TMU Research Center of Cancer Translational Medicine

Projects

Projects per year 2010 2014 2015 2016 2017 2018 2022

• 5 Active
• 531 Finished

Projects per year

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• 幹細胞基礎研究與前臨床動物試驗

  Huang, Y.

  8/1/15 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• The Role of Amyloid-Beta in the Late-Onset Post-Stroke Vascular Cognitive Impairment (I)

  Hu, C., Wu, C., Chiou, H. & Chi, N.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Cognitive Dysfunction 100%
  • Blood Vessels 79%
  • Amyloid 57%
  • Stroke 46%
  • Dementia 45%

• The Development and Preclinical Evaluation of a Theronostic Nanovehicle Drug for Treating Acute Myeloid Leukemia and Leukemia Stem Cells (I)

  Yen, Y., Cheng, T. & Wu, A. T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Leukemia 100%
  • haptoglobin-hemoglobin complex 54%
  • Calicheamicins 53%
  • Neoplasms 49%
  • Multifunctional Nanoparticles 49%

• The Role of EGFR in Prostate Cancer Progression and Combination Therapy

  Liu, Y. & Chen, W.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Prostatic Neoplasms 100%
  • ErbB Receptors 82%
  • Berberis 26%
  • Neoplastic Stem Cells 16%
  • Neoplasms 15%

• The Role of ADAM 17 in Hypoxia-Induced CTGF Expression and Pulmonary Fibrosis (III)

  Chen, B.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • ADAM17 Protein 100%
  • Connective Tissue Growth Factor 83%
  • Hypoxia 49%
  • Small Interfering RNA 38%
  • Fibrosis 21%

• Cocaine Induces Sig-1R Nuclear Envelope Localization to Regulate MAOB Expression by Interacting with Emerin-HDACs Co-Repressor Complex

  Chuang, J.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • sigma-1 receptor 100%
  • Cocaine 63%
  • Monoamine Oxidase 42%
  • emerin 30%
  • Co-Repressor Proteins 29%

• Construction of gene profiles and connectivity map for ER in a Taiwanese population(先期補助)

  Chang, W.

  8/1/15 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Biomarkers for the Early Prediction and Prognosis for Colorectal Cancer---Construction of Kinetic

  Chang, W. & Wei, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Colorectal Neoplasms 100%
  • Calcium Channels 40%
  • Calcium 34%
  • Biomarkers 24%
  • Podosomes 18%

• Reflecting on Issues of End-Of-Life by Approaching Ventilator-Dependent Patients: an Interdisciplinary Educational Action Research

  Chen, C., Lin, W., Lin, S. & Tang, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • team teaching 100%
  • action research 70%
  • curriculum 64%
  • medicine 57%
  • dialogue 56%

• Dementia Care and Quality Improvement

  Chien, L., Chiou, H., Chi, N. & Hu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • dementia 100%
  • health insurance 28%
  • Medical records 19%
  • utilization 17%
  • resources 9%

• A Toxicological Assessment of Air Pollution in the Vicinity of a Petrochemical Complex

  Chuang, H. & Lee, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Particulate Matter 100%
  • Taiwan 54%
  • Toxicology 44%
  • Risk Assessment 38%
  • Methionine 19%

• The Role of Wnt5a and Hsp90 in the Wnt/Beta-Catenin Signaling Pathway of Colorectal Cancer (II)

  Lee, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Disease Trajectories and Its Association with Metabolic Dysfunction of Prostate Cancer Men Following Androgen Deprivation Therapy and the Potential of Pharmacological Medication in Preventing Metastatic Diseases.

  Shao, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of HMGA2 in Chemotherapy Response of Colorectal Cancer Patients with Different APC Status (II)

  Yen, Y., Cheng, Y. & Wei, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Elucidation of the Molecular Mechnism of Aglaia Elliptifolia Extract Rocaglamide Induced Cell Death in Breast Cancer Cells---PHB as a Target

  Huang, T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Rocaglamide 100%
  • Oncogenic 11%
  • Cell Death 8%

• An Association Study of Early Arsenic Exposure and Genes Related to Arsenic Metabolic Capacity on the Risk of Cardiovascular Disease (II)

  Hsieh, F. & Chiou, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Roles of Genetic Polymorphisms for Susceptibility and Clinical Outcomes of Colorectal Cancer in Taiwanese Lynch Syndrome Families

  Yeh, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hereditary Nonpolyposis Colorectal Neoplasms 100%
  • DNA Mismatch Repair 57%
  • Colorectal Neoplasms 54%
  • Genetic Polymorphisms 29%
  • Genes 19%

• Role of miR-21 in Regulating TET I-Hydroxymethylcytosine and Chemotherapeutic Response in Colorectal Cancer (II)

  Yang, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Genetic Polymorphisms in Hypoxia Inducible Factor-1 and Inflammation Pathway Related microRNA and Its Target Genes and Risk of Hyperglycemia in Acute Ischemic Stroke and Its Prognosis Study

  Hsieh, Y., Cho, E., Chi, N. & Chiou, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • MicroRNAs 100%
  • Hyperglycemia 79%
  • Stroke 64%
  • Inflammation 37%
  • Biomarkers 10%

• Age-Related Hearing Loss (Presbycusis)---Cisd2 Deficiency Accelerate the Hearing Defect during Aging Process-Renew

  Chen, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Presbycusis 100%
  • Hearing 57%
  • Longevity 37%
  • Inner Ear 22%
  • Cochlea 22%

• Role of HBX and IL-6 in Regulating SENP1/Stemness Properties of HBV-Related HCC under Hypoxia and Its Clinical Implication

  Huang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Interleukin-6 100%
  • Hepatocellular Carcinoma 94%
  • Hypoxia 55%
  • Drug Resistance 32%
  • Neoplasms 30%

• The Role of Inflammatory Gene Polymorphisms on Risk of Post-Stroke Vascular Dementia (I)

  Chiou, H., Chi, N., Lin, H., Wu, C., Hsieh, F., Hu, C. & Hsieh, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Stroke 93%
  • Cognitive Dysfunction 89%
  • Blood Vessels 52%
  • Inflammation 36%
  • Whole Exome Sequencing 16%

• Drug Discovery and Pharmacological Study of Novel pan-HDAC Inhibitors as Anti-Angiogenic Drugs

  Pan, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone Deacetylase Inhibitors 100%
  • Histone Deacetylases 36%
  • Drug Discovery 23%
  • 3-(1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)-N-hydroxyacrylamide 18%
  • Animal Models 16%

• Pre-Clinical Evaluation of the Tumor Suppression Effectiveness and Mechanism of Small Molecule Drugs in Oral Cancer

  Chen, Y. & Wu, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Pharmaceutical Preparations 100%
  • Mouth Neoplasms 70%
  • Pharmaceutical Databases 22%
  • Neoplasm Genes 17%
  • Biological Products 15%

• Studies on the Role of ORMDL3 in Thrombin-Induced IL-8/CXCL8 Expression and Airway Inflammation

  Chen, B.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Orosomucoid 100%
  • Thrombin 74%
  • Interleukin-8 34%
  • Transcription Factor AP-1 26%
  • Asthma 23%

• Smart Mouth Guard 3D Drug Delivery and Wound Dressing Device Development (Project 1)

  Deng, W. & Ou, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mouth Protectors 100%
  • Bandages 50%
  • Equipment and Supplies 38%
  • Pharmaceutical Preparations 26%
  • Periodontitis 26%

• The Effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) for Patients with Depressive Disorders

  Chang, H. & Chiou, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Cognitive Behavioral Therapy 100%
  • Mindfulness 72%
  • Depressive Disorder 37%
  • Depression 23%
  • Diagnostic and Statistical Manual of Mental Disorders 22%

• The Role of SUV39H1 in Control of Inflammatory Genes and in Chronic Inflammation of Copd

  Lee, K., Feng, P. & Chuang, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chronic Obstructive Pulmonary Disease 100%
  • Inflammation 60%
  • Blood Cells 33%
  • Histone Deacetylase 2 32%
  • Glucocorticoids 27%

• To See Is to Believe- Visualization of the Spectrum on Chronic Kidney Disease (II)

  Jian, W., Li, Y. & Wu, M.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Health care 100%
  • Data visualization 75%
  • Patient treatment 50%
  • Disease control 49%
  • Health insurance 49%

• Application of Regioselective Substitution on 1,4-Benzoquinone Derivatives to Provide Potent Anticancer Agents

  Liou, J.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • 1,4-benzoquinone 100%
  • Wittig Olefination 54%
  • Intramolecular Cyclization 40%
  • Nucleophilic Substitution 38%
  • Regioselectivity 35%

• Discovering Blood Circulating and Bone Micrornas as Biomarker Signatures for Diagnosis or Therapy of Osteoporosis in Men and Male Osteoporotic Fracture

  Chen, R.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • osteoporosis 100%
  • microRNA 57%
  • bones 36%
  • biomarkers 27%
  • bone fractures 19%

• Study of Expression and Functional Mechanisms of Histamine N-Methyltransferase (HNMT) in Tumorigenesis and Correlation with Progression in Lung Cancer

  Wang, L., Lee, W., Ho, Y. & Wu, A. T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histamine N-Methyltransferase 100%
  • Lung Neoplasms 43%
  • Carcinogenesis 18%
  • Neoplasms 10%
  • Genes 9%

• Development of Novel Therapeutic Agents for Breast Cancer through Targeting Nicotinic Acetylcholine Receptors.

  Wu, C., Ho, Y. & Lee, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Resistance 100%
  • Nicotine 97%
  • Acute Toxicity 95%
  • Acetylcholine 85%
  • Drug 83%

• Development of Novel Therapeutic Agents for Herceptin Resistance Breast Cancer Cells through Targeting Nicotinic Acetylcholine Receptors

  Lee, C. & Ho, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Trastuzumab 88%
  • Neoplastic Stem Cells 39%
  • Drug Resistance 27%
  • Luciferases 20%

• Study of Novel Genes Regulated by Aberrant DNA Methylation and Application in Colon Cancer Treatment

  Lin, R. & Ho, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neoplasm Genes 100%
  • Methylation 83%
  • Taiwan 82%
  • DNA Methylation 81%
  • Colonic Neoplasms 66%

• Establish the Research Platform for Studying Triple-Negative Breast Tumor Microenvironment Regulation---The Hyaluronan Synthase-3 Mediated Antitumor Effects as an Example

  Ho, Y. & Wu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Gene Expression 46%
  • Tumor Microenvironment 40%
  • Hyaluronan Synthases 30%
  • Fibroblasts 29%

• 建立多構面癌症防治預測模式:以大腸癌為例－建立多構面癌症防治預測模式:以大腸癌為例

  Shao, Y.

  9/1/15 → 8/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the Carcinogenic Mechanisms of Glucose Transporters in Gastrointestinal Cancer Cells and Its Clinical Therapeutic Applications

  Chen, L. & Wu, C.

  9/1/15 → 8/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glucose 100%
  • Antitumor 19%
  • Occurrence in Nature 17%
  • Pharmacological Metabolism 11%
  • Biological Role 8%

• A Phase I, First-In-Human, Dose-Seeking Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of Orally Administered MPT0E028 in Subjects with Advanced Solid Malignancies without Standard Treatment (II)

  Liou, J.

  9/1/15 → 8/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Differential Machinery of Pluripotency Regulation in Stem Cells in Embryonic Stage and Somatic Cancers and Its Clinical Implications in Human Diseases --Crosstalk among Niche Growth Factor/Cytokine Signaling, Extracellular Matrix, and Epigenetic Netw (II)

  Huang, Y.

  10/1/15 → 9/30/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 105年臺東縣整合式篩檢統計分析案

  Chen, L.

  10/18/16 → 11/30/16

  Project: A - Government Institution › f - Other (Funded by Government)

• 104年度科學及技術類委託研究計畫「健保已給付新藥副作用之風險評估_以口服抗凝血劑為例」計畫案

  Chien, L., Ko, Y., Chien, S. & Chi, N.

  12/23/15 → 12/22/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

• Evaluation on prevention for metabolic syndrome and diabetes mellitus through lifestyle modification intervention in pre-diabetic subjects (100-104)

  Chiou, H.

  12/31/15 → 12/30/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

• TMU102-AE1-B29

  HuangFu, W.

  1/1/14 → 12/30/16

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• Development of DNA methylation biomarker for endometrial cancer detection

  Lai, H.

  1/1/16 → 12/31/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Endometrial Neoplasms 100%
  • Methylation 31%
  • Myoma 17%
  • Genes 14%
  • Taiwan 13%

• Social medicine discipline research Planning and Promotion project

  Chiou, H.

  1/1/16 → 12/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Epigenetic Characterization of Ovarian Cancer Initiating Cells

  Lai, H.

  1/1/16 → 12/31/16

  Project: A - Government Institution › a - National Health Research Institutes

  • Ovarian Neoplasms 100%
  • Neoplastic Stem Cells 64%
  • Epigenomics 43%
  • 5-hydroxymethylcytosine 16%
  • Stem Cell Research 14%

• 高功率奈米製程之摻鉺光纖雷射在皮膚分段光熱分解療法之應用

  HuangFu, W.

  1/1/16 → 12/31/16

  Project: C - Project of Alliance › j - National Taipei University of Technology

• 新聘教師研究補助

  Chen, L.

  1/1/16 → 12/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• In vitro, ex vivo and clinical characterization of novel Salmonella virulence genes

  Fang, S. & Huang, M.

  1/1/16 → 12/31/16

  Project: A - Government Institution › a - National Health Research Institutes

  • Salmonella 100%
  • Virulence 62%
  • Salmonella Infections 59%
  • Salmonella typhimurium 54%
  • Genes 47%