TMU Neuroscience Research Center - Platelet Neurotrophins for Neurorestorative Biotherapy

Research Output 2004 2019

2014
6 Citations (Scopus)
Plasma Volume
Industry
Blood Coagulation Factors
Intravenous Immunoglobulins
Recombinant Proteins
8 Citations (Scopus)

Multifaceted regenerative lives of expired platelets in the second decade of the 21st century

Burnouf, T., Goubran, H. A. & Seghatchian, J., 2014, In : Transfusion and Apheresis Science. 51, 2, p. 107-112 6 p.

Research output: Contribution to journalReview article

Blood Platelets
Hemostatics
Intercellular Signaling Peptides and Proteins
Transfusion Medicine
Regenerative Medicine

New approaches for manufacturing plasma derivatives

Burnouf, T. P. R., Jul 28 2014, In : ISBT Science Series.

Research output: Contribution to journalArticle

Developed Countries
Proteins
Immunoglobulin G
Virus Inactivation
Technology
60 Citations (Scopus)

Platelet-cancer interactions

Goubran, H. A., Stakiw, J., Radosevic, M. & Burnouf, T., 2014, In : Seminars in Thrombosis and Hemostasis. 40, 3, p. 296-305 10 p.

Research output: Contribution to journalArticle

Blood Platelets
Neoplasms
Thrombosis
Platelet Activation
Growth
81 Citations (Scopus)

Platelet microparticles: Detection and assessment of their paradoxical functional roles in disease and regenerative medicine

Burnouf, T., Goubran, H. A., Chou, M. L., Devos, D. & Radosevic, M., 2014, In : Blood Reviews. 28, 4, p. 155-166 12 p.

Research output: Contribution to journalReview article

Regenerative Medicine
Blood Platelets
Regeneration
Thrombosis
Phosphatidylserines
60 Citations (Scopus)

Platelets effects on tumor growth

Goubran, H. A., Stakiw, J., Radosevic, M. & Burnouf, T., 2014, In : Seminars in Oncology. 41, 3, p. 359-369 11 p.

Research output: Contribution to journalArticle

Blood Platelets
Growth
Neoplasms
Angiogenic Proteins
Tumor Microenvironment
17 Citations (Scopus)

Quantifying the thrombogenic potential of human plasma-derived immunoglobulin products

Germishuizen, W. A., Gyure, D. C., Stubbings, D. & Burnouf, T., Sep 1 2014, In : Biologicals. 42, 5, p. 260-270 11 p.

Research output: Contribution to journalArticle

Plasma (human)
Immunoglobulins
Immunoglobulin G
Impurities
Fractionation

Regulation of tumor growth and metastasis: the role of tumor microenvironment

Goubran, H. A., Kotb, R. R., Stakiw, J., Emara, M. E. & Burnouf, T. P. R., 2014, In : Cancer growth and metastasis. 7, p. 9-18 10 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Neoplasm Metastasis
Growth
Neoplasms
Cellular Microenvironment
10 Citations (Scopus)

Treatment of chemotherapy-induced neutropenia in a rat model by using multiple daily doses of oral administration of G-CSF-containing nanoparticles

Su, F. Y., Chuang, E-T., Lin, P. Y., Chou, Y. C., Chen, C. T., Mi, F. L., Wey, S. P., Yen, T. C., Lin, K. J. & Sung, H. W., Apr 2014, In : Biomaterials. 35, 11, p. 3641-3649 9 p.

Research output: Contribution to journalArticle

Chemotherapy
Granulocyte Colony-Stimulating Factor
Neutropenia
Nanoparticles
Oral Administration
2013
58 Citations (Scopus)

Antimicrobial activity of platelet (PLT)-poor plasma, PLT-rich plasma, PLT gel, and solvent/detergent-treated PLT lysate biomaterials against wound bacteria

Burnouf, T., Chou, M. L., Wu, Y. W., Su, C. Y. & Lee, L. W., Jan 2013, In : Transfusion. 53, 1, p. 138-146 9 p.

Research output: Contribution to journalArticle

Platelet-Rich Plasma
Biocompatible Materials
Detergents
Blood Platelets
Gels

Blood-derived biomaterials: What role can they play in regenerative medicine and stem cell therapy?

Su, C. Y. & Burnouf, T., Jan 1 2013, Biomaterials for Stem Cell Therapy: State of Art and Vision for the Future. CRC Press/Balkema, p. 65-86 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Regenerative Medicine
Biocompatible Materials
Cell- and Tissue-Based Therapy
Platelets
Stem cells
97 Citations (Scopus)

Blood-derived biomaterials and platelet growth factors in regenerative medicine

Burnouf, T., Goubran, H. A., Chen, T. M., Ou, K. L., El-Ekiaby, M. & Radosevic, M., Mar 2013, In : Blood Reviews. 27, 2, p. 77-89 13 p.

Research output: Contribution to journalReview article

Regenerative Medicine
Platelet-Derived Growth Factor
Biocompatible Materials
Blood Platelets
Fibrin Tissue Adhesive
29 Citations (Scopus)

Combination therapy via oral co-administration of insulin- and exendin-4-loaded nanoparticles to treat type 2 diabetic rats undergoing OGTT

Chuang, E-T., Nguyen, G. T. H., Su, F. Y., Lin, K. J., Chen, C. T., Mi, F. L., Yen, T. C., Juang, J. H. & Sung, H. W., Oct 2013, In : Biomaterials. 34, 32, p. 7994-8001 8 p.

Research output: Contribution to journalArticle

Insulin
Glucose Tolerance Test
Nanoparticles
Oral Administration
Rats
10 Citations (Scopus)

Dengue virus inactivation by minipool TnBP/Triton X-45 treatment of plasma and cryoprecipitate

Burnouf, T., Chou, M. L., Cheng, L. H., Li, Z. R., Wu, Y. W., El-Ekiaby, M. & Tsai, K. H., Jan 2013, In : Vox Sanguinis. 104, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

Virus Inactivation
Dengue Virus
Octoxynol
Flavivirus
Vero Cells
5 Citations (Scopus)

Human platelet antigen alleles in 998 taiwanese blood donors determined by sequence-specific primer polymerase chain reaction

Pai, S. C., Burnouf, T., Chen, J. W. & Lin, L. I., 2013, In : BioMed Research International. 2013, 973789.

Research output: Contribution to journalArticle

Human Platelet Antigens
Polymerase chain reaction
Blood Donors
Blood
Alleles
33 Citations (Scopus)

Nanoparticle-induced tight-junction opening for the transport of an anti-angiogenic sulfated polysaccharide across Caco-2 cell monolayers

Yu, S. H., Tang, D. W., Hsieh, H. Y., Wu, W. S., Lin, B. X., Chuang, E-T., Sung, H. W. & Mi, F. L., Jul 2013, In : Acta Biomaterialia. 9, 7, p. 7449-7459 11 p.

Research output: Contribution to journalArticle

Caco-2 Cells
Tight Junctions
Polysaccharides
Nanoparticles
Monolayers

Natural Scrub Typhus Antibody Suppresses HIV CXCR4(X4) Viruses

Watt, G., Kantipong, P., Burnouf, T. P. R., Shikuma, C. & Philpott, S., Jan 22 2013, In : Infectious Disease Reports. 5, 1, p. e8

Research output: Contribution to journalArticle

Scrub Typhus
HIV Antibodies
Viruses
Antibodies
HIV-1
31 Citations (Scopus)

Noninvasive imaging oral absorption of insulin delivered by nanoparticles and its stimulated glucose utilization in controlling postprandial hyperglycemia during OGTT in diabetic rats

Chuang, E-T., Lin, K. J., Su, F. Y., Mi, F. L., Maiti, B., Chen, C. T., Wey, S. P., Yen, T. C., Juang, J. H. & Sung, H. W., 2013, In : Journal of Controlled Release. 172, 2, p. 513-522 10 p.

Research output: Contribution to journalArticle

Glucose Tolerance Test
Hyperglycemia
Nanoparticles
Insulin
Egtazic Acid
9 Citations (Scopus)

Single-donor allogeneic platelet fibrin glue and osteoconductive scaffold in orbital floor fracture reconstruction

Chen, T. M., Tzeng, Y. S., Tsai, J. C. & Burnouf, T., Mar 2013, In : Annals of Plastic Surgery. 70, 3, p. 370-374 5 p.

Research output: Contribution to journalArticle

Orbital Fractures
Fibrin Tissue Adhesive
Orbit
Durapatite
Blood Platelets
70 Citations (Scopus)

The platelet-cancer loop

Goubran, H. A., Burnouf, T., Radosevic, M. & El-Ekiaby, M., Jul 2013, In : European Journal of Internal Medicine. 24, 5, p. 393-400 8 p.

Research output: Contribution to journalReview article

Blood Platelets
Neoplasms
Thrombosis
Neoplasm Metastasis
Thrombophlebitis
20 Citations (Scopus)

Treatment of nonhealing diabetic lower extremity ulcers with skin graft and autologous platelet gel: A case series

Tzeng, Y. S., Deng, S. C., Wang, C. H., Tsai, J. C., Chen, T. M. & Burnouf, T., 2013, In : BioMed Research International. 2013, 837620.

Research output: Contribution to journalArticle

Skin Ulcer
Platelets
Grafts
Ulcer
Lower Extremity
2012
23 Citations (Scopus)

Human blood-derived fibrin releasates: Composition and use for the culture of cell lines and human primary cells

Burnouf, T., Lee, C. Y., Luo, C. W., Kuo, Y. P., Chou, M. L., Wu, Y. W., Tseng, Y. H. & Su, C. Y., Jan 2012, In : Biologicals. 40, 1, p. 21-30 10 p.

Research output: Contribution to journalArticle

Fibrin
Cell culture
Blood
Cells
Cell growth
14 Citations (Scopus)

Human platelet concentrates: A source of solvent/detergent-treated highly enriched brain-derived neurotrophic factor

Burnouf, T., Kuo, Y. P., Blum, D., Burnouf, S. & Su, C. Y., Aug 2012, In : Transfusion. 52, 8, p. 1721-1728 8 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Detergents
Blood Platelets
Sepharose
Neuronal Plasticity
15 Citations (Scopus)

Impact of solvent/detergent treatment of plasma on transfusion-relevant bacteria

Chou, M. L., Wu, Y. W., Su, C. Y., Lee, L. W. & Burnouf, T., May 2012, In : Vox Sanguinis. 102, 4, p. 277-284 8 p.

Research output: Contribution to journalArticle

Detergents
Bacteria
Therapeutics
Oils
Growth
12 Citations (Scopus)

Purification of IgG and albumin from human plasma by aqueous two phase system fractionation

Vargas, M., Segura, Á., Herrera, M., Villalta, M., Angulo, Y., Gutiérrez, J. M., León, G. & Burnouf, T., Jul 2012, In : Biotechnology Progress. 28, 4, p. 1005-1011 7 p.

Research output: Contribution to journalArticle

Serum Albumin
Albumins
Immunoglobulin G
Salts
Potassium Chloride
2011
11 Citations (Scopus)

A chromatographically purified human TGF-β1 fraction from virally inactivated platelet lysates

Burnouf, T., Chang, C. W., Kuo, Y. P., Wu, Y. W., Tseng, Y. H. & Su, C. Y., Oct 2011, In : Vox Sanguinis. 101, 3, p. 215-220 6 p.

Research output: Contribution to journalArticle

Blood Platelets
Detergents
Octoxynol
Proteins
Epidermal Growth Factor
51 Citations (Scopus)

Expansion of adipose tissue mesenchymal stromal progenitors in serum-free medium supplemented with virally inactivated allogeneic human platelet lysate

Shih, T-B., Chen, J. C., Chen, W. Y., Kuo, Y. P., Su, C. Y. & Burnouf, T. P. R., Apr 2011, In : Transfusion. 51, 4, p. 770-778 9 p.

Research output: Contribution to journalArticle

Serum-Free Culture Media
Adipose Tissue
Blood Platelets
Detergents
Mesenchymal Stromal Cells
8 Citations (Scopus)

Pathogen reduction technique for fresh-frozen plasma, cryoprecipitate, and plasma fraction minipools prepared in disposable processing bag systems

Burnouf, T., Radosevich, M., El-Ekiaby, M. & Goubran, H., Feb 2011, In : Transfusion. 51, 2, p. 446-447 2 p.

Research output: Contribution to journalLetter

Blood Component Transfusion
Blood Preservation
Blood-Borne Pathogens
Blood Safety
Virus Inactivation
9 Citations (Scopus)

Pharmacokinetic study of minipooled solvent/detergent-filtered cryoprecipitate factor VIII

El-Ekiaby, M., Goubran, H. A., Radosevich, M., Abd-Allah, A., El-Ekiaby, A. & Burnouf, T. P. R., Sep 2011, In : Haemophilia. 17, 5

Research output: Contribution to journalArticle

Factor VIII
Detergents
Pharmacokinetics
Half-Life
Ristocetin
2010
10 Citations (Scopus)

A novel virally inactivated human platelet lysate preparation rich in TGF-β, EGF and IGF, and depleted of PDGF and VEGF

Burnouf, P. A., Juan, P. K., Su, C. Y., Kuo, Y. P., Chou, M. L., Su, C. H., Tseng, Y. H., Lin, C. T. & Burnouf, T., Aug 2010, In : Biotechnology and Applied Biochemistry. 56, 4, p. 151-160 10 p.

Research output: Contribution to journalArticle

Insulin
Platelet-Derived Growth Factor
Somatomedins
Platelets
Epidermal Growth Factor
12 Citations (Scopus)

A virally inactivated platelet-derived growth factor/vascular endothelial growth factor concentrate fractionated from human platelets

Burnouf, T., Kuo, Y. P., Huang, C. T., Tseng, Y. H., Lin, C. T. & Su, C. Y., 2010, In : Transfusion. 50, 8, p. 1702-1711 10 p.

Research output: Contribution to journalArticle

Platelet-Derived Growth Factor
Sepharose
Vascular Endothelial Growth Factor A
Blood Platelets
Detergents
10 Citations (Scopus)

Influence of ethanol on the release of growth factors in human blood-derived platelet gels

Kuo, Y. P., Lee, Y. L., Tseng, Y. H., Su, C. H., Burnouf, T. & Su, C. Y., Jan 2010, In : Biologicals. 38, 1, p. 120-127 8 p.

Research output: Contribution to journalArticle

Platelets
Intercellular Signaling Peptides and Proteins
Blood
Ethanol
Blood Platelets
2009
10 Citations (Scopus)

Assessment of the impact of solvent/detergent treatment on the quality and potency of a whole IgG equine antivenom

Segura, Á., León, G., Su, C. Y., Gutiérrez, J. M. & Burnouf, T., Oct 2009, In : Biologicals. 37, 5, p. 306-312 7 p.

Research output: Contribution to journalArticle

Antivenins
Detergents
Horses
Immunoglobulin G
Plasmas
30 Citations (Scopus)

A virally inactivated functional growth factor preparation from human platelet concentrates

Su, C. Y., Kuo, Y. P., Lin, Y. C., Huang, C. T., Tseng, Y. H. & Burnouf, T., Aug 2009, In : Vox Sanguinis. 97, 2, p. 119-128 10 p.

Research output: Contribution to journalArticle

Intercellular Signaling Peptides and Proteins
Blood Platelets
Vascular Endothelium
Octoxynol
Transforming Growth Factors

New methods of plasma fractionation – a presentation of the ‘mini-pool’ fractionation procedure developed in Egypt

El-Ekiaby, M., Radosevich, M., Goubran, H., El Sayed, M. & Burnouf, T., Mar 1 2009, In : ISBT Science Series. 4, 1, p. 99-106 8 p.

Research output: Contribution to journalArticle

Egypt
Contracts
Virus Inactivation
Technology
Intravenous Immunoglobulins
2008

Quality of plasma and its fractionation

Burnouf, T. P. R., Apr 22 2008, In : ISBT Science Series.

Research output: Contribution to journalArticle

Fractionation
Plasmas
Blood
Plasma (human)
Prions
2004
23 Citations (Scopus)

Platelet-derived growth factor-AB and transforming growth factor-β1 in platelet gels activated by single-donor human thrombin [3]

Su, C. Y., Chiang, C. C., Lai, W-F., Lin, K. W. & Burnouf, T., Jun 2004, In : Transfusion. 44, 6, p. 945 1 p.

Research output: Contribution to journalLetter

Cytoplasmic Granules
Species Specificity
Transforming Growth Factor beta1
Platelet-Derived Growth Factor
Transforming Growth Factors