh, F., Hu, C. & Hsieh, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Stroke 93%
  • Cognitive Dysfunction 89%
  • Blood Vessels 52%
  • Inflammation 36%
  • Whole Exome Sequencing 16%