Projects per year
Organization profile
Organisation profile
宗旨:
促進本校生技醫藥商品化發展,提供一校三院同仁醫藥品研發服務,以開發具有創新性與前瞻性之生技醫藥產品開發為宗旨。
背景:
生技醫藥為我國重要產業,建立藥品及醫材開發的關鍵價值鏈平台是校園研究成果產業化最大的助力。為有效統整及加速本校之新藥及醫材研發能量,規劃成立臺北醫學大學生技醫藥商品化中心(TMU Biomedical Commercialization Center),藉由商品化中心跨院系所專業團隊間的整合運作,提供一校三院同仁生技藥品臨床前到IND申請之臨床前研究(pre-clinical study)諮詢與服務。此外,透過北醫事業發展處協助醫藥品商品化開發策略,包含藥物市場定位分析,法規、專利檢索和諮詢服務,技術轉移或尋求業界承接產學合作案,及衍生新創事業體之相關規劃。
目的:
整合新藥開發及醫療器材從臨床前研究到IND/IDE所需之技術發展平台(Research Development),提供校內外單位委託合作或共同開發之服務。
搭配事業發展處之資源協助擬定生技醫藥品商業化發展策略(Business Development)、專利布局及商業化輔導,以加速產出具有創新性與前瞻性的生技醫藥品。
初期以藥品的商業化平台為目標:規劃由藥物設計/合成與篩選、藥理活性、藥物動力學、藥物代謝、藥效、毒理、小試量產、製劑開發等提供平台服務。
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Network
Profiles
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Wei-Chiao Chang
- Department of Clinical Pharmacy
- Master Program in Clinical Pharmacogenomics and Pharmacoproteomics
- Ph.D. Program in Drug Discovery and Development Industry
- TMU Research Center of Cancer Translational Medicine
- TMU Biomedical Commercialization Center
- Master Program in Applied Molecular Epidemiology
Person: Researcher
Projects
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合成可雙重抑制組織蛋白去乙醯酶6與熱休克蛋白90,並同時調節PD-L1之雜環類抗癌化合物
8/1/20 → 7/1/21
Project: A - Government Institution › b - Ministry of Science and Technology
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標的蛋白降解技術: 含氮三環化合物為骨架利用有機金屬耦合反應合成系列衍生物
8/1/20 → 7/1/21
Project: A - Government Institution › b - Ministry of Science and Technology
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探討非選擇性與選擇性組蛋白去乙醯?抑制劑與免疫檢查點抑制劑合併治療之效用及其機轉(1/3)
8/1/20 → 7/1/21
Project: A - Government Institution › b - Ministry of Science and Technology
Research output
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CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition
Singh, A., Chang, T. Y., Kaur, N., Hsu, K. C., Yen, Y., Lin, T. E., Lai, M. J., Lee, S. B. & Liou, J. P., Apr 5 2021, In: European Journal of Medicinal Chemistry. 215, 113169.Research output: Contribution to journal › Article › peer-review
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Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms
Mehndiratta, S., Chen, M. C., Chao, Y. H., Lee, C. H., Liou, J. P., Lai, M. J. & Lee, H. Y., Dec 2021, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 36, 1, p. 74-84 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Erratum: TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis (Theranostics (2019) 9:22 (6676-6689) DOI: 10.7150/thno.34020)
Huang, H. L., Liu, Y. M., Sung, T. Y., Huang, T. C., Cheng, Y. W., Liou, J. P. & Pan, S. L., Jan 1 2021, In: Theranostics. 11, 5, p. 2079 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access
Datasets
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MOESM9 of Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning
Wong, H. (Contributor), Lin, Y. (Contributor), Lu, H. (Contributor), Liao, W. (Contributor), Chen, C. (Contributor), Wu, J. (Contributor), Chang, W. (Contributor) & Tsai, F. (Contributor), Unknown Publisher, Jan 1 2019
DOI: 10.6084/m9.figshare.10270469.v1, https://springernature.figshare.com/articles/MOESM9_of_Genomic_interrogation_of_familial_short_stature_contributes_to_the_discovery_of_the_pathophysiological_mechanisms_and_pharmaceutical_drug_repositioning/10270469/1
Dataset
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MOESM1 of Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning
Wong, H. (Contributor), Lin, Y. (Contributor), Lu, H. (Contributor), Liao, W. (Contributor), Chen, C. (Contributor), Wu, J. (Contributor), Chang, W. (Contributor) & Tsai, F. (Contributor), Unknown Publisher, Jan 1 2019
DOI: 10.6084/m9.figshare.10270427.v1, https://springernature.figshare.com/articles/MOESM1_of_Genomic_interrogation_of_familial_short_stature_contributes_to_the_discovery_of_the_pathophysiological_mechanisms_and_pharmaceutical_drug_repositioning/10270427/1
Dataset
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MOESM5 of Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning
Wong, H. (Contributor), Lin, Y. (Contributor), Lu, H. (Contributor), Liao, W. (Contributor), Chen, C. (Contributor), Wu, J. (Contributor), Chang, W. (Contributor) & Tsai, F. (Contributor), Unknown Publisher, Jan 1 2019
DOI: 10.6084/m9.figshare.10270451.v1, https://springernature.figshare.com/articles/MOESM5_of_Genomic_interrogation_of_familial_short_stature_contributes_to_the_discovery_of_the_pathophysiological_mechanisms_and_pharmaceutical_drug_repositioning/10270451/1
Dataset