TMU Research Center of Cancer Translational Medicine

Projects

Projects per year 2010 2014 2015 2016 2017 2018 2022

• 5 Active
• 531 Finished

Projects per year

Search results

• 探討細胞自噬在低氧調控多型性神經膠母細胞瘤生成過程所扮演的角色

  Chen, R.

  3/1/15 → 2/29/16

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• 104-105年預防保健服務專案管理計畫

  Chiou, H.

  3/12/15 → 3/11/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

• TMU103-AE1-B19

  Lee, Y.

  4/1/15 → 3/31/16

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• 104年度「空中救護審核機制計畫」

  Tsai, S., Whang-Peng, J., Liu, L., Chang, W., Ho, Y., Cheng, Y., Yeh, S., Chen, K., Sung, S., Hung, K., Chen, R., Chiou, H., Chen, C. & Li, Y.

  1/1/15 → 3/31/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 運用化學基因體學方法開發新穎核糖核?酸還原?抑制劑用以治療大腸直腸癌

  Yang, P.

  5/1/15 → 4/30/16

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• 探討Hsp27在大腸癌的進行、轉移能力與治療上的角色及其作用機制

  Wei, P.

  5/1/15 → 4/30/16

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• 探討Androgen receptor調控WNT 訊號傳遞在攝護腺癌之作用機轉

  Liu, Y.

  5/1/15 → 4/30/16

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 卵巢癌幹細胞之代謝研究-I奉

  Lai, H.

  5/1/15 → 4/30/16

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• 探討TSA透過抑制YAP1訊息傳導作為治療抗藥性胰臟癌之潛力藥物

  Wu, S.

  5/1/15 → 4/30/16

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 從染色體中心節蛋白(CENP)家族中找尋可以用來當作卵巢癌的新腫瘤標的

  Lee, K.

  5/1/15 → 4/30/16

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• TGF-beta誘導人類肺癌細胞JARID2表現之機轉研究

  Chen, B.

  5/1/15 → 4/30/16

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 葡萄糖轉運受體於腸胃肝癌致癌作用與治療之探討

  Chen, L.

  5/1/15 → 4/30/16

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• 退黑激素對於腎細胞癌侵犯轉移之療效及其相關調控機轉探討

  Chien, M.

  5/1/15 → 4/30/16

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 探討乳酸去氫?對胰臟癌Gemcitabine抗藥性的調控與影響

  Huang, M.

  5/1/15 → 4/30/16

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• 探討腫瘤抑制分子FOXO3a在胰臟癌gemcitabine抗藥性的角色

  Chen, H.

  5/1/15 → 4/30/16

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• EGFR反式活化依賴NADPH oxidase/ROS/NF-kB路徑媒介thrombin誘導肺部上皮細胞IL-8/CXCL8表現之探討

  Chen, B.

  6/1/15 → 5/31/16

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 探討integrin αvβ3及EGFR間交叉效應對於甲狀腺賀爾蒙誘發大腸直腸癌細胞增生作用之影響

  Lin, H.

  6/1/15 → 5/31/16

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 篩選一個具有保護神經而且可能發展為腦創傷治療藥物的Sigma 1受體促效劑

  Chuang, J.

  6/1/15 → 5/31/16

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 探討缺氧環境中透過Hif-2α支配的Igf-1r—Cxcr4訊號迴路調控小鼠生殖系幹細胞爬行作用機制

  Huang, Y.

  6/1/15 → 5/31/16

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• TMU102-AE1-B44

  Liu, Y.

  7/1/14 → 6/30/16

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• Activation Autophagy by the Combination of a Histone Deacetylase Inhibitor and Radiation Limits BNIP3 Regulation in Triple-Negative Breast Cancer Cells and Orthotopic Mouse Model

  Chiu, H. & Ho, Y.

  8/1/15 → 6/30/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Triple Negative Breast Neoplasms 100%
  • Histone Deacetylase Inhibitors 97%
  • Ionizing Radiation 42%
  • Autophagy 39%
  • human ERBB2 protein 25%

• 使用超音波導引腹橫肌平面神經阻斷術於減重手術後之止痛作用

  Tam, K.

  3/1/15 → 6/30/16

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• 新北市醫療照護資源垂直整合模式成效評估計畫

  Chiou, H.

  10/22/15 → 7/11/16

  Project: A - Government Institution › f - Other (Funded by Government)

• The Role of EGFR in Prostate Cancer Progression and Combination Therapy

  Liu, Y. & Chen, W.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Prostatic Neoplasms 100%
  • ErbB Receptors 82%
  • Berberis 26%
  • Neoplastic Stem Cells 16%
  • Neoplasms 15%

• Cocaine Induces Sig-1R Nuclear Envelope Localization to Regulate MAOB Expression by Interacting with Emerin-HDACs Co-Repressor Complex

  Chuang, J.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • sigma-1 receptor 100%
  • Cocaine 63%
  • Monoamine Oxidase 42%
  • emerin 30%
  • Co-Repressor Proteins 29%

• Neuroprotective Effects of Sig-1R-Znf179-Sp1 Pathway on Brain Injury

  Chang, W. & Chuang, J.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • sigma-1 receptor 100%
  • Traumatic Brain Injury 50%
  • Hydrogen Peroxide 31%
  • Neuroprotective Agents 19%
  • Wounds and Injuries 12%

• To See Is to Believe- Visualization of the Spectrum on Chronic Kidney Disease (II)

  Jian, W., Li, Y. & Wu, M.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Health care 100%
  • Data visualization 75%
  • Patient treatment 50%
  • Disease control 49%
  • Health insurance 49%

• Effect of HMGA2 in Chemotherapy Response of Colorectal Cancer Patients with Different APC Status (II)

  Yen, Y., Cheng, Y. & Wei, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of SUV39H1 in Control of Inflammatory Genes and in Chronic Inflammation of Copd

  Lee, K., Feng, P. & Chuang, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chronic Obstructive Pulmonary Disease 100%
  • Inflammation 60%
  • Blood Cells 33%
  • Histone Deacetylase 2 32%
  • Glucocorticoids 27%

• HMGA2, a New Target of Thyroid Hormone-Induced Progression in Colorectal Cancers

  Lin, H., Chang, T. & Yen, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • AT-Hook Motifs 100%
  • Thyroid Hormones 75%
  • tetraiodothyroacetic acid 70%
  • Colorectal Neoplasms 43%
  • Integrins 28%

• The Association of Nonage Chronic Arsenic Exposure, Methylation Levels of Arsenic Metabolism Genes, and the Risk of Cancer Development

  Chiou, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • arsenic 100%
  • adulthood 37%
  • neoplasms 27%
  • methylation 24%
  • metabolism 15%

• Construction of gene profiles and connectivity map for ER in a Taiwanese population(先期補助)

  Chang, W.

  8/1/15 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Biomarkers for the Early Prediction and Prognosis for Colorectal Cancer---Construction of Kinetic

  Chang, W. & Wei, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Colorectal Neoplasms 100%
  • Calcium Channels 40%
  • Calcium 34%
  • Biomarkers 24%
  • Podosomes 18%

• Dissected the Role of Glucose-Regulated Protein 94 (GRP94),The Clinically Therapeutic Implication and Drug Development in Colon Cancer

  Wei, P. & Chang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • glucose-regulated proteins 100%
  • Colonic Neoplasms 43%
  • Colorectal Neoplasms 38%
  • Neoplasms 23%
  • Neoplasm Metastasis 19%

• Application of Regioselective Substitution on 1,4-Benzoquinone Derivatives to Provide Potent Anticancer Agents

  Liou, J.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • 1,4-benzoquinone 100%
  • Wittig Olefination 54%
  • Intramolecular Cyclization 40%
  • Nucleophilic Substitution 38%
  • Regioselectivity 35%

• A Toxicological Assessment of Air Pollution in the Vicinity of a Petrochemical Complex

  Chuang, H. & Lee, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Particulate Matter 100%
  • Taiwan 54%
  • Toxicology 44%
  • Risk Assessment 38%
  • Methionine 19%

• Smart Mouth Guard 3D Drug Delivery and Wound Dressing Device Development (Project 1)

  Deng, W. & Ou, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mouth Protectors 100%
  • Bandages 50%
  • Equipment and Supplies 38%
  • Pharmaceutical Preparations 26%
  • Periodontitis 26%

• TMU103-AE1-B31

  Feng, P.

  8/1/15 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Identification of Rewired APC Mutation Signaling Network in Chemotherapy Resistant Response in Colorectal Cancer (II)

  Huang, T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of ADAM 17 in Hypoxia-Induced CTGF Expression and Pulmonary Fibrosis (III)

  Chen, B.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • ADAM17 Protein 100%
  • Connective Tissue Growth Factor 83%
  • Hypoxia 49%
  • Small Interfering RNA 38%
  • Fibrosis 21%

• Pre-Clinical Evaluation of the Tumor Suppression Effectiveness and Mechanism of Small Molecule Drugs in Oral Cancer

  Chen, Y. & Wu, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Pharmaceutical Preparations 100%
  • Mouth Neoplasms 70%
  • Pharmaceutical Databases 22%
  • Neoplasm Genes 17%
  • Biological Products 15%

• Study the Function and Regulation of miRNAs in Pancreatic Cancer Progression (II)

  Huang, M.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 幹細胞基礎研究與前臨床動物試驗

  Huang, Y.

  8/1/15 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Genetic Polymorphisms in Hypoxia Inducible Factor-1 and Inflammation Pathway Related microRNA and Its Target Genes and Risk of Hyperglycemia in Acute Ischemic Stroke and Its Prognosis Study

  Hsieh, Y., Cho, E., Chi, N. & Chiou, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • MicroRNAs 100%
  • Hyperglycemia 79%
  • Stroke 64%
  • Inflammation 37%
  • Biomarkers 10%

• The Effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) for Patients with Depressive Disorders

  Chang, H. & Chiou, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Cognitive Behavioral Therapy 100%
  • Mindfulness 72%
  • Depressive Disorder 37%
  • Depression 23%
  • Diagnostic and Statistical Manual of Mental Disorders 22%

• Discovering Blood Circulating and Bone Micrornas as Biomarker Signatures for Diagnosis or Therapy of Osteoporosis in Men and Male Osteoporotic Fracture

  Chen, R.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • osteoporosis 100%
  • microRNA 57%
  • bones 36%
  • biomarkers 27%
  • bone fractures 19%

• Design and Preclinical Translation Study of Mixed-Bispecific/Trispecific Antibody for Enhancing Therapeutic Effectiveness of Anticancer Drug-Loaded Pegylated Nanocarriers by Simultaneously Targeting to Tumor Cells and Cancer/Tumor Associated Fibrobla (I)

  Sheu, M., Chuang, K. & Ho, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Nanocarrier 100%
  • Antigen 77%
  • Tumor Marker 61%
  • Modification 51%
  • Liposome 42%

• Effects of Ultrafine Particles on Cardiopulmonary System: a Population-Based Approach

  Chuang, K. & Feng, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Particulate Matter 100%
  • Air Pollution 68%
  • Taiwan 34%
  • United States Environmental Protection Agency 33%
  • Organized Financing 13%

• The Role of Amyloid-Beta in the Late-Onset Post-Stroke Vascular Cognitive Impairment (I)

  Hu, C., Wu, C., Chiou, H. & Chi, N.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Cognitive Dysfunction 100%
  • Blood Vessels 79%
  • Amyloid 57%
  • Stroke 46%
  • Dementia 45%

• Dementia Care and Quality Improvement

  Chien, L., Chiou, H., Chi, N. & Hu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • dementia 100%
  • health insurance 28%
  • Medical records 19%
  • utilization 17%
  • resources 9%