TMU Neuroscience Research Center - Retinopathy

Research Output 2000 2020

2020

Aza-PBHA, a potent histone deacetylase inhibitor, inhibits human gastric-cancer cell migration via PKCα-mediated AHR-HDAC interactions

Tsai, C. H., Li, C. H., Liao, P. L., Chang, Y. W., Cheng, Y. W. & Kang, J. J., Feb 2020, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1867, 2, 118564.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Histone Deacetylase Inhibitors
Histone Deacetylases
Stomach Neoplasms
Cell Movement
2019
5 Citations (Scopus)

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
3 Citations (Scopus)

Chloramphenicol induces autophagy and inhibits the hypoxia inducible factor-1 alpha pathway in non-small cell lung cancer cells

Hsu, H. L., Liao, P. L., Cheng, Y. W., Huang, S. H., Wu, C. H., Li, C. H. & Kang, J. J., Jan 1 2019, In : International Journal of Molecular Sciences. 20, 1, 157.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
hypoxia
Autophagy
Chloramphenicol
Non-Small Cell Lung Carcinoma
Open Access
Aquaporin 1
Caveolin 1
Brain Edema
Gold
Nanoparticles

Down-regulation of aryl hydrocarbon receptor intensifies carcinogen-induced retinal lesion via SOCS3-STAT3 signaling

Tsai, C. H., Lee, Y., Li, C. H., Cheng, Y. W. & Kang, J. J., Jan 1 2019, (Accepted/In press) In : Cell Biology and Toxicology.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
STAT3 Transcription Factor
Carcinogens
Down-Regulation
Cytokines

Efficacy of azatyrosine-phenylbutyric hydroxamides, a histone deacetylase inhibitor, on chemotherapy-induced gastrointestinal mucositis

Liao, P. L., Huang, S. H., Hung, C. H., Huang, W. K., Tsai, C. H., Kang, J. J., Wang, H. P. & Cheng, Y. W., Jan 1 2019, In : International Journal of Molecular Sciences. 20, 2, 249.

Research output: Contribution to journalArticle

monocytes
interleukins
Mucositis
Histone Deacetylase Inhibitors
Chemotherapy
1 Citation (Scopus)

Glycemia Lowering Effect of an Aqueous Extract of Hedychium coronarium Leaves in Diabetic Rodent Models

Tse, L. S., Liao, P. L., Tsai, C. H., Li, C. H., Liao, J. W., Kang, J. J. & Cheng, Y. W., Mar 14 2019, In : Nutrients. 11, 3

Research output: Contribution to journalArticle

Open Access
Hedychium coronarium
Zingiberaceae
Type 2 Diabetes Mellitus
blood glucose
Rodentia
1 Citation (Scopus)

HDAC8 inhibitor WK2-16 therapeutically targets lipopolysaccharide-induced mouse model of neuroinflammation and microglial activation

Lin, F. L., Yen, J. L., Kuo, Y. C., Kang, J. J., Cheng, Y. W., Huang, W. J. & Hsiao, G., Jan 2 2019, In : International Journal of Molecular Sciences. 20, 2, p. 410 410.

Research output: Contribution to journalArticle

Neuroglia
inhibitors
mice
Lipopolysaccharides
Chemical activation

Hirsutanol A attenuates lipopolysaccharide-mediated matrix metalloproteinase 9 expression and cytokines production and improves endotoxemia-induced acute sickness behavior and acute lung injury

Jan, J. S., Yang, C. H., Wang, M. H., Lin, F. L., Yen, J. L., Hsieh, I., Khotimchenko, M., Lee, T. H. & Hsiao, G., Jun 17 2019, In : Marine Drugs. 17, 6, 360.

Research output: Contribution to journalArticle

Open Access
Illness Behavior
Endotoxemia
Acute Lung Injury
Matrix Metalloproteinase 9
Lipopolysaccharides
Open Access
Aquaporin 1
Caveolin 1
Brain Edema
Gold
Nanoparticles
1 Citation (Scopus)

Low-luminance blue light-enhanced phototoxicity in A2E-Laden RPE cell cultures and rats

Lin, C. H., Wu, M. R., Huang, W. J., Chow, D. S. L., Hsiao, G. & Cheng, Y. W., Apr 11 2019, In : International Journal of Molecular Sciences. 20, 7, 1799.

Research output: Contribution to journalArticle

Open Access
Phototoxic Dermatitis
Retinal Pigments
luminance
pigments
Cell culture
3 Citations (Scopus)
Urinary Bladder Neoplasms
Antineoplastic Agents
G1 Phase
Ovarian Neoplasms
Solubility
1 Citation (Scopus)

The fungus-derived retinoprotectant theissenolactone C improves glaucoma-like injury mediated by MMP-9 inhibition

Lin, F. L., Cheng, Y. W., Yu, M., Ho, J. D., Kuo, Y. C., Chiou, G. C. Y., Chang, H. M., Lee, T. H. & Hsiao, G., Mar 15 2019, In : Phytomedicine. 56, p. 207-214 8 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Glaucoma
Reperfusion Injury
Interleukin-1
Chemokine CCL2
Open Access
Tissue Inhibitor of Metalloproteinase-3
Colorectal Neoplasms
Neoplasm Metastasis
Growth
Neoplasms
2018

Effect of hydroxyapatite formation on titanium surface with bone morphogenetic protein-2 loading through electrochemical deposition on MG-63 cells

Huang, H. Y., Manga, Y. B., Huang, W. N., Lin, C. K., Tseng, C. L., Huang, H. M., Wu, C. Y. & Wu, C. C., Oct 4 2018, In : Materials. 11, 10, 1897.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 2
Durapatite
Titanium
Hydroxyapatite
Bone
6 Citations (Scopus)

Gelatin–epigallocatechin gallate nanoparticles with hyaluronic acid decoration as eye drops can treat rabbit dry-eye syndrome effectively via inflammatory relief

Huang, H. Y., Wang, M. C., Chen, Z. Y., Chiu, W. Y., Chen, K. H., Lin, I-C., Yang, W-C., Wu, C. C. & Tseng, C-L., 2018, In : International Journal of Nanomedicine. 13, p. 7251-7273

Research output: Contribution to journalArticle

Dry Eye Syndromes
Hyaluronic acid
Ophthalmic Solutions
Hyaluronic Acid
Nanoparticles
1 Citation (Scopus)

Haloperidol Abrogates Matrix Metalloproteinase-9 Expression by Inhibition of NF-κB Activation in Stimulated Human Monocytic Cells

Lee, Y. L., Hsiao, C. J., Lin, F. L., Jan, J. S., Chou, Y. C., Lin, Y. Y., Chen, C. K., Lam, K. K. & Hsiao, G., Jan 1 2018, In : Mediators of Inflammation. 2018, 1 p., 9541459.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Haloperidol
Matrix Metalloproteinases
Lipopolysaccharides
Tumor Necrosis Factor-alpha

New Combination/Application of Polymer-Based Nanoparticles for Biomedical Engineering

Chang, R., Wang, P. Y. & Tseng, C. L., Jan 1 2018, Advances in Experimental Medicine and Biology. Vol. 1078. p. 271-290 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Biomedical Engineering
Nanoparticles
Polymers
Therapeutics
Therapeutic Uses

New terpenoids from Chamaecyparis formosensis (Cupressaceae) leaves with modulatory activity on matrix metalloproteases 2 and 9

Chang, M. L., Mei, H. C., Kuo, I. C., Hsiao, G., Kuo, Y. H. & Lee, C. K., Mar 7 2018, In : Molecules. 23, 3, 604.

Research output: Contribution to journalArticle

Chamaecyparis
Cupressaceae
Terpenes
Metalloproteases
leaves
1 Citation (Scopus)
Cistanche
Light
Retinal Pigments
Staining and Labeling
Phototoxic Dermatitis
15 Citations (Scopus)

Ocular drug delivery: Role of degradable polymeric nanocarriers for ophthalmic application

Tsai, C. H., Wang, P. Y., Lin, I. C., Huang, H., Liu, G. S. & Tseng, C. L., Sep 19 2018, In : International Journal of Molecular Sciences. 19, 9, 2830.

Research output: Contribution to journalReview article

Drug delivery
delivery
Biodegradable polymers
drugs
Tissue
2 Citations (Scopus)

Polypyrrole electrode with a greater electroactive surface electrochemically polymerized in plasmon-activated water

Chen, H. C., Chang, C. C., Yang, K. H., Mai, F. D., Tseng, C. L., Chen, L. Y., Hwang, B. J. & Liu, Y. C., Jan 2018, In : Journal of the Taiwan Institute of Chemical Engineers. 82, p. 252-260

Research output: Contribution to journalArticle

Polypyrroles
Polymerization
Electrodes
Water
Deionized water
11 Citations (Scopus)

Reflections on dry eye syndrome treatment: Therapeutic role of blood products

Drew, V. J., Tseng, C. L., Seghatchian, J. & Burnouf, T., Feb 1 2018, In : Frontiers in Medicine. 5, FEB, 33.

Research output: Contribution to journalReview article

Dry Eye Syndromes
Ophthalmic Solutions
Tears
Serum
Pathology
2 Citations (Scopus)

Role of activating transcription factor 3 in fructose-induced metabolic syndrome in mice

Chou, C. L., Li, C. H., Lin, H., Liao, M. H., Wu, C. C., Chen, J. S., Sue, Y. M. & Fang, T. C., Aug 1 2018, In : Hypertension Research. 41, 8, p. 589-597 9 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Fructose
Knockout Mice
Diet
Blood Pressure
5 Citations (Scopus)

Safety assessment of the Cistanche tubulosa health food product Memoregain®: Genotoxicity and 28-day repeated dose toxicity test

Liao, P. L., Li, C. H., Tse, L. S., Kang, J. J. & Cheng, Y. W., Aug 1 2018, In : Food and Chemical Toxicology. 118, p. 581-588 8 p.

Research output: Contribution to journalArticle

Cistanche
Toxicity Tests
Salmonella
health foods
safety assessment
4 Citations (Scopus)

The characteristics of a preservative-free contact lens care solution on lysozyme adsorption and interfacial friction behavior

Su, C. Y., Lai, C. C., Yeh, L. K., Li, K. Y., Shih, B. W., Tseng, C. L. & Fang, H. W., Nov 1 2018, In : Colloids and Surfaces B: Biointerfaces. 171, p. 538-543 6 p.

Research output: Contribution to journalArticle

Contact Lens Solutions
Food preservatives
preservatives
contact lenses
Contact lenses
4 Citations (Scopus)

Theissenolactone C exhibited ocular protection of endotoxin-induced uveitis by attenuating ocular inflammatory responses and glial activation

Lin, F. L., Ho, J. D., Cheng, Y. W., Chiou, G. C. Y., Yen, J. L., Chang, H. M., Lee, T. H. & Hsiao, G., Apr 9 2018, In : Frontiers in Pharmacology. 9, APR, 326.

Research output: Contribution to journalArticle

Uveitis
Endotoxins
Neuroglia
Microglia
Tumor Necrosis Factor-alpha
2017
4 Citations (Scopus)

1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma

Liu, Y. M., HuangFu, W. C., Huang, H. L., Wu, W. C., Chen, Y. L., Yen, Y., Huang, H. L., Nien, C. Y., Lai, M. J., Pan, S. L. & Liou, J. P., Nov 10 2017, In : European Journal of Medicinal Chemistry. 140, p. 84-91 8 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Multiple Myeloma
Tumors
Lead compounds
Growth
1 Citation (Scopus)
Lactic acid
Scaffolds
Polypropylenes
Carbonates
Lactic Acid
3 Citations (Scopus)

An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells

Chao, M. W., Huang, H. L., HuangFu, W. C., Hsu, K. C., Liu, Y. M., Wu, Y. W., Lin, C. F., Chen, Y. L., Lai, M. J., Lee, H. Y., Liou, J. P., Teng, C. M. & Yang, C. R., 2017, In : Oncotarget. 8, 17, p. 27772-27785 14 p.

Research output: Contribution to journalArticle

Leukemia
Pharmaceutical Preparations
Neoplasms
Glycoproteins
National Cancer Institute (U.S.)
15 Citations (Scopus)

Anti-inflammatory properties of shikonin contribute to improved early-stage diabetic retinopathy

Liao, P. L., Lin, C. H., Li, C. H., Tsai, C. H., Ho, J. D., Chiou, G. C. Y., Kang, J. J. & Cheng, Y. W., Mar 21 2017, In : Scientific Reports. 7, 44985.

Research output: Contribution to journalArticle

Diabetic Retinopathy
Anti-Inflammatory Agents
Retinal Pigments
Inbred C57BL Mouse
Glucose
2 Citations (Scopus)

Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo

Huangfu, W. C., Chao, M. W., Cheng, C. C., Wei, Y. C., Wu, Y. W., Liou, J. P., Hsiao, G., Lee, Y. C. & Yang, C. R., Feb 9 2017, In : Scientific Reports. 7, 42291.

Research output: Contribution to journalArticle

Tubulin
Leukemia
Apoptosis
Caspase 7
Drug Therapy
14 Citations (Scopus)

Bioactive constituents from the termite nest-derived medicinal fungus Xylaria nigripes

Chang, J. C., Hsiao, G., Lin, R. K., Kuo, Y. H., Ju, Y. M. & Lee, T. H., Jan 27 2017, In : Journal of Natural Products. 80, 1, p. 38-44 7 p.

Research output: Contribution to journalArticle

Isoptera
Fungi
Alcohols
Sleep Initiation and Maintenance Disorders
Nitric Oxide Synthase Type II
dendritic cells
interleukin-10
Interleukin-10
Dendritic Cells
Medicine
2 Citations (Scopus)
Anti-Allergic Agents
Regulatory T-Lymphocytes
Interleukin-10
Dendritic Cells
Asthma
12 Citations (Scopus)

Cytoplasmic aryl hydrocarbon receptor regulates glycogen synthase kinase 3 beta, accelerates vimentin degradation, and suppresses epithelial–mesenchymal transition in non-small cell lung cancer cells

Li, C. H., Liu, C. W., Tsai, C. H., Peng, Y. J., Yang, Y. H., Liao, P. L., Lee, C. C., Cheng, Y. W. & Kang, J. J., May 1 2017, In : Archives of Toxicology. 91, 5, p. 2165-2178 14 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Aryl Hydrocarbon Receptors
Vimentin
Non-Small Cell Lung Carcinoma
Cells

Detection and discrimination of maintenance and de novo CpG methylation events using MethylBreak

Hsu, W., Mercado, A. T., Hsiao, G., Yeh, J. M. & Chen, C. Y., May 15 2017, In : Biosensors and Bioelectronics. 91, p. 658-663 6 p.

Research output: Contribution to journalArticle

Methylation
Maintenance
Inborn Genetic Diseases
Digestion
Technology
12 Citations (Scopus)

Development of genipin-crosslinked fucoidan/chitosan-N-arginine nanogels for preventing Helicobacter infection

Lin, Y. H., Lu, K. Y., Tseng, C. L., Wu, J. Y., Chen, C. H. & Mi, F. L., Jun 1 2017, In : Nanomedicine. 12, 12, p. 1491-1510 20 p.

Research output: Contribution to journalArticle

Arginine
Chitosan
Helicobacter Infections
Helicobacter pylori
drug
3 Citations (Scopus)

Herbal supplement in a buffer for dry eye syndrome treatment

Chen, H. C., Chen, Z. Y., Wang, T. J., Drew, V. J., Tseng, C. L., Fang, H. W. & Lin, F. H., Aug 3 2017, In : International Journal of Molecular Sciences. 18, 8, 1697.

Research output: Contribution to journalArticle

ferulic acid
Dry Eye Syndromes
supplements
Buffers
buffers
7 Citations (Scopus)

Hirsutane-Type Sesquiterpenes with Inhibitory Activity of Microglial Nitric Oxide Production from the Red Alga-Derived Fungus Chondrostereum sp. NTOU4196

Hsiao, G., Chi, W. C., Pang, K. L., Chen, J. J., Kuo, Y. H., Wang, Y. K., Cha, H. J., Chou, S. C. & Lee, T. H., May 26 2017, In : Journal of Natural Products. 80, 5, p. 1615-1622 8 p.

Research output: Contribution to journalArticle

Rhodophyta
Sesquiterpenes
Algae
Fungi
Nitric Oxide
23 Citations (Scopus)

Hypoxia-induced downregulation of DUSP-2 phosphatase drives colon cancer stemness

Hou, P. C., Li, Y. H., Lin, S. C., Lin, S. C., Lee, J. C., Lin, B. W., Liou, J. P., Chang, J. Y., Kuo, C. C., Liu, Y. M., Sun, H. S. & Tsai, S. J., Aug 15 2017, In : Cancer Research. 77, 16, p. 4305-4316 12 p.

Research output: Contribution to journalArticle

Dual-Specificity Phosphatases
Dual Specificity Phosphatase 2
Colonic Neoplasms
Down-Regulation
Neoplasms
32 Citations (Scopus)

Idiopathic pulmonary fibrosis: Current status, recent progress, and emerging targets

Liu, Y. M., Nepali, K. & Liou, J. P., Jan 26 2017, In : Journal of Medicinal Chemistry. 60, 2, p. 527-553 27 p.

Research output: Contribution to journalReview article

Idiopathic Pulmonary Fibrosis
Literature
Patents
Interstitial Lung Diseases
Therapeutics
19 Citations (Scopus)
Melatonin
Cognition
Energy Metabolism
Antioxidants
Oxidative Stress
15 Citations (Scopus)

Periodic exposure to smartphone-mimic low-luminance blue light induces retina damage through Bcl-2/BAX-dependent apoptosis

Lin, C. H., Wu, M. R., Li, C. H., Cheng, H. W., Huang, S. H., Tsai, C. H., Lin, F. L., Ho, J. D., Kang, J. J., Hsiao, G. & Cheng, Y. W., May 1 2017, In : Toxicological Sciences. 157, 1, p. 196-210 15 p.

Research output: Contribution to journalArticle

Smartphones
Retina
Luminance
Apoptosis
Light
9 Citations (Scopus)

Preparation of arginine–glycine–aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization

Chang, C. Y., Wang, M. C., Miyagawa, T., Chen, Z. Y., Lin, F. H., Chen, K. H., Liu, G. S. & Tseng, C. L., 2017, In : International Journal of Nanomedicine. 12, p. 279-294 16 p.

Research output: Contribution to journalArticle

Corneal Neovascularization
Endothelial cells
Nanoparticles
Endothelial Cells
Ophthalmic Solutions
2 Citations (Scopus)

Preparation of gelatin/epigallocatechin gallate self-assembly nanoparticles for transdermal drug delivery

Drew, V. J., Huang, H. Y., Tsai, Z. H., Tsai, H. H. & Tseng, C. L., Oct 1 2017, In : Journal of Polymer Research. 24, 11, 188.

Research output: Contribution to journalArticle

Gelatin
Drug delivery
Self assembly
Skin
Nanoparticles
15 Citations (Scopus)

The inhibition of lung cancer cell migration by AhR-regulated autophagy

Tsai, C. H., Li, C. H., Cheng, Y. W., Lee, C. C., Liao, P. L., Lin, C. H., Huang, S. H. & Kang, J. J., Feb 14 2017, In : Scientific Reports. 7, 41927.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Autophagy
Cell Movement
Lung Neoplasms
Epithelial-Mesenchymal Transition
14 Citations (Scopus)
Methylnitrosourea
Photoreceptor Cells
Apoptosis
Retinitis Pigmentosa
Cassia
5 Citations (Scopus)
Matrix Metalloproteinase 9
inhibitors
Lipopolysaccharides
interleukins
necrosis
2016
3 Citations (Scopus)

Anti-MMP-2 Activity and Skin-Penetrating Capability of the Chemical Constituents from Rhodiola rosea

Lee, T-H., Hsu, C. C., Hsiao, G., Fang, J. Y., Liu, W. M. & Lee, C. K., May 1 2016, In : Planta Medica. 82, 8, p. 698-704

Research output: Contribution to journalArticle

Rhodiola
Matrix Metalloproteinase 2
Matrix Metalloproteinases
Skin
Collagenases