TMU Research Center of Cancer Translational Medicine

Projects

Projects per year 2010 2014 2015 2016 2017 2018 2022

• 5 Active
• 531 Finished

Projects per year

Search results

• 藉由活化JNK路徑以治療Osimertinib抗藥性肺腺癌的策略研究

  Yao, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以IgA1 O-聯結醣基為標靶開發IgA腎病變之診斷試劑重塑臨床評估之準則(2/3)

  Lee, Y.

  8/1/20 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以深度學習來預測細胞表面蛋白並應用單細胞轉錄體之功能分類鑑別

  Chen, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 絲氨酸/蘇氨酸蛋白激?(SIK3)參與乳癌致癌過程的分子機制探討

  Chen, L.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以IgA1 O-聯結醣基為標靶開發IgA腎病變之診斷試劑重塑臨床評估之準則(3/3)

  Lee, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 奈米HEVnp於晚期大腸直腸癌患者的治療策略(2/3)

  Whang-Peng, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role and Mechanism of Dendritic Cell Pd-L1/Pd-L2 Dysregulation in Aberrant Inflammation of Copd

  Lee, K.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Roles of the Hdacs/Sp1-Mediated Microrna-106b~25 Axis in Drug Resistance of Glioblastomas(1/3)

  Chen, R.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role and Mechanism of Cd155/Tigit in Mdsc/Tam Induced Nk Cell Dysfunction -A Link to Lung Cancer Resistance to Immune Checkpoint Blockade

  Feng, P.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the Mechanisms of Histamine N-Methyl-Transferase (Hnmt) as a Novel Molecular Marker to Help Clinician for Identifying of Herceptin Responder in Breast Cancer Patients(1/3)

  Ho, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Translational Study to Verify Roles of Circulating Mir-19b and Mir-93 as Biomarker Signatures for Early Diagnosis of Osteoporosis in Men(2/3)

  Chen, R.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating the Oncogenic Roles of A9-Nicotinic Acetylcholine Receptor Variants on Breast Cancer( III )

  Ho, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Synthetic and Medicinal Utility of Organometallics in the Development of Anticancer Epigenetic Inhibitors: Applications and Explorations( I )( I )(1/2)

  Liou, J.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of the Role of Gut Microbiota in Antipsychoticinduced Metabolic Dysfunction in Patient with Schizophrenia

  Liu, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 新聘教師研究補助

  Shih, J.

  8/1/18 → 7/31/20

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• Development of Leukemia Based Precision Medicine Research Model on Non-Invasive Apoptosis Detection Platform – Application of Crispr/Cas9 Gene and Target Therapy on Philadelphia Chromosome of Chronic Myelogenous Leukemia as an Example

  Chen, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Precision Medicine 100%
  • Leukemia 88%
  • Heterografts 41%
  • Philadelphia Chromosome 39%
  • Myeloid Leukemia 37%

• Nano-Hevnp Theranostic Strategy for Late-Stage Colorectal Cancer Patients(1/3)

  Whang-Peng, J.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Develop Novel Treatment Options for Hepatocellular Carcinoma via Drug Repurposing(2/2)

  Whang-Peng, J.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Repurposing of a Positive Allosteric Modulator of M5 Muscarinic Acetylcholine Receptor as a Microtubule-Targeting Agent and Its Application for Treating Pancreatic Ductal Adenocarcinoma

  Hsieh, Y.

  1/1/19 → 6/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 激肽釋放酶-激肽系統調控惡性神經膠質瘤細胞基質金屬蛋白酶表現之機轉

  Chen, R.

  3/1/19 → 2/1/20

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• 調節第一型神經衍生孤兒核受體 (Neuron-derived orphan receptor 1, NOR-1)之蛋白質表現可能是 Pomalidomide對創傷性腦損傷之神經保護作用之一

  Chen, R.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 21121 發展特色研究，推動轉譯醫學（CRISPR基因編輯核心實驗室）

  Chu, C.

  1/1/19 → 12/31/19

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 發展抗肺纖維化劑-合成抗肺纖維化合物

  Liou, J.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 具抗藥性多形性膠質母細胞瘤的新穎治療策略研究-Bradykinin-TIMP-MMP 軸在抗藥性神經膠質瘤細胞調控血瘤障壁通透性過程中扮演的角色

  Chen, R.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 神經內分泌型前列腺癌的轉譯研究-ADAM9在神經內分泌型前列腺癌的轉譯研究

  Sung, S.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 雙打擊在瀰漫大B細胞淋巴瘤所扮演的角色-致病機轉與臨床特色之探討-JARID1B蛋白在雙打擊瀰漫大B細胞淋巴瘤的角色及其臨床定義

  Liu, Y.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 探討CD155/TIGIT 在類骨髓衍生抑制細胞/腫瘤衍生巨噬細胞誘導自然殺手細胞失調的機轉- 研究肺癌病人免疫檢查點阻斷藥物抗藥性機轉

  Feng, P.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 亞太生醫矽谷精準醫療旗艦計畫-臺北醫學大學合作案

  Liou, J.

  1/1/19 → 12/1/19

  Project: A - Government Institution › a - National Health Research Institutes

• PM2.5對慢性阻塞性肺病在肺修復和再生受損的影響-IL-17和新穎生物標記在環境PM2.5誘導COPD肺損傷的影響

  Lee, K.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• A Novel Lifr Axis in Metabolism Unhinged and Neuroendocrine Differentiation of Prostate Cancer(I)

  Liu, Y.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Genetic Polymorphisms on Efficacy and Safety of Opioid Analgesics in Patients with Postoperative Pain in a Taiwanese Population

  Tai, Y.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Opioid Analgesics 100%
  • Genetic Polymorphisms 59%
  • Analgesics 38%
  • Pain Management 34%
  • Postoperative Pain 22%

• 探討腸道菌相在抗精神病藥物誘發思覺失調症患者代謝症候群之作用

  Liu, Y.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Gastrointestinal Microbiome 100%
  • Antipsychotic Agents 61%
  • Schizophrenia 41%
  • Treatment Adherence and Compliance 38%
  • Metabolic Diseases 35%

• Role of Niche Inflammatory Cytokine and Epigenetic Regulation in Expressions of Pluripotent Transcription Factor Oct4 and Sorafenib Refractoriness in Hbv-Related Hepatocellular Carcinoma and Its Clinical Implication.(I)(1/3)

  Huang, Y.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Generate Anti-Fibroblast Growth Factor Receptor 2 (Fgfr2) Antibody Drugs and Study on Their Potential Application against Gastric Cancer

  Lee, Y.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Study the Role of Sp1 in Cancer Drug Resistance(3/3)

  Chuang, J.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of the Role of L1cam on Neuroendocrine Prostate Cancer Progression

  Hsieh, C.

  8/1/18 → 9/30/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Prostatic Neoplasms 100%
  • Neural Cell Adhesion Molecule L1 91%
  • Castration 16%
  • Phenotype 9%
  • RNA-Binding Proteins 5%

• Investigation of Long Noncoding Rna in Dicer-Mediated Micro-Rna Reprogramming and Sorafenib Resistance in Hepatocellular Carcinoma

  Chen, H.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Sorafenib 100%
  • Liver Neoplasms 80%
  • Long Noncoding RNA 75%
  • MicroRNAs 63%
  • Hepatocellular Carcinoma 23%

• To Study the Role of Pctk1 in the Progression of Colorectal Cancer and Molecular Mechanism (Continuation Project)(1/3)

  Wei, P.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Aspm-Wnt Signaling in Hepatoma Cancer Stemness and Progression and the Development of the Related Nano- and Gene-Therapy(2/3)

  Tsai, K. K.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of Hmga2-Microrna Regulatory Network to Tune Oncogenesis

  Huang, T.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • AT-Hook Motifs 100%
  • MicroRNAs 16%
  • Colorectal Neoplasms 12%
  • Carcinogenesis 9%
  • Neoplasms 7%

• Study of the Angiogenesis Promoting Effect of Irradiation Induced Mir-17-5p in Oral Cancer Cells

  Wu, S.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mouth Neoplasms 100%
  • Neoplasms 51%
  • Angiogenesis Inducing Agents 51%
  • Angiogenesis Inhibitors 27%
  • Cell Culture Techniques 26%

• 新聘教師研究補助

  Huang, Y.

  8/1/18 → 7/31/19

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• Identifying Cancer-Stem-Cell-Invadopodia-Related Prognostic Biomarkers in Gastric Cancer

  Chan, T.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Podosomes 100%
  • Neoplastic Stem Cells 71%
  • Stomach Neoplasms 27%
  • Neoplasms 18%
  • Neoplasm Metastasis 11%

• Drug Discovery and Pharmacological Investigation of Novel Selective Hdac Inhibitors as Anticancer Drugs(1/3)

  Pan, S.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Functional Study of a Novel Long Non-Coding Rna Linat in Colorectal Cancer Progression(2/3)

  Chen, H.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development a Risk Scoring System for Predicting the Risk of Poststroke Epilepsy to Improve the Quality of Care among Patients with Stroke

  Chien, L.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Epilepsy 100%
  • Stroke 45%
  • Anticonvulsants 24%
  • National Health Programs 20%
  • University Hospitals 15%

• Using Genome-Wide Linkage Analysis and Next Generation Sequencing Approaches to Identify the Genes Responsible for the Familial Colorectal Cancer Type X(2/3)

  Wang, W.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Develop Novel Treatment Options for Hepatocellular Carcinoma via Drug Repurposing(1/2)

  Whang-Peng, J.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Mass Spectrometry-Based Quantification Strategies for Onco-Proteogenomics Investigation of Cancer-Specific Mutated Proteins (2nd~3rd Year)

  Han, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mutation 100%
  • Proteogenomics 74%
  • Mass Spectrometry 70%
  • Proteins 49%
  • Peptides 35%

• Anti-Egfr×Anti-Fap Bi-Specific Targeting Antibody Combined with Irinotecan Encapsulated Liposomes for Pancreatic Cancer Therapy

  Lin, S.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology